Application of histamine receptor inhibitor and derivatives thereof in preparation of anti-Zika virus drugs

A histamine receptor and Zika virus technology, applied in the field of medicine, can solve problems such as the application of histamine receptor inhibitors and their derivatives that have not been seen
CN110694065AActive Publication Date: 2020-01-17MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
Publication Date
2020-01-17

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Abstract

The invention provides a histamine receptor inhibitor and derivatives thereof in the preparation of anti-Zika virus drugs. The histamine receptor inhibitor is preferably one or more of mebhydrolin napadisylate, ketotifen fumarate, flunarizine hydrochloride, cyproheptadinehydrochloride, JNJ-7777120, desloratadine, brompheniramine maleate, brompheniramine maleate, chlorpheniramine maleate and cetirizine hydrochloride. The invention brings forward for the first time that the histamine receptor inhibitor and its derivatives have clear anti-Zika virus effect and can significantly inhibit the expression level of Zika virus protein and Zika virus RNA. The invention also screens out histamine receptor inhibitors with better inhibitory effect on Zika virus, including mebhydrolin napadisylate, cyproheptadinehydrochloride, JNJ-7777120, desloratadine, etc., whose inhibition effect on Zika virus at a concentration of 10 uM is equivalent to inhibition effect of ribavirin at a concentration of 40 uM.The histamine receptor inhibitor and the derivatives can be used as good candidate drugs for anti-Zika virus drugs.
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Description

technical field

[0001] The invention relates to the technical field of medicine, and more specifically, relates to the application of a histamine receptor inhibitor and its derivatives in the preparation of anti-Zika virus drugs. Background technique

[0002] Zika virus is a mosquito-borne flavivirus. The genome is a single-stranded positive-sense RNA with a total length of about 11kb, which encodes an open reading frame (ORF) that can form a polyprotein. Zika virus was first isolated in Ugandan rhesus monkeys in 1947. The first recorded case of human infection with Zika virus was in 1952. In 2007, there was an outbreak of Zika virus on Yap Island in the Pacific Ocean. According to data released by the World Health Organization (WHO) in 2016, Zika virus infection occurred in 73 countries or regions. After a person is infected with Zika virus, the main clinical manifestations are rash, fever, muscle pain, non-suppurative conjunctivitis, and headache. In addition, after th...

Claims

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