36results about How to "Novel mechanism of action" patented technology

The invention relates to a compound synergistic bactericidal composition for preventing and treating main diseases of tomatoes and pear trees and an application thereof. Active ingredients of the pesticide composition comprise pydiflumetofen and an active ingredient B, and the active component B comprises one of a substituted aniline bactericide and bacillus subtilis BAB-1. The pesticide composition disclosed by the invention is applied to prevention and treatment of main diseases of tomatoes and pear trees, such as gray mold, early blight, leaf mold, gray leaf spot, scab, ring spot and blackspot, and the bactericidal composition has the advantages of good fast-acting property and persistence, novel action mechanism and multiple sites, can effectively delay the occurrence and developmentof drug resistance of pathogenic bacteria, and not only has a protective effect on diseases, but also has a good treatment effect. The compound synergistic composition has the advantages that the dosage is small, and the pollution of medicaments to fruits and the environment is effectively reduced.

The invention relates to new pharmacological effects of a compound pinocembrin and an application of pinocembrin to preparation of products for preventing, relieving and / or treating pulmonary hypertension and complications thereof. Pinocembrin has the beneficial effects that pinocembrin has the pharmacological effects of relaxing pulmonary arteries, reducing the pulmonary artery pressure, protecting pulmonary vessels from injuries caused by pulmonary hypertension, restoring lung tissue functions, repairing heart and liver injuries, alleviating right ventricular hypertrophy and enlargement, improving heart failure and liver functions, obviously reducing the mortality of animals with pulmonary hypertension and preventing and treating pulmonary hypertension and complications thereof; pinocembrin is an active monomer separated from a natural product propolis, achieves complete synthesis at present, has good application and development prospects, is an ideal compound for treating pulmonary hypertension and complications thereof and can be applied to preparation of the products for preventing, relieving and / or treating pulmonary hypertension and complications thereof, such as chronic obstructive emphysema, chronic pulmonary heart diseases, right heart failure and liver function injuries.

The invention discloses an acrylamide compound and a preparation method and medical application thereof, and relates to a compound shown in formula I and an isomer or a pharmaceutically acceptable salt thereof. The acrylamide compound and the isomer or the pharmaceutically acceptable salt thereof can be applied to prepare HBV (hepatitis B virus)-resistant medicines. The formula is shown in the specification.

The invention relates to a compound synergistic bactericidal composition containing benzovinfluconazole and its application. The active ingredients of the pesticide composition include benzovinfluconazole and active ingredient B; wherein the active ingredient B includes methoxyl One of acrylate fungicides, sterol synthesis inhibitors, and biological source fungicides. The pesticide composition of the present invention is applied to the prevention and treatment of major diseases of fruits and vegetables, and has good quick-acting and long-lasting effects, novel mechanism of action and multiple sites, can effectively delay the occurrence and development of drug resistance of pathogenic bacteria, and not only has a protective effect on diseases but also has a good therapeutic effect. Compared with a single agent, the compound and synergistic combination significantly reduces the dosage and effectively reduces the pollution of the agent to fruits and the environment.

Salts of kukoamine B, their preparation method and their pharmaceutical use in preparation of drugs for preventing and treating sepsis. Experiments indicate that salts of kukoamine B have a good effect on antagonizing the key factors inducing sepsis, and can be used in the preparation of drugs for preventing and treating sepsis. Under the current circumstances of the lack of effective measures for the treatment of sepsis in clinical practice, the medicinal formulations, which comprise the salts of kukoamine B, pharmaceutically acceptable carrier and / or diluent, provide a new approach for the prevention and treatment of sepsis.