38 results about "Cyproheptadine" patented technology

The present invention relates to a naphthol / graphene / bipyridinium electrochemiluminescence sensor preparation method and an application thereof to determining cyproheptadine hydrochloride. The methodis characterized in that: a Nafion membrane method is used to fix graphene and bipyridylium on a gold electrode, and electrochemiluminescence of cyproheptadine hydrochloride is detected; the result isa high voltage of 850 V of a photomultiplier tube and a scan rate of 0.1 V / s; a boric acid buffer solution with pH=7.5 is used; the luminescence intensity of the cyproheptadine hydrochloride standardin the concentration range of 1x10-7 to 6x10-5 mol / L satisfies the linearity; and the adding standard recovery of cyproheptadine hydrochloride is between 99.7% and 104.9%. The method provided by thepresent invention has good sensitivity and stability for testing cyproheptadine hydrochloride, and has a good effect; and compared with the bare electrode, by using the method, the utilization efficiency of bipyridylium can be improved, environmental pollution can be reduced, and a test cot can be saved, and the method has important significance for expanding the application of electrochemiluminescence in drug analysis.

The invention discloses allergy-removal rhinitis cream which is prepared from, by weight, 8-10% of astragalus membranaceus, 8-10% of codonopsis pilosula, 10-15% of scutellaria baicalensis, 3-5% of lumbricus, 3-5% of as arum, 3-5% of honeysuckle, 3-5% of menthol, 3-5% of radix aconiti carmichaeli and the balance finished product western medicine supplementary materials; the finished product western medicine supplementary materials comprise ketotifen, cyproheptadine, prednisone, chlortrimeton and magnesium sulfate; the traditional Chinese medicine is crushed and ground in proportion, the western medicine supplementary materials are crushed and ground in proportion, the traditional Chinese medicine ingredients and the western medicine supplementary materials are stirred and mixed, polyving akohol, sodium methyl cellulose and glycerinum are added and blended into a paste shape, and the allergy-removal rhinitis cream is obtained. The Chinese herbal medicine has the effects of clearing away heat and dispelling wind-evil, dispelling cold to dredge main and collateral channels, tonifying the lungs and the spleen, and nourishing the kidney and supplementing the yang; the finished product western medicine supplementary materials have the functions of inhibiting exudation of inflammation, lowering the permeability of blood capillary, resisting to histamine, acetyl choline and 5-hydroxytryptamine are achieved, cytomembranes of mast cells can be stabilized, and releasing of anaphylactic mediators is inhibited.

The invention provides treating cachexia and eating disorders in humans and veterinary animals by administering a composition including: (i) cyproheptadine (CYP); and (ii) a cannabis compound selected from the group of cannabidiol (CBD) and mixtures of CBD and up to 50% tetrahydrocannabinol (THC).

The invention discloses a medicine composition for treating tuberculous pleurisy, a method for preparing the medicine composition and application thereof. The medicine composition comprises, by weight, 1-3 parts of artemisinin, 3-7 parts of cyproheptadine, 15-23 parts of taurine and 11-19 parts of cefuroxime. The method includes mixing and grinding the cyproheptadine and the cefuroxime with each other, adding deionized water into the cyproheptadine and the cefuroxime and stirring and treating the deionized water, the cyproheptadine and the cefuroxime at the temperature of 66 DEG C for 48-50 min to obtain mixtures A; mixing the taurine and the mixtures A with one another, stirring and treating the taurine and the mixtures A at the temperature of 60 DEG C for 23-25 min, adding the artemisinin into the taurine and the mixtures A to obtain other mixtures, carrying out ultrasonic treatment on the other mixtures at the temperature of 43 DEG C for 33 min, then stirring the other mixtures at the temperature of 55 DEG C until the other mixtures are dried and granulating the other mixtures to obtain the medicine composition. The medicine composition, the method and the application have the advantages that the medicine composition can be used for treating the tuberculous pleurisy, is high in cure rate, short in treatment time, free of toxic and side effects or allergic reaction and low in manufacturing cost and dosage, can become effective fast and is a perfect medicine, obvious treatment effects can be realized, and the tuberculous pleurisy is low in recurrence rate.

The invention relates to a multifunctional vanishing cream, belonging to cosmetic field, which comprises isopropanol, benzoin tincuture, glycerin monostearate, ascorbic acid double palmitic acid ester, cimetidine, indomethacin, cyproheptadine, Vitamin C, levamisol, diphenhydramine, talcum powder, Ludi and angelica through mixing. The multifunctional vanishing cream has special efficacy upon skin and can remove stain, facially pack and soothe skin, diminish inflamination and relieve itching, whiten, resist crease and make skin fine and tender and white due to long term use. The multifunctionalvanishing cream has the advantages of ideal product for skin care, health care and beauty treatment and high efficiency without poison and side effect. Following phenomena cannot occur after the vanishing cream is used: red swelling, peeling, scaring and print keeping. Skin is becoming more white after 10 days of using the vanishing cream.

The invention relates to a hybridoma cell line capable of secreting a CHP (cyproheptadine) monoclonal antibody and a preparation method, and belongs to the field of food safety immunodetection. The preservation number of the hybridoma cell line is CGMCC No.14697. The method comprises the following steps: a BALB / c mouse is immunized for the first time with a complete Freund's adjuvant, subjected tobooster immunization three times with an incomplete Freund's adjuvant and subjected to impact immunization once with an adjuvant-free CHP complete antigen, and the BALB / c mouse acquires immunity; splenocytes of the high-tilter and low-IC50 mouse which acquires immunity are fused with myeloma cells of the mouse with a PEG method, and the cell line is obtained through indirect competitive ELISA (enzyme-linked immunosorbent assay) screening and three times of subcloning. The monoclonal antibody secreted by the cell line has better specificity and detection sensitivity on CHP (IC50 is 0.370 ng / ml) and can be used for detecting CHP residues in food.

The invention provides a cyproheptadine semiantigen, an artificial antigen, an antibody, preparation methods of cyproheptadine semiantigen and the artificial antigen, and application of the artificial antigen and the antibody. The cyproheptadine semiantigen has a molecular structure shown as a formula (I), and the cyproheptadine artificial antigen has a molecular structure shown as a formula (II). The titer of a monoclonal antibody obtained from the antigen reaches 1:300000, and the 50% inhibiting concentration is 0.20 mu g / L. The generated antibody is high in specificity, high in sensitivity and high in accuracy. The antigen and the antibody have wide application prospect on detection of cyproheptadine residue in food.

The present invention discloses a cyproheptadine hapten, a corresponding artificial antigen and a corresponding monoclonal antibody, and further discloses preparation method and applications of the cyproheptadine hapten, the corresponding artificial antigen and the corresponding monoclonal antibody. According to the present invention, the cyproheptadine hapten is the product represented by a formula I, and the product represented by the formula I and carrier protein are connected to obtain the cyproheptadine antigen, wherein the cyproheptadine antigen can be used for preparing the cyproheptadine specific antibody; the preparation method has characteristics of simpleness, feasibility, low cost, and high hapten yield; and after the cyproheptadine artificial antigen of the present invention is used to immunize animals, the cyproheptadine-specific antibodies can be produced, wherein the antibodies can be used for preparing the enzyme-linked immunosorbent assay kit for detecting the cyproheptadine residue, and the kit has advantages of simpleness, rapidness, large sample treatment amount, high sensitivity, strong specificity, and the like.

The invention discloses a medicine composition for treating tuberculous pleuritis, and a preparation method and application thereof. The medicine composition is prepared from the following raw materials in parts by weight: 1 to 3 parts of allicin, 3 to 7 parts of cyproheptadine, 15 to 23 parts of radix puerariae flavone, and 11 to 19 parts of cefuroxime. The preparation method comprises the steps of mixing and grinding the cyproheptadine and the cefuroxime, adding deionized water, stirring for 48 to 50 min at the temperature of 66 DEG C, and preparing a mixture A; mixing the radix puerariae flavone and the mixture A, stirring for 23 to 25 min at the temperature of 60 DEG C, adding the allicin, then carrying out ultrasonic treatment for 33 min at the temperature of 43 DEG C, stirring at the temperature of 55 DEG C until dry, and pelleting. The medicine composition for treating tuberculous pleuritis provided by the invention is remarkable in treatment effect, high in cure rate, short in treatment time, fast in effect, free of toxic and side effect and anaphylactic reaction, high in cure rate, low in recurrence rate, low in cost, and less in dosage, and is a more ideal medicine.

The invention provides a composite liniment for curing acne and comedo, which comprises the following raw materials by weight ratio: 0.5 to 2.0 parts of tetracycline, 0.3 to 2.0 parts of erythrocin, 0.4 to 2.0 parts of cyproheptadine, 0.3 to 1.0 part of pennyroyal, 0.1 to 1 part of borneol, 1.0 to 2.5 parts of vitamin B6, 3 to 10 parts of radix notoginseng and 100 parts of plant extractive. The preparation method of the liniment comprises the following steps: weighing tetracycline, erythrocin, cyproheptadine, vitamin B6 and borneol; adding the plant extractive; stirring uniformly; adding pennyroyal; stirring uniformly; homogenizing for 10 to 30 minutes by the ultrasonic wave at the temperature of 0 DEG C to 10 DEG C; and split-charging to obtain the finished product. The liniment conformsto the chemical property of the skin, facilitates the performance of the physiological function of the skin, plays a role in not only curing but also protecting the skin, has multiple curative effects compared with the simple application of tetracycline and erythrocin, and reduces the dry and tension senses of the skin when in administration, furthermore, the liniment has low irritation and is easily accepted by the patients, thereby the application prospect is wide.

The invention provides a compound liniment for treating acne rosacea, which consists of the following raw materials by weight percentage: cyproheptadine, vitamin B6, sulfur, mercurous chloride, radix sileris, clove oil, borneol and the like. The compound liniment accords with the chemical characteristics of skin, is advantageous for giving play to physiological functions of the skin, is safe and reliable for treating the acne rosacea, can quickly deliver drugs to a pathologic change part to diminish inflammation, kill mites and sterilize powerfully, and play a direct action on the root of niduses to thoroughly dispel symptoms of itching, red, blains and the like of the acne rosacea. By combining with DS reparative factors, the compound liniment can repair the microcirculation of the skin in a short time, regulate sebum secretion metabolism, and reconstruct the immunologic function of normal skin to thoroughly cure the acne rosacea and prevent recurrent attacks; and in the using process, the compound liniment reduces the dryness and tension of nose skin, has small acrimony, can be accepted by patients easily, and has broad application prospect.

The invention discloses a hydrochloric acid cyproheptadine cream which is prepared by the following ingredients, cyproheptadine hydrochloride, corn mint, stearic acid, glyceryl monostearate, triethanolamine, glycerin, white petrolatum and purified water. Wherein, hydrochloric acid cyproheptadine is antihistamine and used for relieving the allergic reaction caused by the histamine; the corn mint is distributed in substrate with the form of pellets and melts under the body surface temperature, so as to have cool, comfortable aroma and good psychological curative effect. The hydrochloric acid cyproheptadine cream is used for the treatment of allergic dermatitis contact dermatitis, pruritus and eczema. The hydrochloric acid cyproheptadine cream has the advantages of novel substrate appearance, good stability, convenient carrying and storage.

Production of 10,11-dihydro-dibenzo(b, f)chedder-10-ketone compound is carried out by taking o-nitrophenylacetic acid as initial raw material, reducing, diazotizing, coupling with phenyl-sulfhydrate derivatives, acylating, and cyclizing to obtain (I). It achieves simple process, gentle reaction and more yields.

The invention discloses a dermatosis medicine composed of several Chinese and western medicines, and relates to the field of dermatosis medicines.The dermatosis medicine is characterized in that 1, the medicine is prepared, and tablets including vitamin b1, vitamin b2, vitamin b12, vitamin b6, prednisone, compound pyrimidine, ground rice, vitamin c, chlortrimeton and cyproheptadine are prepared; the ointment comprises fluocinonide vitamin 6 cream and white vaseline; the traditional Chinese medicines comprise borneol and camphor; 2, medicine treatment, wherein the used solid medicine is smashed, and then the smashed medicine is filtered through a screen; 3, adding the prepared vaseline into a mixing barrel; 4, the used medicines are sequentially added into the mixing barrel according to the proportion; 5, the medicine in the mixing barrel is stirred till the color of the medicine is uniform, the skin disease can be treated through the prepared medicine, meanwhile, the irritation to the treatment position can be reduced through the introduced borneol and camphor, and meanwhile damage to the human body is reduced.