Anarexol cream and preparation method thereof

A technology of cyproheptadine hydrochloride cream and cyproheptadine hydrochloride, applied in anti-inflammatory agents, ointment delivery, pharmaceutical formulations, etc., can solve the problem of novel appearance, insufficient unique effect, unsatisfactory clinical treatment, narrowing application range, etc. problems, to achieve the effect of good spiritual curative effect, unique administration method, and uniform content of the main drug

Active Publication Date: 2011-05-18
CHANGZHOU NO 4 PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the weak anti-inflammatory or antipruritic properties of the above-mentioned external preparations or the addition of antibacterial and antifungal drugs, the prescription is complicated, the scope of application is narrowed, dependence and secondary allergies are easily generated, and the clinical treatment is not satisfactory.
On the other hand, such topical creams are deficient in novel appearance, unique effect, or suggestion of spiritual healing

Method used

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  • Anarexol cream and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1: batch number 20080201

[0033] Cyproheptadine Hydrochloride 55.5g

[0034] Mint pellets 200g

[0035] Stearic acid 825g

[0036] Glyceryl monostearate 515g

[0037] Triethanolamine 100g

[0038] White Vaseline 720g

[0039] Glycerin 720g

[0040] Ethylparaben 10g

[0041] Fragrance 10ml

[0042] Purified water 7500g

[0043] 1000 pieces

[0044] Preparation:

[0045] 1. Preparation of Peppermint Pellets:

[0046] (1) Glyceryl monostearate of 20 to 40 meshes is used as the core material of the skeleton ball;

[0047] (2) Take mint equal to the weight of the glyceryl monostearate ball core, and dissolve it in 50% medicinal ethanol aqueous solution, and prepare a mint slurry with a concentration of 20%;

[0048] (3) Put the glyceryl monostearate pellet core in the coating granulator, make (2) an atomized slurry through compressed air (pressure 0.2MPa), keep the pellet temperature at 25°C to 30°C, and spray the slurry The ro...

Embodiment 2

[0056] Example 2: batch number 20080202

[0057] Cyproheptadine Hydrochloride 54.5g

[0058] Peppermint Pellets 201g

[0059] Stearic acid 825g

[0060] Glyceryl monostearate 515g

[0061] Triethanolamine 100g

[0062] White Vaseline 720g

[0063] Glycerin 720g

[0064] Ethylparaben 10g

[0065] Fragrance 10ml

[0066] Purified water 7500g

[0067] 1000 pieces

[0068] Prepared according to the method described in Example 1. The loading capacity is 10g / piece.

Embodiment 3

[0070] Cyproheptadine Hydrochloride 53.5g

[0071] Peppermint Pellets 202g

[0072] Stearic acid 825g

[0073] Glyceryl monostearate 515g

[0074] Triethanolamine 100g

[0075] White Vaseline 720g

[0076] Glycerin 720g

[0077] Ethylparaben 10g

[0078] Fragrance 10ml

[0079] Purified water 7500g

[0080] 1000 pieces

[0081] Prepared according to the method described in Example 1. The loading capacity is 10g / piece.

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Abstract

The invention discloses a hydrochloric acid cyproheptadine cream which is prepared by the following ingredients, cyproheptadine hydrochloride, corn mint, stearic acid, glyceryl monostearate, triethanolamine, glycerin, white petrolatum and purified water. Wherein, hydrochloric acid cyproheptadine is antihistamine and used for relieving the allergic reaction caused by the histamine; the corn mint is distributed in substrate with the form of pellets and melts under the body surface temperature, so as to have cool, comfortable aroma and good psychological curative effect. The hydrochloric acid cyproheptadine cream is used for the treatment of allergic dermatitis contact dermatitis, pruritus and eczema. The hydrochloric acid cyproheptadine cream has the advantages of novel substrate appearance, good stability, convenient carrying and storage.

Description

technical field [0001] The invention relates to pharmaceutical preparations, in particular to a cyproheptadine hydrochloride cream and a preparation method thereof. Background technique [0002] Skin diseases are mostly allergic and inflammatory skin diseases. Except for a few inflammatory skin diseases, patients all have varying degrees of itching, which will affect the work, life and physical and mental health of patients in severe cases. [0003] The treatment of dermatitis and eczema generally adopts a combination of systemic and topical medication, wherein topical medication is an important means for the treatment of dermatitis and eczema. At present, glucocorticoids are the most commonly used drugs clinically, and there are also antihistamines, immunosuppressants, antibacterials, and antifungals. [0004] Glucocorticoids are widely used in non-infectious inflammatory skin diseases, especially dermatitis eczema-like allergic diseases due to their rapid action and signi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61P17/00A61K31/4418A61P17/04A61K9/06
CPCA61K9/0014A61K31/445A61K9/06A61P17/00A61P17/04A61P29/00
Inventor 范新华贺赟杨京华张巍屠永锐
Owner CHANGZHOU NO 4 PHARMA FACTORY
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