The invention relates to a blend of fluorine rubber and silicone rubber, as well as a preparation method thereof. The composition in weight percentage of the blend of fluorine rubber and silicone rubber is as follows: 12 to 50 percent of fluorine rubber, 12 to 50 percent of silicone rubber, 2.5 to 10 percent of compatibilizer, 2.5 to 10 percent of acid-acceptor, 12 to 35 percent of reinforcing filler, 0.5 to 7 percent of constitution controller, 0.5 to 3 percent of vulcanizing agent and 0.5 to 4 percent of crosslinking additive. The blend of fluorine rubber and silicone rubber is prepared by a mechanical blending method and is vulcanized by use of peroxides. Vulcanized rubber has good mechanical properties, heat resistance, low-temperature resistance, oil resistance and low-compression permanent deformation performance, and can be used for producing and manufacturing high-performance rubber tubes, adhesive tapes, sealing elements, rubber linings and the like needed in automobile, mechanical, chemical, aerospace and other industries.