Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
Hiro

67 results about "Dermatomyositis" patented technology

An inflammatory disease characterized by muscle weakness and skin rash.

Molecular marker for diagnosing anti-MDA5 positive dermatomyositis and application thereof

The invention belongs to the technical field of biological medicines, and particularly relates to a molecular marker for diagnosing anti-MDA5 positive dermatomyositis and application thereof. The invention relates to an application of a molecular marker in preparation of a diagnostic kit for diagnosing anti-MDA5 positive dermatomyositis. The molecular marker is a serum soluble intercellular adhesion molecule-1 (ICAM-1) and a vascular cell adhesion molecule-1 (VCAM-1). Experiments prove that ICAM-1 and VCAM-1 levels of dermatomyositis patients are higher than those of normal people, the levels of anti-MDA5 antibody positive dermatomyositis serum of the ICAM-1 and VCAM-1 are higher than those of anti-MDA5 antibody negative groups, ICAM-1 and VCAM-1 serve as markers for diagnosing anti-MDA5 positive dermatomyositis, and the problems that in the prior art, an anti-MDA5 antibody detection method is complex, kit manufacturing and standard substance selection are difficult, an immunoprecipitation method is complex in operation, and the detection method cannot be popularized in clinical application. The early detection of the increased adhesion molecule level is beneficial to diagnosis of anti-MDA5 antibody positive dermatomyositis, guidance of next treatment is facilitated, and the risk of disease deterioration and death of dermatomyositis patients is reduced.
Owner:THE FIRST HOSPITAL OF CHINA MEDICIAL UNIV

Application of chemotactic factor CCL8 in preparation of dermatomyositis condition and prognosis evaluation reagent

The invention belongs to the field of biological diagnosis and medicine, and particularly relates to an application of a chemotactic factor CCL8 in preparation of a dermatomyositis condition and prognosis evaluation reagent. According to the invention, a patient plasma specimen for definite diagnosis of dermatomyositis is used as a research object; protein chip detection is carried out; a sample is expanded; a protein chip result is verified by an ELISA method; by combining biochemical indexes and clinical manifestation judgment correlation of patients, it is proved that the blood plasma CCL8level of dermatomyositis patients is remarkably higher than that of healthy people, the expression level of the blood plasma CCL8 is related to the illness state and prognosis of the patients, the blood plasma CCL8 level of dermatomyositis patients effective in treatment is remarkably reduced, and CCL8 can aggravate pulmonary lesions of interstitial pneumonia mice. Therefore, the CCL8 can be usedas a potential biomarker to be applied to a reagent for evaluating the illness state and prognosis of dermatomyositis patients, experimental data and theoretical basis are provided for the applicationof the CCL8 to the illness state and prognosis evaluation of the dermatomyositis patients, and the invention further provides a corresponding kit for evaluating the illness state and prognosis of thedermatomyositis patients.
Owner:NANJING DRUM TOWER HOSPITAL

Traditional Chinese medicine composition for treating dermatomyositis

The invention relates to traditional Chinese medicine composition for treating dermatomyositis. The traditional Chinese medicine composition comprises raw materials of traditional Chinese medicines in parts by weight as follows: 5-25 parts of donkey-hide gelatin, 5-20 parts of acanthopanax root bark, 10-30 parts of Japanese cayratia herbs, 5-20 parts of long-nosed pit viper, 5-25 parts of dodder seeds, 5-20 parts of duckweed, 2-8 parts of garden balsam, 5-25 parts of desertliving cistanche, 5-20 parts of flatstem milkvetch seeds, 10-30 parts of prepared rehmannia roots, 5-25 parts of wooly datchmanspipe herbs, 10-30 parts of coix seeds, 5-20 parts of morinda roots, 5-20 parts of herbs of variegate ladyslipper, 5-25 parts of glassy ganoderma, 5-20 parts of burdock, 5-20 parts of ephedra herbs, 10-30 parts of European verbena herbs, 5-20 parts of loose knots, 5-20 parts of siegesbeckia herbs and 5-15 parts of liquorice roots. The traditional Chinese medicine composition has effects of tonifying the liver and the kidney, nourishing the spleen, benefiting qi, dispelling the wind, removing dampness, clearing heat, removing toxins, promoting blood circulation, removing meridian obstruction, relaxing tendons and removing pain or numbness, has the significant effect on the dermatomyositis and has the reliable action.
Owner:刘连强

Traditional Chinese medicine composition containing cicada-shell for treating dermatomyositis and preparation thereof

The invention provides a traditional Chinese medicine composition containing cicada shell for treating dermatomyositis and a preparation thereof. The dermatomyositis is classified as 'flaccidity syndrome' by the theory of collateral diseases of the Chinese traditional medicine, and the pathogenesis of the dermatomyositis is mainly the deficiency of the spleen and the kidney, no source for the production and transformation of qi and blood, inability of the weakened body resistance to conquer pathogen, and obstruction of the collaterals of muscles and skin by wind cold dampness, thus affecting the liver, the kidney and the spleen and causing the yin collaterals stasis of internal organs, qi-blood disharmony, and malnutrition of the limbs, skin, tendons and channels. Aiming at treating syndromes of obstruction of channels and collaterals and collateral deficiency caused by pathogen of the dermatomyositis, the traditional Chinese medicine composition determines the treatment based on differentiation of symptoms and signs by the theory of the collateral deficiency of Chinese traditional medicine, and is made from dried rehmannia root, turtle shell, white mustard seed, angelica root, astragalus root, scorpion, spatholobus stem and cicada shell to regulate the nutrient and tonify deficiency, and eliminate the pathogenic factors and activate the channels. Clinical studies prove that the traditional Chinese medicine composition can treat the dermatomyositis effectively.
Owner:HEBEI YILING MEDICINE INST

Blood poison eliminating capsules

The invention relates to blood poison eliminating capsules, which is prepared from the following raw materials: antelope horn, scorpio, centipede, unprepared rehmannia root, sinkiang arnebia root, glabrous greenbrier rhizome and talc powder. A preparation method of the blood poison eliminating capsules comprises the following steps of: smashing antelope horn, scorpio, centipede and a half of the glabrous greenbrier rhizome into fine powder and mixing uniformly for later use; decocting unprepared rehmannia root, sinkiang arnebia root and the remaining glabrous greenbrier rhizome respectively, extracting, combining decoction liquids, filtering and concentrating the filtrate into thick paste for later use; and mixing the thick paste with the fine powder, drying, smashing, mixing uniformly, adding the talc powder, mixing uniformly and filling into capsules. The blood poison eliminating capsules have a simple preparation process, low cost, high medicament bioavailability, high stability, remarkable curative effect and no remarkable toxic or side effect, are scientifically prepared from Chinese medicinal herbs serving as raw materials, and have the effects of cooling the blood and removing the toxic materials, are mainly used for treating blood poisons such as psoriasis, erythroderma, systemic lupus erythematosus, dermatomyositis and pemphigus at acute stages, severe dermatitis medicamentosa, and the like. A more convenient and quicker Chinese traditional treatment mode is provided for the clinical treatment of skin diseases.
Owner:刘巧 +1

Formula traditional Chinese medicine for treating dermatosis

The invention discloses a formula traditional Chinese medicine for treating dermatosis and belongs to the technical field of traditional Chinese medicines. The formula traditional Chinese medicine comprises an external main formula and an internal auxiliary formula, and has special effects on treating psoriasis, eczema, prurigo nodosa, amyloid lichen, pruritus cutanea, pityriasis rosea, neurodermatitis, rhagadia of hands and feet, contact dermatitis, tinea capitis, tinea manuum, tinea pedis, tinea corporis, tinea versicolor, dermatitis, urticaria, acne and folliculitis. In the traditional Chinese medicine science, the cause of sores and stubborn dermatophytosis is mixture of wind, phlegm fire, dampness and pathogenic toxins. The leading cause of all diseases is wind, trembling and dizziness are caused by lesions of the liver, liver qi is stagnated to generate phlegm fire, the liver transfers malignant infections to spleen, dampness is generated due to spleen deficiency, water is retained in the earth, spleen diseases are transferred to the kidney to cause kidney deficiency, yin and yang imbalance of the human body is caused, and wind, phlegm fire, dampness, pathogenic toxin and deficiency are caused and need to be treated. The medicine can be used in four seasons, has a relatively strong repairing effect on skin epidermis, dermis, subcutaneous tissue and the like, and has the effects of relieving itching and pain, removing necrotic tissue and promoting tissue regeneration, clearing heat and drying dampness, purging fire and removing toxin, cooling blood and removing freckles and the like.
Owner:余朝权

Traditional Chinese medicine preparation for treating dermatomyositis

The invention discloses a traditional Chinese medicine preparation for treating dermatomyositis. The traditional Chinese medicine preparation is prepared from the following medicinal materials in parts by weight: 25-36 parts of radix knoxiae, 17-35 parts of processed radix aconiti lateralis, 10-25 parts of red halloysite, 5-17 parts of perfoliote knotweed herb, 10-20 parts of tea prepared from coix chinensis root, 5-11 parts of common clubmoss herb, 3-12 parts of Chinese honeylocust spine, 5-12 parts of root of mountain spicy tree, 10-20 parts of ophicalcite, 12-25 parts of deer-horn glue, 13-26 parts of epimedium wushanense and 11-26 parts of honeysuckle stem. The traditional Chinese medicine preparation disclosed by the invention is a pure traditional Chinese medicine preparation and good in curative effect, has no toxic or side effects, and can effectively take the effects of enhancing effects, decreasing toxicity and stabilizing patient's conditions; for internal pathogenic factors of dermatomyositis, the medicine composition is used for treating on the basis of syndrome differentiation, takes effect quickly, is low in cost and obvious in effect, can treat both symptoms and root causes, and further can be used for treating deficiency of the liver-yin and kidney-yin.
Owner:王璐

Traditional Chinese medicine composition containing ephedra for treating dermatomyositis and preparation thereof

The invention provides a traditional Chinese medicine composition which contains Chinese ephedra and is used for treating dermatomyositis and a preparation thereof. The dermatomyositis is classified as 'flaccidity syndrome' by the theory of collateral diseases of the Chinese traditional medicine, and the pathogenesis of the dermatomyositis is mainly the deficiency of the spleen and the kidney, nosource for the production and transformation of qi and blood, inability of the weakened body resistance to conquer pathogen, and obstruction of the collaterals of muscles and skin by wind cold dampness, thus affecting the liver, the kidney and the spleen and causing the yin collaterals stasis of internal organs, qi-blood disharmony, and malnutrition of the limbs, skin, tendons and channels. Aiming at treating syndromes of collaterals obstruction due to cold and dampness, and dysphagia and blood stasis caused by the dermatomyositis, the traditional Chinese medicine composition determines the treatment based on differentiation of symptoms and signs by using the theory of the collateral diseases of Chinese traditional medicine, and is made from the Chinese ephedra, astragalus root, asarum, Chinese yam, preparation, white mustard seed, pangolin, leatherleaf milletia, winged euony twigs, cassia twig and garter snake to warm yang and expel cold and activate blood circulation for removing obstruction in the channels. Clinical studies prove that the traditional Chinese medicine composition can treat the dermatomyositis effectively.
Owner:HEBEI YILING MEDICINE INST

Simple and convenient senile plaque removal plaster

The invention discloses a simple and convenient senile plaque removal plaster. The simple and convenient senile plaque removal plaster is characterized by consisting of a medical adhesive tape, an ethylene vinyl acetate copolymer (EVA) foaming layer, a salicylic acid-phenol ointment and SOD (Superoxide Dismutasen) cream, wherein the EVA foaming layer (2) is arranged on the medical adhesive tape (1); the salicylic acid-phenol ointment (3) is arranged in the middle of the EVA foaming layer (2); and the SOD cream (5) is arranged on the salicylic acid-phenol ointment (3). The senile plaque removal plaster has the technical effects that treatment medicine is fixed at a treating point of the senile plaque in the way that the EVA foaming layer is fixed through the medical adhesive tape; and through the EVA foaming layer, a hole for containing the medicine can be conveniently cut according to the size of the senile plaque, thus sealing the medicine; the salicylic acid-phenol ointment, which is used for treating the senile plaque, namely keratosis of melanocyte, is strong in penetrating power and relatively low in irritation; and the SOD cream can relieve the irritation of the salicylic acid-phenol ointment, eliminate harmful materials generated during metabolism, prevent and treat dermatomyositis and resist skin aging, thus effectively removing the senile plaque.
Owner:邵宏
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products