Externally applied pharmaceutical composition of abafungin

A technology of abafungin and composition, which is applied in the field of pharmaceutical preparations to achieve the effects of alleviating skin lesions, novel action mechanism and inhibiting inflammatory response

Inactive Publication Date: 2007-05-30
CHONGQING PHARMA RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Adrenal cortex hormone drugs, with anti-inflammatory effects, no antifungal effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 cream

[0024] Formula: (1) Abafungin 10g, (2) Halcinonide 1g, (3) Vaseline 10g, (4) Stearic acid 110g, (5) Liquid paraffin 60g, (6) Glyceryl monostearate 35g , (7) propylparaben 0.2g, (8) stearyl alcohol 50g, (9) triethanolamine 4.5g, (10) methylparaben 1.8g, (11) di-tert-butylhydroxytoluene 2g, ( 12) Glycerin 40g, (13) sodium metabisulfite 10g, (14) ethylenediaminetetraacetic acid 1g, (15) add distilled water to 1000g.

[0025] Preparation method: put glycerin and sodium pyrosulfite into a mortar and grind them evenly, add abafungin and dexamethasone, grind them well, and set aside to obtain the main drug mixture ①; Vaseline, stearic acid, glyceryl monostearate , stearyl alcohol, liquid paraffin, and propylparaben, put in a water bath at 70-80°C to stir and dissolve to obtain an oil phase②; , distilled water, put in a water bath at 70-80°C, stir and dissolve to obtain the water phase ③; slowly add ② to ③, stir vigorously while adding to emulsify completely...

Embodiment 2

[0026] Implement 2 creams

[0027] Formula: (1) Abafungin 15g, (2) triamcinolone acetonide acetate 0.15g, (3) fludrosolone acetate 0.05g, (4) lanolin 45g, (5) acetylated monoglyceride 70g, (6 ) 60g of liquid paraffin, (7) 80g of cetyl alcohol, (8) 1.8g of ethylparaben, (9) 2g of sodium sulfite, (10) 35g of magnesium aluminum silicate, (11) add distilled water to 1000g.

[0028] Preparation method: mix lanolin, acetylated monoglyceride, liquid paraffin, and cetyl alcohol, place in a water bath at 65-75°C, stir and dissolve to obtain the oil phase ①; mix ethyl paraben, sodium sulfite, and magnesium silicate Put aluminum and distilled water in a water bath at 70-80°C to stir and dissolve to obtain the water phase ②; add ① while stirring ②, and cool; mix abafungin, triamcinolone acetonide, and fludroxone acetate to obtain the main drug mixture③ , Add the above-mentioned mixture of ①② to ③ in equal amounts, mix well, and fill it up, that is to say.

Embodiment 3

[0029] Embodiment 3 cream

[0030] Formula: (1) Abafungin 40g, (2) Betamethasone acetate 0.3g, (3) Glycerin 100g, (4) Stearyl alcohol 40g, (5) Glyceryl monostearate 35g, (6) Vaseline 100g, (7) Tween-8020g, (8) butylparaben 1.5g, (9) di-tert-butylhydroxytoluene 1.8g, (10) add distilled water to 1000g.

[0031] Preparation method: Mix stearyl alcohol, glyceryl monostearate, vaseline, and Tween-80, place in a water bath at 70-80°C, stir and dissolve to obtain the oil phase①; mix butylparaben, ditert-tert Butylated hydroxytoluene, mixed with distilled water, placed in a water bath at 70-80°C, stirred and dissolved, to obtain the water phase ②; while stirring ②, add ①; mix abafungin, betamethasone acetate, and glycerin evenly to obtain the main drug mixture ③; then add the above-mentioned ①② mixture in equal amounts to ③, mix evenly, fill it up, and you get it.

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PUM

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Abstract

The invention discloses an external compound abafenjing drug composition, which comprises the following parts: 0.01-20% abafenjing, 0.005-1% adrenal cortex hormone, medical auxiliary material and antibacterial material. The invention reduces the injury of infected skin, which can treat vaginal candidiasis and vulvopathy.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a compound abafungin pharmaceutical composition for external use, which contains an effective therapeutic dose of abafungin (abafungin) and adrenocorticosteroids, and is a compound with broad-spectrum antibacterial, anti-inflammatory and anti-itching effects. external preparations. The composition is used for treating skin fungus infection, pruritus, mixed infection of fungus and bacteria, vaginal candidiasis, vulvovaginitis (especially when bacteria are also involved), various dermatitis, and has almost no stimulating effect on the local area. Background technique [0002] Superficial mycosis is a kind of common disease, frequently-occurring disease. Superficial fungal infections are caused by dermatophytes such as Epidermophyton, Trichophyton, and Microsporum. All three can invade the skin, causing tinea manus, pedis, tinea corporis, jock itch, tinea imbricate, etc....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7056A61K31/5383A61K31/7036A61K31/573A61K31/58A61K45/06A61K47/00A61P15/02A61P17/00A61P31/10A61P31/02A61K31/425A61K31/351A61K31/345A61K31/165A61K31/155
CPCA61K31/155A61K9/0014A61K31/165A61K31/345A61K31/351A61K31/506A61K31/5383A61K31/57A61K31/573A61K31/58A61K31/7036A61K31/7056A61P15/02A61P17/00A61P31/02A61P31/10
Inventor 李佳张涛牟才华樊斌陈伟海
Owner CHONGQING PHARMA RES INST
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