36results about How to "Novel mechanism of action" patented technology

The invention relates to a pesticide, in particular to a compound bactericide for mainly treating grey mold of fruits and vegetables. The compound bactericide consists of active ingredients, a filler and/or aids, wherein the active ingredients consist of fluazinam and other bactericides; the weight ratio of the fluazinam to other bactericides is 1-50:1-50; and other bactericides are one or a mixture of more of mancozeb, iprodione, fludioxonil, SYP-Z048, pyrametostrobin and azoxystrobin. Product forms of the compound bactericide for mainly treating the grey mold of fruits and vegetables are usually wettable powder, water dispersible granules and suspension agents. The compound bactericide is applicable to the prevention and control of the grey mold of various fruits and vegetables and has remarkable synergism and long effective duration, the medicaments have a novel action mechanism and a large number of action sites, and the occurrence and development of medicament resistance of grey mold bacteria can be effectively delayed; and the preparation method of the compound bactericide is simple, and the compound bactericide has high biological safety and remarkable economic benefit.

The invention discloses a 3D-crosslinked supramolecular polymer based on a column [n] arene conjugated polymer as well as a preparation method and application of the 3D-crosslinked supramolecular polymer. The preparation method comprises the following step: mixing a conjugated polymer host molecule with a conjugated guest molecule according to a certain proportion to form the 3D-crosslinked supramolecular polymer based on the column [n] arene conjugated polymer. The polymer provided by the invention has good film forming property, the host molecule and the guest molecule are respectively an energy donor and an energy acceptor, and energy can be transferred from a host to a guest according to an antenna effect and a fluorescence resonance energy transfer mechanism so that the color of the guest is embodied; and a film and a spraying load of the 3D-crosslinked supramolecular polymer show multi-stimulus discoloration property according to different properties embodied by the 3D-crosslinked supramolecular polymer based on the column [n] arene conjugated polymer in a liquid environment and a solid state, and therefore, the 3D-crosslinked supramolecular polymer can be used as an erasableencrypted writing material.

The invention relates to 2-indolone derivative series (formula I), medicinal salts thereof, isomers thereof, hydrates thereof or solvates thereof and the preparation method thereof; and the invention also relates to a pharmaceutical composition containing the same with an effective dosage and the application thereof in prevention and treatment of tumor diseases by blocking the HGF/c-Met signal channels.

The invention discloses an external compound abafenjing drug composition, which comprises the following parts: 0.01-20% abafenjing, 0.005-1% adrenal cortex hormone, medical auxiliary material and antibacterial material. The invention reduces the injury of infected skin, which can treat vaginal candidiasis and vulvopathy.

The invention relates to a benzovindiflupyr-containing compound synergistic bactericidal composition and application thereof. The pesticidal composition comprises benzovindiflupyr and an active component B as active components, wherein the active component B comprises one of a methoxy acrylate bactericide, a sterol synthesis inhibitor and a biogenic bactericide. The pesticidal composition is applied to control of major diseases of fruits and vegetables, has good quick-acting and long-lasting properties, has a novel acting mechanism and many sites, can effectively delay occurrence and development of the pesticide resistance of pathogenic bacteria, and not only has a disease protection effect, but also has a good therapeutic effect. Compared with a single preparation, the compound synergistic composition has the advantages as follows: the dosage is significantly reduced, and pollution of the pesticide to the fruits and the environment is effectively reduced.

The invention discloses a formula and a preparation method of a mosquito-repellent liquid capable of repelling mosquitoes, killing bacteria and purifying air. The mosquito-repellent liquid comprises the following raw materials in parts by weight: 0.5-28 parts of glucoside, 12 to 40 parts of ethanol, 0.12 to 20 parts of an eucalyptus extract, 0.12 to 20 parts of citronella extract and 46 to 89 parts of distilled water; or 0.5 to 28 parts of Tween 20-100, 12 to 40 parts of ethanol, 0.12 to 20 parts of the eucalyptus extract, 0.12 to 20 parts of Melaleuca alternifolia extract, 0.12 to 20 parts ofcitronella extract and 46-89 parts of distilled water. The mosquito-repellent liquid provided by the invention has remarkable mosquito repellent effect and is safe and pollution-free; a eucalyptus isrich in aromatic oil, has killing or repelling effect on various germs and pests, and can be made into insecticides, preservatives, mosquito-repellent oil and the like; and in addition, a certain bactericidal effect is achieved, and the breeding and spreading of pathogenic bacteria carried by mosquitoes can be reduced. The mosquito-repellent liquid is prepared from plant essential oil, does not contain artificially synthesized essence, preservatives and chemical pigments, smells pleasant and is beneficial to physical and psychological health. The components of the mosquito-repellent liquid are environmentally friendly and low in cost, and the mosquito-repellent liquid produces good social, ecological and economic benefits.

The invention discloses a multifunctional deodorant based on plant essential oil, which can be used for removing unpleasant odor of tobacco and alcohol and the like. The deodorant is prepared from thefollowing raw materials in parts by weight: 0.5-20 parts of Tween or Span; 20-70 parts of lower alcohol, 10-44 parts of essential oil, 60-82 parts of distilled water and 6-18 parts of mint extract, or 0.5-20 parts of Tween or Span, 20-70 parts of lower alcohol, 10-44 parts of essential oil, 60-82 parts of distilled water and 4-20 parts of essence. The deodorant provided by the invention is simpleto prepare and easy to obtain, has a remarkable deodorizing effect and is safe and free of pollution. Essential oil molecules can mutually chelate with odorous gases such as tobacco and alcohol odorto completely remove the odor, and also have a bactericidal effect to purify the air. The multifunctional deodorant is prepared from environment-friendly ingredients, is low in cost, and has good social, ecological and economic benefits.

The invention discloses an acrylamide compound and a preparation method and medical application thereof, and relates to a compound shown in formula I and an isomer or a pharmaceutically acceptable salt thereof. The acrylamide compound and the isomer or the pharmaceutically acceptable salt thereof can be applied to prepare HBV (hepatitis B virus)-resistant medicines. The formula is shown in the specification.

The invention discloses an application of DYZ-9 in preparation of an anti-cardiac hypertrophy product. Compared with the prior art, the DYZ-9 provided by the invention has the following advantages: (1) the DYZ-9 studied in the invention can be synthesized by known methods, has a mature preparation process, can provide a reliable compound source, and has the advantages of a reliable substance source, low production costs, a novel mechanism of action and good market prospects; (2) the DYZ-9 has the effects of inhibiting phosphorylation of AKT and adenosine cyclophosphate effector element bindingprotein caused by isoproterenol (ISO), reducing the levels of myocardial hypertrophy markers ANP and BNP and a cardiac weight index, and improving myocardial hypertrophy; and (3) the DYZ-9 contributes to the research and development of the novel anti-cardiac hypertrophy drug, can bring direct economic benefits, and the drug can reduce the possibility of forming heart failure and malignant arrhythmia caused by further deterioration of the myocardial hypertrophy, and can save a lot of health expenses from a long-term perspective.

The invention relates to application of compound puerarin in the preparation of drugs for preventing, relieving and/or treating pulmonary arterial hypertension and complications thereof. A large amount of clinical practice shows that the puerarin is good in curative effect on the pulmonary arterial hypertension and is an ideal compound for treating the pulmonary arterial hypertension and the complications thereof, and the puerarin can be used for preparing products for preventing, relieving and/or treating lung injury diseases caused by the pulmonary arterial hypertension, chronic pneumonia and exogenous materials and unexplained pulmonary arterial pressure increasing and complications thereof such as chronic obstructive emphysema, chronic pulmonary heart disease and cardiac failure.

The invention relates to the technical field of biology, in particular to application of fusion protein in preparation of a drug for treating hepatitis C. An amino acid sequence of the fusion proteinis selected from one of the followings: 1) an amino acid sequence shown in SEQ ID NO: 1; 2) an amino acid sequence with at least 80% identity; and 3) a modified amino acid sequence. Research finds that the fusion protein reduces liver injury caused by the hepatitis C by blocking cell apoptosis pathways to have a function of protecting liver functions. As a novel candidate drug for treating the hepatitis C, the fusion protein has a novel acting mechanism and clear targets, significant therapeutic effects, high safety and great development potentials.

The invention discloses ACM thermoplastic vulcanized rubber and a preparation method and application thereof. The preparation method comprises the following steps of: adding ACM rubber, a polymer, a compatilizer, a vulcanizing agent, an anti-UV agent and an antioxidant into a twin-screw extruder together by a weightless metering scale; the ACM thermoplastic vulcanized rubber is obtained through extrusion, the plasticity of the ACM rubber is improved through addition of the polymer, the rubber blend is subjected to phase inversion in the processing process, the obtained product can be repeatedly used, recycling of leftover materials and waste products is facilitated, the utilization rate of rubber materials is increased, and pollution of solid waste is reduced.

The invention relates to new pharmacological effects of a compound pinocembrin and an application of pinocembrin to preparation of products for preventing, relieving and/or treating pulmonary hypertension and complications thereof. Pinocembrin has the beneficial effects that pinocembrin has the pharmacological effects of relaxing pulmonary arteries, reducing the pulmonary artery pressure, protecting pulmonary vessels from injuries caused by pulmonary hypertension, restoring lung tissue functions, repairing heart and liver injuries, alleviating right ventricular hypertrophy and enlargement, improving heart failure and liver functions, obviously reducing the mortality of animals with pulmonary hypertension and preventing and treating pulmonary hypertension and complications thereof; pinocembrin is an active monomer separated from a natural product propolis, achieves complete synthesis at present, has good application and development prospects, is an ideal compound for treating pulmonary hypertension and complications thereof and can be applied to preparation of the products for preventing, relieving and/or treating pulmonary hypertension and complications thereof, such as chronic obstructive emphysema, chronic pulmonary heart diseases, right heart failure and liver function injuries.

The invention discloses application of a human sDR5-Fc recombinant fusion protein in preparation of a medicine for preventing and treating myocardial infarction and ischemia reperfusion injury. A nucleotide sequence for encoding the sDR5-Fc recombinant fusion protein has a) a base sequence as shown in SEQ ID NO: 1, or b) a complementary pairing sequence of SEQ ID NO: 1, or c) a protein having thesame sequence as the nucleotide sequence of a or b, but having a sequence different from the nucleotide sequence of a or b due to the degeneracy of a genetic code; or the amino acid sequence of the sDR5-Fc recombinant fusion protein is shown as SEQ ID NO: 2, or the amino acid sequence of the sDR5-Fc recombinant fusion protein is shown as SEQ ID NO: 2, and one or more amino acids are substituted, but the biological activity is not changed; or the amino acid sequence of the sDR5-Fc recombinant fusion protein is shown as SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5 or SEQ ID NO: 6.

The invention provides Sargassum henslowianum fucosan sulfate which is composed of fucose and galactose and which has molecular weight of 4.0*10<5> to 6.0*10<5>. The Sargassum henslowianum fucosan sulfate is extracted from Sargassum henslowianum. By extracting Sargassum henslowianum crude polysaccharide and subjecting the crude polysaccharide to multiple times of purification with h ion exchange chromatography and molecular sieve chromatographic columns, the Sargassum henslowianum fucosan sulfate capable of being used for anti-herpes virus research is obtained. According to the scheme, the natural polysaccharide which has a novel antiviral action mode, is low in toxicity, efficient, safe and easy to accept can be separated from the marine medicinal resource Sargassum henslowianum, and a research basis can be provided for further developing antiviral drugs which have novel action mechanisms, definite curative effects and definite targets. The Sargassum henslowianum fucosan sulfate can play an antiviral role by effectively inhibiting herpes viruses from being adsorbed to the surface of host cells, and the acting site of the Sargassum henslowianum fucosan sulfate is the surface of thecells, can act on the first step of virus infection and does not enter the cells, so that the possibility of causing toxic and side effects is relatively small.