23 results about "Antiparasitic" patented technology

The present invention provides diazo compounds having anti-trypanosomal activity, with less or no side-effects. The diazo compounds are structural analogue of quinapyramine and possess characteristics necessary for the targeted pharmacologic action of anti trypanosomosis, with reduced cytotoxicity. The compounds were found to have less cytotoxicity, and identical or better anti- parasitemia effect as compared to conventional quinapyramine sulfate.

The present invention provides an anti-parasitic composition for use in the treatment or prevention of a parasitic infection in a mammal, the anti-parasitic composition comprising a macrolide, in particular a combination of ivermectin, abamectin and doramectin. The invention also provides a method of treating a parasitic infection in a mammal by administering to the mammal an effective amount of an anti-parasitic composition comprising ivermectin, abamectin, and doramectin, and a method of preparing the anti-parasitic composition.

A strap (3), two complementary fastening elements (4, 5) configured to close the collar (1) into a self-closing loop, a sheath (2) attached to the strap (3), said sheath (2) having an inner face with a micro-perforated body and an outer face made of waterproof material, the inner face having a pouch (11) with an opening (12) configured to allow the diffusion of an antiparasitic treatment molecule through said micro-perforated body. Figure for the abstract: Fig 1

The application belongs to the field of natural medicines, and particularly relates to cyclic peptide natural products-xylonic acid peptides and the use thereof in the preparation of anti-parasitic drugs. Specifically, 12 cyclic peptide natural products containing xylonic acid structural units are disclosed, which exhibit different degrees of anti-parasitic activity in biological activity tests and have wide application value.

The invention relates to a substituted benzamide derivative as well as a preparation method and application thereof, and belongs to the technical field of medicine synthesis. Specifically, the invention discloses a substituted benzamide derivative as shown in a general formula (I), a pharmaceutical composition containing the derivative and application of the derivative in preparation of anti-parasitic drugs. The structural general formula (I) of the substituted benzamide derivative is shown in the specification, wherein R1 is substituted amine. The substituted benzamide derivative disclosed by the invention has a remarkable effect on resisting parasites, vector insects and agricultural and forestry pests, and has a wide application prospect.

The present disclosure provides a method of inhibiting proliferation of a parasite or treating a disease caused by a parasite in a subject by administration of a mitochondria-targeted drug. Nonlimiting examples of the parasites include Brugia malayi and Dirofilaria immitis. Advantageously, movement of both male and female microfilaria can be inhibited by the mitochondria-targeted drug.

The invention discloses an application of kochia saponin in preparation of a medicine for treating helminthosis, an in-vitro effectiveness experiment result of the kochia saponin on an echinococcosis multilocularis protoscolex shows that the killing effect of the kochia saponin on the protoscolex has time and concentration dependence, the death rates of 10 [mu] M, 20 [mu] M and 50 [mu] M of kochia saponin treated for 6 h are 8.05% + / -0.39%, 89.23% + / -1.48% and 100% respectively, and the death rates of 10 [mu] M, 20 [mu] M and 50 [mu] M of kochia saponin treated for 24 h are all 100%; meanwhile, results of in-vitro effectiveness experiments of kochia saponin on trichina at different development stages show that after the trichina is treated for 72 hours under the concentration of 50 mu M, 80 mu M and 100 mu M, the death rates of muscular larvae are 86.24% + / -1.15%, 90.17% + / -1.24% and 90.86% + / -2.10% respectively; after treatment for 24 hours, the death rates of the newborn larvae are respectively 12.71% + / -2.36%, 57.80% + / -2.23% and 79.60% + / -1.52%, all the newborn larvae die after 48 hours, and the killing effect is obvious. Besides, the applicant confirms that the mogroside can directly destroy the epidermis structure and cell integrity of the insect body for the first time through microscope observation, and the discovery provides visual morphological evidence for the anti-parasitic effect of the mogroside.

The present disclosure is directed to a method of detecting a helminth a antigen in a sample comprising (a) contacting a sample with human antibodies and fragments thereof, comprising clone-paired heavy and light chain CDR sequences, and (b) detecting a helminth antigen in said sample by binding of said human antibody or antibody fragment to a helminth antigen in said sample.

Anti-parasitic compounds and uses thereof. Compounds comprising a C-terminal peptide adjuvant conjugated to an N-terminal peptide antigen via a protease-cleavable linker, said peptide adjuvant comprising a peptide analog of C5a, wherein said peptide antigen comprises an antigenic epitope of a parasitic organism, such as T. gondii. Methods of therapeutic or prophylactic treatment of a parasitic infections.

The invention discloses an application of psoralen B in preparation of a medicine for treating helminthosis, an in-vitro effectiveness experiment result of psoralen B on an echinococcosis multilocularis protoscolex shows that the killing effect of maduramicin ammonium on the protoscolex has concentration dependence, the death rate of the protoscolex can reach 90.63% + / -0.96% after the maduramicin ammonium is treated for 6 h at the concentration of 50 mu M, and the death rate of the protoscolex can reach 90.63% + / -0.96% at the concentration of 100 mu M, and the death rate of the maduramicin ammonium can reach 90.63% + / -0.96% at the concentration of 100 mu M. The death rate of the original head section can directly reach 100%; meanwhile, in-vitro effectiveness experiment results of psoralen B on trichina at different development stages show that after the trichina is treated for 72 hours under the concentration of 50 mu M, 80 mu M and 100 mu M, the death rates of muscular larvae reach 89.44% + / -0.81%, 96.29% + / -1.30% and 96.68% + / -1.06% respectively; after 48 hours of treatment, the death rate of the adults is 100%, and the killing effect is remarkable. More importantly, the applicant verifies that IBC can directly destroy the epidermal structure and cell integrity of the insect body for the first time through observation by an optical microscope and an electron microscope, and the discovery provides intuitive morphological evidence for the anti-parasitic effect of IBC.

The invention belongs to the field of synthetic biology and microbial pharmacy, and particularly relates to recombinant streptomyces, a construction method of the recombinant streptomyces and application of the recombinant streptomyces in preparation of savermectin B. According to the present invention, after the aveA1 gene segment in the abamectin biosynthesis gene cluster in the streptomyces avermectin is replaced with the nemA1 gene segment in the nemadectin biosynthesis gene cluster in the streptomyces blue griseolus, the recombinant streptomyces capable of producing the 16-membered macrolide compound-Sesvermectin B (Senvermectin B), such as the recombinant streptomyces avermectin HU520-M provided by the invention, is obtained; experiments show that the savermectin B has efficient insecticidal, acaricidal and anti-parasitic activity, and shows good industrial development potential.

Compounds of formula (I), and pharmaceutically acceptable salts thereof, useful as treatments for parasitic diseases are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including parasitic disease or infection.

The invention discloses a duplex mRNA (messenger ribonucleic acid) vaccine for echinococcus granulosus and coenuriasis and a preparation method of the duplex mRNA vaccine, and the duplex mRNA vaccine comprises mRNA for simultaneously expressing Eg95 recombinant protein and TM16 recombinant protein and LNP for encapsulating the mRNA, and the LNP is recorded as Eg95-TM16 mRNA-LNP. According to the invention, Eg95 and TM16 recombinant proteins and Eg95-TM16 mRNA-LNP are respectively used for immunizing mice and sheep, and results show that the Eg95 and TM16 mixed recombinant proteins and the Eg95-TM16 mRNA-LNP can activate immune response of CD8 + T lymphocytes so as to play a protective role in resisting parasitic infection; meanwhile, the Eg95-TM16 mRNA-LNP shows good stability and consistent immunogenicity in a sheep body and mainly causes humoral immune response which mainly takes IgG antibody level rise, and antibody dynamics is similar to mouse data. The Eg95-TM16 mRNA-LNP immune group enhanced cell factor induction is superior to the immune stimulation capability of recombinant protein, so that the Eg95-TM16 mRNA-LNP can simultaneously play the immune protection role of the echinococcus granulosus and the coenuriasis, and the Eg95-TM16 mRNA-LNP is expected to become a novel immunoprophylaxis means for resisting the echinococcus granulosus and the coenuriasis.

The invention belongs to the field of natural medicines, and particularly relates to an anti-parasitic cyclopeptide and application thereof. In particular to 12 cyclic peptide natural products containing xylonic acid structural units, and the cyclic peptide natural products show different degrees of anti-parasitic activity in a biological activity test and have wide application value.

The invention discloses genetically engineered streptomyces as well as a construction method and application thereof. According to the present invention, with the application of the CRISPR-Cas9 gene editing technology, the aveA3 fragment in the Streptomyces avermitilis gene cluster capable of generating the ivermectin B1b compound is replaced with the milA3 fragment in the Streptomyces hygroscopicus gene cluster so as to obtain the gene engineering Streptomyces, such as Streptomyces avermitilis HU501-M, and the gene engineering Streptomyces HU501-M can be used to produce the ivermectin B1b compound, the constructed genetically engineered streptomyces can be used for preparing milbemycin D, and the compound has efficient insecticidal, acaricidal and antiparasitic activity, is high in safety to human beings and animals, and is environment-friendly. The main fermentation product of the genetically engineered streptomyces is milbemycins D, and the genetically engineered streptomyces has a good industrial development prospect.

The invention relates to a plant (100) for antiparasitic treatment of crops or spaces comprising an emitter (10) of electromagnetic signals and an electronic control unit (40), to which the emitter (10) is operatively connected. The electronic control unit is configured to control the emitter so that it emits, in succession or simultaneously, a plurality of cycles of electromagnetic signals, said electromagnetic signals having a selectable frequency, cycle by cycle, based on the type of crop or space to be treated or the parasite to be defeated. The invention also relates to a method for antiparasitic treatment of crops or spaces conducted using the plant (100) as defined above.

A feed additive mixture includes thymol, carvacrol, and at least two other active compounds selected from monoterpenoids, monoterpenes, polyphenolic compounds, and aromatic aldehydes. A feed additive mixture includes thymol, and at least two other active compounds comprising eugenol and cinnamaldehyde and optionally one or more active compounds selected from monoterpenoids, monoterpenes, polyphenolic compounds, and aromatic aldehydes. A feed additive mixture includes eugenol, cinnamaldehyde, and at least two other active compounds selected from monoterpenoids, monoterpenes, polyphenolic compounds, and aromatic aldehydes. An animal feed includes a base feed and the feed additive mixture. The feed additive mixture has an anti-parasitic effect. A method for making the feed additive mixture, a method for making the animal feed, and a method for feeding an aquatic animal are also provided.

The invention discloses a transmembrane drug-loaded delivery system and a preparation method and application thereof, and particularly relates to the technical field of aquaculture disease prevention and control. Wherein the transmembrane drug-loading delivery system is formed by compounding a polyphenol compound with anti-parasitic activity, a drug carrier and a penetration enhancer. Meanwhile, the invention also discloses a preparation method of the transmembrane drug-loaded delivery system, and the method comprises the following steps: adding the polyphenol compound into the drug carrier, and stirring in a water bath until the polyphenol compound is completely dissolved to prepare a drug-containing oil phase; mixing the permeation promoter A, the permeation promoter B and the penetration enhancer, and uniformly stirring to obtain a mixed phase; fully mixing the medicine-containing oil phase with the mixed phase to form a premix; and adding the premix into ultrapure water which is preheated to 35-40 DEG C, and continuously stirring to obtain the transmembrane drug-loading delivery system. The transmembrane drug-loading delivery system can permeate host mucus and a parasite barrier, so that effective components are accurately delivered to a target spot, and the effect of killing parasites in fish bodies is achieved.

Movable apparatus (5) with automatic autonomous operation (AGV) slidable along pre-established paths (9) among rows of vineyard (10, 11), for the anti-bacterial, fungicide and anti-parasitic treatment in general of the same vineyards, and in particular of the leaves, the trees and the bunches of grapes, comprising a base structure (12) supported on to the ground by sliding by means of wheels (6) or tracks (7), comprising a plurality of ultraviolet lamps (53) with germicide function, which are supported by panels overlapped to each other (42-45), in a manner to direct the ultraviolet radiation against the component parts of the vineyards. There are described accurately all the component parts of the apparatus and the displacements of the apparatus and the different operative steps thereof, for performing the required anti-parasitic treatment in to all the vineyards, also in those in which the advancement paths of the apparatus are displaced and not communicating with other advancement paths for the same apparatus.