A kind of compound ivermectin injection and preparation method thereof
A technology of ivermectin and injection, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, drug delivery, etc., to achieve the effects of wide clinical application, expanding insect resistance spectrum, and reducing drug resistance
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Embodiment 1~5
[0016] Embodiments 1-5 all prepared a compound ivermectin injection of the present invention, and the raw material formula of each 100ml injection of each embodiment is shown in Table 1 below.
[0017] Table 1
[0018] components
Example 1
Example 2
Example 3
Example 4
Example 5
Ivermectin (g)
0.5
0.5
1
1.5
2
Albendazole sulfoxide (g)
2.5
2.5
5
7.5
10
Ethyl acetate (ml)
1
2
5
10
10
PEG400(ml)
5
7.5
10
12
15
Dimethyl sulfoxide (ml)
10
15
20
25
30
α-thioglycerol (ml)
0.05
0.1
0.1
0.1
0.2
Benzyl alcohol (ml)
1
1.5
2
0.5
1.5
margin
margin
margin
margin
margin
[0019] The raw material of above-mentioned formula makes the method step of compound reci...
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