This invention discloses a dressing for treating
atopic dermatitis, its preparation method, and its application, relating to the field of medical materials technology. The dressing for treating
atopic dermatitis is composed of PH
powder and Que@CD nanoparticles. The technical solution provided by this invention utilizes amino-rich ε-
polylysine and NHS ester-modified
hyaluronic acid for rapid cross-linking via an amidation reaction in a moist environment, forming a three-dimensional gel network encapsulating Que@CD nanoparticles. Utilizing the water
solubility of Que@CD,
quercetin can be rapidly released to relieve
itching. Simultaneously, it exerts anti-inflammatory and
antioxidant effects by
scavenging excess
reactive oxygen species, alleviating
oxidative stress, regulating the
immune microenvironment, and inhibiting the release of
inflammatory factors. Therefore, the dressing proposed in this invention possesses in-situ gelling properties and
drug burst release capability, enabling it to closely adhere to irregular
skin wounds and comprehensively exert
antioxidant, anti-inflammatory, and immunomodulatory effects.