5 results about "Ketotifen" patented technology

The present application relates to a kind of quercetin and ketotifen co-assembly nanomedicine and its construction method and application, belong to nanomedicine technical field;The construction method includes the following steps: S1, quercetin and ketotifen are dissolved in organic solvent, and mixed uniformly;S2, remove organic solvent, so that quercetin and ketotifen co-assembly occurs, and forms co-assembly solid;S3, to co-assembly solid is added dispersion medium and is hydrated, and is treated by ultrasonic dispersion, and the dispersion liquid of quercetin and ketotifen co-assembly nanomedicine is obtained.The present application is creatively constructed as co-assembly nanomedicine without any exogenous carrier, not only simultaneously solves the technical problems of poor water-solubility of quercetin and obvious central inhibition side effects of ketotifen, but also realizes the treatment goal of high efficiency, low toxicity, synergistic anti-asthma, with significant clinical conversion prospect and industrial application value.

The present invention is directed to a combination treatment using ketotifen and a checkpoint inhibitor that is effective in treating cancer or inhibiting the proliferation of tumor cells in a subject and / or that can initiate, enhance or prolong the immune response to tumor cells.

The present disclosure in various aspects and embodiments provides formulations that solubilize and / or suspend poorly soluble active ingredients, such as but not limited to ketotifen and indomethacin, for use in coating processes to manufacture drug products. In other aspects, the disclosure provides spray-coated products with low impurities and high homogeneity and mass transfer efficiencies relative to products produced with conventional pan coating or spray-coating processes. In aspects, the disclosure provides pharmaceutical compositions and methods of treatment involving these spray-coated products.

The present invention relates to pharmaceutical compositions of Ketotifen and its pharmaceutically acceptable salts, and processes for their preparation, for oral administration that provides a colon specific delivery of Ketotifen. The pharmaceutical composition is in the form of single or multiple dosage units for selectively administering Ketotifen to the colon.