134 results about "Alopecia areata" patented technology

The invention provides a Chinese arborvitae twig and folium artemisiae argyi lotion and a preparation method and application thereof, and relates to the technical field of alopecia prevention, the Chinese arborvitae twig and folium artemisiae argyi lotion is prepared from the following traditional Chinese medicines: Chinese arborvitae twig, rhizoma drynariae, folium artemisiae argyi, chrysanthemum, mint, schizonepeta, divaricate saposhnikovia root, ligusticum, wrinkled gianthyssop herb, rhizoma nardostachyos, fructus viticis, radix polygoni multiflori preparata and garden balsam stem, and the Chinese arborvitae twig and folium artemisiae argyi lotion is prepared by soaking and decocting the traditional Chinese medicines in distilled water and filtering out traditional According to the prepared folium artemisiae argyi lotion, the medicinal materials are reasonably matched, the traditional Chinese medicinal materials are combined together according to the compatibility of monarch, minister, assistant and guide, the effects of stimulating hair follicle conversion, inhibiting the activity of 5-alpha reductase, adjusting the scalp microenvironment, relieving scalp greasiness and the like are achieved, heat clearing, dampness eliminating, liver and kidney nourishing and blood cooling and nourishing can be achieved, meanwhile, blood circulation promoting and collateral dredging can be achieved, and the effect of removing blood stasis is achieved. The traditional Chinese medicine composition has a good effect on androgen alopecia, alopecia areata, scalp seborrheic dermatitis or scalp psoriasis with symptoms such as alopecia, more oily hair, scalp desquamation or itching and the like.

The invention discloses an application of betulinic acid 28-O-beta-D-glucoside (BA-6 for short) in preparation of a medicine for preventing and treating skin inflammation. The problems that an existing medicine for treating dermatitis is limited in curative effect, slow in effect taking, multiple in side effect, high in long-term use risk, large in individual difference, high in treatment cost, likely to cause immunoreaction and the like are solved. The invention discloses application of BA-6 in prevention and treatment of atopic dermatitis, contact dermatitis, eczema, rash, psoriasis, lupus erythematosus, papule squamous skin disease, pityriasis rosea, seborrheic dermatitis, pemphigus, celestial abscess, acne, tinea corporis, impetigo, SAPHO syndrome, hidradenitis suppurativa, dermatitis caused by drugs, lichen planus, pityriasis rubra pilaris, vitiligo, prurigo nodularis, dermatitis caused by drugs, and the like for the first time. The traditional Chinese medicine composition can be used for treating skin diseases, systemic sclerosis, hidradenitis suppurativa, granulomatous skin diseases, vitiligo, dermatomyositis, chronic skin itch and alopecia areata, and has the technical progress of obviously improving skin erythema, papule, edema, scale, moss and ulceration symptoms.

The invention relates to the field of biological medicine, in particular to a hair follicle targeted delivery system and hair growth and hair loss prevention cosmetics, the hair follicle targeted delivery system comprises: a lipid nanoparticle core which is internally loaded with a bioactive component with hair growth and hair loss prevention effects; the hair follicle targeting molecule can specifically recognize and bind to a receptor on the surface of a hair follicle cell; a targeting anchoring conjugate composed of a linker covalently linked to the hair follicle targeting molecule and an anchoring lipid; wherein the targeting anchoring conjugate is embedded into the lipid bilayer of the lipid nanoparticle core through the anchoring lipid, so that the hair follicle targeting molecule is displayed on the surface of the lipid nanoparticle core. According to the application, through an innovative targeted anchoring conjugate structure, the targeting property and enrichment efficiency of hair growth and hair loss prevention active ingredients on hair follicle tissues can be remarkably improved, and the effect that a medicine accurately acts on a focus part is ensured, so that the number of hair follicles at an alopecia areata modeling part can be remarkably increased.

The invention relates to application of seroalarm as a biomarker in predicting the curative effect of a JAK inhibitor on alopecia areata. Particularly, S100A8 / A9 and S100B are the most preferable biomarkers, and the curative effect of the JAK inhibitor on alopecia areata can be effectively predicted by detecting the concentration of the biomarkers in the serum of an alopecia areata patient, so that valuable reference is provided for selection of an alopecia areata treatment scheme.

Disclosed is a method for preventing, treating, or ameliorating alopecia areata, comprising administering a therapeutically effective amount of a thyromimetic compound or a pharmaceutically acceptable salt thereof to a subject in need thereof, wherein said thyromimetic compound is a compound of Formula I, wherein R1,R2,R3,R4,R5,R6,R7,R8,R9,G,T,and X are defined as herein.

Provided herein are methods of treatment of alopecia areata and / or atopic dermatitis comprising administering to an individual in need thereof the anti-OX40 antibody provided herein. Provided herein are uses of the anti-OX40 antibody methods described herein in the treatment of alopecia areata and / or atopic dermatitis.

The invention belongs to the technical field of microorganisms, and particularly discloses lactobacillus paracasei and application thereof, the lactobacillus paracasei is named as lactobacillus paracasei Jlus66, the lactobacillus paracasei is preserved in China General Microbiological Culture Collection Center on March 31, 2021, the preservation address is No.3, No.1 Yard, Beichen West Road, Chaoyang District, Beijing, and the preservation number is CGMCC No.22101. The lactobacillus paracasei is named as lactobacillus paracasei Jlus66. The lactobacillus paracasei Jlus66 has the obvious beneficial effects in the treatment of the alopecia areata, and the obvious beneficial effects comprise the immune regulation, the anti-oxidation and anti-inflammatory effects and the optimization of the intestinal tract-skin axis. In addition, the medicine is high in safety and small in side effect, so that the medicine becomes a promising adjuvant therapy means.

The invention discloses a small nucleic acid targeting androgen receptor AR, provides various modification methods, enhances sequence stability after modification, effectively knocks down AR mRNA, has a remarkable curative effect, and can be used together with various delivery prescriptions. The small nucleic acid provided by the invention can be efficiently delivered to a target spot through lipid nanoparticles, and also can be effectively delivered to cells without other delivery carriers by coupling an alkyl chain structure in a sequence. The small nucleic acid and the preparation method thereof provided by the invention can be used as a technical means for treating diseases caused by abnormal androgen expression or treating diseases related to androgen receptors, and the indications of the small nucleic acid include but are not limited to androgenetic alopecia, alopecia areata, neuropathic alopecia, scar alopecia, diffuse alopecia, acne and the like.

The present invention relates to new pyrrolopyridine compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of JAK1 and JAK3 kinase activity in a human or animal subject are also provided for the treatment diseases such as pruritus, alopecia, androgenetic alopecia, alopecia areata, vitiligo and psoriasis.

Solid forms of compound of (2R)-1-[4-[(R)-amino(5-chloro-2-hydroxy-4-methylphenyl)methyl]piperidin-1-yl]-2,3-dihydroxypropan-1-one are described. The solid form may be a pharmaceutically acceptable salt of the compound. The salt may be a carboxylic acid salt, such as a benzoic acid salt, a cinnamic acid salt, or a glutaric acid salt. Pharmaceutical compositions comprising the same and method of using the same in treating a condition such as psoriasis, rheumatoid arthritis, systemic lupus erythematosus, lupus nephritis, atopic dermatitis, and alopecia areata are also described.

Methods of treating autoimmune skin diseases and disorders are provided. The methods typically include administrating to a subject with an autoimmune skin disease or disorder an effective amount of a hypoxia-inducible factor-1 (HIF-1) inhibitor. In preferred embodiments, the autoimmune disease is mediated at least in-part by T cells, particularly skin-infiltrating T cells. In some embodiments, the subject has cutaneous lupus (e.g., discoid cutaneous lupus, subacute cutaneous lupus, acute cutaneous lupus), pemphigus, pemphigoid, epidermolysis bullosa acquisita, vitiligo, lichen planus, lichen sclerosus, dermatomyositis, alopecia areata, or Sjögren's syndrome. HIF-1 inhibitors and pharmaceutical compositions including the same for use in the disclosed methods are also provided. The HIF-1 inhibitor can be, for example, a small molecule, functional nucleic acid, or inhibitory polypeptide or protein. The pharmaceutical composition can be formulated to suitable for the type and mode of administration, e.g., systemically or locally to skin effected by the autoimmune disease.

This invention relates to the field of biomedicine, and more particularly to a hair follicle-targeted delivery system and a hair growth and anti-hair loss cosmetic. The hair follicle-targeted delivery system comprises: a lipid nanoparticle core loaded with bioactive ingredients having hair growth and anti-hair loss effects; a hair follicle-targeting molecule capable of specifically recognizing and binding to receptors on the surface of hair follicle cells; and a targeting and anchoring conjugate consisting of a linker covalently linked to the hair follicle-targeting molecule and an anchoring lipid. The targeting and anchoring conjugate is embedded in the lipid bilayer of the lipid nanoparticle core via the anchoring lipid, thereby exposing the hair follicle-targeting molecule on the surface of the lipid nanoparticle core. This application, through its innovative targeting and anchoring conjugate structure, can significantly improve the targeting and enrichment efficiency of the hair growth and anti-hair loss active ingredients on hair follicle tissue, ensuring precise drug action on the lesion site, thereby significantly increasing the number of hair follicles in the alopecia areata modeling area.

The invention discloses a combined medicine, a medicine composition and a preparation method and application of the medicine composition. The invention provides a combined medicine. Active ingredients of the combined medicine comprise an active ingredient A and an active ingredient B, wherein the active ingredient A is a compound as shown in a formula I, a pharmaceutically acceptable salt thereof, a solvate thereof or a solvate of the pharmaceutically acceptable salt thereof; and the active ingredient B is minoxidil, pharmaceutically acceptable salt of minoxidil, solvate of minoxidil or solvate of pharmaceutically acceptable salt of minoxidil. The combined medicine and the pharmaceutical composition have better permeability, stability and safety, have a better treatment effect on alopecia areata, and are suitable for local external use.

The invention discloses a traditional Chinese medicine for treating alopecia areata. The traditional Chinese medicine is prepared from the following components in parts by weight: 0.15 part of menthol, 0.17 part of white vaseline, 0.3 part of glycerol, 0.8 part of liquid paraffin, 0.9 part of cortex dictamni, 0.1 part of radix sophorae flavescentis, 0.15 part of rheum officinale, 9-15 parts of poria cocos, 13-19 parts of herba lysimachiae, 13-19 parts of centipede, 5-11 parts of radix euphorbiae lantu, 15-21 parts of honeysuckle, 17-23 parts of horse oil, 11-17 parts of liquorice, 25-31 parts of aloe, 27-33 parts of radix arnebiae seu lithospermi, 0.5 part of borneol, 0.3 part of methyl salicylate and 0.9 part of zaocys dhumnade. The medicine has obvious effect on treating alopecia areata and small toxic and side effects.

Provided is the use of a compound of formula I, a pharmaceutically acceptable salt, a stereoisomer, a polymorph, a solvate, a metabolite or a prodrug thereof, or a composition thereof in the preparation of a drug for treating alopecia such as alopecia areata. An azetidine derivative has clear action mechanisms and pharmacodynamic effects, good pharmacokinetic properties and a good safety, which greatly improves the medication compliance of patients.

The invention discloses a novel traditional Chinese medicine honeyed pill for treating alopecia, and relates to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: radix rehmanniae praeparata, angelica sinensis, raw radix paeoniae alba, semen cuscutae fried with wine, radix saposhnikoviae, gastrodia elata, ligusticum wallichii, radix ophiopogonis, asparagus cochinchinensis, radix bupleuri, radix puerariae, cassia twig, radix curcumae, caulis spatholobi and other traditional Chinese medicines which are subjected to superfine grinding and then are matched according to a specific proportion. The preparation process comprises the steps of crushing; refining honey; and mixing and waking up the medicine. The traditional Chinese medicine composition has the following effects: the composition takes effect at multiple targets: up-regulating hair follicle survival promoting factors and down-regulating inflammatory mediators; the process has the advantages that the stability of pills is improved by controlling the viscosity of refined honey; the clinical application has the advantages that the cure rate of severe alopecia totalis is improved compared with the traditional prescription The recurrence rate is low after the medicine is stopped for one year. The formula is mainly used for treating alopecia, alopecia areata, sticktight and alopecia totalis.

The invention provides a traditional Chinese medicine composition for treating alopecia areata and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine composition is prepared from the following components in parts by mass: 10 to 30 parts of radix rehmanniae recen, 10 to 30 parts of radix rehmanniae preparata, 10 to 30 parts of caulis spatholobi, 10 to 30 parts of caulis polygoni multiflori, 30 to 50 parts of radix astragali, 10 to 20 parts of rhizoma chuanxiong, 10 to 30 parts of radix paeoniae alba, 5 to 20 parts of rhizoma gastrodiae, 5 to 20 parts of cordyceps sinensis, 10 to 30 parts of herba ecliptae, 10 to 30 parts of mulberry and 5 to 20 parts of fructus chaenomelis. The effect is stronger, and no side effect exists. The tincture prepared by the invention is a pure external preparation without systemic toxicity, has no side effects such as hirsutism and skin atrophy after long-term use, and is especially suitable for sensitive scalp patients.

Provided are compounds, compositions and methods for treating alopecia areata (AA) in patients in need thereof.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses a tablet composition for treating alopecia areata and a preparation method thereof.The tablet composition is a composition comprising two main drugs including finasteride and baricitinib and is prepared by mixing and pressing finasteride particles and baricitinib particles which are prepared through specific auxiliary materials and a process, the finasteride granules and the baricitinib granules have good Karl index and Hausner ratio after being mixed, the pressed tablet composition has good performance in a plurality of test items such as acceleration for 6 months, long-term 6 months and high-humidity test, and the auxiliary material formula and the process can simultaneously meet the quality requirements of finasteride and baricitinib. Meanwhile, the degradation condition of the main medicine is relieved, the increase of related impurities of finasteride and baricitinib is reduced, the quality stability of the medicine under different storage conditions is improved, and the safety and effectiveness of the medicine within the period of validity and the integrity of the appearance of the tablet are ensured.

This invention belongs to the field of traditional Chinese medicine technology and discloses the application of *Saposhnikovia divaricata* in the preparation of drugs for treating alopecia areata. The preparation method of *Saposhnikovia divaricata* extract is as follows: *Saposhnikovia divaricata* is dried in the shade, pulverized, and then soaked in ethanol for at least 24 hours. The supernatant is then collected. This invention's *Saposhnikovia divaricata* extract can significantly shorten the time for skin to darken and the time for new hair to grow, enabling skin and hair to enter the growth phase more quickly. It can significantly increase the length and weight of newly grown hair and increase the number of primary hair follicles in the skin, thus promoting hair growth in alopecia areata and providing ideas and theoretical basis for the research and development of new drugs.

1. The name of the product of this design: packaging box (alopecia areata hair growth cream). 2. Purpose of this design product: used for packaging alopecia areata hair growth cream. 3. The design key point of this appearance design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The present invention relates to a novel compound acting as a functional antagonist for S1PR1 and S1PR4, and a use thereof. The compound according to the present invention exhibits significantly excellent binding strength to S1PR1 and S1PR4 receptors, thus exhibiting an excellent effect in preventing or treating inflammatory bowel disease, alopecia areata (AA), or an autoimmune disease.

The application provides an application of a hair follicle immune homeostasis regulation strategy in treating alopecia diseases. A group of pathological LAMP3 + CCR7 + IL4I1 + DC3 dendritic cell subpopulation. A DC3 dendritic cell subpopulation marker gene Il4i1 Drive conditionally knockout one of the CGRP receptor complexes Calcrl The constructed spontaneous alopecia areata animal model can well simulate the progressive and active hair loss of alopecia areata patients, form stable hair loss patches, and combine with pathological changes such as hair follicle immune cell infiltration, which indicates that the dendritic cell CGRP signal loss is an important inducement for mediating systemic alopecia areata. The application also discloses a pharmaceutical composition or kit for preparing a drug for relieving / treating hair loss, improving hair follicle homeostasis, or enhancing hair growth / black coloration (reducing white hair), which comprises: (a) a JAK kinase inhibitor, and (b) a neuropeptide CGRP or a receptor agonist thereof.

The invention discloses a traditional Chinese medicine composition for treating alopecia areata and belongs to the field of alopecia areata treatment, and the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials by weight: 4000 g of fresh cacumen biotae, 300 g of codonopsis pilosula, 1000 g of radix polygoni multiflori preparata, 300 g of angelica sinensis, 300 g of herba epimedii, 250 g of campsis grandiflora and 250 g of caulis spatholobi. The traditional Chinese medicine composition for treating alopecia areata, provided by the invention, is used as a special medicine for treating alopecia areata in undergraduate, does not contain any glucocorticoid, is convenient to use, causes no pain in the treatment process, has a remarkable curative effect and is suitable for people of all ages. The traditional Chinese medicine rhizoma drynariae has the effects of tonifying kidney, strengthening bone, continuing injury and relieving pain, and can be externally applied to treat alopecia areata by improving hair follicle nutrition and inhibiting hair follicles from entering a degeneration period. When the traditional Chinese medicine composition is used, the rhizoma drynariae is dipped and externally applied to an affected part, so that the hair growing and fixing effects are enhanced. In addition, the traditional Chinese medicine composition for treating alopecia areata provided by the invention is simple in preparation method and relatively low in cost, and can be suitable for industrial production or production of ointment prepared after effective components of medicines are extracted.

The present disclosure provides methods and compositions for treating a disease or condition involving inflammation in the skin, e.g., atopic dermatitis, eczema other than atopic dermatitis, hidradenitis suppurativa, vitiligo, alopecia areata, scleroderma (including systemic sclerosis), dermatomyositis, epidermolysis bullosa, mastocytosis, keloids, acne, rosacea, or bullous pemphigoid, with a therapeutic dose of an anti-TNF-like ligand 1A (TL1A) antibody (Afimkibart).

Provided herein are method of thyroid hormone receptor beta (THRβ) agonist and combinations comprising a glucagon-like peptide-1 receptor (GLP-1R) agonist and a thyroid hormone receptor beta (THRβ) agonist and methods comprising administering to a subject in need thereof such combinations.

The invention provides a method for improving the self-reproduction capability and yield of naturally-growing stipa capillata seeds, and relates to the technical field of seed breeding, the method comprises the following steps: S1, investigating a site, and selecting an area where natural stipa capillata grows alopecia areata or grows unevenly; s2, supplementing water, namely supplementing water to the natural stipa capillata growth area by adopting arrow insertion micro-spraying; s3, sunshade net blocks are laid, specifically, the sunshade net blocks are laid at the sparse or blank positions of the naturally-growing stipa capillata at the plant row spacing of 50-70 cm; s4, compacting the middle and four corners of the sunshade net block; s5, when the stipa capillata above the sunshade net grows to 7-10 cm, the sunshade net blocks are removed; s6, management and protection; the lower ends of stipa capillata caryopses are as thin as needles, the surfaces of the stipa capillata caryopses are densely provided with inverted hairs, the caryopses are shaken, and the caryopses can be easily hung on the sunshade net block, penetrate through meshes and are inserted into ground soil, so that seed implantation, rooting and germination are realized, plants in a sparse area or blank land of natural stipa capillata are increased, and the vegetation growth of the natural stipa capillata is recovered.

The invention belongs to the technical field of traditional Chinese medicine, and discloses a traditional Chinese medicine formula for treating qi and blood deficiency type alopecia areata through acupuncture and moxibustion comprehensive therapy and application. According to the formula, fructus psoraleae and radix polygoni multiflori are used as monarch drugs and mainly used for tonifying liver and kidney and providing fundamental treatment for qi and blood deficiency type alopecia areata; the safflower, the peach kernel, the ligusticum chuanxiong hort, the salvia miltiorrhiza and the angelica sinensis are used as ministerial drugs and have the main effects of activating and nourishing blood, promoting blood circulation and improving nutrition supply of scalp; chinese arborvitae twig, divaricate saposhnikovia root and tribulus terrestris are used as adjuvant drugs, have the effects of dispelling wind, promoting hair growth and arresting itching, and are beneficial to relieving uncomfortable symptoms of scalp and promoting hair follicle health; the ginger has the effect of warming meridians and collaterals and assists other medicines in exerting medicine properties. The medicinal materials in the formula are soaked in 75% alcohol to extract effective components, and the liniment is prepared. In clinical treatment, plum-blossom needle stabbing and mild moxibustion are combined, and medicine introduction and absorption are improved. Research shows that the formula can remarkably improve the alopecia areata symptom and improve the treatment efficiency and patient compliance, and has high clinical application value.

The invention discloses a traditional Chinese medicine composition for caring scalp hair and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine composition is blood-nourishing and hair-growing liquid and consists of traditional Chinese medicine powder and home-brewed white spirit, wherein the traditional Chinese medicine powder comprises radix polygoni multiflori preparata, fructus psoraleae, rhizoma drynariae, flos carthami, rhizoma chuanxiong, fructus cnidii, cortex dictamni, cacumen biotae and radix rehmanniae preparata, and the home-brewed white spirit is prepared by cooking, fermenting and distilling black glutinous rice, sorghum, black beans and triticale. The traditional Chinese medicine composition can be used for specifically solving the problems of hair follicle blockage, epifolliculitis, alopecia areata, alopecia, white hair and the like caused by large working pressure, staying up late, chemical washing and care residues and the like of modern people, is safe and mild, has no obvious adverse reaction, gives consideration to treatment and daily maintenance, and is wide in application range.

The invention belongs to the field of medicines, and discloses a finasteride-containing composition and application thereof. The composition comprises finasteride, graphene and more than one pharmaceutically acceptable auxiliary material. The composition can well prevent and / or treat alopecia, alopecia seborrhoeica, androgenetic alopecia and alopecia areata or promote hair growth, compared with finasteride tablets, the dosage of active ingredients of the composition is greatly reduced, related side effects of the active ingredients are relieved, and the composition is quick in effect taking, long in drug effect lasting time and good in curative effect.