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Electrochemiluminescence detection method of cyproheptadine hydrochloride

A technology of cyproheptadine hydrochloride and electrochemistry is applied in the field of electrochemiluminescence detection of cyproheptadine hydrochloride, electrospinning of nitrogen and phosphorus co-doped porous carbon nanofibers to prepare modified electrodes, and can solve the problem of detection of cyproheptadine hydrochloride, which is not known to exist. pyridine etc.

Pending Publication Date: 2020-08-21
GUANGXI UNIVERSITY OF TECHNOLOGY
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  • Abstract
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Problems solved by technology

[0007] At present, there is no relevant report on the detection of cyproheptadine hydrochloride by electrochemiluminescence method

Method used

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  • Electrochemiluminescence detection method of cyproheptadine hydrochloride
  • Electrochemiluminescence detection method of cyproheptadine hydrochloride
  • Electrochemiluminescence detection method of cyproheptadine hydrochloride

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Embodiment 1

[0022] Embodiment 1: a kind of electrochemiluminescent detection method of cyproheptadine hydrochloride, comprises the following steps:

[0023] (1) Synthesis of N,P-PCNF: 1.2g polyacrylonitrile (PAN, Mw=85000 g·mol -1 ) and 0.4g polyvinylpyrrolidone (PVP, Mw=54000 g·mol -1 ) was added to 7mL N, N-dimethylformamide (DMF) and stirred at room temperature for 12h, then 0.16g H 3 PO 4 Add it into the mixed solution and continue to stir for 12 hours to obtain the spinning precursor solution; spin the spinning precursor solution, that is, pour the spinning precursor solution into a 10mL syringe for spinning, and the parameters of the electrospinning device are set as: voltage 18kV; the distance between the needle tip and the collector is 10cm; the flow rate is 2.0 mL·h -1 ; The rotating speed of spinning collector is 180 r min -1 , to obtain mixed nanofibers; -1 The rate was raised to 280°C for pre-oxidation for 2h, and then in N 2 The temperature was raised to 800°C for 2 hou...

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Abstract

The invention relates to an electrochemiluminescence detection method of cyproheptadine hydrochloride. According to the method, polyacrylonitrile, polyvinylpyrrolidone and phosphoric acid are used asraw materials, N, P-PCNF is successfully prepared by adopting a method of combining electrostatic spinning with high-temperature carbonization, a glassy carbon electrode is modified to be used as a working electrode, and an electrochemiluminescence method is used for detecting the content of cyproheptadine hydrochloride in a sample. Experiments show that the N, P-PCNF has the advantages of large specific surface area, high conductivity, multiple edge defects, multiple active sites, high electron transfer speed and the like, and has good electrocatalytic activity on cyproheptadine hydrochloride. Under the optimal experimental conditions, the concentration of cyproheptadine hydrochloride and the luminous intensity have a good linear relationship. The method for detecting cyproheptadine hydrochloride has the characteristics of high sensitivity, low detection limit and wide detection range, and can be used for detecting actual samples.

Description

technical field [0001] The invention relates to a method for detecting the content of cyproheptadine hydrochloride in a sample, in particular to a method for electrospinning nitrogen and phosphorus co-doped porous carbon nanofibers to prepare modified electrodes for electrochemiluminescence detection of cyproheptadine hydrochloride. Background technique [0002] Cyproheptadine hydrochloride (CPH) is an antiallergic drug that effectively relieves allergic symptoms such as urticaria, watery eyes, and itching by blocking the histamine produced by the human body during an allergic reaction. In China, CPH is found in some animal feed products, because CPH can promote livestock weight gain by increasing appetite. But for humans, excessive use of CPH may cause coma or even death, especially for children and the elderly, so CPH has become one of the banned ingredients in animal feed and drinking water in our country. So far, the methods for detecting CPH mainly include HPLC, LC-MS,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/76G01N27/30D01F9/22D01D5/00
CPCG01N21/76G01N27/308D01D5/003D01F9/22
Inventor 程昊李彦青冯军黄文艺孔红星周正元樊静静
Owner GUANGXI UNIVERSITY OF TECHNOLOGY
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