10 results about "Papule" patented technology

The invention belongs to the technical field of medical experimental animal models, and particularly relates to a construction method of a rabbit ear acne model for studying acne pathogenesis and drug curative effect. A healthy New Zealand large-ear white rabbit is selected, a testosterone solution is subcutaneously injected to induce endocrine disorder, oleic acid is smeared at an opening of an external auditory canal on the inner side of an ear, dermatobacterium acnes suspension is subcutaneously injected, and whether acne-like lesions such as erythema, papule and comedo appear on the skin of the ear or not is observed. The method is easy and convenient to operate, low in cost, good in repeatability, capable of simulating the pathological process of human acne and suitable for acne pathogenesis research and drug screening.

The present disclosure provides methods of treating skin acne-like rash in a subject in need thereof. The method comprises applying an effective amount of picosterone-17 alpha-propionate to the surface of the subject. The acne-like rash may include papules, pustules, nodules, scabs, cysts, or any combination thereof on an affected area of the subject. An effective amount of the picosterone-17 [alpha]-propionate can be administered in a surface pharmaceutical formulation comprising the picosterone-17 [alpha]-propionate and one or more pharmaceutically acceptable carriers.

The invention relates to application of cembratrienediol in preparation of a medicine for preventing and treating rosacea, and belongs to the technical field of biological medicine. The invention provides an application of cembratrienediol in preparation of a medicine for preventing / or treating rosacea. The cembratrienediol can obviously improve erythema and inflammation of an injection area of a rosacea mouse model for a long time and a short time; the skin tissue pathological inflammation of the rosacea mouse model can be obviously relieved (including the thickening of the skin epidermis of the rosacea mouse model, the inflammatory cell infiltration of the skin tissue of the rosacea mouse model and the capillary hyperplasia of the skin tissue of the rosacea mouse model); skin inflammation of a rosacea patient can be remarkably relieved (including relieving pain of the skin of the rosacea patient and relieving the red and swollen degree of the skin of the rosacea patient), and skin injuries of the rosacea patient can be remarkably improved (including improving papules and pustules of the skin of the rosacea patient).

The application relates to application of cedrene diol in preparation of medicines for preventing and treating rosacea, and belongs to the technical field of biological medicines. The application provides application of cedrene diol in preparation of medicines for preventing and / or treating rosacea. The cedrene diol can significantly improve redness and inflammation of an injection area of a rosacea mouse model in long and short terms, can significantly relieve skin histopathological inflammation of the rosacea mouse model (including improving thickening of skin epidermis of the rosacea mouse model, reducing inflammatory cell infiltration of skin tissue of the rosacea mouse model, and reducing capillary proliferation of skin tissue of the rosacea mouse model), can significantly reduce skin inflammation of a rosacea patient (including reducing pain of the skin of the rosacea patient and relieving redness of the skin of the rosacea patient), and can significantly improve skin damage of the rosacea patient (including improving papules and pustules of the skin of the rosacea patient).

This invention belongs to the field of traditional Chinese medicine, specifically relating to a traditional Chinese medicine composition for treating rosacea, its preparation method, and its application. This invention provides a traditional Chinese medicine composition for treating rosacea, comprising dandelion, purslane, sophora flavescens, sophora japonica flower, and rhubarb. The traditional Chinese medicine composition of this invention has the effects of clearing heat and detoxifying, reducing inflammation and antibacterial properties, cooling blood and promoting blood circulation, and repairing the skin barrier. It can be used to treat erythematous rosacea, relieving erythema, telangiectasia, papules, itching, and burning sensation on the skin, and reducing the risk of recurrence.

The present application relates to the technical field of computer vision and medical image processing, and discloses a facial acne intelligent grading method and system based on image analysis, which comprises the following steps: facial image standardization acquisition and skin color normalization preprocessing, facial key point positioning and region of interest analysis, multi-type acne lesion instance segmentation and automatic counting, region weighted multi-feature fusion lesion severity comprehensive score, acne grade determination based on clinical grading standard, and image registration before and after treatment and curative effect quantitative evaluation. The present application eliminates the differences in illumination and skin color through skin color normalization, realizes fine identification of five types of skin lesions including comedones, papules, pustules, nodules and cysts, and outputs corresponding clinical grading results and curative effect evaluation report by combining region weight and category weight to calculate comprehensive score.

This invention discloses an artificial intelligence-based rosacea diagnostic system, including a data governance module and a multimodal model training and inference module. The data governance module is used to process the collected facial data, and the multimodal model training and inference module is used to uniformly model the images and derived modal features output by the data governance module, perform erythema region segmentation, papule / pustule and comedo detection, and further obtain diagnostic probability and severity classification, providing interpretable structured results.

The application provides a traditional Chinese medicine gel for treating acne and refractory furuncle and a preparation method thereof. The traditional Chinese medicine gel is prepared from the following raw materials in parts by mass: 15-22 parts of Herba Hyperici Japonici, 15-20 parts of Fructus Gardeniae, 2-6 parts of Lignum Caesalpiniae, 15-20 parts of Herba Hedyotis, 13-20 parts of Herba Taraxaci, 4-8 parts of Panax notoginseng, 60-65 parts of purified water, 1-4 parts of carbomer, 1-3 parts of xanthan gum, 2-4 parts of propylene glycol, 135-150 parts of vegetable oil, 100-120 parts of ethanol and 5-8 parts of monoglyceride. The prepared traditional Chinese medicine gel has the effects of clearing heat and cooling blood, removing blood stasis and relieving pain, and detoxifying and reducing swelling, can quickly eliminate blood stasis, swelling, subcutaneous cyst, papules, papulovesicles, abscesses and the like at a skin lesion site, repair damaged skin tissue, has strong antibacterial effect, has remarkable effect on treating acne and refractory furuncle and has no side effect.

The invention discloses an external traditional Chinese medicine composition for treating acne and a preparation method thereof, the composition is prepared from divaricate saposhnikovia root, camphor, borneol, walnut meat, chaulmoogra seed and mercury according to a specific proportion, and the composition acts on an affected part in a physical wiping mode. Through clinical verification, the traditional Chinese medicine composition can effectively relieve red and swollen acnes and reduce the number of papules, and has the characteristics of quick response and high safety.

The present application belongs to the technical field of pharmacy, and mainly relates to a kind of ointment for treating dermatophytosis based on traditional Chinese medicine composition and a preparation method thereof.In the present application, the traditional Chinese medicinal materials such as biofermented sophora, belamcanda, bauhinia, gallnut, cnidium, aloe, vitex, kochia, oak, stemona, saposhnikovia, gleditsia, and smilax can inhibit fungal growth, and can also relieve itching and swelling.The present application has less side effects.In the present application, Ti / ZIF-8 is further added, and the bacteriostatic effect is more obvious.Acute and chronic dermatitis, eczema, beriberi, foot rot, tinea, foot sweat, fungal infection, skin itching, papules, maculopapular rash, erythroderma, stubborn skin eczema, and redness and itching caused by mosquito bites can be inhibited, and white candida and staphylococcus aureus can be inhibited.In general, the present application has very wide application prospects in the field.