4 results about "Mebendazole" patented technology

This invention relates to the field of chemical pharmaceuticals, and more particularly to a mebendazole crystal form and its preparation method. The mebendazole crystal form has a single-crystal structure belonging to the triclinic crystal system; space group Triclinic P; cell parameters a = 6.10 Å, b = 15.69 Å, c = 20.35 Å; α = 94.14°; β = 97.22°, γ = 90.70°, V = 1926 Å. 3 The optimization and development of the crystalline form of p-toluimidazole provided by this invention is of great value.

The application discloses a kind of R8 and Tf co-modified mebendazole liposome targeted preparation and its preparation method, application, belong to the field of biological medicine. In view of the poor solubility of mebendazole in water, difficult to penetrate blood-brain barrier, the problem of insufficient tumor targeting in brain glioma treatment, the application adopts film hydration-step modification process, and octaarginine (R8) and targeting ligand transferrin (Tf) are simultaneously modified on the surface of mebendazole-loaded liposome, and the preparation prepared by the application has an encapsulation efficiency of not less than 95%. The preparation can break through blood-brain barrier and precisely enrich in brain glioma lesions, and the in-vivo tumor inhibition rate is more than 90%, with low toxicity and side effects. The preparation can be used for preparing brain glioma therapeutic drugs, and provides a new drug for targeted treatment of brain glioma.

The present invention discloses the application of MoMtg1 protein and its encoding gene in regulating the growth and pathogenicity of rice blast fungus. MoMTG1 Gene deletion will lead to slow growth of rice blast fungus, reduced spore production, deformed conidia, and a significant decrease in pathogenicity to susceptible rice. MoMTG1 The small molecule compound mebendazole obtained by virtual screening has a good control effect on rice blast by targeting the encoded protein. MoMTG1 The encoded protein can be used as a drug target and has good application prospects in the development of new targeted fungicides and disease prevention and control.

Embodiments of the present disclosure relate to use of Mebendazole, a tyrosine kinase inhibitor or both in combination to treat a coronavirus infection in a subject.