5 results about "Rheumatic fever" patented technology

The invention discloses an old people rheumatism hot compress device based on internal medicine of traditional Chinese medicine, and relates to the technical field of hot compress devices. A storage battery and a PLC are installed on the rear side of the installation box, a heating assembly is installed in the installation box, a fastening assembly and a supporting assembly are installed on the rear side of the installation box, a sealing assembly is installed on the front side of the installation box, a connecting assembly is installed on the upper side of the sealing assembly, and a fixing assembly is installed on the upper side of the installation box. The fixing assembly is connected with the connecting assembly; the coating assembly comprises a connecting rod, a connecting strip, an I-shaped strip and a rotating shaft, strip-shaped grooves are formed in the left side and the right side of the mounting box, the connecting rod is fixed in the strip-shaped grooves, a controllable constant-temperature heat source can be provided, a traditional Chinese medicine bag can be conveniently replaced, the device adapts to coating of different joint parts, and the heat source can be automatically far away from the skin after heating is stopped.

The invention discloses a traditional Chinese medicine ointment for treating eczema. Traditional Chinese medicine believes that eczema is related to invasion of wind, dampness and heat evil and is often caused by improper diet, emotional disorder, external environment and the like, the key of pathogenesis is that dampness evil disturbs the spleen to cause unsmooth qi and blood, skin dystrophy and skin macular itching, and eczema is related to internal organ disorder. Aiming at the pathogenesis of eczema, rhizoma smilacis glabrae, orpiment, radix cynanchi paniculati, cortex dictamni and radix scutellariae are selected and blended into paste with medical glycerin, the paste is smeared on an affected part to achieve the purposes of clearing heat, eliminating dampness, nourishing blood, dispelling wind, relieving itching, inducing diuresis, diminishing swelling and dispelling wind and eliminating dampness so as to treat both symptoms and root causes, and clinical verification shows that the ointment is remarkable in curative effect, convenient to use and worthy of popularization and application.

A composition comprising isolated Streptococcus pyogenes extracellular vesicles (EVs) suspended in a vehicle, for use in eliciting an adaptive immune response against group A streptococcus (GAS) in a subject. The EVs may comprise antigens MtsA, Spy_1228, PrsA1, PrsA2, SPy_0319 and / or GlnP. A composition comprising isolated S. pyogenes protein(s) MtsA, SPy_1228, PrsA1, PrsA2, GlnP, SPy_0319 and / or MalX. The compositions may be used for inducing protective immunity in a subject against a GAS infection, such as streptococcal pharyngitis, scarlet fever, impetigo, streptococcal meningitis, streptococcal sinusitis, necrotizing fasciitis, cellulitis, streptococcal toxic shock syndrome, rheumatic fever and post-streptococcal glomerulonephritis.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for preventing and treating lupus nephritis and a preparation method and application thereof. The traditional Chinese medicine composition for preventing and treating lupus nephritis is prepared from the following raw materials: 25 to 35 parts of radix astragali seu hedysari, 8 to 12 parts of radix angelicae sinensis, 8 to 12 parts of radix salviae miltiorrhizae, 25 to 35 parts of herba artemisiae annuae, 12 to 18 parts of caulis sinomenii, 25 to 35 parts of herba centellae, 25 to 35 parts of raw fructus hordei germinatus and 25 to 35 parts of ramulus euonymi. The traditional Chinese medicine has the effects of eliminating and tonifying the whole prescription, not only aims at the superficial symptom of wind-damp heat toxin and blood stasis in an active period, but also considers the base deficiency of kidney deficiency and collateral stasis in a remission period, is matched with the core pathogenesis of deficiency, blood stasis and rheumatism interlaced of lupus nephritis, and has the effects of dispelling wind and eliminating dampness, tonifying kidney and qi, and removing blood stasis and dredging collaterals. Animal experiment results show that the traditional Chinese medicine composition can significantly reduce urine protein, dsDNA and ANA of lupus nephritis mice, and has a good pharmacodynamic effect.

This invention belongs to the field of animal model analysis technology, specifically relating to a method for establishing a model of gouty rheumatic fever subtypes, the application of a biomarker group, and a detection method. This invention constructs two subtype models of gouty rheumatic fever with more emphasis on dampness and fever with more emphasis on dampness, and establishes a UPLC-MS detection method for serum biomarkers, obtaining a biomarker group including lauroylcarnitine, taurine, palmitoyl-L-carnitine, L-leucine, leukotriene A4, and 13-Oxo-9,11-tridecadienoic acid. Studies show that this biomarker group can simply and effectively distinguish between gouty rheumatic fever with more emphasis on dampness and fever with more emphasis on dampness, and determine the success of model establishment for the two subtypes. Therefore, it can replace conventional characterization and biochemical pathological evaluation methods, improving the objectivity and operability of the assessment.