A kind of compound ivermectin injection and preparation method thereof

A technology of ivermectin and injection, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, drug delivery, etc., to achieve the effects of wide clinical application, expanding insect resistance spectrum, and reducing drug resistance

Active Publication Date: 2011-11-30
长沙施比龙动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In view of the fact that the two drugs have strong anti-insect activity and have complementary effects on the anti-insect spectrum, the successful development of their compound injection is of great significance, and no relevant research reports have been seen so far.

Method used

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  • A kind of compound ivermectin injection and preparation method thereof
  • A kind of compound ivermectin injection and preparation method thereof
  • A kind of compound ivermectin injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～5

[0016] Embodiments 1-5 all prepared a compound ivermectin injection of the present invention, and the raw material formula of each 100ml injection of each embodiment is shown in Table 1 below.

[0017] Table 1

[0018] components

Example 1

Example 2

Example 3

Example 4

Example 5

Ivermectin (g)

0.5

0.5

1

1.5

2

Albendazole sulfoxide (g)

2.5

2.5

5

7.5

10

Ethyl acetate (ml)

1

2

5

10

10

PEG400(ml)

5

7.5

10

12

15

Dimethyl sulfoxide (ml)

10

15

20

25

30

α-thioglycerol (ml)

0.05

0.1

0.1

0.1

0.2

Benzyl alcohol (ml)

1

1.5

2

0.5

1.5

Propylene Glycol

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margin

margin

margin

margin

[0019] The raw material of above-mentioned formula makes the method step of compound reci...

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PUM

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Abstract

The invention belongs to the technical field of veterinary anti-parasitic medicaments, particularly relates to a compound ivermectin injection and a preparation method thereof, and aims to provide an injection for treating parasitic infection of livestock, expanding an anti-parasitic spectrum and enhancing a therapeutic effect and a preparation method thereof. Every 100ml of compound ivermectin injection comprises 0.5-2g of ivermectin, 2.5-10g of albendazole sulfoxide, 5-15ml of polyethylene glycol 400 (PEG400), 1-10ml of acetic ether, 0.5-2ml of benzyl alcohol, 0.05-0.2ml of alpha-thioglycerol, 10-30ml of dimethyl sulfoxide and the balance of propylene glycol. In the injection, the ivermectin and the albendazole sulfoxide are used as anti-parasitic main components; the injection has double complementary advantages; the anti-parasitic spectrum is expanded; the drug resistance probability of parasites can be effectively reduced; and the sensitivity of the parasites is improved. The invention brings a completely new situation for safely, effectively and conveniently preventing and treating parasitic diseases in animal husbandry and aquaculture of China.

Description

technical field [0001] The invention relates to the technical field of veterinary antiparasitic drugs, in particular to a compound ivermectin injection and a preparation method thereof. Background technique [0002] Ivermectin is a new type of macrolide antiparasitic drug, with its broad-spectrum, high efficiency (it has a high-efficiency repellent effect on nematodes, insects and mites), small toxic and side effects, small dosage, safety, and is widely used in animals. It is widely used in livestock production due to its short residual time in non-toxic food. [0003] At present, ivermectin only has common preparations. The maintenance time of each administration is short, multiple administrations are required, it is inconvenient to use, and consumes a lot of manpower and material resources. It is urgent to study new products to adapt to the development of animal husbandry. Ivermectin has a strong killing effect on animal internal parasites (nematodes) and external parasit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/4184A61K9/08A61P33/00
CPCY02A40/70
Inventor 操继跃张卫元陈翠兰张永丹李荣张翠平
Owner 长沙施比龙动物药业有限公司
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