18 results about "Pinocembrin" patented technology

The invention aims to provide a method for determining the content of main effective components of Xiaoyianmi cream and an application of the method, and aims to solve the technical problem that a Xiaoyianmi cream compound preparation is lack of efficient and accurate multi-component synchronous quality evaluation due to complex components of the Xiaoyianmi cream compound preparation. According to the method, a chromatography-tandem mass spectrometry technology is adopted, chromatography and mass spectrometry conditions are optimized, and an analysis method for simultaneously determining six components such as phloridine, piperlonguminine, piperine, N-trans-feruloyltyramine, DL-B-phenyllactic acid and pinocembrin is established. The determination method provided by the invention has the advantages of being simple and convenient to operate, high in sensitivity, good in repeatability, high in accuracy and the like, can realize rapid and synchronous determination of multi-index components in the Xiaoyi honey paste, and provides reliable technical support for quality control and standardization of the Xiaoyi honey paste.

The present invention provides a sweetener composition with improved taste quality of a sweet substance. The present invention relates to a sweetener composition containing the following components (A), (B), and (C): (A) at least one γ-glutamyl peptide selected from the group consisting of a compound represented by the formula (I): γ-Glu-X-Gly (I) wherein X is an amino acid residue or an amino acid derivative residue, and a compound represented by the formula (II): γ-Glu-Y (II) wherein Y is an amino acid residue or an amino acid derivative residue, or a salt thereof, (B) at least one compound selected from the group consisting of naringenin, hesperetin, and pinocembrin, or a salt thereof, and (C) a sweet substance.

The invention belongs to the technical field of medicines, and particularly relates to a KRAS-G12D protein inhibitor as well as a preparation method and application thereof. The protein inhibitor comprises a compound I and pinocembrin, the mass ratio of the compound I to the pinocembrin is 1: (0.03-0.05). Wherein the compound I can be used for directly targeting and blocking the interaction between KRAS G12D and CRAF, and shows strong inhibitory activity on KRAS G12D mutation tumors on biochemical and cellular levels. Further research finds that the compound I and pinocembrin are combined for use to achieve a synergistic tumor inhibition effect, so that the use dosage of the compound I is remarkably reduced on the premise of maintaining the same curative effect, and a new scientific basis is provided for subsequent development of a low-toxicity and high-efficiency tumor treatment scheme.

This invention belongs to the field of pharmaceutical technology, and particularly relates to a pharmaceutical composition for treating pancreatic cancer and its preparation method. The pharmaceutical composition comprises, by weight, the following components: 20-25 parts gemcitabine, 0.3-0.5 parts pinocembrin, and 5-12 parts sophoridine derivative. This invention, by combining gemcitabine, sophoridine derivative, and pinocembrin, maintains synergistic antitumor activity while significantly reducing liver damage, achieving the dual goals of "enhanced efficacy and reduced toxicity."

The invention belongs to the technical field of medicines, and particularly relates to a pharmaceutical composition for treating pancreatic cancer and a preparation method thereof. The pharmaceutical composition is prepared from the following components in parts by weight: 20 to 25 parts of gemcitabine, 0.3 to 0.5 part of coniferyl glycoside and 5 to 12 parts of sophocarpine derivatives. The gemcitabine, the sophocarpine derivative and the coniferyl glycoside are combined for use, so that the synergistic anti-tumor activity is maintained, meanwhile, the liver injury is obviously relieved, and the dual goals of synergism and toxicity reduction can be achieved.

The invention relates to the technical field of medicines, in particular to application of coniferyl glycoside in treatment of neurodegenerative diseases. The medicine prepared from the product disclosed by the invention has the effects of improving cognitive function and inhibiting neurodegenerative change by reducing neuron loss and improving synaptic plasticity.

The present invention relates to a composition comprising a mixture of molecules, said mixture comprising at least chrysin, pinocembrin and CAPE, for its use in the prevention or treatment of neuroinflammation and / or diseases or disorders associated with neuroinflammation.

The invention relates to the technical field of traditional Chinese medicine detection, in particular to a method for detecting the quality of a Dezhihua preparation for treating depression, and further relates to a specific chromatogram of the Dezhihua preparation, an establishment method of the specific chromatogram and a method for detecting alpinetin and pinocembrin in the Dezhihua preparation. And performing chromatographic detection on the reference substance solution and the Dezhihua preparation test solution through high performance liquid chromatography to determine a common characteristic peak, thereby establishing a characteristic spectrum and detecting the content of alpinetin and pinocembrin. According to the specific chromatogram established by the method for establishing the specific chromatogram of the Xuezhida tablet and the method for determining the contents of the alpinetin and the pinocembrin, positive significance can be achieved for quality control of the Xuezhida preparation, and the method plays an important role in treatment of depression diseases.

The invention belongs to the technical field of biological medicines, and particularly relates to application and a method of flavonoid compounds in enhancing nucleic acid molecule delivery efficiency of lipid nanoparticles. The invention aims to solve the problems of limited LNP in-vivo and in-vitro delivery efficiency, toxic risk and the like. According to the invention, seven low-toxicity and biocompatible natural compounds such as genistein, glabridin, rhoifolin, luteolin, hesperetin, galangin or pinocembrin are used as an LNP high-efficiency expression enhancer, the compounds and target cells are co-incubated, and then LNP containing nucleic acid molecules is added. According to the scheme, the LNP-mediated gene expression efficiency can be remarkably improved, the cytotoxicity can be reduced, and in-vivo experiments prove that LNP biological distribution can be optimized, target tissue expression can be enhanced, and collaborative optimization of LNP safety and high efficiency is achieved.

The invention relates to a method for preparing high-purity pinocembrin by high-speed counter-current chromatography separation, which comprises the following steps: taking propolis extract as a raw material, fully shaking a solvent system, standing for phase separation, and separately collecting an upper phase and a lower phase; the propolis extract is dissolved in an upper phase, the upper phase serves as a stationary phase, a lower phase serves as a mobile phase, high-speed counter-current chromatography is used for separation and purification, a mixed solution of the pinobufagin and the mobile phase is obtained, the mobile phase is removed, and the pinobufagin is obtained. According to the method, the high-speed counter-current chromatography technology is utilized for the first time to separate and purify the pinocembrin with the purity larger than 98% from the propolis, and the method has the advantages of no sample loss, no pollution, high efficiency, large-scale preparation, solvent recycling and the like; reagents of a solvent system adopted by the method can be recycled and reused, so that the method has a good environment-friendly function.

The invention discloses a low caffeine nerve stimulation tea wine based on bung aged wine and a preparation method thereof, the low caffeine nerve stimulation tea wine is mainly prepared by blending cherry bung aged tea wine and litchi bung aged tea wine with different baking degrees, the mass ratio of pinocembrin to syringic acid to apigenin in the wine body is (1.4-3.5): 1: (1-3), the mass ratio of chrysin to vanillic acid is 1: (0.06-0.35), and the mass ratio of the pinocembrin to the syringic acid to the apigenin is (1.4-3.5): 1: (1-3). The mass ratio of the quercetin to the dihydroquercetin to the isofraxidin is (1.5-4): 1: (0.5-2), and the total content of the pinocembrin, the syringic acid, the apigenin, the chrysin, the vanillic acid, the quercetin, the dihydroquercetin and the isofraxidin in the wine is 50-400mg / 100mL. By combining and matching the functional components in the wood and the proportion of the functional components, the antagonistic effect on caffeine nerve stimulation in the tea wine is achieved.

The present application relates to the technical field of honey detection, and particularly relates to a vitexin, a preparation method thereof and a method for identifying vitex honey. The vitexin has a structure shown in formula 1: The present application finds a new compound, vitexin, in vitex honey through research on the vitex honey. The present application also finds that when the to-be-tested honey contains vitexin (p-hydroxybenzoic acid 1-O-gentio-bioside-5-hydroxy-3,7-diene-[2,6] cyclopentanopyranyl-3-methyl ester), or contains vitexin and new chlorogenic acid, 4-hydroxybenzoic acid, chlorogenic acid, caffeic acid, p-coumaric acid, red flower phaseolus acid, trans, trans-epiabscisic acid, cis, trans-epiabscisic acid, 5-methoxy pinocembrin, pinocembrin, kaempferol, pinocembrin, benzyl caffeate, kojic acid, galangin at the same time, the to-be-tested honey can be determined as vitex honey. The present application also provides a new method for constructing a vitex honey authenticity and quality evaluation system.

The application belongs to the technical field of medicine, and particularly relates to application of pinocembrin combined with polymyxin in preparation of antibacterial drugs, wherein the bacteria targeted by the antibacterial drugs are one or more of escherichia coli, salmonella and klebsiella pneumoniae. The bacteria targeted by the antibacterial drugs are polymyxin-resistant bacteria. The bacteria targeted by the antibacterial drugs are multiple drug-resistant gram-negative bacteria. The application proves that pinocembrin effectively restores the sensitivity of bacteria to polymyxin through checkerboard minimum inhibitory concentration test and in-vitro time-kill curve, and simultaneously proves that pinocembrin can effectively enhance the antibacterial activity of polymyxin on bacteria by destroying the integrity of bacterial cell membranes and inhibiting the transcription and expression of polymyxin-resistant genes through staining experiment and fluorescence quantitative PCR. mcr-1 The application provides a new use of pinocembrin in synergizing the antibacterial activity of polymyxin antibiotics, and can solve the technical problems of polymyxin clinical drug resistance and low therapeutic index.

The invention discloses an HPLC characteristic chromatogram construction method of a pigeon pea leaf medicinal material, a concentrated solution, extract powder and a finished product, and belongs to the technical field of analysis and detection. The method specifically comprises the following steps: (1) preparing a reference substance solution; (2) preparing a test solution; (3) chromatographic conditions; and (4) determination. According to the method, a high performance liquid chromatography method is adopted, methanol-0. 1% formic acid is selected as a mobile phase for gradient elution, orientin, vitexin, pinocembrin monomethyl ether, pinocembrin, pigeon pea stilbene A and pigeon pea stilbene acid are used as reference substances, and the HPLC characteristic chromatograms of pigeon pea leaf medicinal materials, concentrated liquor, extract powder and finished products (the capsules for dredging collaterals and growing bones) are established. The method is good in precision, repeatability, stability and durability, the operability is high, analysis is convenient, stable and reliable, and the obtained high performance liquid fingerprint spectrum can effectively control the quality of pigeon pea leaf medicinal materials, concentrated solutions, extract powder and finished products.

The invention relates to an application of pinocembrin 7-O-[3 ''-O-galloyl-4 '', 6 ''-hexahydroxybiphenyl dicarbonyl]-beta-D-glucoside in preparation of a medicine for preventing and treating liver cancer, and the medicine comprises any one medicine preparation form which can be taken, or any one medicine preparation form which can be taken, or any one medicine preparation form which can be taken, or any one medicine preparation form which can be taken, or any one medicine preparation form which can be taken. The pharmaceutical preparation can be used for treating liver cancer, such as an injection, a capsule, a pill, a tablet, a granule, a tincture, an inhalation preparation, an oral solution, an oral suspension or an oral emulsion, the form of the pharmaceutical preparation is selected from oral and injection forms, the liver cancer comprises primary liver cancer and secondary liver cancer, the primary liver cancer comprises hepatocellular carcinoma, intrahepatic cholangiocarcinoma and mixed liver cancer, and the secondary liver cancer comprises hepatocellular carcinoma, intrahepatic cholangiocarcinoma and mixed liver cancer. The secondary liver cancer comprises a giant block type, a nodule type and a diffuse type.

The present application belongs to the field of agriculture, and provides application of pinoresinol in inhibiting bacteria, inducing Panax notoginseng to produce resistance, relieving Panax notoginseng leaf disease and / or promoting Panax notoginseng growth, and further provides a method for inhibiting bacteria, inducing Panax notoginseng to produce resistance, relieving Panax notoginseng leaf disease and / or promoting Panax notoginseng growth, and a biological pesticide, a Panax notoginseng resistance inducer and a Panax notoginseng growth regulator. Research shows that within a certain concentration range, pinoresinol can not only directly inhibit the growth of Alternaria panax, but also stimulate the plant to produce resistance, induce the synthesis of jasmonic acid, salicylic acid and auxin plant hormones, enhance the resistance of Panax notoginseng to leaf black spot, and regulate the growth and development of Panax notoginseng. Compared with other biological pesticides, inducers and growth regulators, the pinoresinol has the characteristics of non-toxic, non-polluting and environment-friendly, and is an effective way for Panax notoginseng green ecological prevention and control.

The present invention provides a sweetener composition with improved taste quality of a sweet substance. The present invention relates to a sweetener composition containing the following components (A), (B), and (C): (A) at least one γ-glutamyl peptide selected from the group consisting of a compound represented by the formula (I): γ-Glu-X-Gly (I) wherein X is an amino acid residue or an amino acid derivative residue, and a compound represented by the formula (II): γ-Glu-Y (II) wherein Y is an amino acid residue or an amino acid derivative residue, or a salt thereof, (B) at least one compound selected from the group consisting of naringenin, hesperetin, and pinocembrin, or a salt thereof, and (C) a sweet substance.

The application discloses a propolis extract and a production process thereof. According to mass percentage, the propolis extract comprises 25-40% of total flavones, 15-30% of total phenolic acids, 10-20% of propolis anthracene acid compounds, ≤3% of moisture, ≤2% of ash, and the balance of other natural propolis components; and the sum of acacetin, galangin and pinocembrin in the total flavones accounts for 30-50% of the mass of the total flavones. The production process comprises freezing and crushing, complex enzymolysis, ultrasonic-assisted ethanol extraction, dewaxing, macroporous adsorption resin purification and drying. The application combines enzymolysis and ultrasonic to significantly improve the extraction rate and purity of active ingredients, and the obtained propolis extract has clear components, high active ingredient content, few impurities, and the process is green and efficient, and is suitable for industrial production.