124 results about "Mycosis" patented technology

Topically applicable dermatological / cosmetic compositions suited for ungual / peri-ungual administration for the treatment of a variety of pathologies, including fungal pathologies, such as onychomycosis, contain (a) at least one biologically active agent (e.g., antifungal) and (b) at least two of the pro-penetrating agents selected from the group consisting of urea, an organic acid and an ethoxydiglycol, the at least two-pro-penetrating agents respectively being present in effective amounts as to synergistically improve the ungual / peri-ungual bioavailability of the at least one biologically active agent.

The invention includes devices and methods for obtaining samples of blood or other bodily fluids with reduced levels of contamination. Fluid obtained from a subject may be contaminated by skin cells, bacteria, fungi, viruses, phages, their respective RNA, DNA, and / or other undesirable molecules, or disinfectants. A first amount of fluid is injected from the subject through an distal needle and a proximal needle penetrates a first portion of a device having a sequestration chamber with sub-atmospheric pressure therein. A first portion of the fluid, containing contaminants, is deposited into the sequestration chamber. The proximal needle is then moved through a second portion of the sequestration chamber and into a collection container. Because contaminants are removed from the sample, analysis and diagnosis of a subject's condition becomes more reliable and accurate. Additional devices and methods can be used to obtain relatively uncontaminated samples from cell culturing vessels.

The present invention relates to methods for treating and completely curing fungal, yeast and / or mold infections in human subjects comprising topically administering to a human subject in need thereof an antifungal nanoemulsion composition.

The present invention relates to novel heterocyclic amide compounds of Formula I: as disclosed herein or a pharmaceutically acceptable salt, solvate, ester, prodrug or stereoisomer thereof. Also disclosed are compositions comprising said compounds, and methods for using said compounds for treating or preventing a proliferative disease, an anti-proliferative disorder, inflammation, arthritis, a neurological or neurodegenerative disease, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease or a fungal disease.

The present invention aims to provide a gel composition for mycosis treatment, which ensures good absorption and permeation of (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1H-1,2,4-triazol-1-yl)-butan-2-ol into a target site (skin and nail). The present invention also aims to provide a gel composition for mycosis treatment, which is excellent in stability of this drug.It is a gel composition for mycosis treatment, which comprises (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1H-1,2,4-triazol-1-yl)-butan-2-ol or an acid addition salt thereof, a lower alcohol, a polyhydric alcohol and a gel-forming polymer.The gel composition of the present invention is excellent in permeation of KP-103 into a target site and also excellent in permeation into the nail. Thus, the gel composition of the present invention allows the drug to be directly and rapidly absorbed and permeated into a target site in a constant manner, and thereby produces an excellent effect in mycosis treatment, particularly onychomycosis treatment.

The present invention relates to compounds of formula I wherein R1, R2, R3, R4, R5, U, V, W, k and m are as defined in the description and claims, and pharmaceutically acceptable salts and / or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and / or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, parasit infections, gallstones, tumors and / or hyperproliferative disorders, and treatment and / or prophylaxis of impaired glucose tolerance and diabetes.

The Chinese medicine preparation for preventing and treating disease of bee is prepared with basket kern, skullcap root, pine needle, licrorice, purslane, taraxacum, haw and rhubarb. It is used to treat bee's pericystis mycosis, lava disease, crawl disease, etc. caused by fungi, bacteria, virus and sporozoan infection, strengthening bee's immunity and prolong bee's life. It has also disinfection effect, no toxic side effect and pollution on bee and no harm to human body.

The present invention relates to a staining kit and its preparation method, staining method and its application in several detection items for detecting canceration cell, red blood cell, campylobacteriosis, vaginal cleaning degree, estrogen level, garlandosus, trichomoniasis, mycosis, diplococcus gonorrhoeae and chlamydi trachomatis on a cervical smear. Said invented kit is formed from fixatino fluid, staining solution and differentiatino solution. Its staining method includes the steps of fixation, staining, differentiation and water-washing. Its film-making speed is quick, only has need oftwo main, and its detection accuracy rate is high, can be up to 98%.

The nanometer antifungal econazole nitrate emulsion medicine consists of econazole nitrate, surfactant, oil and distilled water. Its preparation process includes the following steps: weighing the materials; mixing the surfactant and oil and dissolving econazole nitrate in dimethyl sulphoxide; mixing the solution of econazole nitrate with the surfactant and oil; and final adding distilled water slowly while stirring to form stable homogeneous transparent nanometer antifungal econazole nitrate emulsion medicine. The medicine is used in treating candidal tinea corporis, tinea cruris and tinea pedis, aural mycosis, seborrheic dermatitis, etc. The medicine is absorbed through skin to enter into blood circulation, and this avoids the first pass effect of liver, prolongs the medicine release and prevents stimulation to gastrointestinal tract. The preparation process is simple and low in power consumption.

The invention discloses a seed coating agent for resisting cotton pollenosis, whose essential components include natural abscisic acid and strong bacillus, the pesticide has prevention effect for cotton sprout damping-off disease, carbon anthrax and other mycosis.

The invention provides an antifungal drug composition for external use, and a preparation method of an external preparation, and application of the composition in treating superficial fungal infections, such as tinea manus and pedis, tinea corporis, tinea cruris, tinea unguium, tinea versicolor and oidiomycosis cutis. The drug composition contains terbinafine or pharmaceutical salt thereof, sertaconazole or pharmaceutical salt thereof, and any one or multiple pharmaceutically acceptable excipient. An experimental study shows that the terbinafine or pharmaceutical salt thereof and the sertaconazole or pharmaceutical salt thereof have obvious synergistic effect when the proportion thereof in the drug composition for treating the superficial fungal infections is (1: 10) to (5: 1)(w / w). The antifungal drug composition for treating the superficial fungal infections has the advantages of being good in security, excellent in curative effect, short in treatment course, high in curing rate, low in relapse rate and the like.

The invention provided Mucorales CotH polypeptides and encoding nucleic acid molecules. The Mucorales CotH polypeptides and encoding nucleic acids can be advantageously used to diagnose, treat or prevent fungal conditions, in particular mucormycosis.

The invention discloses a preparing method of active metabolite sesquiterpenes compound Trichothec-9-en-4-ol, 12, 13-epoxy-, acetate, (4beta)-(8CI, 9CI) of Chinese holly endogenetic fungus HaCi wood mildew strain L and appliance to prevent and cure mycosis of plant in microbe pesticide technical domain, which comprises the following steps: active-culturing bacterial; culturing seeds; proceeding ferment culture; extracting fermentate. This invention first utilizes ferment metabolite of Chinese holly endogenetic fungus into prevent and cure mycosis, which adds a new approach for agricultural bactericide.

The invention discloses an efficient method for breeding and freely raising high-quality Jing Yuan chickens and belongs to the cultivation technical field. The efficient method for breeding and freely raising high-quality Jing Yuan chickens comprises following steps: purebred seed selecting, purebred propagating, hatching egg disinfecting, hatching, brooding, free raising management and disease preventing and controlling. The breeding time is shortened, the breeding precision, the egg fertilization rate, the hatching rate and the survival rate of broods are increased and the hatching period of chicks is shortened by using the method of artificial breed protection and selection and artificial insemination of the Jing Yuan chicken of the present invention; at the same time, the method of the present invention adopts Chinese herbal medicine to control chicken diseases, improve the resistance of chickens, reduce the incidence of pullorum disease, mycosis and coccidiosis; by means of the method of ecological freely raising Jing Yuan chicken, the output of eggs is increased, the oviposition time is advanced, the slaughtering time is shortened, the body weights of hens and cocks when slaughtering are substantially increased so that the chicken is delicious, there is no residual medicine and the chicken quality of Jing Yuan chicken is increased.

The invention discloses an externally-used medicament for treating skin mycosis diseases, which is prepared from the raw materials of (by weight percent) terbinafine hydrochloride or miconazole or ketoconazole 0. 5-2%, Clobetasol Propionate 0. 01-0. 2%, neomycin sulphate 0. 3-1%, bee glue 5-25%, and balancing distilled water.

The purpose of the invention is to provide an agent for the prevention or treatment of septicemia caused by the infection of microorganism. The present invention relates to: (1) an agent for the prevention and / or treatment of septicemia caused by the infection of microorganism, comprising soybean extract or soybean fermented product as an effective; (2) An agent for the prevention and / or treatment of septicemia caused by the infection of microorganism, comprising isoflavone as an effective component; and (3) Food and drink, medicine, or cosmetics, comprising the agent for the prevention and / or treatment according to the above (1) or (2). The agent according to the present invention, which has a high suppressing activity of the abnormal production of TNF-α, is useful in the fields of medicines, cosmetics and foods, especially for the profundus mycosis patient.

The invention discloses an oil-in-water compound ketoconazole nano-medicament. The grain diameter of the medicament is 1-100nm. The oil-in-water compound ketoconazole nano medicament comprises the following raw materials in percentage by weight: 0.01-8.0 percent of ketoconazole, 0.01-10 percent of eugenol, 0.001-5.0 percent of clobetasol propionate, 25.0-45.0 percent of surfactant, 0-10.0 percentof cosurfactant, 0.1-25.0 percent of oil and the balance of distilled water. The oil-in-water compound ketoconazole nano-medicament can be used for treating stubborn skin mycotic infection, mycodermatitis, chronic mucocutaneous candidiasis, dermatitis blastomycosis, coccidioidomycosis, histoplasmosis, chromoblastomycosis and paracoccidioidomycosis, and dermatomycosis and tinea versicolor caused by dermatophyte and microzyme as well as trichophyton disease, scytitis and pruritus. The oil-in-water compound ketoconazole nano-medicament has the advantages of strong osmosis, favorable stability, favorable infiltrating property, durable acting time, remarkable effect, low cost, simple preparation method and convenience in popularization and application.

The present invention relates to novel dihydroindole and tetrahydroquinoline derivatives and pharmaceutically acceptable salts and / or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and / or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and / or hyperproliferative disorders, and treatment and / or prophylaxis of impaired glucose tolerance and diabetes.

The invention belongs to the technical field of hypochlorous acid, and particularly relates to a preparation method of high-performance hypochlorous acid. According to the method, the high-performancehypochlorous acid is prepared from chlorine-containing metal salt and water through electrolysis equipment. The effective chlorine concentration of the high-performance hypochlorous acid prepared bythe method is 200 to 800 mg / L; the high-performance hypochlorous acid can effectively kill bacteria, fungi, viruses and spores, is small in molecule and free of charges, so that the high-performance hypochlorous acid is extremely easy to diffuse and permeate to simultaneously generate an oxidation effect on the inner side and the outer side of the bacteria, the sterilization speed and the sterilization effect are obviously higher than those of common disinfectant fluid, and an environment in which resistant bacteria cannot breed can be generated.

The invention relates to Chinese and western medicament compound cream for preventing and treating onychomycosis infected by candidiasis albrican and a preparation method thereof. The cream is yellow cream formed by evenly dispersing mixture of a Chinese medicament extract and a western medicament in a substrate by use of the action of a mixed emulsifying agent. The cream prepared by the method has the advantages of even dispersed main medicament, even and smooth cream, proper viscosity, as long as easily coating on skin, mucous membrane and wound surface, and meeting the requirement of Chinese pharmacopoeia with controllable quality. Pharmacodynamic research proves that the cream has actions of preventing and treating the onychomycosis infected by Candida albicans, and has assistant treatment action on secondary inflammation because of mycotic infection, such as whitlow.

The invention discloses a heterometrus spinifer breeding method and belongs to the field of arthropod breeding study. The problems of low farrowing rate of female scorpion, low survival rate of young scorpion, difficulty in decrustation of young scorpion, death of adult scorpion and the like are solved. A heterometrus spinifer bred by the method is high in disease resistance, high in farrowing rate and high in growing speed, the survival rate is up to 95 percent, and the economic benefit is increased by 30 percent. The method comprises the following steps of selecting and breeding male scorpions, breeding and managing pregnant scorpions, breeding and managing young scorpions, performing daily management, preventing and controlling diseases, and preventing and controlling main natural enemy, wherein the indoor temperature is kept to be 32+ / -2 DEG C, the air humidity is kept to be between 70 and 80 percent, robust adult female scorpions and male scorpions are selected to be separately bred for 20 to 30 days, two female scorpions and a male scorpion are placed in a breeding room to copulate and propagate, the pregnant scorpion gives birth to young scorpions 4 to 6 months later, about 50 days after the young scorpions are born, the young scorpions are separated from the female scorpions, the density is that 200 to 250 young scorpions are contained in one box, the young scorpions which are 3 years old are grouped, and after being bred for 14 to 16 months, the young scorpions are grown into adult scorpions. Mycosis and bacterial wilt are prevented and controlled by enhancing daily management, and natural enemies, such as ants and geckos are prevented and controlled by taking effective measures.

The invention relates to the technical field of microorganisms, in particular to a bacillus velezensis strain wr8 and application thereof. The bacillus velezensis wr8, fungicide and metabolite have the wide antibacterial and disease-resistant effects, and have the inhibiting effect on penicillium, penicillium, botrytis cinerea, escherichia coli, listeria monocytogenes and other germs, and in the direct application, the strain can be used for preventing and treating southern blight and root rot of siraitia grosvenorii, and can be used for preventing and treating banana fusarium wilt, orange mycosis, citrus reiculata mycosis and the like; the bacillus velezensis strain wr8 can be applied to fruit preservation of the plants, and the application range of the bacterial fertilizer biocontrol field is quite wide; and meanwhile, the strain can inhibit escherichia coli and listeria monocytogenes, can also be applied to the field of food preservation, has multiple functions and wide application fields, and has good prospects in the fields of later food processing, fruit and vegetable preservation, biological control and biological bacterial fertilizers.

The Chinese medicine preparation for preventing and treating disease of bee is prepared with basket kern, skullcap root, pine needle, licrorice, purslane, taraxacum, haw and rhubarb. It is used to treat bee's pericystis mycosis, lava disease, crawl disease, etc. caused by fungi, bacteria, virus and sporozoan infection, strengthening bee's immunity and prolong bee's life. It has also disinfection effect, no toxic side effect and pollution on bee and no harm to human body.

The invention discloses a preparation for preventing and treating post-harvest mycosis of fruits, and belongs to the field of post-harvest fresh-keeping. The preparation consists of 0.08-0.15% boric acid and 0.8-1.2% chitosan oligosaccharide. According to the invention, the boric acid and chitosan oligosaccharide composite preparation has a better bacteriostatic effect on penicillium expansum, byssochlamys and penicillium citrinum. Compared with single treatment of the chitosan oligosaccharide or the boric acid, the chitosan oligosaccharide and the boric acid can generate a synergistic effect,can effectively inhibit the growth of spores and hyphae, and have a better bactericidal effect. In addition, the preparation of the invention obviously improves the hardness of fruits, maintains highcontent of soluble solid matters in the fruits, obviously reduces the incidence rate of the fruits, reduces the occurrence of mildew, improves the fresh-keeping effect, and prolongs the preservationtime.

A Chinese medicine in the form of powder or lotion for treating skin mycosis is prepared from 15 Chinese-medicinal materials including green tea, dandelion herb, phellodendron bark, mint, etc.

The invention relates to a traditional Chinese medicinal composition for treating dermatophytosis, which is prepared from crab's shell, corktree bark, flavescent sophora root, sea tangle and clam shell. The dosage form of the preparation includes ointment, cream, gelling agent, liniment and lotion.

The invention discloses an antibacterial and itching-relieving medicine composition and a preparing method thereof. The medicine composition is prepared from, by weight, 4 parts to 8 parts of fructus kochiae, 4 parts to 8 parts of calamine, 2 parts to 5 parts of mint and 1 part to 3 parts of borneol, and further comprises 6 parts to 10 parts of folium artemisiae argyi, 2 parts to 6 parts of radix sophorae flavescentis, 1 part to 4 parts of rhizoma atractylodis, 4 parts to 8 parts of folium mori, 2 parts to 6 parts of coptis chinensis, 2 parts to 6 parts of cortex phellodendri, 2 parts to 5 parts of semen plantaginis, 4 parts to 8 parts of lophatherum gracile and 4 parts to 8 parts of stephania tetrandra. The antibacterial and itching-relieving medicine composition has the effects of effectively resisting bacteria and rapidly relieving itching, the clinical cure rate for superficial-part fungal diseases is high, treatment time is short, relapsing is avoided after curing, and good application prospects are achieved.