419 results about "Quercitrin" patented technology

The invention relates to a hollyhock sunflower chromocor extractive, wherein it is characterized in that: the chromocor content is 50-90%; the chromocor comprises 1. 0-5. 0% meletin-3-acacia glycoside, 8-24. 0% hyperin, 7. 0-20.0% isoquercitrin, 5. 0-15. 0% meletin-3-glucosidase, 3. 0-10.0% cotton-3-glucosidase, 0.5-5. 0% gale element, 0.5-5. 0% cotton, and 2. 0-8. 0% meletin, etc. The inventive extractive can be used to prepare the drug that treats nephritis, with high reliability.

The invention relates to application of an alpha-L-rhamnoside enzyme in the directional synthesis of isoquercitrin by the biological conversion of rutin. Because the crude enzyme preparation or the immobilized enzyme preparation of the alpha-L-rhamnoside enzyme is used for catalyzing and hydrolyzing the rutin and directionally and biologically synthesizing the isoquercitrin, the application has the advantages of wide source, easy preparation and low cost of catalysts, high stability, and high catalysis efficiency and specificity of the enzyme preparation, and is easy to store. Thus, the alpha-L-rhamnoside enzyme can greatly reduce the production cost of quercetin, the catalysis and conversion rate of the enzymes is high, and the products are single.

Methods and compositions are described that comprise pyrone analogs such as flavonoids and cyclodextrins including quercetin and quercetin derivatives and sulfoalkyl ether cyclodextrins. In some cases the compounds of the invention are administered with a therapeutic agent such as an analgesic. In some cases, treatment with the compositions of the invention can result in the modulation of central nervous system and / or fetal effects of substances. Methods and compositions are described for the modulation of efflux transporter activity to increase the efflux of drugs and other compositions out of a physiological compartment and into an external environment. In particular, the methods and compositions disclosed herein provide for the increase of efflux transporter activity at blood-brain, blood-CSF and placental-maternal barriers to increase the efflux of drugs and other compositions from physiological compartments, including central nervous system and fetal compartments.

An extract from Sunset Abelmoschus, containing 50-75wt% of total flavone counted by hyperin, wherein, the contents of hyperin, isoquercitrin and quercetin-3'-glucoside are 10.0-15.0wt%, 7.0-12.0wt% and 8.0-12.0wt% respectively, and a total flavone finger-print is provided. The extract is obtained by the following steps: a concentrated solution of a Sunset Abelmoschus ethanol extract undergoes chromatography through an HPD400 or HPD700 macroporous absorbent resin column to derive a crude extract or is extracted by normal butanol to derive the crude extract; a refined extract is obtained by refluxing extraction with ethyl acetate-ethanol azeotropic mixture or ethyl acetate-methanol mixture; the refined extract goes through pressure reducing exsolution and drying. Corresponding contents and a method for detecting finger-print are also provided. The extract preparation is a dripping pill, tablet, capsule or soft capsule obtained through processing with the extract as an active ingredient and pharmaceutical excipients. The extract can be used for preparing a medicine preparation for treating cardiac anencephalohemia diseases.

The invention discloses a quercetin drug-loading system based on a copper sulphide-metal organic frame material. A metal organic frame zeolite imidazolate framework material (ZIF-8) is generated on the surfaces of copper sulphide nano-particles (CuS NPs) as a photothermal preparation to obtain a CuS@ZIF-8 carrier, quercetin is adsorbed into a carrier, and then is modified by a stabilizer and a targeting agent FA-BSA, and thus, a nano delivery system (FA-BSA / CuS@ ZIF-8) with a targeting active effect and pH response can be formed. The water solubility and the chemical stability of the quercetinare improved, good curative effect of treating tumors by combination of phototherapy and chemotherapy can further be played, meanwhile, drug can be rapidly released under the condition of low pH in atumor microenvironment, the tumor cell intake of a pharmaceutic preparation is further enhanced, and the quercetin drug-loading system based on the copper sulphide-metal organic frame material has low toxicity to normal cells, and is good in biological compatibility.

The invention discloses an effective part of stevia and the activity and the application thereof. The effective part mainly comprises stevioside category and flavone category which are obtained by extracting and separating from dried stevia leaves, wherein the sum of the percentage content of the stevioside components in the stevioside part is 5 to 100 percent (w / w), and the stevioside components mainly contains the stevioside, stevibioside, rebaudioside A, B, C, D, E, and F, dulcoside A and the derivative thereof, etc.; the sum of the percentage content of the flavone components in the flavone part is 5 to 100 percent (w / w), and the flavone components mainly contains luteolin, quercetin, luteolin-7-O-Beta-D-glucoside, apigenin-7-O-Beta-D-glucoside, quercitrin, quercetin-3-O-Beta-D-arabinoside, quercetin-3-O-(4-O-anti form-caffeoyl acyl-Alpha-L-rhamnose-(1 to 6)-Beta-D-galactoside) and the derivative thereof, etc., and 4, 5-dicaffeoylquinic acid and the derivative thereof, etc. The effective part has significant sugar-reducing and fat-reducing effects, can be used singly or combined with any other Chinese medicines and Western medicines or foods in any proportion, is used for preparing medicines or functional foods, and is used for treating hyperglycemia and hyperlipoidemia.

The invention relates to a method for preparing osmanthus wine. Cereal raw materials are soaked and stewed, quyao is added for solidifying and saccharifying the raw materials, osmanthus soused by fresh osmanthus or white sugar is added to well saccharified flavor according to the content of 2 to 6 percent of cereal raw materials by weight, and the step of pit entry solid fermentation of blended grains is carried out; and well fermented grains are distilled and taken out to be stored with original degree in an oak barrel for three or more years, thereby obtaining the osmanthus wine. The osmanthus wine prepared by the method of the invention belongs to fermented and distilled osmanthus wine, the distilled wine is stored in the oak barrel for three or more years, and oaken quercitrin enters into the wine during storage. The wine is golden yellow transparent liquid, is glittering and translucent, and has pleasing and harmoniously mixed osmanthus fragrance, alcoholic fragrance and oaken fragrance and sweet and refreshing mouthfeel, the osmanthus fragrance thereof is naturally and harmoniously mixed with the wine fragrance, and the osmanthus wine is not provided with any spice and food addiitive and has high drinking safety; and the invention integrates Chinese white spirit and international distilled liquor into a whole, and can enable the Chinese wine to step into the international market.

The invention discloses an artemisia sacrorum extract which contains total-flavone compounds, wherein the total-flavone compounds comprise one or more of 6-methoxy-quercetagetin-7-O-beta-D-glucoside, quercetin-3-O-beta-D-glucoside, isorhamnetin, queretagetin-3-O-beta-D-glucoside, acacetin-7-O-beta-D-glucoside, rutin, 5,7,4'-trihydroxyflavone, 3,3',4',5,7-pentahydroxyflavone, 5,7,4'-trihydroxy-3'-methoxyflavone, kaempferol, 3,5,7,4'-tetrahydroxy-6-methoxyflavone, 3',4',5,7-tetrahydroxyflavone, 5,7,4'-trihydroxy-6,3'-dimethoxyflavone, 5,7,4'-trihydroxy-6-methoxyflavone, quercitrin, 7,3',4'-trimethyl quercetin, 5-hydroxy-7,4'-dimethoxyflavone, 5,4'-dihydroxy-7-methoxyflavone genkwanin, 5,7-dihydroxy-4'-methoxyflavone, 5,7,3'-dihydroxy-4-methoxyflavone and derivatives. The artemisia sacrorum extract has remarkable prevention and treatment effects on liver injury.

The present invention is kinder leaf total flavone extract and its preparation process and application, and features that the kinder leaf total flavone extract contains total flavone in 50-95 %, including rutin 0.2-30.0 %, hyperin 0.5-30.0 %, isoquercitrin 10.0-30.0 %, trifolin 3.0-20.0 %, astragaloside 2.0-5.0 %, 6''-O-acetyl isoquercitrin 1.0-6.0 %, quercitrin 0.5-4.0 %, trifolitin 0.2-3.0 %, etc. The kinder leaf total flavone extract is applied in preparing medicine for treating cardiac and cerebral ischemia.

The invention relates to a method for detecting mercury ions by nucleic acid aptamer based photoelectrochemistry. An On-Off type nucleic acid aptamer based photoelectrochemical sensor is adopted for detecting the mercury ions with different concentrations and is constructed based on quercetin copper sensitization perylene tetracarboxylic-oxidized graphene heterojunction. Based on double advantages of a quercetin copper compound as a photosensitizer and a reducing agent, the method can be used for double amplifying photoelectrical signals, and has the characteristics of being convenient, simple, super sensitive, economical, high in specificity and the like. The constructed On-Off type nucleic acid aptamer based photoelectrochemical sensor adopts current-time technology to detect the mercury ions with different concentrations in a 0.1 mol / L phosphate buffered solution at the offset electric potential of 0.2V and under optical radiation of more than 450 nm.

The present invention discloses a quercetin metal nano drug and a preparation method and an application thereof. In the provided quercetin metal nano drug, quercetin and transition metal elements arecoordinated by coordination bonds, and the quercetin metal nano drug is formed by surface modification of polymers containing carbonyl groups or hydroxyl groups. The nano drug is a multifunctional nanomaterial with a tumor targeting function, can inhibit growth, invasion, metastasis, recurrence, etc. of tumor cells, even eliminates the tumor cells, and has various modes of preventing the tumors such as photothermal therapy, photodynamic therapy and radiation therapy. In addition, when the nano drug is degraded and metabolized in vivo, a produced quercetin molecule can exert the anti-tumor effect for a longer period of time, aggregation, distribution and metabolism in vivo can also be traceable, an excellent diagnosis and treatment integrated nano-platform can be formed, and the quercetin metal nano drug has a good application prospect and a broad development space in the field of medicines.

The invention discloses a rice continuous cropping disease-resistant yield increase agent and relates to a high-yield rice cultivation technology. The rice continuous cropping disease-resistant yield increase agent comprises the raw materials in parts by weight; 30-35 parts of turf, 30-35 parts of biogas residues, 15-20 parts of ammonium humate, 5-8 parts of sodium silicate, 1-3 parts of magnesium amino acid chelate, 1-3 parts of zinc amino acid chelate, 1-3 parts of manganese amino acid chelate, 1-3 parts of boric amino acid chelate, 1-3 parts of rare earth nitrate, 0.5-3 parts of dicyandiamide, 1-3 parts of polyaspartic acid, 1-2 parts of bacillus subtilis, 1-2 parts of verticillium chlamydosporium and 0.5-2 parts of quercitrin. The rice continuous cropping disease-resistant yield increase agent has the beneficial effects that the feeding amounts of organic fertilizers and organic matters are greatly increased, and medium elements and trace elements are comprehensively supplemented; a proper amount of agricultural rare earth is applied, and the soil nutrition environment is improved; sodium silicate serving as a lodging-resistant agent, dichloramine serving as a nitrogen solidifier and the polyaspartic acid serving as an activation growth promoting agent are used; meanwhile, microbial agents such as the bacillus subtilis and the verticillium chlamydosporium are applied, and an insecticide such as the quercitrin is also applied, so that the continuous cropping diseases of rice can be comprehensively treated, and the aims of rice continuous cropping disease resistance, high quality and high yield are fulfilled.

A composition including an aliquot of the herb Herba Epimedii; and an aliquot of at least three supplemental herbs selected from the group consisting of Fructus Rosae Laevigatae; Fructus Rubi; Fructus Psoralea; Radix Morindae Officinalis; Fructus Schisandrac Chinensis; Fructus Ligustri Lucidi; Semen Cuscutae; and Radix Astragali. A composition including icariin; ursolic acid; ellagic acid; psoralen; deoxyschizandrin; oleanolic acid; quercetin; aslvagaloside; and an extract of the herb Radix Morindae Officinalis. Methods including administering a composition directed at treatment of various kidney disorders or the promotion of kidney health and to the overall health of the kidney, including the use of a composition in the treatment of prostate cancer, prophylatic prostate health, reduction of polyuria, incontinence, proteinuria, as well as for sexual satisfaction.

The invention discloses a preparation method of a quercetin amide derivative and application of the quercetin amide derivative in preparing an antitumor drug. The preparation method of the quercetin amide derivative comprises the following steps of: carrying out benzyl selective protection, a Williamson ether forming reaction, a DCC (Dicyclohexylcarbodiimide) condensation reaction, catalytic hydrogenation and the line by using cheap rutin as the material. The preparation method of the quercetin amide derivative can be used for realizing the orientation and efficient modification of the quercetin, and is gentle in reaction conditions, simple to operate, simple in post-treatment and convenient for industrial production. The obtained quercetin amide derivative obviously has a stronger inbibitional effect to proliferation of a human esophageal squamous carcinoma cell EC (Ethyl Cellulose)109, a human esophageal squamous carcinoma cell EC9706, a human gastric carcinoma cell SGC (Soluble Guanylyl Cyclase) 7901 and a mouse melanoma cell B16-f10 relative to the quercetin, and therefore, the quercetin amide derivative is an anti-tumor candidate compound with great potential.

The invention relates to a preparation method and application of macrophage membrane bionic bismuth selenide nanoparticles. The preparation problem of macrophage membrane bionic bismuth selenide nanoparticles and the application problem in preparing bionic anti-tumor drugs and photothermal treatment drugs based on cell membrane wrapping can be effectively solved. According to the technical scheme,the surface of hollow bismuth selenide nanoparticles is physically loaded with an anti-tumor drug quercetin, and then the hollow bismuth selenide nanoparticles with the quercetin is co-extruded withcell membrane vesicles obtained by low-permeability lysis solution pyrolysis treatment of cells and homogenization, so as to obtain a pharmaceutical composition of the cell membrane bionic bismuth selenide nanoparticles with a particle size of 120-150nm. The preparation process is simple and feasible; the particle size distribution is uniform; the sensitivity of cancer cell to light and heat is enhanced, and the anti-tumor effect of photothermal therapy is enhanced; the macrophage membrane bionic bismuth selenide nanoparticles have multiple functions such as metastatic lesions targeting capability, CT imaging and the like; and the anti-tumor efficacy of the drug is improved.

The invention relates to a pharmaceutical composition having alpha-glucosidase inhibition activity, wherein the pharmaceutical composition comprises a flavone compound and an alpha-glucosidase inhibitor, the flavone compound is at least one selected from a monomer such as baicalein, quercetin, luteolin, baicalein-7-O-glucoside and catechin, an organic salt of the monomer, and an inorganic salt of the monomer, and the alpha-glucosidase inhibitor is at least one selected from a monomer such as acarbose, voglibose and miglitol, an organic salt of the monomer, and an inorganic salt of the monomer. According to the present invention, the pharmaceutical composition can effectively reduce postprandial blood glucose, can inhibit the activity of alpha-glucosidase adopting starch, maltose and sucrose as substrates, and less uses the alpha-glucosidase inhibitor, such that the efficacy can be improved, the side effect of the alpha-glucosidase inhibitor can be effectively reduced, and hypoglycemia and other problems easily caused by drug combination are effectively solved.

The invention relates to a quercetin hydroxypropyl Beta-cyclodextrin inclusion liposome, a preparation method and application thereof, belonging to the field of pharmaceutical preparation. The invention provides a medicine capable of improving the bioavailability of quercetin and a preparation method of the medicine. The medicine capable of improving the bioavailability of the quercetin is the quercetin hydroxypropyl Beta-cyclodextrin inclusion liposome which is prepared from the following components in parts by weight and a pharmaceutically-acceptable solvent: 1 part of quercetin, 1-100 parts of hydroxypropyl Beta-cyclodextrin, 5-50 parts of granulesten, 1-10 parts of cholesterol and 0.1-5 parts of polyethylene glycol-distearin phosphatidyl ethanolamine.

The present invention provides an +--glycosyl isoquercitrin-containing novel composition which has a high in vivo absorbability, and hence exhibits a significant in vivo antioxidative activity. The present invention further provides preparation methods for such a composition. The composition contains a mixture of quercetin glycosides represented by the following formula: wherein Glc represents a glucose residue, and n is 0 or a positive integer of 1 or more, includes at least a quercetin glycoside wherein n is 3, and satisfies the following requirement (a): (a) the total proportion of quercetin glycosides in which n is 3, and in which other n values may be 1 or 2, or 1 and 2, is 50 mol% or more, and the total proportion of quercetin glycosides wherein n is 4 or more is 15 mol% or less, in the composition. The composition can be prepared by treating an enzymatically modified isoquercitrin with -amylase.

Disclosed is a Hypericum perforatum flavones extract, its preparation and use. the content of the flavones in the extract is 80-95%, the flavone-containing ingredients include birutan 5.0-50.0%, hyperoside 6.0-70.0%, isoquercitrin 3.0-10.0%, quercetin-3-O-alpha-L-arabinoside 0.5-5.0%, quercetin 0.5-5.0%, meletin 0.1-1.0%, and other balancing flavones components.

The present invention relates to a traditional Chinese medicine composition content determination method, wherein the traditional Chinese medicine composition comprises the following herbs such as forsythia suspensa, honeysuckle, radix isatidis, bitter almond, menthol, herba houttuyniae, rheum palmatum l, pogostemon cablin, dryopteris crassirhizoma, rhodiola rosea l, ephedra sinica stapf, licorice root and gypsum. According to the present invention, with the content determination method, the contents of seven components such as neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, isoforsythiaside A, 4,5-di-O-caffeoylquinic acid, quercitrin and glycyrrhizic acid are simultaneously determined, such that the energy source can be effectively saved, and the analysis cost can be reduced, wherein the traditional Chinese medicine composition content determination method of the present invention is not disclosed in the prior art.

The invention discloses a high efficiency liquid chromatography method for simultaneously quantitatively detecting six flavonoid components in polygonum hydropiper. The method comprises the following steps of selecting a Waters chromatographic column, selecting methanol and a 0.4% formic acid water solution as flowing phases, performing gradient elution, wherein the flowing speed of the flowing phase is 1ml / min, the gradient elution is finished in 3 gradients, and the volume ratios of methanol and 0.4% formic acid water solution of 3 gradients are respectively 45:55, 55:45 and 70:30, respectively performing ultraviolet detection on eluates at 359 nm, and determining the concentration of each component. The method provided by the invention has the advantages that the method is exact and simple and convenient, the replicability is good, the method is used for measuring the contents of rutin, hyperin, quercetin, quercetinic acid, isorhamnetin and kaempferol in the polygonum hydropiper, and the reference is provided for controlling quality of a polygonum hydropiper drug.

The invention belongs to the technical field of traditional Chinese medicine and particularly relates to a method for extracting rutin from Japanese pagodatree flower buds and preparing quercetin. The quercetin as an effective component in the Japanese pagodatree flower buds belongs to flavonoid compounds, rutin is rutinoside of the quercetin, and the rutin and the quercetin belong to different substances and have different pharmacological characteristics. By the aid of the property that the rutin has different solubility in cold water and hot water, the rutin is separated and extracted from the Japanese pagodatree flower buds and subjected to ethyl alcohol reflux refining, refined rutin with higher purity can be obtained, then the rutin is hydrolyzed in an acidic condition, the quercetin can be obtained and subjected to recrystallization with ethyl alcohol, and yellow acicular crystals can be obtained and are refined quercetin products.

The invention relates to a method for separating and purifying three flavonoid glycosides from trichosanthes bark. According to the method, three high-purity flavonoid glycosides, namely quercetin-3-O-beta-rutinoside, apigenin-7-O-beta-glucoside and diosmetin-7-O-beta-glucoside, are obtained from the trichosanthes bark through the following steps of: (1) preparing a crude trichosanthes bark extract; (2) extracting; (3) carrying out crude separation by using a polyamide column; and (4) carrying out separation and purification by using semi-preparative high-performance liquid chromatography: carrying out separation and purification on total flavonoid glycosides of the trichosanthes bark by using the semi-preparative high-performance liquid chromatography, wherein the mobile phase is methanol-water. The method disclosed by the invention has the advantages that the process flow is environment-friendly, the damage to the environment is not serious, and the comprehensive cost is low.

The invention discloses an application of a folium eucalypti extractive serving as an active ingredient in preparation of medicines for treating hyperuricemia, and also provides a preparation method of the folium eucalypti extractive. Main active ingredients of the folium eucalypti extractive are 6-12% of scabish essence B, 1-2% of tellimagrandin I, 1-1.5% of quercetin-3-O-glucoside acid, 0.8-1.2% of ellagic acid, 0.2-0.5% of tellimagrandin II, 0.1-0.15% of 1,2,3,4,6 pentagalloylglucose and 25-50% of total phenols. The pharmacological experiment shows that the folium eucalypti extractive has an inhibiting effect on xanthine oxidase and relatively strong effects of reducing uric acid, protecting renal injury caused by the hyperuricemia and the like in bodies.

The present invention relates to a microorganism source liver-protecting natural nutrient health care product and a preparation method thereof, which is characterized in that prebiotics and fungi strains which are allowed to be used by National Drugs Supervision Bureau are adopted; the traditional Chinese medicines that are normally used and the health care foods of microorganism source can produce a great deal of active protective protein and are taken as raw materials to carry out compound ferment; the product contains a great deal of active nutrient components which can improve detoxification and oxidation resistance capability of the liver. The present invention provides a biological anti-oxygen source nutrient product which is produced by fermenting microorganism and is a green health care product enriched in renieratene, B vitamins, reduction type vitamin C, queretin-3-D glucopyranose (quercitrin), queretin (flavonoid), phaseomannite and the metal derivative with various microelements, so as to obviously improve the restoring function of human liver after being damaged, enhance the ability of organism for eliminating free radical, reduce the damage on organism caused by the free radical, thus being a safe green liver-protecting natural nutrient health care product.

The invention relates to a Chinese herbal medicine compound preparation for treating skin and mucous membrane disease. The Chinese herbal medicine compound preparation is prepared from the following raw materials: cortex moutan, polygonum chinense, radix salviae miltiorrhizae, herba lycopi, common dayflower herb, rhizoma smilacis glabrae, ramulus cinnamomi, caulis dendrobii officinalis, gorgon fruit and cortex cinnamomi; the ingredient of the Chinese herbal medicine compound preparation comprises a cortex moutan extract, a polygonum chinense extract, a radix salviae miltiorrhizae extract, a herba lycopi extract, a common dayflower herb extract, a rhizoma smilacis glabrae extract, a ramulus cinnamomi extract, a caulis dendrobii officinalis extract, a gorgon fruit extract and a cortex cinnamomi extract; and the effective ingredient of the cortex moutan extract is paeonol, the effective ingredient of the polygonum chinense extract is quercitrin, the effective ingredient of the radix salviae miltiorrhizae extract is tanshinone IIA, the effective ingredient of herba lycopi is ursolic acid, the effective ingredient of common dayflower herb is commelinin, the effective ingredient of rhizoma smilacis glabrae is astilbin, the effective ingredient of ramulus cinnamomi is cinnamaldehyde, the effective ingredient of caulis dendrobii officinalis is erianin, the effective ingredient of gorgon fruit is cyclo(profilum), and the effective ingredient of cortex cinnamomi is cinnamaldehyde.

The invention relates to hand cream, in particular to hand cream containing rose essence and belongs to the field of cosmetics. The hand cream is rich in rose essence, rose is rich in haematochrome, uranidin, beta-carotene, quercitrin, fatty oil, organic acid and other cosmetic materials, further antiallergic agents are added in the rose essence, so that when used on hands, faces and the like, the rose essence can repair expanded blood capillaries and relieve redness and has the effect of whitening and moisturizing. Therefore, the hand cream containing rose essence has the effect of whitening and moisturizing and can fully improve skin quality of the hands in winter.

The invention discloses a purification method for two active monomer compounds in saxifrage and application of product of the same. The method is as below: extracting saxifrage with ethanol; extracting the extract successively with petroleum ether and ethyl acetate; and separating the ethyl acetate extract by silica gel column chromatography, medium pressure column chromatography and gel column chromatography, so as to separate out the two monomer compounds (quercetin 3-O-beta-L-rhamnoside, quercetin 5-O-beta-D glucoside) from saxifrage. Biological activity determination results indicate that the saxifrage extract and the two monomer compounds have good inhibition effect on growth and proliferation of prostate cancer cells, can be used in preparation of medicine for treating prostate cancer, and have good application prospects in drugs for treating prostate cancer.

The invention relate to a ginkgo biloba leaf extract injection quality control method based on quantitative analysis of multi-components by a single marker and a fingerprint spectrum. The method comprises the steps that rutin is adopted as a reference sample, flavonols kaempferol-3-O-rutinoside, isorhamnetin-3-O-rutinoside, kaempferol-3-O-rhamnose-2-glucoside, quercetin-3-O-rhamnose-2-O-(6-O-p-hydroxy cinnamoyl) glucosyl and kaempferol-3-O-rhamnose-9-O-6-O-(p-hydroxy cinnamoyl) glucosyl are quantified through quantitative analysis of multi-components by a single marker, and the ginkgo biloba leaf extract injection batched quality stability is controlled through the fingerprint spectrum. The problem that ginkgo biloba leaf extract injection multi-component quantification and multi-index quality control lack reference samples is solved, and the quality of the ginkgo biloba leaf extract injection is ensured while the product batched quality stability is controlled through the fingerprint spectrum.