91 results about "Dermatomycosis" patented technology

A device is provided that allows for target treatment of infections, caused by dermatophytes, yeast fungus, and mould fungus, such as onychomycosis and dermatophytosis. The device comprises a nitric oxide (NO) eluting polymer arranged to contact the infected area, such that a therapeutic dose of nitric oxide is eluted from said nitric oxide eluting polymer to said area. The nitric oxide (NO) eluting polymer is integrated with a carrier material, such that said carrier material, in use, regulates and controls the elution of said therapeutic dosage of nitric oxide (NO). Furthermore, a corresponding manufacturing method is provided.

The invention discloses a skin wound repair hydrogel and a preparation method thereof. The skin wound repair hydrogel contains aloe original gel, chitosan, beta-sodium glycerophosphate and water; pH is 7.0-7.5. The preparation method mainly comprises the following steps: mixing 1-4% (w / v) chitosan solution and aloe original gel in volume ratio of 1: 1-2 at 2-10 degrees centigrade, then dropwise adding beta-sodium glycerophosphate aqueous solution, adjusting pH of solution to 7.0-7.5, and forming the hydrogel at 4-50 degrees centigrade. The skin wound repair hydrogel provided by the invention is capable of promoting generation of skin capillarity tubes, is beneficial to growth of tissue to protect nerve endings of wounds and reduce pain, is used for treating suppurative dermatosis, superficial dermatomycosis, skin trauma and ultraviolet dermatitis, and is featured with effects of diminishing inflammation, sterilizing, alleviating pain, absorbing heat, anti-swelling, softening skins, relieving pain and improving scars.

The present invention relates to a pharmaceutical formulation comprising a pharmaceutically activeagent; water; a polyethylene glycol or a poloxamer; and a polyethylene glycol mono- or di-ether. Preferably the pharmaceutically active agent is an anti-fungal or anti-mycotic agent. Preferably the pharmaceutically active agent is lipophilic and / or keratinophilic. The present invention also relates to the use of the formulation in treating diseases, disorders or pathological conditions of the nail or skin, such as onychomycosis, dermatomycosis and other mycoses. The present invention also relates to a method of administering a pharmaceutically active agent to a subject by applying the formulation comprising the pharmaceutically active agent to a nail or skin of the subject. The present invention further relates to a method of preparing the formulation.

The invention discloses a Qin fish feed. The Qin fish feed is prepared by cooking raw materials of fresh sweet potatoes and soybeans, which are wild in resource, swine fat meat, mussel meat, and silkworm chrysalis, crushing, and adding pumpkin fermented glutinous rice, corn starch, locust meal, poultry eggs, and the like, burdening, thickening, performing extrusion forming, drying and the like so as to prepare the earthworm-shaped nutrient and health-care daily Qin fish feed which is rich in fat, protein, dietary fiber, pectin, multiple kinds of vitamins, microelement and the like, interesting, nutrient and capable of promoting the growth; in addition, the feed has the effects of preventing and curing diseases such as dermatomycosis and rotted gill, which are easily caused by Qin fish. The feed has the advantages of being well chewy, softened when being put in water, fragrant, palatable, low in cost, and convenient to process, storage and feed, the ratio of output to input is high.

The invention relates to amorolfine cream for treating dermatomycosis and cutaneous candidiasis caused by dermatophytes. The amorolfine cream comprises amorolfine or pharmacologically tolerable salt thereof and polyethyleneglycol-7 stearate. The amorolfine cream which is refined, has the particle size meeting the requirements of Chinese pharmacopoeia on cream quality and has good coating performance can be prepared by use of low-speed stir during preparation. The cream has better high-temperature resistant stability, and is not easy to have oil-water separation. Therefore, the amorolfine cream has the advantages of better suitability for industrial production and better stability.

The invention discloses an oil-in-water compound ketoconazole nano-medicament. The grain diameter of the medicament is 1-100nm. The oil-in-water compound ketoconazole nano medicament comprises the following raw materials in percentage by weight: 0.01-8.0 percent of ketoconazole, 0.01-10 percent of eugenol, 0.001-5.0 percent of clobetasol propionate, 25.0-45.0 percent of surfactant, 0-10.0 percentof cosurfactant, 0.1-25.0 percent of oil and the balance of distilled water. The oil-in-water compound ketoconazole nano-medicament can be used for treating stubborn skin mycotic infection, mycodermatitis, chronic mucocutaneous candidiasis, dermatitis blastomycosis, coccidioidomycosis, histoplasmosis, chromoblastomycosis and paracoccidioidomycosis, and dermatomycosis and tinea versicolor caused by dermatophyte and microzyme as well as trichophyton disease, scytitis and pruritus. The oil-in-water compound ketoconazole nano-medicament has the advantages of strong osmosis, favorable stability, favorable infiltrating property, durable acting time, remarkable effect, low cost, simple preparation method and convenience in popularization and application.

A Chinese medicine in the form of liquid for treating tinea manuum, tinea pedis, rhagas, desquamation, onychomycosis, etc is prepared from more than 10 Chinese-medicinal materials including Sichuan prickly ash, Chinese gall, etc through proportioning, decocting for 30-60 min, filter, proportionally mixing the decoction with acetic acid and essence. Its advantages are unique curative effect, high safety and low cost.

The invention discloses a special-purpose feed for juvenile fishes of Matsue perches. The feed is prepared from the following components in parts by weight: 50-70 parts of clams, 10-15 parts of fish meal, 20-30 parts of sesame seed meal, 5-10 parts of purslane, 5-10 parts of garlic, 6-12 parts of wild chrysanthemums, 2-4 parts of pomegranate rind, 3-5 parts of Chinese scholartree leaves, 8-16 parts of Chinese dates, 1-5 parts of pomelo peel, and 4-8 parts of onions. The preparation technology is simple and the operability is high. The content of crude proteins in the feed can be increased through fermentation treatment, the traditional Chinese medicine plants are added, so that the feed can play the action of disease and pest resistance, and virus resistance, and the feed has the effects of preventing and treating dermatomycosis, bacterial gill-rot diseases and the like. The Chinese dates are added in the feed, so that the immunity of the juvenile fishes is convenient to improve; the pomelo peel and the onions, which are added, can effectively improve the tastiness of the feed. The particle feed disclosed by the invention has the advantages that the stability of the feed in water is good, breed water is not easy to pollute, the survival rate of the juvenile fishes of the Matsue perches is increased, the feed coefficient is reduced, and the feed conversion rate is increased.

The invention relates to a traditional Chinese medicinal composition for treating dermatophytosis, which is prepared from crab's shell, corktree bark, flavescent sophora root, sea tangle and clam shell. The dosage form of the preparation includes ointment, cream, gelling agent, liniment and lotion.

Disclosed is a Chinese medicinal powder or lotion preparation for treating dermatophytosis and process for preparing, wherein the constituents include (by weight portions) green tea 850-1050g, dandehon herb 750-950g, sweet wormwood 950-1150g, yellow corktree bark 750-950g, spearmint 550-750g, alkanna tinctoria 550-750g, broom cypress fruit 650-850g, cnidium fruit 450-650g, knotgrass 750-950g, bunge corydalis herb 650-850g, flavescent sophora root 950-1150g, dahurian angelica root 950-1150g, dittany bark 550-750g, Chinese pink herb 850-1050g, and cocklebur fruit 650-850g.

The invention discloses a dermatomycosis treatment emulsifiable paste which comprises the following raw materials by weight: an A component comprising 2.0% of miconazole nitrate, 0.2-0.5% of clobetasol propionate, 2.0-5.0% of dimethyl sulfoxide and 4.0-6.0% of propylene glycol; a B component comprising 1.0-3.0% of menthol, 1.0-3.0% of camphor and 0.4-0.6% of borneol; a C component comprising 2.0-5.0% of an emulsifying thickener; a D component comprising 0.2-0.3% of a DMDMH preservative and 0.5% of the essence; and balance water. The emulsifiable paste preparation method is as follows: according to the dosage, mixing the miconazole nitrate and the clobetasol propionate in the A component, heating for dissolving the mixed miconazole nitrate and clobetasol propionate with the propylene glycol, then adding into the dimethyl sulfoxide for fully dissolving, then mixing and stirring with menthol, camphor and borneol melt of the B component; then slowly adding the emulsifying thickener into the water, stirring while adding, after the completion of the adding, homogenizing for 15 minutes to obtain the C component; and finally mixing and homogenizing the A, B, C and D components into a paste, and filling to obtain the dermatomycosis treatment emulsifiable paste. The dermatomycosis treatment emulsifiable paste can be used in the treatment of a variety of fungal infection caused skin diseases.

The invention discloses a compound terbinafine nanomedicine used for treating skin diseases. The grain size of the medicine is 1nm-10nm, and the compound terbinafine nanomedicine comprises the following components: 0.1%-10% of terbinafine, 0.1%-15% of eugenol, 0.1%-5% of erythromycin, 0.1%-10% of oil, 10%-40% of surfactant, 4%-20% of cosurfactant and the balance of distilled water, and the total percentage by weight of the components is 100%. The medicine disclosed by the invention has the advantages of small particle size, low viscosity, good liquidity, stable properties and better percutaneous permeability, and not only has a stronger curative effect on pet dermatomycosis, but also has a strong therapeutical effect on pet bacterial skin diseases and parasitic skin diseases. The compound terbinafine nanomedicine disclosed by the invention is easy to prepare, is low in energy consumption, and can be in mass production without special equipment. The compound terbinafine nanomedicine has wide application prospects in the aspect of pet skin disease treatment.

The present invention discloses crataegus pit extract or its medicinal composition and its application in preparation of medicine for curing or preventing mycetes, specially for resisting dermatomycosis and candidiosis. Said invention uses the crataegus pit as raw material, and adopts the existent technological process including the steps of pyrogenic distillation, purification and others to obtain the crataegus pit distillate oil raw liquor. Said medicine has no any toxic side effects, and its therapeutic effect is obvious.

The present invention relates to the preparation of universal inactivated vaccines and their use in preparing compositions for the prophylaxis and therapy of dermatomycosis. Vaccines according to the present invention have the advantage of conferring immunity against all important causes of dermatomycosis in animals and are characterized by stable immunogenic properties, easy preparation, high content of microconidia and lack of side reactions in animals.

The invention discloses a Chinese herbal compound film for treating dermatomycosis and a preparation method thereof. The compound film comprises the following raw materials: turmeric extract, blackberry lily extract and gardenia extract. The turmeric extract, blackberry lily extract and gardenia extract are added into a film forming solution prepared from auxiliary materials such as polyvinyl alcohol, glycerol and the like in a ratio of (2-8):(1-5):(1-3), and then a suitable solubilizer and a transdermal enhancer are added to prepare the Chinese herbal compound film. The prepared film has the advantages of high viscosity, high medicine penetrating power, convenience in use and the like; the film has an effect of resisting microsporum canis, alpha fungus, microsporum gypseum and candida albicans, and can be used for treating dermatomycosis caused by the fungus above.

The invention discloses a Chinese herbal medicament for treating dermatomycosis of rabbits and a treatment method thereof. The medicament is prepared from 5-15 parts of phellodendron bark as a bulk drug and 5-15 parts of vaseline as an auxiliary drug by pulverizing and mixing uniformly. According to the treatment method, the raw materials are mixed uniformly and then applied to an affected part once per day continuously for 5-7 days, so that dermatomycosis can be healed. The medicament disclosed by the invention selects phellodendron bark as the bulk drug combined with vaseline, and has a good therapeutic effect on dermatomycosis of rabbits clinically; the phellodendron bark has bacteriostatic and antifungal effects, and the vaseline as a chemical raw material has viscosity and an effect of adhering to skin, so that the phellodendron bark and the vaseline after being mixed can continuously play drug effects on the affected part, thereby achieving the healing effect. In treating sick rabbits, the effective rate of treatment is above 90%, and the medicament has the characteristics of being lower in cost, convenient to prepare, simple to use, obvious in effect and the like.

The present invention addresses the problem of providing, in order to treat dermatomycosis accompanying severe inflammations such as flare ups, an externally applied pharmaceutical composition which includes a combination of an anti-fungal agent and a steroidal agent, and in which the anti-fungal agent and the steroidal agent do not interfere with each other. This externally applied pharmaceutical composition for treating mycosis is characterized by including: a compound represented by general formula (1) shown below (in general formula (1), R represents hydrogen or a halogen, and X represents a halogen), and / or a salt thereof; and a steroid selected from prednisolone, dexamethasone, hydrocortisone, clobetasone, clobetasol, betamethasone, and mometasone.

The invention discloses a method for purifying body-surface fungal diseases of livestock in a livestock farm at a time. The method is characterized in that fungal disease pathogens in the body surfaces and environments of rabbits are killed at a time by using a medicine to achieve the aim of purifying epidemic diseases in the livestock farm. By virtue of natural infection, artificial infection, observation of infection focuses of baby rabbits, young rabbits and adult rabbits, separation of body-surface and in-vivo pathogenic fungi, observation of the effects of series prevention and treatment methods and analysis of the susceptibility of the rabbits of different day ages, a propagation mode and a propagation medium of body-surface fungal diseases and a body-surface fungal parasitism mechanism are determined; a medicine for purification is screened out, the dosage is determined, and a using method of the medicine is adopted. The cost is equal to the full one-time sterilization cost, and the method is simple and easy to operate. The method is applicable to purification of the body-surface fungal diseases of pigs, cattle, sheep, rabbits, dogs, cats, horses, mules, donkeys and other special animals in the livestock farm. A simple livestock farm of which colony houses are non-standard in design and construction is needed to be repeatedly reinforced when the method is applied, so that the aim of purification can be achieved.

The invention discloses a medicine composition for treating dog dermatomycosis and a preparation method and application thereof, and belongs to the field of preparation and application of medicine for treating the dog dermatomycosis. The medicine composition for treating the dog dermatomycosis comprises a sorpio extract, a radix curcuma extract and a laminaria extract. The invention further discloses a preparation method of the compound antifungal medicine composition. The preparation method comprises the steps that all the components are weighed by mass, then appropriate auxiliary materials or carriers are added, and the external preparation for livestock is prepared according to a conventional preparation method. The invention further discloses medicine which has the better effect on dog dermatomycosis treatment, and the medicine is composed of a first component and a second component which are independent to each other; the first component comprises the sorpio extract, the radix curcuma extract and the laminaria extract, and the second component adopts itraconazole. The medicine composition for treating the dog dermatomycosis has the advantages of being low in cost, good in safety and treatment effect, small in side effect and the like.

An anti-Trichophyton film containing calcium hydrogen carbonate and an anti-Trichophyton forming agent enable easy formation, on a human skin, of an antibacterial film containing calcium hydrogen carbonate while assigning antibacterial effect possessed by a natural material thereto by using scallop shell as a raw material, and form an antibacterial film of calcium hydrogen carbonate with the antibacterial effect of the natural material added thereto through a simple structure, thereby enhancing the curative effect to athlete's foot. The anti-Trichophyton film forming agent is obtained by mixing a powder obtained by calcinating scallop shell mainly composed of calcium carbonate with distilled water. Remedies for dermatophytosis are prepared by grinding and calcinating scallop shells having a crystalline structure due to the calcite structure of calcium carbonate.

The invention discloses a Chinese herbal medicine complex formula for preventing and treating freshwater fish dermatomycosis and a preparation method. The preparation method comprises the steps that by weight, 5-15 parts of tobacco leaves, 2-8 parts of sodium chloride and 50-110 parts of water are obtained, mixed and heated to obtain the Chinese herbal medicine complex formula for preventing and treating freshwater fish dermatomycosis. The Chinese herbal medicine complex formula has no toxic or side effect on growth of freshwater fish, and is easy and convenient to use, small in dosage, remarkable in treatment effect, low in cost and suitable for being used under the condition of intensive cultivation of various kinds of freshwater fishes.

The invention relates to a method for preparing nanosilver and finishing a fabric. The method comprises the steps: according to the volume ratio of 100:1-1:1, mixing a 0.01-1 g / L thymol solution with a 0.01-100 g / L silver nitrate solution, carrying out uniform-velocity stirring for 10-600 min under the condition of the temperature of 30 DEG C-80 DEG C, to obtain a nanosilver colloidal solution, repeatedly washing with ethanol and deionized water, centrifuging, carrying out drying treatment to obtain silver nanoparticles, then dipping the fabric into a nanosilver solution with the concentration of 0.01-10 g / L, and dipping for two times and rolling for two times. Thymol is used as a reductant and a stabilizer, and the method has the advantages of simple process, mild reaction, green environmental protection and the like. The prepared nanosilver is used in the textile field, can prepare the blended fabric having multiple efficacies of fragrance, corrosion prevention, sterilization, mite removal, dermatomycosis and tinea disease prevention, and greatly improves the added value of textiles.

An antibacterial composition for external application, particularly, a remedial formulation for external use containing fluconazole is disclosed. The formulation comprises a base material, 0.1-5.0 percent by weight of fluconazole and 1.0-40.0 percent by weight of any one compound selected from a group consisting of fatty acid, fatty alcohol, higher fatty acid ester and lower alcohol based on weight of the base material. The composition according to the present invention has various advantages of a favorable absorption into a system through the skin of a human body and delivery of active material into horny layer of the skin, a reduced skin stimulation and an excellent stability. Therefore, the composition is efficiently useable in a medical treatment application for dermatomycosis-related infectious diseases including tinea pedis, tinea corporis, tinea cruris, tinea versicolor and / or candidiasis and the like.

The invention relates to an oral blood-clearing preparation made by nine crude drugs of humifuse euphorbia, chinaroot greenbrier, aloe, myrobalam, fructus canarli, tamarind, date, polypodium, scammony resin which are commonly used by Uighur doctors. The preparation has the functions of clearing sepsis, regulating succus disorder, unblocking retardarce and strengthening control organs and is an oral blood-clearing preparation applicable to the skin diseases of psoriasis, allergic dermatitis, urticaria, shingles, acne, neurodermitis, dermatomycosis, and the like caused by the succus disorder as well as diseases such as constipation and the like.

The invention relates to a compound clotrimazole combination for treating livestock dermatomycosis and a preparation method thereof. The combination is prepared by uniformly mixing the following components in parts by weight: 3-5 parts of clotrimazole, 2-4 parts of ketoconazole, 1-3 parts of lauryl sodium sulfate, 3-5 parts of octadecanoic acid, 3-5 parts of white vaseline, 24-28 parts of liquid paraffin, 2-4 parts of castor oil, 0.4 parts of ethylparaben, 1-3 parts of PEG-400 (polyethylene glycol-400), 1-3 parts of essence, 40-60 parts of distilled water and the like. The compound clotrimazole combination has the beneficial effects of reasonable formulation, simplicity in preparation, quite obvious curative effect and special livestock dermatomycosis treatment effect proven by clinical application.

The invention provides a pharmaceutical composition for treating dermatomycosis infection. The pharmaceutical composition is prepared from the components: azole antifungal drugs, radix sophorae flavescentis, fructus cnidii, spikes of Chinese mustard, radix angelicae dahuricae, fructus forsythiae, rhizoma atractylodis, radix clematidis, rhizoma smilacis glabrae, chaulmoogra, gallnut, cortex dictamni, cortex phellodendri, rheum officinale and auxiliary materials. The invention provides the pharmaceutical composition for treating dermatomycosis infection and a preparation process thereof. By adopting the theory of combination of traditional Chinese medicine and western medicine, the selected western medicine has an antifungal effect, and the selected traditional Chinese medicines have the effects of clearing heat and drying dampness. The pharmaceutical composition can treat both symptoms and root causes, has the advantages of wide treatment range, remarkable clinical effect, small toxic and side effects, convenient and safe use, simple and feasible preparation process, low cost and remarkable clinical application effect, and is suitable for wide popularization.

The present invention relates to a liquid medicine in treating tinea, ringworm and dermatomycosis and its preparation method. It is prepared by the following steps: using the Chinese medicinal materials of clove, stemona root, alum and sumac gallnut as raw material, proportioning them, soaking them in alcohol for several days, adding edible vinegar essence so as to obtain the invented product. Said liquid medicine not only can be used in effectively treating tinea corporis, tinea manuum and tinea pedis, but also can be used in treating general dermatosises of eczema, red swelling and titillation, and its therapeutic effect is obvious.

The invention discloses a saffron feature-beautifying perfumed soap, and belongs to the field of daily washing products. The perfumed soap is prepared by mixing a natural soap base and a traditional Chinese medicine mixed powder with the mass ratio of 3:2 and then pressing. The traditional Chinese medicine mixed powder includes the components: saffron, cortex pseudolaricis, radix paeoniae rubra, cortex moutan, wild chrysanthemum flower, radix angelicae, borax, and calamine. The saffron feature-beautifying perfumed soap adopts the natural plant soap base, does not contain chemical additives, can play basic roles in removing dirt, sterilizing, keeping moisture, and cleaning skin; traditional Chinese medicine ingredients are in reasonable collocation to be added into the perfumed soap, and the saffron feature-beautifying perfumed soap can treat dermatomycosis and other beauty damaging diseases, is capable of promoting blood circulation to remove blood stasis, and makes the skin restoring or maintaining ruddy and healthy.

The invention discloses an antifungal capsule for dogs and cats. The drug provided in the invention is the capsule prepared by making itraconazole into particles. Nearly 10 years of wide-range application of the drug itraconazole proves its efficacy and safety. With definite curative effects, the drug disclosed in the invention can effectively alleviate the development of dermatomycosis in dogs and cats.