3 results about "Halcinonide" patented technology

The invention discloses a short-contact washing agent for treating scalp seborrheic dermatitis and bacterial folliculitis, and relates to the technical field of external preparations and scalp care, the short-contact washing agent comprises the following components by weight: an active component combination: 0.01-0.05 wt% of halcinonide; 0.5 to 1.0 wt% of piroctone ethanolamine; 0.1 to 0.3 wt% of total alkaloids of sophora flavescens; 0.05 to 0.1 wt% of berberine; standardized traditional Chinese medicine effective part extracts are compounded with modern active ingredients, and the problem that the quality difference between batches of traditional Chinese medicine lotion is large is solved. The combination of a plurality of active components aims to synergistically act on a plurality of targets such as anti-inflammation, antibiosis and oil control, so as to comprehensively improve the scalp condition. In addition, the specific semi-solid colloid dosage form improves the staying performance of the product on the scalp, and aims to improve the refreshing feeling after use while ensuring the cleaning effect. The lotion provides a hormone-containing and hormone-free double-version design, and provides choices for requirements of different severity degrees and different use stages.

The present invention is applicable to the technical field of chemical drug synthesis, and provides a preparation method of halcinonide intermediate, comprising the following steps: adding acetic acid to anecortave acetate in an organic solvent, reacting under the common catalysis of p-toluenesulfonic acid and trifluoroacetic anhydride, adjusting the pH value with ammonia, separating, washing, concentrating under reduced pressure, beating, filtering, and drying to obtain D-1; adding D-1 to dimethyl sulfoxide, reacting under the catalysis of potassium acetate, cooling, precipitating a solid, filtering, and drying to obtain D-2; adding an aqueous solution of sodium hydroxide or lithium hydroxide to D-2 in a reaction solvent, and hydrolyzing the reaction to obtain D-3; reacting D-3 with an acyl chloride in an aprotic solvent under alkaline conditions to obtain D-4; adding D-4 to DMF, and reacting with lithium chloride under nitrogen protection to obtain D-5. The raw material anecortave acetate used in the present invention is easily available and cheap, and the method for preparing D-5 is efficient, green, safe, and has a high yield.

The present disclosure provides a culture medium for cell culturing, the culture medium containing a combination of specific components. The present disclosure provides a culture medium which contains a combination of components selected from the group consisting of: (1) a halcinonide component; (2) an ALK4 / 7 inhibitor or a TGFβ receptor type-1 kinase inhibitor; (3) a BRD7 / 9 double degradation factor or a BRD7 / 9 binding molecule (degradation factor); (4) an LATS1 / 2 inhibitor, a PKA inhibitor, or an AKT1 inhibitor; (5) a CK1 / 2 inhibitor, an insulin receptor inhibitor, a Tyr kinase inhibitor, a PKA inhibitor or a PKC inhibitor, or an adenosine kinase inhibitor; (6) an E-selectin inhibitor, a VCAM1 inhibitor, or an ICAM1 inhibitor; and (7) an LATS1 inhibitor + an LATS2 inhibitor.