9 results about "Impetigo" patented technology

The invention discloses an application of betulinic acid 28-O-beta-D-glucoside (BA-6 for short) in preparation of a medicine for preventing and treating skin inflammation. The problems that an existing medicine for treating dermatitis is limited in curative effect, slow in effect taking, multiple in side effect, high in long-term use risk, large in individual difference, high in treatment cost, likely to cause immunoreaction and the like are solved. The invention discloses application of BA-6 in prevention and treatment of atopic dermatitis, contact dermatitis, eczema, rash, psoriasis, lupus erythematosus, papule squamous skin disease, pityriasis rosea, seborrheic dermatitis, pemphigus, celestial abscess, acne, tinea corporis, impetigo, SAPHO syndrome, hidradenitis suppurativa, dermatitis caused by drugs, lichen planus, pityriasis rubra pilaris, vitiligo, prurigo nodularis, dermatitis caused by drugs, and the like for the first time. The traditional Chinese medicine composition can be used for treating skin diseases, systemic sclerosis, hidradenitis suppurativa, granulomatous skin diseases, vitiligo, dermatomyositis, chronic skin itch and alopecia areata, and has the technical progress of obviously improving skin erythema, papule, edema, scale, moss and ulceration symptoms.

A composition comprising isolated Streptococcus pyogenes extracellular vesicles (EVs) suspended in a vehicle, for use in eliciting an adaptive immune response against group A streptococcus (GAS) in a subject. The EVs may comprise antigens MtsA, Spy_1228, PrsA1, PrsA2, SPy_0319 and / or GlnP. A composition comprising isolated S. pyogenes protein(s) MtsA, SPy_1228, PrsA1, PrsA2, GlnP, SPy_0319 and / or MalX. The compositions may be used for inducing protective immunity in a subject against a GAS infection, such as streptococcal pharyngitis, scarlet fever, impetigo, streptococcal meningitis, streptococcal sinusitis, necrotizing fasciitis, cellulitis, streptococcal toxic shock syndrome, rheumatic fever and post-streptococcal glomerulonephritis.

A composition comprising isolated Streptococcus pyogenes extracellular vesicles (EVs) suspended in a vehicle, for use in eliciting an adaptive immune response against group A streptococcus (GAS) in a subject. The EVs may comprise antigens MtsA, Spy_1228, PrsA1, PrsA2, SPy_0319 and / or GlnP. A composition comprising isolated S. pyogenes protein(s) MtsA, SPy_1228, PrsA1, PrsA2, GlnP, SPy_0319 and / or MalX. The compositions may be used for inducing protective immunity in a subject against a GAS infection, such as streptococcal pharyngitis, scarlet fever, impetigo, streptococcal meningitis, streptococcal sinusitis, necrotizing fasciitis, cellulitis, streptococcal toxic shock syndrome, rheumatic fever and post-streptococcal glomerulonephritis.

The present invention relates to the cosmetic use of phytosterols to protect and / or restore the skin microbiota and / or to prevent and / or reduce the unsightly, unpleasant, and / or uncomfortable manifestations of skin microbiota alteration. It further relates to a cosmetic treatment method comprising the topical application of phytosterols to at least one area of ​​skin, advantageously the scalp, to protect and / or restore the skin microbiota and / or to prevent and / or reduce the unsightly, unpleasant, and / or uncomfortable manifestations of skin microbiota alteration.Finally, it concerns phytosterols for their use in the treatment and / or prevention and / or reduction of the occurrence of a pathology associated with an alteration of the skin microbiota, in particular chosen from the group consisting of acne, psoriasis and bacterial and / or fungal infections, ulcers, herpes, boils, folliculitis, abscesses, sycosis, impetigo, ecthyma, erysipelas, mycoses such as candidiasis or dermatophytoses such as ringworm and / or scabies, pigmentary and / or acne scars as well as their combinations and / or in the treatment and / or prevention of superinfection of wounds and / or in the prevention of spots.

The invention belongs to the technical field of biological medicines, and particularly discloses a Pi scorpion polypeptide and application thereof. Through molecular biology, site-specific mutagenesis, chemical synthesis and other methods, the obtained Pi scorpion polypeptide can effectively inhibit the growth of escherichia coli, pseudomonas aeruginosa, staphylococcus aureus, propionibacterium acnes and related drug-resistant bacteria at low concentration. The pemai Pi scorpion polypeptide has a very good effect in treating or preventing folliculitis, furuncle, impetigo, acne and whelk caused by escherichia coli, pseudomonas aeruginosa, acinetobacter baumannii, propionibacterium acnes, staphylococcus aureus, related drug-resistant bacteria and the like. The pemai Pi scorpion polypeptide disclosed by the invention has good activity in resisting escherichia coli, pseudomonas aeruginosa, acinetobacter baumannii, propionibacterium acnes, staphylococcus aureus and related drug-resistant bacteria, and can be further developed and utilized as an antibacterial drug for treating folliculitis, furuncle, impetigo, acne, whelk and the like.

A peptide-ionic liquid conjugate for the prevention and / or treatment of skin disorders. The peptide-ionic liquid conjugate comprises a cosmeceutical peptide comprising up to 10 amino acids and at least one ionic liquid comprising saturated or unsaturated hydrocarbon chain substituents from C1 to C18. The peptide-ionic liquid conjugates herein disclosed are suitable against skin disorders, such as, e.g., melanoma, non-melanoma skin cancers, diabetic foot ulcers, venous leg ulcers, pressure ulcers, acne, candidiasis, cellulitis, dermatophytoses, erysipelas, folliculitis, impetigo, psoriasis, rosacea, or eczema (atopic dermatitis), since they present potent activity against either antibiotic-susceptible strains or multidrug resistant clinical isolates of both Gram-positive and Gram-negative, a bactericidal type of action, anti-inflammatory and immunomodulatory effects, and collagenesis-inducing effects. Further disclosing a topical composition comprising the peptide-ionic liquid conjugates and uses thereof.

The invention discloses an application of betulinic acid 28-O-beta-D-glucoside (BA-6 for short) in preparation of a medicine for preventing and treating skin inflammation. The problems that an existing medicine for treating dermatitis is limited in curative effect, slow in effect taking, multiple in side effect, high in long-term use risk, large in individual difference, high in treatment cost, likely to cause immunoreaction and the like are solved. The invention discloses application of BA-6 in prevention and treatment of atopic dermatitis, contact dermatitis, eczema, rash, psoriasis, lupus erythematosus, papule squamous skin disease, pityriasis rosea, seborrheic dermatitis, pemphigus, celestial abscess, acne, tinea corporis, impetigo, SAPHO syndrome, hidradenitis suppurativa, dermatitis caused by drugs, lichen planus, pityriasis rubra pilaris, vitiligo, prurigo nodularis, dermatitis caused by drugs, and the like for the first time. The traditional Chinese medicine composition can be used for treating skin diseases, systemic sclerosis, hidradenitis suppurativa, granulomatous skin diseases, vitiligo, dermatomyositis, chronic skin itch and alopecia areata, and has the technical progress of obviously improving skin erythema, papule, edema, scale, moss and ulceration symptoms.

The invention discloses a traditional Chinese medicine composition for preventing and / or treating inflammatory skin diseases and application thereof.The traditional Chinese medicine composition is composed of Sichuan rhizoma coptidis, Sichuan cortex phellodendri, scutellaria baicalensis and betel nuts, the Sichuan cortex phellodendri serves as a monarch drug to clear away heat and dry dampness, purge fire to remove toxin and astringe dampness and heal sores, the Sichuan rhizoma coptidis, the scutellaria baicalensis and the betel nuts serve as ministerial drugs, the Sichuan rhizoma coptidis purges fire to remove toxin and directly fold heat toxin, and the Sichuan cortex phellodendri and the betel nuts serve as monarch drugs. Baikal skullcap root is used for clearing heat, drying dampness, cooling blood and detoxifying, rhizoma coptidis from Sichuan of China and baikal skullcap root are cooperated with monarch drugs to strengthen the effects of eliminating dampness and detoxifying, betel nut is used for promoting the circulation of qi, promoting urination, helping rhizoma coptidis from Sichuan of China, baikal skullcap root and golden cypress to dredge damp evil and relieve swelling and exudation, and the pungent and divergent properties of betel nut can slightly prevent excessive stasis of drug properties, facilitate penetration of drug properties to skin, kill parasites to relieve itching and directly relieve itching caused by insect epidemic. According to the traditional Chinese medicine composition, only four medicines are combined, the composition is simple, all the medicines have a synergistic effect, damp-heat toxin can be attacked by drying, clearing, benefiting and killing, pathogenic factors can be strongly removed, and skin diseases such as acute eczema, impetigo and contact dermatitis can be effectively treated.

The invention discloses a neonatal impetigo compound preparation which is characterized by comprising the following components in parts by mass: 6-8 parts of pollen typhae, 40-45 parts of balsam pear leaves, 6-9 parts of rhizoma bletillae, 13-15 parts of lophatherum gracile, 16-19 parts of radix rehmanniae recen, 8-12 parts of rhizoma anemarrhenae, 6-9 parts of cortex phellodendri, 10-12 parts of fructus forsythiae, 12-15 parts of semen plantaginis, 6-8 parts of radix aucklandiae and 4-6 parts of raw longan fruit. Through compatibility of the medicines, the traditional Chinese medicine composition has the effects of resisting bacteria and inflammation and enhancing immunity. The traditional Chinese medicine composition has a strong inhibition effect on various pathogenic bacteria, such as bacteria, fungi and viruses, and can be used for effectively treating the neonatal impetigo disease by enhancing the immunity of the organism through the synergistic transportation and transformation of internal organs. The treatment thought of clearing heat, astringing, promoting the circulation of qi and dispelling cold is provided, that is, the compatibility synergistic interaction mechanism of balsam pear leaves (clearing heat and reducing blood sugar), rhizoma bletillae (astringing to stop bleeding), radix aucklandiae (promoting the circulation of qi and relieving pain) and raw longan fruits (dispelling cold and warming middle-jiao) is differentiated from the single antibacterial mechanism of existing antibacterial drugs.