The present invention relates to a composition of a long-acting
bioadhesive endoparasiticide
gel based on an isoxazoline alone or in combination with other
antiparasitic agents, having a high degree of adhesion to
oral mucosa and high
palatability greatly facilitating the dosing thereof, and to methods for preparing the same. Ectoparasitosis is a
parasitic disease caused by fleas, ticks and mites that infest the surface
layers of the
skin in small animals. Control of this illness is of great importance and advantageously achievable through the use of appropriate
antiparasitic agents such as isoxazolines, being a
chemical compound widely administered by
oral route in tablet form due to the
organoleptic and physicochemical characteristics of the compositions known up to the present. The present invention demonstrates that it is possible to administer isoxazolines in the pharmaceutical form of an oral gel at concentrations of up to 20.0% weight / volume, overcoming the
organoleptic and physicochemical restrictions of the compositions known up to the present. Factors never heretofore included in oral endoparasiticide compositions based on isoxazolines, presenting a wide differential
advantage compared with the compositions known up to the present.