15 results about "Papule" patented technology

The invention discloses an application of betulinic acid 28-O-beta-D-glucoside (BA-6 for short) in preparation of a medicine for preventing and treating skin inflammation. The problems that an existing medicine for treating dermatitis is limited in curative effect, slow in effect taking, multiple in side effect, high in long-term use risk, large in individual difference, high in treatment cost, likely to cause immunoreaction and the like are solved. The invention discloses application of BA-6 in prevention and treatment of atopic dermatitis, contact dermatitis, eczema, rash, psoriasis, lupus erythematosus, papule squamous skin disease, pityriasis rosea, seborrheic dermatitis, pemphigus, celestial abscess, acne, tinea corporis, impetigo, SAPHO syndrome, hidradenitis suppurativa, dermatitis caused by drugs, lichen planus, pityriasis rubra pilaris, vitiligo, prurigo nodularis, dermatitis caused by drugs, and the like for the first time. The traditional Chinese medicine composition can be used for treating skin diseases, systemic sclerosis, hidradenitis suppurativa, granulomatous skin diseases, vitiligo, dermatomyositis, chronic skin itch and alopecia areata, and has the technical progress of obviously improving skin erythema, papule, edema, scale, moss and ulceration symptoms.

Compositions and methods for treating and preventing inflammatory and autoimmune skin conditions, particularly rosacea, using one or more topically applied benzimidazole compounds in a pharmaceutically acceptable carrier for use on skin. A preferred benzimidazole compound comprises mebendazole. A treatment composition preferably comprises 0.05-0.075 weight percent mebendazole, and may comprise up to 20.0% mebendazole, in an aqueous carrier or vehicle comprising a cream, gel, lotion, liquid, emulsion, aerosol spray, non-aerosol spray,, suspension, or ointment and is applied at least once daily over a treatment period of at least two weeks to result in a reduction of cutaneous cytotoxic CD+8 T-cells, papules, pustules, swelling, appearance of redness or inflammation, and / or reduction in itchiness, and hot or burning sensation in the affected area compared to pre-treatment levels.

Compositions and methods for treating and preventing inflammatory and autoimmune skin conditions, particularly rosacea, using one or more topically applied benzimidazole compounds in a pharmaceutically acceptable carrier for use on skin. A preferred benzimidazole compound comprises mebendazole. A treatment composition preferably comprises 0.05-0.075 weight percent mebendazole, and may comprise up to 20.0% mebendazole, in an aqueous carrier or vehicle comprising a cream, gel, lotion, liquid, emulsion, aerosol spray, non-aerosol spray,, suspension, or ointment and is applied at least once daily over a treatment period of at least two weeks to result in a reduction of cutaneous cytotoxic CD+8 T-cells, papules, pustules, swelling, appearance of redness or inflammation, and / or reduction in itchiness, and hot or burning sensation in the affected area compared to pre-treatment levels.

The invention belongs to the technical field of medical experimental animal models, and particularly relates to a construction method of a rabbit ear acne model for studying acne pathogenesis and drug curative effect. A healthy New Zealand large-ear white rabbit is selected, a testosterone solution is subcutaneously injected to induce endocrine disorder, oleic acid is smeared at an opening of an external auditory canal on the inner side of an ear, dermatobacterium acnes suspension is subcutaneously injected, and whether acne-like lesions such as erythema, papule and comedo appear on the skin of the ear or not is observed. The method is easy and convenient to operate, low in cost, good in repeatability, capable of simulating the pathological process of human acne and suitable for acne pathogenesis research and drug screening.

The present disclosure provides methods of treating skin acne-like rash in a subject in need thereof. The method comprises applying an effective amount of picosterone-17 alpha-propionate to the surface of the subject. The acne-like rash may include papules, pustules, nodules, scabs, cysts, or any combination thereof on an affected area of the subject. An effective amount of the picosterone-17 [alpha]-propionate can be administered in a surface pharmaceutical formulation comprising the picosterone-17 [alpha]-propionate and one or more pharmaceutically acceptable carriers.

The invention relates to application of cembratrienediol in preparation of a medicine for preventing and treating rosacea, and belongs to the technical field of biological medicine. The invention provides an application of cembratrienediol in preparation of a medicine for preventing / or treating rosacea. The cembratrienediol can obviously improve erythema and inflammation of an injection area of a rosacea mouse model for a long time and a short time; the skin tissue pathological inflammation of the rosacea mouse model can be obviously relieved (including the thickening of the skin epidermis of the rosacea mouse model, the inflammatory cell infiltration of the skin tissue of the rosacea mouse model and the capillary hyperplasia of the skin tissue of the rosacea mouse model); skin inflammation of a rosacea patient can be remarkably relieved (including relieving pain of the skin of the rosacea patient and relieving the red and swollen degree of the skin of the rosacea patient), and skin injuries of the rosacea patient can be remarkably improved (including improving papules and pustules of the skin of the rosacea patient).

【Solution】A composition and method for treating and preventing inflammatory and autoimmune skin conditions, particularly rosacea, using one or more topically applied benzimidazole compounds in a pharmaceutically acceptable carrier for use on the skin. Preferred benzimidazole compounds include mebendazole. The therapeutic composition preferably contains 0.05 to 0.20% by weight of mebendazole in an aqueous or non-aqueous carrier or vehicle including creams, gels, lotions, liquids, emulsions, microemulsions, aerosol sprays, non-aerosol sprays, serums, solutions, suspensions, or ointments, may contain up to 20.0% of mebendazole, and is applied at least once a day over a treatment period of at least two weeks, resulting in a reduction in the appearance of skin cytotoxic CD+8 T cells, papules, pustules, swelling, redness or inflammation, and / or itching at the affected site compared to pre-treatment levels.

The application relates to application of cedrene diol in preparation of medicines for preventing and treating rosacea, and belongs to the technical field of biological medicines. The application provides application of cedrene diol in preparation of medicines for preventing and / or treating rosacea. The cedrene diol can significantly improve redness and inflammation of an injection area of a rosacea mouse model in long and short terms, can significantly relieve skin histopathological inflammation of the rosacea mouse model (including improving thickening of skin epidermis of the rosacea mouse model, reducing inflammatory cell infiltration of skin tissue of the rosacea mouse model, and reducing capillary proliferation of skin tissue of the rosacea mouse model), can significantly reduce skin inflammation of a rosacea patient (including reducing pain of the skin of the rosacea patient and relieving redness of the skin of the rosacea patient), and can significantly improve skin damage of the rosacea patient (including improving papules and pustules of the skin of the rosacea patient).

This invention belongs to the field of traditional Chinese medicine, specifically relating to a traditional Chinese medicine composition for treating rosacea, its preparation method, and its application. This invention provides a traditional Chinese medicine composition for treating rosacea, comprising dandelion, purslane, sophora flavescens, sophora japonica flower, and rhubarb. The traditional Chinese medicine composition of this invention has the effects of clearing heat and detoxifying, reducing inflammation and antibacterial properties, cooling blood and promoting blood circulation, and repairing the skin barrier. It can be used to treat erythematous rosacea, relieving erythema, telangiectasia, papules, itching, and burning sensation on the skin, and reducing the risk of recurrence.

The present application relates to the technical field of computer vision and medical image processing, and discloses a facial acne intelligent grading method and system based on image analysis, which comprises the following steps: facial image standardization acquisition and skin color normalization preprocessing, facial key point positioning and region of interest analysis, multi-type acne lesion instance segmentation and automatic counting, region weighted multi-feature fusion lesion severity comprehensive score, acne grade determination based on clinical grading standard, and image registration before and after treatment and curative effect quantitative evaluation. The present application eliminates the differences in illumination and skin color through skin color normalization, realizes fine identification of five types of skin lesions including comedones, papules, pustules, nodules and cysts, and outputs corresponding clinical grading results and curative effect evaluation report by combining region weight and category weight to calculate comprehensive score.

This invention discloses an artificial intelligence-based rosacea diagnostic system, including a data governance module and a multimodal model training and inference module. The data governance module is used to process the collected facial data, and the multimodal model training and inference module is used to uniformly model the images and derived modal features output by the data governance module, perform erythema region segmentation, papule / pustule and comedo detection, and further obtain diagnostic probability and severity classification, providing interpretable structured results.

The application provides a traditional Chinese medicine gel for treating acne and refractory furuncle and a preparation method thereof. The traditional Chinese medicine gel is prepared from the following raw materials in parts by mass: 15-22 parts of Herba Hyperici Japonici, 15-20 parts of Fructus Gardeniae, 2-6 parts of Lignum Caesalpiniae, 15-20 parts of Herba Hedyotis, 13-20 parts of Herba Taraxaci, 4-8 parts of Panax notoginseng, 60-65 parts of purified water, 1-4 parts of carbomer, 1-3 parts of xanthan gum, 2-4 parts of propylene glycol, 135-150 parts of vegetable oil, 100-120 parts of ethanol and 5-8 parts of monoglyceride. The prepared traditional Chinese medicine gel has the effects of clearing heat and cooling blood, removing blood stasis and relieving pain, and detoxifying and reducing swelling, can quickly eliminate blood stasis, swelling, subcutaneous cyst, papules, papulovesicles, abscesses and the like at a skin lesion site, repair damaged skin tissue, has strong antibacterial effect, has remarkable effect on treating acne and refractory furuncle and has no side effect.

The invention relates to a composition and application thereof in preparation of a product with an eczema treatment effect. The composition mainly comprises the following components: aesculus chinensis, radix rehmanniae recen, liquorice, semen coicis, golden cypress, coptis chinensis, rhizoma atractylodis, schizonepeta, poria cocos and radix angelicae. According to the invention, the main medicinal materials are firstly crushed, then boiled with water to extract beneficial components, and finally effective components are concentrated for nano-liposome embedding treatment, so that the loss of the beneficial components of the medicinal materials is effectively prevented, and meanwhile, the absorption of the body is promoted. The traditional Chinese medicine composition and the traditional Chinese medicine extract provided by the invention are natural in raw materials, wide in source and simple in preparation method, have a remarkable treatment effect on acute eczema, subacute eczema and chronic eczema, can remarkably improve skin symptoms such as itching, papule, seepage, erythema, skin lesion erosion and the like of patients, are exact in curative effect, are not easy to relapse after being cured, and are free of toxic and side effects. Good clinical application values are realized.

The invention discloses an external traditional Chinese medicine composition for treating acne and a preparation method thereof, the composition is prepared from divaricate saposhnikovia root, camphor, borneol, walnut meat, chaulmoogra seed and mercury according to a specific proportion, and the composition acts on an affected part in a physical wiping mode. Through clinical verification, the traditional Chinese medicine composition can effectively relieve red and swollen acnes and reduce the number of papules, and has the characteristics of quick response and high safety.

The present application belongs to the technical field of pharmacy, and mainly relates to a kind of ointment for treating dermatophytosis based on traditional Chinese medicine composition and a preparation method thereof.In the present application, the traditional Chinese medicinal materials such as biofermented sophora, belamcanda, bauhinia, gallnut, cnidium, aloe, vitex, kochia, oak, stemona, saposhnikovia, gleditsia, and smilax can inhibit fungal growth, and can also relieve itching and swelling.The present application has less side effects.In the present application, Ti / ZIF-8 is further added, and the bacteriostatic effect is more obvious.Acute and chronic dermatitis, eczema, beriberi, foot rot, tinea, foot sweat, fungal infection, skin itching, papules, maculopapular rash, erythroderma, stubborn skin eczema, and redness and itching caused by mosquito bites can be inhibited, and white candida and staphylococcus aureus can be inhibited.In general, the present application has very wide application prospects in the field.