15 results about "Antiparasitic agent" patented technology

The invention discloses an application of compounds N-(1-naphthyl)-2-phenoxy acetamide and N-(1-naphthyl)-2-(phenylamino) ethyl thioamide in preparation of cryptosporidium resisting medicines, and belongs to the technical field of medicines and veterinary medicines of anti-parasitic medicines. The compound is obtained through functional group modification by taking NSC158011 as a pilot structure and can efficiently inhibit the activity of cryptosporidium parvum lactic dehydrogenase, and the inhibition rates respectively reach 60-70% and gt; 90%. An in-vitro experiment shows that parasite load is obviously reduced in HCT-8 cells by the two; in vivo, in a gamma-interferon gene knockout mouse and calf infection model, the fecal oocyst load is reduced by 40-100 times, the intestinal barrier repair can be promoted, and the safety is good. The invention reveals that the compound has efficient insect-resistant activity, high safety and intestinal protection effect for the first time, and provides important material basis and technical support for developing a new generation of cryptosporidium-resistant drugs.

The invention relates to the technical field related to medicines, in particular to a method for preventing and controlling orbiculaeas on the basis of an artemisia apiacea extract, which comprises the following specific steps: step 1, purchasing the artemisia apiacea extract from Shanghai Yuan Leaf Biotechnology Co., Ltd; step 2, separating blood egg whipstock in the economic crustacean animals to obtain an amoeboid-shaped trophozoite and microspores of the economic crustacean animals; 3, the amoeboid-shaped trophozoite is inoculated into a culture medium containing specific components to be cultured, the culture medium comprises 0.1% of mycillin, 5% of healthy portunus trituberculatus serum, 10% of fetal calf serum and 85% of NephropsSaline buffer solution, and the microspores are cultured with sterile filtered seawater. According to the method for preventing and controlling the oryza sativa based on the artemisia apiacea extracts, in-vitro experiments verify that the artemisia apiacea extracts with different concentrations (10-1000mg / L) can remarkably promote apoptosis of oryza sativa somatic cells, destroy microstructures of the oryza sativa somatic cells and inhibit physiological activity, and a new way is provided for developing novel green anti-parasitic drugs.

The application provides a derivative of an isoxazoline compound and application thereof in preventing and treating parasitic infections, and a structural general formula of the derivative is as follows: The derivative has obvious inhibiting and killing effects on most in-vitro parasites, and is suitable for preparing animal anti-parasite drugs. The derivative has high safety, small irritation, good curative effect and obvious target effect, and has wide application prospects in preventing and treating in-vitro parasites and external environment parasites of animals and agricultural pests.

The present invention relates to a method for the production of a (poly)hydroxylated pentacyclic triterpene composition including a 3-O-p-coumaroyl ester of tormentic acid from a plant suspension cell culture, to a pharmaceutical composition comprising at least 3-O-p-coumaroyl ester of tormentic acid for a use in the prevention and / or the treatment of trypanosomiasis, optionally in admixture with other (poly)hydroxylated pentacyclic triterpenes, and to 3-O-p-coumaroyl ester of tormentic acid for its use as an antiparasitic agent for the prevention and / or the treatment of trypanosomiasis, optionally in admixture with other (poly)hydroxylated pentacyclic triterpenes.

The application belongs to the field of natural medicines, and particularly relates to cyclic peptide natural products-xylonic acid peptides and the use thereof in the preparation of anti-parasitic drugs. Specifically, 12 cyclic peptide natural products containing xylonic acid structural units are disclosed, which exhibit different degrees of anti-parasitic activity in biological activity tests and have wide application value.

Compounds of formula (I) and pharmaceutically acceptable salts thereof, useful as treatments for parasitic diseases are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including parasitic disease or infection.

Methods of reducing viability of a parasite in a subject involve administering an effective amount of an inhibitor of guanosine-5′-triphosphate cyclohydrolase I (GCH) to the subject. Methods of identifying an agent that reduces viability of an apicomplexan parasite involve culturing an apicomplexan parasite in a cell culture; adding an agent to the cell culture; and detecting a concentration of one or more of 7,8-dihydroncopterin triphosphate, 6-pynivoyl-tetrahydropterin, tetrahydrobiopterin, tetrahydrofolate, folate, dihydrofolate, or dihydrobiopterin in the cell culture after a period of time.

The invention discloses a praziquantel derivative PT-28 as well as a preparation method and application thereof. According to the praziquantel derivative PT-28, a thymol precursor and amino-praziquantel react to generate the derivative. The praziquantel derivative PT-28 can be used as a drug for resisting third-generation insect diseases, and compared with the national standard anti-parasitic drug praziquantel, the safety index-therapeutic index (TI value) of the drug is improved by 8.89 times. The compound has the characteristics of being safe to fishes, low in toxicity and good in killing effect on third-generation insects, and has wide application prospects in development of novel insect-resistant fishery drugs.

The present disclosure provides multi-layered therapeutics, methods of manufacture thereof, and methods of treatment. More particularly, the disclosure provides compositions formulated for administration to an animal comprising a core particle comprising a first antiparasitic agent and a coating, wherein the coating may comprise a second antiparasitic agent; methods of producing such compositions; and methods of treating and / or preventing parasitic infection in animals in need thereof.

The present invention relates to cyclopropyl-(hetero)aryl substituted ethylsulphonyl-pyridine derivatives of formula (1)wherein the variables are as defined in the description and in the claims, which can be used as antiparasitic agents for the treatment, prevention and / or control of parasitic infections and / or infestations in animals.

The present invention relates to compounds of general formula (I), or to a pharmaceutically acceptable salt thereof, as well as to their therapeutic use, particularly as antibiotic and / or antiparasitic agents. The present invention likewise discloses pharmaceutical compositions comprising said compounds. Formula (I)

The present invention relates to a composition of a long-acting bioadhesive endoparasiticide gel based on an isoxazoline alone or in combination with other antiparasitic agents, having a high degree of adhesion to oral mucosa and high palatability greatly facilitating the dosing thereof, and to methods for preparing the same. Ectoparasitosis is a parasitic disease caused by fleas, ticks and mites that infest the surface layers of the skin in small animals. Control of this illness is of great importance and advantageously achievable through the use of appropriate antiparasitic agents such as isoxazolines, being a chemical compound widely administered by oral route in tablet form due to the organoleptic and physicochemical characteristics of the compositions known up to the present. The present invention demonstrates that it is possible to administer isoxazolines in the pharmaceutical form of an oral gel at concentrations of up to 20.0% weight / volume, overcoming the organoleptic and physicochemical restrictions of the compositions known up to the present. Factors never heretofore included in oral endoparasiticide compositions based on isoxazolines, presenting a wide differential advantage compared with the compositions known up to the present.

The application belongs to the field of anti-parasitic drugs, especially a silica aerogel loaded ivermectin drug-loaded particle processing production line. The existing problems of the need to transport the prepared drug-loaded solid, complicated operation, the need for multiple power devices to stir, mix, high cost, incomplete discharge and complicated operation are solved. The scheme comprises a first mixing box and a collecting box, the outer wall of the first mixing box is fixedly connected with three support rods, the collecting box is located directly below the first mixing box, and the top of the first mixing box is fixedly communicated with a hollow circular table cylinder. In the application, the stirring assembly can fully stir the material, the first mixing box and the second mixing box utilize the power of one servo motor, the cost is greatly reduced, the first support block and the second support block can be lifted by the lifting assembly, the feeding and discharging process is completed, and the loading and unloading are not needed, so the work load is greatly reduced.