531 results about "Quercitrin" patented technology

The invention relates to injectable hydrogel for rapid hemostasis and antibiosis of an oral cavity as well as a preparation method and application of the injectable hydrogel, and the injectable hydrogel comprises the following components in percentage by weight: 5-15% of aminated chondroitin sulfate, 5-15% of oxidized dextran, 1-3% of platelet-rich fibrin and 0.5-1% of quercetin modified zeolite imidazole acid framework nanoparticles. According to the invention, Chs-ADH and ODex are adopted as matrix materials, PRF and ZIF-8 (at) QCT are introduced, the hydrogel is endowed with antibacterial, anti-oxidation and immunoregulation functions, and by optimizing the proportion of the components, the obtained hydrogel has good injectability, stability and degradation resistance, so that the hydrogel can still maintain an effective blood coagulation function in a high-humidity and high-enzymatic-activity oral environment.

The invention relates to the technical field of exosomes, in particular to an exosome compound preparation with a hair growing effect and a preparation method of the exosome compound preparation. Comprising 12 to 22 parts of ginsenoside Rb1, 15 to 12 parts of biotin tripeptide-15, 8 to 15 parts of diammonium glycyrrhizinate, 50 to 70 parts of fish collagen peptide, 10 to 20 parts of soybean peptide, 0.5 to 4.5 parts of SHH protein, 0.5 to 2.5 parts of SMO inhibitor, 0.5 to 1.5 parts of HhSP protein, 5 to 10 parts of N-acetyl tyrosine, 0.1 to 2 parts of hyaluronic acid, 0.1 to 1 part of melatonin, 0.1 to 1 part of quercetin, 0.1 to 1 part of kaempferol, 0.1 to 1 part of tanshinone, 0.1 to 1 part of biotin and 0.1 to 1 part of vitamin A. The compound preparation is combined with exosomes from various sources, so that the hair papilla cell function is synergistically enhanced, and the damaged hair follicle structure is repaired.

The invention provides a gamma delta T cell preparation as well as a preparation method and application thereof, and belongs to the technical field of T cells. The liposome is prepared from the following raw materials in parts by weight: 15-20 parts of modified gamma delta T cell liposome, 1-3 parts of cell stimulating factors and 4-7 parts of culture medium freeze-dried powder, the modified gamma delta T cell lipidosome is prepared by embedding gamma delta T cells through lipidosome, coupling with acetylenic bond modified chitosan, and further mixing with MFAP4 protein and b4GALT1 protein. The culture medium freeze-dried powder is prepared by freeze-drying the culture medium in the engineering culture process of gamma delta T cells, and the cell stimulating factors are resveratrol and quercitrin. According to the gamma delta T cell preparation prepared by the invention, the survival ability and resistance of gamma delta T cells are improved, the anti-tumor activity of the gamma delta T cells is improved, and the gamma delta T cell preparation has relatively good antioxidant and anti-inflammatory effects, reduces the inhibition of inflammation on an immune system and has a very good treatment effect on pancreatic ductal adenocarcinoma.

The application discloses a galactosyltransferase mutant and application thereof in preparation of flavonoid compounds, and belongs to the technical field of enzymology. The application provides a UDP-galactosyltransferase mutant, which is obtained by site-directed mutation of one amino acid in the amino acid sequence of wild-type galactosyltransferase VcUFGT into alanine (A). The effects of a series of mutants H82A, V139A, G141A, P186A, N245A, V282A and S307A are verified in the examples, the mutants can perform enzyme catalysis reaction with quercetin and UDP-galactoside as substrates, and generate flavonoid compound hyperoside, and the specific enzyme activity of the mutants is more than 1.5 times that of the wild type, thereby providing an effective application basis for biosynthesis of flavonoid compounds.

The invention discloses gallium ion-quercetin coordination nanoparticles (GQNPs) as well as a preparation method and application thereof, specifically, quercetin, gallium nitrate hydrate and polyvinylpyrrolidone are respectively dissolved in an absolute methanol solution to prepare a quercetin solution, a gallium nitrate hydrate solution and a polyvinylpyrrolidone solution; secondly, fully mixing the quercetin solution and the polyvinylpyrrolidone solution, dropwise adding the gallium nitrate hydrate solution, and rapidly changing the color of the mixed solution from faint yellow to orange yellow in the dropwise adding process; and finally, dialyzing the orange-yellow mixed solution to remove excessive gallium ions and polyvinylpyrrolidone, thereby finally obtaining the GQNPs. The prepared GQNPs and deferiprone show excellent treatment effects on cell and living body levels, are expected to be applied to treatment of Parkinson's disease through multi-dimensional anti-ferroptosis, do not show obvious toxic and side effects in the embodiment, and are expected to be applied to further preclinical research.

The invention provides a stem cell culture medium and a preparation method and application of a stem cell exosome with oxidation resistance. The stem cell culture medium comprises baicalin, quercetin, liquiritin and catechin. According to the stem cell culture medium provided by the invention, a mixture of baicalin, quercetin, liquiritin and catechin is adopted as a component of the culture medium to stimulate the stem cells, and the oxidative stress state of the stem cells is changed, so that the stem cells can secrete exosomes with an antioxidant effect, and the secreted exosomes have higher antioxidant capacity. The corresponding stem cell exosome is relatively excellent in the aspect of oxidation resistance.

The invention discloses application of a glucosyl modified quercetin derivative and a composition containing the glucosyl modified quercetin derivative. Specifically, the invention discloses an application of glucosyl modified quercetin as an anti-skin photoaging agent. According to the application disclosed by the invention, glucosyl modified quercetin, especially glucosyl modified isoquercitrin, has a remarkable effect in the aspect of resisting skin photoaging; cosmetics prepared from glucosyl modified quercetin have good anti-aging ability, and can significantly improve percutaneous water loss, skin elasticity and skin roughness.

The invention discloses a glycosylated quercetin amphiphilic prodrug, a preparation method and application of the glycosylated quercetin amphiphilic prodrug. The glycosylated quercetin amphiphilic prodrug, the preparation method of the glycosylated quercetin amphiphilic prodrug and the application of the glycosylated quercetin amphiphilic prodrug are included. According to the glycosylated quercetin amphiphilic prodrug as well as the preparation method and the application thereof, the pH-sensitive glycosylated quercetin amphiphilic prodrug is obtained through parallel connection of the boric acid ester and the hydrophilic targeting sugar molecule lactobionic acid and the hydrophobic quercetin, and the pH-sensitive glycosylated quercetin amphiphilic prodrug and clinical common anti-tumor drugs are further assembled into a nano-drug; the invention aims at improving the physicochemical / pharmacological activity of quercetin and exploring the anti-tumor effect of quercetin cooperating with clinical drugs at the same time. The glycosylated quercetin amphiphilic prodrug is designed according to a drug combination principle, a formula 3 is used as a substrate, molecular quercetin is combined to obtain the glycosylated quercetin amphiphilic prodrug, and pH-sensitive borate bonds are introduced, so that drug release and tumor resistance can be controlled, the drug has certain targeting property, and the biological activity is remarkably improved.

The invention belongs to the technical field of quality control of traditional Chinese medicines, and particularly relates to a method for establishing a fingerprint spectrum of kidney-tonifying and anti-aging tablets. The establishment method of the fingerprint spectrum of the kidney-tonifying anti-aging tablet comprises the following steps: mixing the kidney-tonifying anti-aging tablet and a methanol aqueous solution, and carrying out ultrasonic treatment to obtain a test solution; reference substances in the mixed reference substance solution comprise ferulic acid, hyperoside, quercitrin, hesperidin, rosmarinic acid and salvianolic acid B; and respectively carrying out UHPLC detection on the test solution and the mixed reference substance solution, and introducing obtained chromatograms into fingerprint spectrum software for processing to obtain the fingerprint spectrum of the kidney-tonifying and anti-aging tablets. The pretreatment method is simple, and the characteristic components of the kidney-tonifying and anti-aging tablet are completely reserved; the ultra-high performance liquid chromatography is adopted, so that the precision is high, the reproducibility is good, and the stability is good; according to the fingerprint spectrum obtained by the invention, 15 common peaks are determined, so that the overall characteristics of the kidney-tonifying and anti-aging tablet can be reflected, and the quality of the kidney-tonifying and anti-aging tablet can be effectively monitored.

The invention relates to an exosome-coated phosphorus-containing dendrimer nano-composite as well as a preparation method and application thereof. The nano-composite is prepared from exosome derived from mesenchymal stem cells, a hydroxyl-terminal phosphorus-containing dendrimer and quercetin. The exosome derived from the mesenchymal stem cells is used as a carrier, so that not only are good biocompatibility and anti-inflammatory activity achieved, but also the bioavailability of the phosphorus-containing dendrimer and quercetin can be improved. The phosphorus-containing dendrimer and quercetin exert anti-inflammatory and anti-oxidation effects by promoting microglial cells to be polarized to M2 type and removing active oxygen, so that neuronal cells are protected from apoptosis. The preparation method has the advantages of being simple, easy to operate, good in biocompatibility and the like, and the provided strategy has good development prospects and application values in treatment of Parkinson's disease or other neurodegenerative diseases.

The invention belongs to the technical field of chemical drugs, and particularly relates to application of a polyphenol composition in preparation of drugs for treating inflammatory bowel diseases and the drugs. The polyphenol composition contains isorhamnetin, kaempferol, quercetin, ferulic acid and caffeic acid, and has an obvious anti-inflammatory effect on the inflammatory bowel disease; when the composition is used as a medicine for treating the inflammatory bowel disease, the treatment cost can be reduced, and the composition is effective in treating the inflammatory bowel disease and small in toxic and side effects after being taken for a long time.

The invention belongs to the technical field of biological medicines, and particularly relates to application of quercetin combined with curcumin in preparation of an anti-allergic reaction medicine. Through a large number of researches, the inventor finds that combined administration of quercetin and curcumin with a specific concentration can effectively inhibit mast cell degranulation, and the inhibition rate of mast cell degranulation reaches 90% or more, so that I-type anaphylaxis mediated by immune globulin E is inhibited, especially systemic anaphylaxis, and the curative effect is good. The compound can be used for preparing anti-anaphylaxis drugs. The drug combination scheme provided by the invention has important significance and wide application prospect in drugs for treating or preventing anaphylactic reactions.

The invention belongs to the technical field of medicines, and particularly relates to a flavonoid compound-meglumine co-amorphous substance and a preparation method thereof. The flavonoid compounds comprise baicalein, hesperetin, naringenin, kaempferol, quercetin, isoliquiritigenin and the like, and the co-amorphous substance consists of a single flavonoid compound and meglumine and is prepared by adopting a melting shock cooling method or a rotary evaporation method. The miscibility of the flavonoid compounds and the meglumine is screened through Hansen solubility. The crystal diffraction characteristics, thermodynamic properties and intermolecular interaction of the co-amorphous substance are measured through PXRD, DSC and FTIR, and it is shown that the six flavonoid compounds and meglumine successfully form a co-amorphous system. The solubility and the dissolution rate of the six flavonoid compound-meglumine co-amorphous substance are obviously superior to those of flavonoid bulk drugs, and the physical stability of the formed co-amorphous substance is obviously superior to that of a single amorphous drug, so that the co-amorphous substance shows good patent medicine performance.

The invention is applicable to the technical field of biomedicine, and provides a preparation method and application of a multifunctional nano composite material. The material has good biocompatibility and can be used as a safe preparation for tumor treatment; the preparation is simple, green and pollution-free; the application of the quercetin in anti-tumor immunotherapy is expanded; the probe has excellent fluorescence / computed tomography dual-mode imaging performance, and can be used for determining tumor boundaries and realizing accurate treatment guidance; the nano-material has excellent photo-thermal and photo-thermal enhanced catalytic performance, has the advantages of being minimally invasive, efficient, small in toxic and side effect, controllable and the like, and can effectively treat primary, metastatic or recurrent head and neck squamous cell carcinoma by activating immunity; by inducing tumor cells to release 2 '3'-cGAMP and preventing the 2 '3'-cGAMP from being degraded, a cGAS-STING signal channel is efficiently activated, and finally the anti-tumor immune effect is enhanced.

The invention discloses a preparation method of linolenic acid structural ester with synergistic biological activity, and relates to the technical field of linolenic acid structural ester preparation.The preparation method comprises the steps that specific lipase is prepared through rhizopus wei, and after an SBA-15 molecular sieve is treated, the lipase is fixed to prepare a composite catalyst; the preparation method comprises the following steps: after hydroxyl protection of quercetin, esterifying quercetin with EPA to obtain quercetin-EPA ester; esterifying glycerol and linolenic acid in the presence of a composite catalyst and microwaves, and purifying to obtain an intermediate product; carrying out microwave catalytic ester exchange on the intermediate product and quercetin-EPA ester in tert-butyl alcohol through a composite catalyst to obtain a crude product; and removing impurities from the crude product by a urea adduction method, and carrying out molecular distillation graded purification, column chromatography, deodorization and filtration to obtain a final product. According to the invention, linolenic acid, quercetin and EPA are combined through molecular design to form a compound structure ester with a multi-target effect, and the linolenic acid, quercetin and EPA achieve functional complementation through a synergistic effect, so that the biological activity of the compound structure ester is enhanced.

The invention belongs to the technical field of chemical drugs, and particularly relates to application of a polyphenol composition containing gallic acid to preparation of drugs for treating inflammatory bowel diseases and the drugs. The polyphenol composition contains caffeic acid, ferulic acid, gallic acid, hesperidin, isoquercitrin, isorhamnetin, kaempferol, protocatechuic acid and quercetin, and has an obvious anti-inflammatory effect on the inflammatory bowel disease; when the composition is used as a medicine for treating the inflammatory bowel disease, the treatment cost can be reduced, and the composition is effective in treating the inflammatory bowel disease and small in toxic and side effects after being taken for a long time.

The invention relates to the technical field of biology, in particular to an inducer for promoting exosome secretion and application of an exosome. The inducer comprises the following three components: N-methyldopamine hydrochloride, quercetin and ascorbic acid, has the advantages of stable effect and simplicity in use, can increase the yield of exosomes by at least 3-5 times when the umbilical cord mesenchymal stem cells in a good state are subjected to induction culture, and has a remarkable effect of promoting the secretion of the exosomes in the stem cells. In addition, the engineering exosome which is derived from the umbilical cord mesenchymal stem cells and simultaneously contains miR-125b-5p, miR-126-3p, miR-146a and miR-542-3p is prepared through an electroporation transfection technology, animal experiment results show that the engineering exosome has a wound repairing effect, and the comprehensive application of an inducer and an electrotransformation technology has relatively high application value; popularization and application are facilitated.

The invention relates to the technical field of traditional Chinese medicine analysis, in particular to a method for determining the content of five flavonoid components in a hypericum perforatum medicinal material. The content determination method comprises the following steps: preparing rutin, hyperoside, isoquercitrin, quercitrin and quercetin into a mixed reference solution; extracting a hypericum perforatum medicinal material by using an extraction solvent to prepare a test solution; the mixed reference substance solutions and the test solution with different volumes are subjected to high performance liquid chromatography respectively, a mobile phase A is acetonitrile, a mobile phase B is a phosphoric acid aqueous solution with the volume concentration of 0.08-0.12%, and elution gradient is adopted. The content determination method has the advantages of high sensitivity, simplicity and convenience in operation, low cost and high detection speed.

The invention discloses a rapid quantitative detection method for quantitative analysis of multi-components by single marker (QAM) of a pharmaceutical composition containing three-ingredient rhizoma polygonati decoction, and belongs to the technical field of detection and analysis. Specific components of the traditional Chinese medicinal materials in the medicine composition containing the three-component rhizoma polygonati decoction are quantified, three components of the three traditional Chinese medicinal materials are quantified, and determination is carried out under two detection wavelengths in a gradient elution mode. The detection wavelength is as follows: the 5-hydroxymethylfurfural is 270nm, the quercetin-3-O-gentiobioside and the isorhamnetin-3-O-gentiobioside are 330nm, the wave crests are appropriate in size, the 5-hydroxymethylfurfural, the quercetin-3-O-gentiobioside and the isorhamnetin-3-O-gentiobioside do not interfere with each other, the quantitative analysis of multiple components by one marker is realized, and the method is simple, convenient, rapid, accurate, low in cost, high in efficiency and beneficial to market supervision.

The invention belongs to the technical field of biological medicine, and particularly relates to an extracellular vesicle drug delivery system, a preparation method thereof and application of the extracellular vesicle drug delivery system in treatment of Alzheimer's disease. According to the invention, one or more of stilbene glucoside, emodin, kaempferol, resveratrol and quercetin are used for regulating and controlling the expression of miRNA (micro Ribonucleic Acid) related to the disease progress in the extracellular vesicles, and the result shows that one or more of miR-let-7c-5p, miR-486-5p, miR-132-3p, miR-160b and miR-129-5p is remarkably up-regulated, and one or more of miR-342-3p, miR-16-5p and miR-125b-5p is remarkably down-regulated. The regulated extracellular vesicles can be used for treating Alzheimer's disease, relieving Tau protein abnormal phosphorylation, reducing amyloid protein beta deposition, inhibiting microglial cell activation, protecting neuronal cells and relieving memory deficits.

The invention provides an antibacterial, anti-inflammatory and osteogenesis-promoting two-dimensional bimetallic MOF (Metal Organic Framework) as well as preparation and application thereof. The two-dimensional bimetal MOF can effectively resist bacteria and inflammation, has good biological safety and long-acting function exerting capacity, can efficiently remove bacteria under the action of low-strength medical US before degradation, and can exert the function of removing ROS through nano-enzyme activity. After degradation, copper and manganese ions slowly released by the two-dimensional bimetal MOF and quercetin can be chelated, SOD and CAT-like effects are achieved through metal-ion charge transfer MLCT, the ROS adsorption effect can be continuously achieved, and in addition, due to the fact that the copper and manganese ions and quercetin have osteogenesis and antibacterial effects, bone tissue repair can be continuously and efficiently promoted.

The invention relates to a multi-targeting nanogel drug and application thereof in relieving neuroinflammation and promoting spinal cord injury repair, the multi-targeting nanogel drug comprises quercetin-loaded liposome, the quercetin-loaded liposome comprises TAT peptide and CAQK peptide, the quercetin-loaded liposome is incorporated into double-network gel, and the double-network gel is used as a drug carrier. The dual-network gel is jointly formed by a dopamine grafted hyaluronic acid polymer and methacrylated gelatin. The multi-targeting nanogel drug can improve the dissolving property of quercetin, reduce toxic and side effects, promote targeting of an injured part, and contribute to passing through a blood spinal cord barrier, so that the integrity of the blood spinal cord barrier is protected, the spinal cord microenvironment is optimized, formation of glial scars is reduced, axon regeneration is promoted, and the recovery of a motor function is enhanced.

The invention relates to the technical field of medical sutures, and particularly discloses a PDO barb suture with an antibacterial coating and a preparation method of the PDO barb suture. According to the PDO barb suture line with the antibacterial coating, a PDO mixed suture line base body with good mechanical performance is obtained by blending, spinning and weaving L-polylactic acid and poly (p-dioxanone) according to a certain proportion; hyaluronic acid is used as a gel matrix, 4-(oxirane-2-yl methoxyl) butyl acrylate is grafted to hyaluronic acid for alkenyl modification, then the hyaluronic acid is mixed with quercetin-3-O-glucoside and TCS-ZIF-8 loaded with oridonin, and the antibacterial gel coating is obtained. And finally, dipping the PDO mixed suture line matrix into the antibacterial gel coating and carrying out ultraviolet irradiation in the presence of a photoinitiator to prepare the PDO mixed suture line. The suture line prepared by the invention has the advantages of smooth coating, efficient and lasting antibacterial performance, high strength, good flexibility, small friction force and high operability.

The invention belongs to the technical field of supramolecules, and discloses a supramolecule constructed by quercetin and ergothioneine as well as a preparation method and application of the supramolecule. The preparation method of the supramolecule constructed by quercetin and ergothioneine comprises the following steps: respectively dissolving quercetin and ergothioneine in a solvent to obtain a quercetin solution and an ergothioneine solution; the preparation method comprises the following steps: adding an ergothioneine solution into a quercetin solution in an inert atmosphere, mixing, carrying out an ionizing salt formation reaction under a heating condition, concentrating, distilling, crystallizing, filtering, washing and drying to obtain the supramolecule constructed by quercetin and ergothioneine. According to the invention, quercetin is taken as an anion precursor, ergothioneine is taken as a cation precursor, the supramolecular quercetin-ergothioneine is synthesized through ionizing salt formation reaction, the supramolecular quercetin-ergothioneine has excellent biocompatibility, solubility, skin permeability and high bioavailability, a host molecular skeleton of a quercetin monomer is completely reserved, and the supramolecular quercetin-ergothioneine can be used for preparing the supramolecular quercetin-ergothioneine. Meanwhile, the quercetin and ergothioneine compound has biological activity and effects of quercetin and ergothioneine.

This invention relates to the fields of enzyme engineering and genetic engineering, specifically to the α-L-rhamnosidase BtRha78A mutant, its preparation method, and its applications. The amino acid sequence of the mutant differs from the BtRha78A enzyme shown in SEQ ID NO.1 by a single amino acid mutation: the phenylalanine at position 44 is mutated to aspartic acid or serine. The mutant of this invention exhibits higher catalytic efficiency in a shorter time, providing theoretical guidance for the industrial-scale production of isoquercetin from the large-scale hydrolysis of rutin.

A method for constructing a chicory-poria compound fingerprint, comprising: (1) preparing a test solution from a chicory-poria compound; (2) using chlorogenic acid, 6'-O-β-D-glucosylgentiopicroside, swertiamarin, gentiopicroside, sweroside, 3-O-caffeoylshikimic acid, neoastilbin, astilbin, rutin, isoastilbin, isochlorogenic acid C, quercitrin, kaempferol-3-O-rutinoside, and narcissin to prepare a mixed reference solution; and (3) respectively injecting the test solution and the mixed reference solution into a high performance liquid chromatograph, and performing similarity analysis on the obtained chromatograms to obtain a chicory-poria compound fingerprint. Also provided is a use of the chicory-poria compound fingerprint obtained by means of the construction method in identifying and / or evaluating the quality of a chicory-poria compound. The quality of the chicory-poria compound can be comprehensively, objectively and accurately tested and evaluated, thereby ensuring the safety and effectiveness of patient medication.

The invention belongs to the technical field of pest control, and discloses application of a nitrogen-containing heterocyclic compound in control of ampullaria gigas. According to the invention, a nitrogen-containing heterocyclic compound with the activity of killing ampullaria gigas is screened by taking ampullaria gigas arginine kinase as an action target, and the nitrogen-containing heterocyclic compound is N-[4-(3, 5-diphenyl-4, 5-dihydro-1H-pyrazole-1-yl) benzyl]-N-(1-hexyl-1H-benzimidazole-2-yl) amine. The nitrogen-containing heterocyclic compound is used as an active component to be prepared into a suspending agent or a granule, the suspending agent or the granule has an excellent killing effect on ampullaria gigas, and compared with an existing arginine kinase inhibitor quercetin, the nitrogen-containing heterocyclic compound is higher in activity, good in selectivity, low in toxicity to vertebrates and huge in application potential.

The invention belongs to the technical field of preparation of sepsis acute lung injury drugs, relates to a novel quercetin drug delivery system or dosage form, and particularly relates to a quercetin-loaded TPP-PEG-PCL nano microcapsule as well as a preparation method and application thereof. The preparation method comprises the following steps: by taking (3-carboxypropyl) triphenylphosphonium bromide, polyethylene glycol-b-polycaprolactone, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hydroxysuccinimide as raw materials, preparing a TPP-PEG-PCL (Triphenyl Polyethylene Glycol-Polycaprolactone) nano-micelle; and then loading the quercetin on the TPP-PEG-PCL nano-micelle, so as to obtain the TPP-PEG-PCL nano-microcapsule loaded with the quercetin. The quercetin-loaded TPP-PEG-PCL nano-micelle obtained by the method disclosed by the invention is used as a quercetin drug delivery system to be applied to preparation of drugs for treating acute lung injury caused by sepsis.

The invention provides an anti-aging composition as well as a preparation method, a skin care product and application thereof. The anti-aging composition is prepared from a C6-C3-C6 skeleton compound, cationic amino acid and beta-alanyl hydroxyprolyl diaminobutyric acid benzylamine. The C6-C3-C6 structural compound is natural plant extracts such as quercetin, baicalin and the like, and has excellent oxidation resistance and high safety. Cell and in-vitro experiments prove that the combined action of the three components can effectively reduce the generation of reactive oxygen species (ROS) and enhance the anti-inflammatory action, thereby delaying the cell senescence process. On the basis, carbon dioxide is injected into the anti-aging composition, so that the anti-oxidation and anti-inflammatory capacities of the anti-aging composition are further improved. In addition, the preparation process of the anti-aging composition is simple, the safety and the anti-aging performance of the anti-aging composition are evaluated through various cell experiments and human body trials, and the anti-aging composition is suitable for human skin and can be widely added into various skin care products such as face cream, emulsion and essence.

The invention belongs to the field of hydrogel wound dressings, and particularly relates to hydrogel with anti-infection and drug-loaded slow-release functions, a preparation method and application. Based on HA-PBA (hyaluronic acid-phenylboronic acid) and four-arm PEG dopamine as a skeleton, the hydrogel dressing is formed through boric acid ester bond crosslinking; antibacterial peptides and drug-loaded micelles are doped in the hydrogel dressing, and the micelles load quercetin, so that the hydrogel dressing has a slow release function. The antibacterial peptide is combined with cell membranes of bacteria through the charge effect, the powerful anti-infection function is achieved, and breeding and colonization of pathogenic bacteria can be effectively inhibited. Quercetin plays an anti-inflammatory role through an Akt / STAT6 pathway, inflammatory response can be remarkably reduced, and tissue repair is promoted. In addition, the hydrogel has good biocompatibility and mechanical properties, and can provide a suitable moist environment for wounds and promote healing.