Traditional Chinese medicine formula for treating qi and blood deficiency type alopecia areata through acupuncture and moxibustion comprehensive therapy and application

Abstract

The invention belongs to the technical field of traditional Chinese medicine, and discloses a traditional Chinese medicine formula for treating qi and blood deficiency type alopecia areata through acupuncture and moxibustion comprehensive therapy and application. According to the formula, fructus psoraleae and radix polygoni multiflori are used as monarch drugs and mainly used for tonifying liver and kidney and providing fundamental treatment for qi and blood deficiency type alopecia areata; the safflower, the peach kernel, the ligusticum chuanxiong hort, the salvia miltiorrhiza and the angelica sinensis are used as ministerial drugs and have the main effects of activating and nourishing blood, promoting blood circulation and improving nutrition supply of scalp; chinese arborvitae twig, divaricate saposhnikovia root and tribulus terrestris are used as adjuvant drugs, have the effects of dispelling wind, promoting hair growth and arresting itching, and are beneficial to relieving uncomfortable symptoms of scalp and promoting hair follicle health; the ginger has the effect of warming meridians and collaterals and assists other medicines in exerting medicine properties. The medicinal materials in the formula are soaked in 75% alcohol to extract effective components, and the liniment is prepared. In clinical treatment, plum-blossom needle stabbing and mild moxibustion are combined, and medicine introduction and absorption are improved. Research shows that the formula can remarkably improve the alopecia areata symptom and improve the treatment efficiency and patient compliance, and has high clinical application value.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a traditional Chinese medicine formula for treating qi and blood deficiency type alopecia areata by comprehensive acupuncture therapy and its application. Background Art

[0002] Alopecia areata is a sudden localized patchy hair loss, mostly caused by mental factors. Modern medicine believes that the occurrence of this disease is related to factors such as long-term tension, anxiety, depression or excessive fatigue, which causes abnormalities in the body's stress response system, autonomic nervous system disorders, hair follicle vasospasm and ischemia, etc., resulting in hair absorption disorders and leading to hair loss. Currently, the commonly used drugs in clinical practice are mainly glucocorticoids, immunosuppressants, etc., but long-term use of the above drugs will cause patients to experience a series of adverse reactions, such as low immune function and susceptibility to infection.

[0003] At present, the clinical prevention and treatment methods for alopecia areata are very limited. Most of them use glucocorticoids, immunomodulators, minoxidil, direct immunization and other methods for intervention, but the effect is not ideal and the adverse reactions are serious. In addition, the drug is prone to excessive hair growth after contacting non-bald areas. Western medicine for this disease is relatively simple, and various photoelectric therapies based on minoxidil are also under continuous research, but there is no consensus on their efficacy. Traditional Chinese medicine in my country has a long history. The study of alopecia areata began in the "Yellow Emperor's Internal Classic", but there is still no effective prevention and treatment method. Therefore, this project aims to explore new ways for traditional Chinese medicine to treat alopecia areata, in order to promote the adjustment of the surrounding environment, promote their normal physiological activities, and relieve their anxiety and depression symptoms through the treatment of alopecia areata patients, laying a foundation for the research and practice of traditional Chinese medicine intervention in the treatment of alopecia areata.

[0004] Traditional Chinese medicine believes that alopecia areata is a sudden localized patchy hair loss, which is closely related to liver, spleen and kidney dysfunction. The occurrence of alopecia areata is related to factors such as irregular diet, excessive thinking, emotional frustration, fatigue and internal injuries. "The Treatise on the Causes and Symptoms of Various Diseases" believes that "if the liver blood is deficient, the hair will be dry, and if the liver blood is deficient, the hair cannot be nourished, so the hair is not in the hair, but it falls out." "The Golden Mirror of the Medical Ancestral" records: "The root of hair lies in blood." "Suwen: Ancient Innocence Theory" also says: "Therefore, leucorrhea is caused by spleen deficiency." Qi and blood are the material basis of human life activities. Insufficient qi and blood can cause hair to lose nourishment and fall out. "Huangdi Neijing" also states that "all winds and dizziness belong to the liver" and "lack of liver and kidney, lack of nourishment of tendons and bones, so soreness and pain stop." Traditional Chinese medicine believes that the cause of alopecia areata is related to kidney essence deficiency, liver and kidney yin deficiency, and qi and blood deficiency. Therefore, replenishing kidney essence and nourishing liver and kidney are the main treatments. The "Lingshu·Jingmai" records: "The collaterals of the hand Shaoyin heart meridian originate in the heart... inside the meridians, outside the meridians..." Therefore, from the perspective of traditional Chinese medicine, this disease belongs to the category of "blood deficiency and wind dryness", which is related to the liver and kidneys, and is mostly related to eating heavy foods, emotional distress, or thinking that damages the spleen and stomach.

[0005] In traditional Chinese medicine, the head is where all yang gathers. Through the method of plum blossom needle buckle, the yang of the human body can be stimulated, so that the yang of the human body is vigorous, the qi and blood are sufficient, and the hair will be moisturized. It is recorded in the Compendium of Materia Medica that this therapy is mainly aimed at the symptom of "no hair growth". In addition, moxibustion, as one of the external treatment methods of traditional Chinese medicine, has the advantages of simple operation, no side effects, and significant efficacy. It has been widely used in China. Moxibustion can not only promote the imbalance of yin and yang in the local hair follicles through the warming effect on the hair loss area, restore its normal physiological function, but also nourish the patient's liver and kidneys, so that the patient's body tends to the balance of yin and yang. From the pathogenesis of traditional Chinese medicine, it improves the patient's physical condition and achieves the purpose of treating both the symptoms and the root causes.

[0006] In recent years, despite the continuous research on this disease and the emergence of new treatment plans, satisfactory clinical results have not been achieved. At present, when using the traditional Chinese medicine model to treat this type of patients, more attention is paid to replenishing qi and blood, replenishing the liver and kidneys, and good clinical results have been achieved. Therefore, under the guidance of traditional Chinese medicine, how to combine acupuncture and moxibustion comprehensive therapy to develop an external hair growth tincture to use traditional Chinese medicine external therapy to treat qi and blood deficiency type alopecia areata from multiple angles at the lesion site, thereby improving the scalp environment, promoting hair regeneration, and significantly improving the patient's alopecia areata symptoms. Summary of the invention

[0007] In view of the shortcomings of the above-mentioned patients with alopecia areata due to qi and blood deficiency in traditional Chinese medicine treatment, we combined the acupuncture comprehensive therapy with the self-prepared tincture for promoting blood circulation, replenishing qi and promoting hair growth to treat the selected patients. The clinical effect of the patients in the experimental group was significant, and the compliance with the treatment was higher, which has good promotion value. The tincture for promoting blood circulation, replenishing qi and promoting hair growth (i.e., liniment) is made of psoralea corylifolia, ginger, Platycladus orientalis leaves, Tribulus terrestris, Salvia miltiorrhiza, Polygonum multiflorum, Angelica sinensis, Dictamni peel, Chuanxiong, Saposhnikovia divaricata, peach kernel, safflower, and 75% alcohol. The Compendium of Materia Medica states that it is mainly used to treat "no hair growth": Tribulus terrestris, Salvia miltiorrhiza, Polygonum multiflorum, Angelica sinensis, Dictamni peel, Chuanxiong, Saposhnikovia divaricata, peach kernel, and safflower can promote blood circulation and remove blood stasis; ginger can move and guard, dredge blood vessels, and promote hair growth. Alcohol has a strong permeability, and its nature is good, which can penetrate the hair layer and enhance the efficacy. The combination of internal and external treatment, local and systemic treatment, plays an obvious role in nourishing qi and blood, promoting blood circulation, replenishing deficiency and promoting hair growth. Based on this, the present invention provides a Chinese medicine formula and application for treating qi and blood deficiency type alopecia areata with acupuncture comprehensive therapy.

[0008] To achieve the above purpose, the present invention adopts the following technical scheme: a Chinese medicine formula for treating alopecia areata of qi and blood deficiency type by comprehensive acupuncture therapy, characterized in that it is prepared from the following raw materials in weight ratio: 8-12g of psoralea corylifolia, 10-15g of polygonum multiflorum, 5-15g of safflower, 5-15g of peach kernel, 12-20g of chuanxiong, 5-15g of salvia miltiorrhiza, 10-20g of angelica sinensis, 10-20g of oriental arborvitae leaf, 8-15g of siler, 5-15g of tribulus terrestris, 8-15g of dittany, and 5-12g of ginger.

[0009] Preferably, the weight ratio of the formula is 10g of Psoralea corylifolia, 12g of Polygonum multiflorum, 10g of Carthamus tinctorius, 10g of Peach Kernel, 15g of Ligusticum chuanxiong, 10g of Salvia miltiorrhiza, 15g of Angelica sinensis, 15g of Platycladus orientalis, 10g of Saposhnikovia divaricata, 10g of Tribulus terrestris, 10g of Dictamni cortex, and 9g of ginger.

[0010] The invention further discloses application of the traditional Chinese medicine formula in preparing a medicine for treating alopecia areata of qi and blood deficiency type.

[0011] Preferably, the medicine is prepared by soaking the above-mentioned traditional Chinese medicine formula in 75% alcohol in a sealed container.

[0012] Preferably, the sealed container needs to be placed in a cool place at room temperature.

[0013] Preferably, the sealed container is required to avoid direct sunlight, maintain a temperature of 10-20°C, and maintain a humidity of 40%-60%.

[0014] Preferably, the medicine needs to be soaked for at least 1 week.

[0015] Preferably, the sealed container comprises a bottle body made of glass and a bottle stopper made of rubber.

[0016] Preferably, the drug is in the form of a spray or an ointment.

[0017] Compared with the prior art, the present invention has the following advantages: 1. The Chinese medicine formula designed by the present invention uses Psoralea corylifolia and Polygonum multiflorum as the main medicine, and the main function is to nourish the liver and kidney, providing a fundamental treatment for the treatment of alopecia areata caused by deficiency of qi and blood. Carthamus tinctorius, peach kernel, Chuanxiong, Salvia miltiorrhiza and Angelica sinensis are used as ministerial medicines, and the main functions are to promote blood circulation and nourish blood, promote blood circulation, improve the nutritional supply of the scalp, and thus help hair growth. Platycladus orientalis, Saposhnikovia divaricata and Tribulus terrestris are used as adjuvants, which have the effects of dispelling wind, promoting hair growth and dispelling wind and relieving itching, which help to relieve the discomfort symptoms of the scalp and promote the health of hair follicles. Ginger has the effect of warming and unblocking meridians, and can assist other drugs to play a better role. These medicinal materials are soaked in 75% alcohol for one week in order to extract the effective ingredients in the medicinal materials and prepare them into liniments to make them easier for human body to absorb. Through this compatibility, the present invention can treat alopecia areata caused by deficiency of qi and blood from multiple angles, improve the scalp environment, and promote hair regeneration.

[0018] 2. The present invention prepares a blood-activating, qi-invigorating and hair-growing tincture (i.e., an ointment) by soaking the traditional Chinese medicine formula in 75% alcohol. After the selected patients are treated with acupuncture comprehensive therapy combined with the blood-activating, qi-invigorating and hair-growing tincture, the clinical effect of the patients in the experimental group is significant, the compliance to the treatment is higher, and the ointment has good promotion value.

[0019] 3. The preparation process of the drug for treating alopecia areata of qi and blood deficiency type provided by the present invention is simple, no complicated equipment is required, and the raw materials of the drug are easy to purchase, the cost is low, and it is suitable for wide clinical application. Since the drug is easy to prepare and use, patients can use it at home, which reduces the number and cost of hospital visits and improves the convenience of treatment for patients.

[0020] 4. The Chinese medicine formula of the present invention has been clinically verified in the treatment of alopecia areata of qi and blood deficiency type, and has a definite curative effect and high patient satisfaction. It is worthy of being vigorously promoted in clinical treatment. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 This is a comparison chart of the therapeutic effects between the control group and the experimental group in the clinical application embodiment of the present invention; Figure 2 This is a comparison chart of the key index means between the control group and the experimental group in the clinical application embodiment of the present invention; Figure 3 A comparison chart of the compliance between the control group and the experimental group in the clinical application example of the present invention; Figure 4 is a graph showing changes in hair follicle density, hair density and vellus hair rate among different embodiments of the present invention; Figure 5 This is a comparison chart of patients in the control group before and after treatment in the clinical application embodiment of the present invention; Figure 6 This is a comparison chart of the patients in the experimental group before and after treatment in the clinical application embodiment of the present invention. DETAILED DESCRIPTION

[0022] In order to further illustrate the technical solution of the present invention, Figures 1 to 6 , the present invention is further described in detail in conjunction with clinical application examples.

[0023] Theory and mechanism of Chinese medicine formula

[0024] 1. Chinese medicine formula and TCM theory 1) King of medicines Psoralea corylifolia: warm in nature, pungent and bitter in taste, and enters the kidney and spleen meridians. It has the effects of warming the kidney and supporting yang, absorbing qi and relieving asthma, warming the spleen and stopping diarrhea. In this formula, as the main drug, it mainly plays the role of tonifying the liver and kidney. The liver and kidney are homologous, the liver stores blood, the kidney stores essence, and the essence and blood are mutually generated. Tonifying the liver and kidney helps promote hair growth. Modern research shows that psoralea corylifolia contains a variety of active ingredients, such as psoralen, isopsoralen, etc. These ingredients have the effects of regulating the body's immune function and promoting cell proliferation, thereby providing a certain pharmacological basis for the treatment of alopecia areata.

[0025] Polygonum multiflorum: Processed Polygonum multiflorum is slightly warm in nature, bitter, sweet and astringent in taste, and enters the liver, heart and kidney meridians. It has the effects of nourishing the liver and kidney, replenishing the essence and blood, blackening the hair, and strengthening the tendons and bones. As the main drug, it works synergistically with psoralea corylifolia to enhance the effect of nourishing the liver and kidney, providing a fundamental treatment for the treatment of alopecia areata caused by deficiency of qi and blood. The active ingredients in Polygonum multiflorum, such as diphenylethylene glycosides, have the effects of anti-oxidation, regulating blood lipids, and improving blood rheology. They can improve scalp blood circulation, provide sufficient nutrition for hair, and promote hair regeneration.

[0026] 2) Minister medicine Safflower: warm in nature, pungent in taste, enters the heart and liver meridians. It has the effects of promoting blood circulation, dredge menstruation, dissipating blood stasis and relieving pain.

[0027] Peach kernel: neutral in nature, bitter and sweet in taste, enters the heart, liver and large intestine meridians. It can promote blood circulation, remove blood stasis, moisten the intestines and promote bowel movements.

[0028] Chuanxiong: warm in nature, pungent in taste, enters the liver, gallbladder, and pericardium meridians. It has the effects of promoting blood circulation, promoting qi, dispelling wind and relieving pain.

[0029] Danshen: slightly cold in nature, bitter in taste, enters the heart and liver meridians. It can promote blood circulation and remove blood stasis, relieve menstruation and pain, clear the heart and relieve restlessness, cool blood and eliminate carbuncle.

[0030] Angelica: warm in nature, sweet and spicy in taste, enters the liver, heart and spleen meridians. It has the effects of nourishing blood and activating blood circulation, regulating menstruation and relieving pain, and moistening the intestines and relieving constipation.

[0031] These ministerial drugs work together to promote blood circulation and nourish blood, promote blood circulation in the scalp, and improve the nutritional supply of the scalp. After the blood circulation improves, the hair follicles can obtain sufficient nutrients, which is conducive to hair growth. Among them, safflower, peach kernel, and salvia miltiorrhiza mainly focus on promoting blood circulation and removing blood stasis, while Chuanxiong promotes blood circulation and qi circulation, making the blood circulation stronger and able to promote qi in the blood, and blood circulation when qi flows; Angelica sinensis nourishes blood and promotes blood circulation, which can not only nourish blood but also make blood circulation smooth and avoid stasis. Modern research has confirmed that most of these drugs have the effects of improving microcirculation, resisting platelet aggregation, regulating immunity, etc., which are beneficial to the treatment of alopecia areata.

[0032] 3) Adjuvant Platycladus orientalis leaves: cold in nature, bitter and astringent in taste, and enter the lung, liver, and spleen meridians. It has the effects of cooling blood and stopping bleeding, resolving phlegm and relieving cough, and promoting hair growth and darkening hair. Its hair growth and darkening effect helps promote hair growth. In this formula, it plays a role in dispelling wind and promoting hair growth, improving the scalp environment, and making hair easier to grow. Platycladus orientalis leaves contain volatile oils, flavonoids and other ingredients, which have antibacterial and anti-inflammatory effects, can reduce scalp inflammatory reactions, and create favorable conditions for the healthy growth of hair follicles.

[0033] Saposhnikovia divaricata: slightly warm in nature, pungent and sweet in taste, and enters the bladder, liver, and spleen meridians. It can dispel wind and relieve exterior symptoms, overcome dampness and relieve pain, and stop spasms. It has the effect of dispelling wind and relieving itching, which can relieve the discomfort of the scalp, reduce the damage to the hair follicles caused by scratching due to itching and other discomforts, and promote the health of hair follicles. The pharmacological effects of Saposhnikovia divaricata include anti-inflammatory and anti-allergic effects, which can regulate the immune status of the scalp and is beneficial for the treatment of alopecia areata.

[0034] Tribulus terrestris: slightly warm in nature, pungent and bitter in taste, slightly toxic, and enters the liver meridian. It has the effects of calming the liver and relieving depression, promoting blood circulation and dispelling wind, improving eyesight, and relieving itching. In the formula, it plays the role of dispelling wind and promoting hair growth, dispelling wind and relieving itching, and synergizes with Platycladus orientalis and Saposhnikovia divaricata to improve the local environment of the scalp and promote hair regeneration. Modern research has found that Tribulus terrestris contains a variety of alkaloids and flavonoid compounds, which have the effects of regulating immunity and anti-oxidation, and are helpful in treating alopecia areata.

[0035] 4) Use medicine Ginger: slightly warm in nature, pungent in taste, and enters the lung, spleen, and stomach meridians. It can dispel cold, warm the middle and stop vomiting, resolve phlegm and stop coughing, and detoxify fish and crabs. It also has the effect of warming and unblocking the meridians. In this formula, ginger can assist other drugs to play a better role, promote the absorption of drugs and the effect of drugs. Its warming and unblocking nature can promote blood circulation in the scalp and enhance the effect of drugs on the scalp. Gingerol and other ingredients in ginger have the effects of promoting local blood circulation, antibacterial and anti-inflammatory, etc., which are beneficial to the treatment of alopecia areata.

[0036] 2. Overall mechanism of action of Chinese medicine formula The Chinese medicine formula of the present invention regulates the functions of human organs as a whole and improves the state of qi and blood deficiency through the effects of tonifying the liver and kidney, replenishing qi and blood, promoting blood circulation and removing blood stasis, and dispelling wind and relieving itching. Tonifying the liver and kidney provides the fundamental power for the growth of hair, and hair can be nourished if qi and blood are sufficient. Promoting blood circulation and removing blood stasis improves the blood circulation of the scalp, so that nutrients can smoothly reach the hair follicles, and dispelling wind and promoting hair growth and dispelling wind and relieving itching create a good growth environment for the hair follicles. Through the synergistic effect of these drugs, the scalp environment can be effectively improved, hair regeneration can be promoted, and alopecia areata due to qi and blood deficiency type is played a therapeutic effect, which proves the beneficial effect of the present invention in treating alopecia areata due to qi and blood deficiency type. At the same time, the formula is made into a tincture for promoting blood circulation, replenishing qi and promoting hair growth, and the drug is more easily absorbed by the human body through the osmotic effect of alcohol, further enhancing the therapeutic effect.

[0037] Design, selection and preparation of drugs for treating alopecia areata of qi and blood deficiency type

[0038] 1. Formula weight design Example 1: Psoralea corylifolia 8g, Polygonum multiflorum 10g, Carthamus tinctorius 5g, Peach kernel 5g, Ligusticum chuanxiong 12g, Salvia miltiorrhiza 5g, Angelica sinensis 10g, Platycladus orientalis 10g, Saposhnikovia divaricata 8g, Tribulus terrestris 5g, Dictamni cortex 8g, and Ginger 5g.

[0039] Example 2: Psoralea corylifolia 8g, Polygonum multiflorum 10g, Carthamus tinctorius 15g, Peach kernel 15g, Ligusticum chuanxiong 20g, Salvia miltiorrhiza 15g, Angelica sinensis 20g, Platycladus orientalis 20g, Saposhnikovia divaricata 15g, Tribulus terrestris 15g, Dictamni cortex 8g, and Ginger 9g.

[0040] Example 3: Psoralea corylifolia 8g, Polygonum multiflorum 10g, Carthamus tinctorius 10g, Peach kernel 10g, Ligusticum chuanxiong 15g, Salvia miltiorrhiza 10g, Angelica sinensis 15g, Platycladus orientalis 15g, Saposhnikovia divaricata 10g, Tribulus terrestris 10g, Dictamni cortex 10g, and Ginger 12g.

[0041] Example 4: Psoralea corylifolia 8g, Polygonum multiflorum 10g, Carthamus tinctorius 5g, Peach kernel 5g, Ligusticum chuanxiong 12g, Salvia miltiorrhiza 5g, Angelica sinensis 10g, Platycladus orientalis 10g, Saposhnikovia divaricata 8g, Tribulus terrestris 5g, Dictamni cortex 8g, and Ginger 5g.

[0042] Example 5: Psoralea corylifolia 8g, Polygonum multiflorum 10g, Carthamus tinctorius 15g, Peach kernel 15g, Ligusticum chuanxiong 20g, Salvia miltiorrhiza 15g, Angelica sinensis 20g, Platycladus orientalis 20g, Saposhnikovia divaricata 15g, Tribulus terrestris 15g, Dictamni cortex 8g, and Ginger 9g.

[0043] Example 6: Psoralea corylifolia 8g, Polygonum multiflorum 10g, Carthamus tinctorius 10g, Peach kernel 10g, Ligusticum chuanxiong 15g, Salvia miltiorrhiza 10g, Angelica sinensis 15g, Platycladus orientalis 15g, Saposhnikovia divaricata 10g, Tribulus terrestris 10g, Dictamni cortex 10g, and Ginger 12g.

[0044] Example 7: Psoralea corylifolia 10g, Polygonum multiflorum 12g, Carthamus tinctorius 10g, Peach kernel 10g, Ligusticum chuanxiong 15g, Salvia miltiorrhiza 10g, Angelica sinensis 15g, Platycladus orientalis 15g, Saposhnikovia divaricata 10g, Tribulus terrestris 10g, Dictamni cortex 10g, and ginger 9g.

[0045] Example 8: Psoralea corylifolia 10g, Polygonum multiflorum 12g, Carthamus tinctorius 10g, Peach kernel 10g, Ligusticum chuanxiong 15g, Salvia miltiorrhiza 10g, Angelica sinensis 15g, Platycladus orientalis 15g, Saposhnikovia divaricata 10g, Tribulus terrestris 10g, Dictamni cortex 10g, and ginger 9g.

[0046] Example 9: Psoralea corylifolia 10g, Polygonum multiflorum 12g, Carthamus tinctorius 10g, Peach kernel 10g, Ligusticum chuanxiong 15g, Salvia miltiorrhiza 10g, Angelica sinensis 15g, Platycladus orientalis 15g, Saposhnikovia divaricata 10g, Tribulus terrestris 10g, Dictamni cortex 10g, and ginger 9g.

[0047] Example 10: Psoralea corylifolia 10g, Polygonum multiflorum 12g, Carthamus tinctorius 5g, Peach kernel 5g, Ligusticum chuanxiong 12g, Salvia miltiorrhiza 5g, Angelica sinensis 10g, Platycladus orientalis 10g, Saposhnikovia divaricata 8g, Tribulus terrestris 5g, Dictamni cortex 8g, and Ginger 9g.

[0048] Example 11: Psoralea corylifolia 10g, Polygonum multiflorum 12g, Carthamus tinctorius 5g, Peach kernel 5g, Ligusticum chuanxiong 12g, Salvia miltiorrhiza 5g, Angelica sinensis 10g, Platycladus orientalis 10g, Saposhnikovia divaricata 8g, Tribulus terrestris 5g, Dictamni cortex 8g, and Ginger 9g.

[0049] Example 12: Psoralea corylifolia 10g, Polygonum multiflorum 12g, Carthamus tinctorius 5g, Peach kernel 5g, Ligusticum chuanxiong 12g, Salvia miltiorrhiza 5g, Angelica sinensis 10g, Platycladus orientalis 10g, Saposhnikovia divaricata 8g, Tribulus terrestris 5g, Dictamni cortex 8g, and Ginger 9g.

[0050] 2. Selection of formula ratio This study collects key data from multiple implementation examples, explores their value, combines them with traditional Chinese medicine theory, screens and optimizes treatment strategies, promotes academic and clinical development, and helps patients restore their hair.

[0051]

[0052] See also Figure 4Combined with the above statistical results, it is shown that the data of the 12 design embodiments present a regular distribution trend, which also shows that in the treatment of qi and blood deficiency type of alopecia areata, the selected Chinese medicine formula shows certain efficacy advantages. Combined with data analysis, we found that the hair follicle density, hair density and vellus hair rate among different embodiments were improved to varying degrees, indicating that the formula adjustment has an important influence on the therapeutic effect. Further research will focus on these key indicators to optimize the treatment plan and improve the clinical cure rate. For these key indicators, we plan to conduct in-depth clinical trials and efficacy analysis in order to find a more accurate drug ratio, enhance the stimulating effect of the drug on the hair follicles, thereby effectively improving the growth quality and quantity of hair. In addition, a personalized treatment plan will be formulated in combination with the specific conditions of the patient, such as age, constitution, course of disease, etc., to maximize the advantages of Chinese medicine in the treatment of alopecia areata, and bring more significant improvement and hope of recovery to patients.

[0053] In this regard, we combine statistical data with formula ratio design to explain in detail. First, the hair follicle density is stable in the range of 583 to 594.36, which is closely related to the circulation of qi and blood in the scalp, the conduction of meridians, and the distribution of essence and qi in the internal organs, and is highly consistent with the classic theory of traditional Chinese medicine that "hair is the residue of blood" and "the kidney governs the bones and produces marrow, and its beauty is in the hair." Second, the hair density gradually increased from 96.82 to 102.51, which shows that it is in synergy with the inherent rhythm of the rise and fall of qi and blood in the internal organs, the fullness and emptiness of qi and blood in the meridians, and the nourishment of kidney essence in the hair. Its dynamic evolution accurately demonstrates the practical effect of the treatment plan on regulating the hair growth cycle and improving its quality. Third, the vellus hair rate fluctuates flexibly between 25.18% and 29%, just like a sensitive "detection needle" of the differentiation potential of hair follicles. It accurately measures the key life process variations such as the activation of the differentiation potential of hair follicle stem cells, the optimization of the proliferation and differentiation rate of hair matrix cells, and the precise regulation of hair type-specific gene expression in the process of vellus hair follicles transforming into terminal hair follicles under the stimulation of qi and blood and the warmth of kidney essence, which effectively opens up a new path for in-depth research and development of alopecia areata treatment.

[0054] In summary, according to the design, the follicle density, hair density and vellus hair rate per square centimeter are measured under the dermatoscope every 4 weeks during the treatment period. Example 7 The synergistic advantages in the three core indicators of follicle density, hair density and vellus hair rate are significant. At the level of follicle density, its high value indicates that it can strongly activate hair follicle stem cells, repair damaged hair follicle structure, and effectively break the growth stagnation dilemma; the peak value of hair density witnesses that it can deeply optimize the functional state of hair follicles and accelerate the process of hair growth and maturation; the high vellus hair rate highlights the excellent stimulation of hair follicle differentiation potential, promotes the efficient transformation of vellus hair to terminal hair, and optimizes the hair hierarchy structure. These three indicators synergistically confirm the unique role of Chinese medicine compatibility in the treatment strategy, and provide strong evidence for the application of traditional Chinese medicine in the field of modern hair regeneration. In addition, while improving the quality of hair, this strategy also pays attention to the balance of the patient's overall health, reflecting the holistic view and syndrome differentiation principle of Chinese medicine treatment. In this regard, our department's self-prepared prescription for promoting blood circulation, replenishing qi and promoting hair growth adopts Example 7: 10g of Psoralea corylifolia, 9g of ginger, 15g of Platycladus orientalis leaves, 10g of Tribulus terrestris, 10g of Salvia miltiorrhiza, 12g of Polygonum multiflorum, 15g of Angelica sinensis, 10g of Dictamni, 15g of Chuanxiong, 10g of Saposhnikovia divaricata, 10g of Prunus persica, 10g of Safflower, and 75% alcohol soaked for 1 week. The sealed container is made of glass and the bottle stopper is made of rubber.

[0055] 3. Preparation of blood-activating, qi-invigorating and hair-growing tincture The Chinese medicine composition of Example 7 is respectively put into a sealed container and soaked in 75% alcohol, and all sealed containers are placed in a cool place at room temperature (the sealed container is required to avoid direct sunlight, the temperature is maintained at 10-20°C, and the humidity is maintained at 40%-60%), and soaked for at least 1 week to prepare a blood-activating, qi-invigorating and hair-growing tincture. In addition to being prepared as a liniment, it can also be prepared as a spray. In order to effectively prevent the chemical reaction between the drug and the container and ensure the stability and purity of the drug components, the sealed container includes a glass bottle body and a rubber stopper.

[0056] Clinical application examples 1. Materials and Methods 1.1 General Information A total of 120 patients with mild to moderate alopecia areata of qi and blood deficiency type were selected from the Affiliated Hospital of Integrated Traditional Chinese and Western Medicine of Shanxi University of Traditional Chinese Medicine from August 2023 to December 2024. The patients were randomly divided into two groups according to the random number table method: a control group and an experimental group. The control group had 60 cases, the male-to-female ratio of the patients in this group was 1:1, and the age of the patients was (46.96±12.35) years old. The experimental group had 60 cases, the male-to-female ratio of the patients in this group was 1:1, and the age was (45.08±12.66) years old. All the selected patients met the requirements of this study, and P>0.05, which was comparable.

[0057] The diagnostic criteria for alopecia areata in the selected patients are as follows: ① The number of hair loss: unilateral or bilateral alopecia areata, with a hair loss area ≥ 10 cm2; ② The color of hair loss: the normal scalp is silvery white or light gray; ③ The course of disease: less than 1 month is the acute stage, 1 month to 1 year is the subacute stage, and more than 1 year is the chronic stage.

[0058] Inclusion criteria: ① meet the criteria for the relevant symptoms and signs in the "Diagnostic Criteria for Alopecia Areata"; ② exclude alopecia area caused by other diseases through examination; ③ no history of drug and food allergies; ④ no history of serious heart, liver, kidney and other diseases and mental illness; ⑤ aged between 18 and 65 years old, with a disease course of less than 1 year.

[0059] Exclusion criteria: ① patients with mental illness; ② pregnant or lactating women; ③ patients with serious diseases of the heart, liver, kidney and other systems; ④ patients with a history of head surgery; ⑤ patients with local skin lesions and infection foci.

[0060] 1.2 Methods Control group: conventional symptomatic treatment, plum blossom needle tapping and moxibustion treatment were given to the patients twice a week, one month as a course of treatment, and the treatment lasted for 6 months.

[0061] Experimental group: Based on the control group, the combined acupuncture and moxibustion therapy combined with the tincture for promoting blood circulation, replenishing qi and promoting hair growth was used to observe the efficacy of alopecia areata. The specific measures were as follows: first, plum blossom needles were used to tap the affected area, and when the affected scalp was red or bleeding, Chinese medicine was applied on it. After the application, mild moxibustion was used to promote drug introduction. During this process, local point acupuncture was performed intermittently to promote drug absorption. During this period, subjects who had adverse drug reactions and could not tolerate them after symptomatic treatment were excluded from this study.

[0062] Note: During the treatment, patients should keep a good mood and avoid mood swings; pay attention to the combination of work and rest and avoid excessive fatigue; eat a reasonable diet, with a light diet as the main focus; strengthen physical exercise to enhance their own resistance; smoking and drinking are prohibited during treatment.

[0063] 1.3 Observation indicators This study summarized and compared the overall intervention effect, SALT score improvement, dermatoscopic hair follicle density per square centimeter, hair density, vellus hair rate, and compliance of the selected patients.

[0064] Evaluation indicators: Clinical cure: hair stops falling, all hair in the hair loss area grows out, and its distribution density, thickness, and color under dermatoscope are the same as those in the healthy hair area, and the efficacy index is >90%; markedly effective: hair stops falling, and the hair regrowth rate in the hair loss area is more than 70%, and its density, thickness and color under dermatoscope are close to those in the healthy hair area, and sebum secretion is significantly reduced, 90%≥efficacy index>60%; effective: hair stops falling, and the hair regrowth rate in the hair loss area is more than 30%, including the growth of vellus hair and white hair, 60%≥efficacy index>30%; ineffective: hair regrowth is less than 30% or hair loss continues, and the efficacy index is ≤30%.

[0065] Efficacy index = (efficacy score before treatment - efficacy score after treatment) ÷ efficacy score before treatment × 100%.

[0066] Total effective rate = cure rate + marked effective rate + effective rate.

[0067] The onset time (unit: day) refers to the time from the start of treatment to the end of the treatment course when the patient's hair loss is relieved.

[0068] 1.4 Statistical methods (1) This study used SPSS23.0 statistical software to establish a database and conduct general data balance tests.

[0069] (2) The chi-square test was used to compare the two groups of qualitative data; 2. Results 2.1 Comparison of treatment effects between the two groups As attached Figure 1 As shown in Table 1, the treatment effect of Group B was better than that of Group A, and P < 0.05.

[0070] Table 1 Comparison of treatment effects between the two groups of patients (cases / %)

[0071] 2.2 Comparison of SALT score improvement, dermatoscopic hair follicle density per square centimeter, hair density, and vellus hair rate between the two groups As attached Figure 2 As shown in Table 2, the improvement of SALT score, hair follicle density per square centimeter, hair density and vellus hair rate in the experimental group after treatment were better than those in the control group, and P < 0.05.

[0072] Table 2 Comparison of SALT score, hair follicle density, hair density and vellus hair rate between the two groups (cases / %)

[0073] 2.3 Comparison of the two groups of patients' compliance with the treatment process The compliance of group B patients to the treatment process was higher than that of group A, and P < 0.05, see Table 3.

[0074] Table 3 Comparison of compliance between the two groups of patients (cases / %)

[0075] The research results show that if Figure 5 and 6 As shown in the results, after the selected patients with alopecia areata of qi and blood deficiency type were treated with comprehensive acupuncture therapy combined with tincture for promoting blood circulation, replenishing qi and promoting hair growth, the improvement of SALT score, hair follicle density per square centimeter under dermatoscopy, hair density and vellus hair rate in the experimental group were better than those in the control group. The patients' compliance with the treatment process was better than that in the control group. The difference in research data between the two groups of patients was significant and statistically significant.

[0076] Therefore, after the patients with alopecia areata caused by qi and blood deficiency were treated with comprehensive acupuncture therapy combined with blood-activating, qi-invigorating and hair-generating tincture, the patients' alopecia areata symptoms were significantly improved, and the patients' compliance and satisfaction with the treatment were higher. The clinical application value is significant and worthy of promotion.

[0077] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A Chinese medicine formula for treating alopecia areata of qi and blood deficiency type by comprehensive acupuncture therapy, characterized in that: The drug is prepared from the following raw materials in the following weight ratio: 8-12g of psoralea corylifolia, 10-15g of polygonum multiflorum, 5-15g of safflower, 5-15g of peach kernel, 12-20g of chuanxiong, 5-15g of salvia miltiorrhiza, 10-20g of angelica sinensis, 10-20g of oriental arborvitae leaf, 8-15g of siler, 5-15g of tribulus terrestris, 8-15g of dittany, and 5-12g of ginger.

2. The Chinese medicine formula according to claim 1, characterized in that: The weight ratio of the formula is 10g of Psoralea corylifolia, 12g of Polygonum multiflorum, 10g of Carthamus tinctorius, 10g of Peach Kernel, 15g of Ligusticum chuanxiong, 10g of Salvia miltiorrhiza, 15g of Angelica sinensis, 15g of Platycladus orientalis, 10g of Saposhnikovia divaricata, 10g of Tribulus terrestris, 10g of Dictamni cortex, and 9g of ginger.

3. Use of the Chinese medicine formula according to claim 1 or 2 in preparing a medicine for treating alopecia areata of qi and blood deficiency type.

4. A drug for treating alopecia areata of qi and blood deficiency type, characterized in that: The medicine comprises the Chinese medicine formula according to claim 3, which is prepared by soaking a sealed container in 75% alcohol.

5. A medicine for treating alopecia areata of qi and blood deficiency type according to claim 4, characterized in that: The sealed container needs to be placed in a cool place at room temperature.

6. A medicine for treating alopecia areata of qi and blood deficiency type according to claim 5, characterized in that: The sealed container is required to avoid direct sunlight, maintain the temperature at 10 - 20°C, and maintain the humidity at 40% - 60%.

7. A medicine for treating alopecia areata of qi and blood deficiency type according to claim 4, characterized in that: The medicine needs to be soaked for at least 1 week.

8. A medicine for treating alopecia areata of qi and blood deficiency type according to claim 4, characterized in that: The sealed container comprises a bottle body made of glass and a bottle stopper made of rubber.

9. A drug for treating alopecia areata of qi and blood deficiency type according to any one of claims 4 to 8, characterized in that: The dosage form of the medicine is spray or ointment.

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