Antiparasitic closantel sodium transdermal solution for ox and sheep and preparation method thereof

Abstract

The invention relates to an antiparasitic closantel sodium transdermal solution for ox and sheep and a preparation method thereof, the composing components of the solution and the parts by weight thereof are respectively that 5-15 parts of ethyl acetate, 20-30 parts of dimethyl sulfoxide, 2-6 parts of azone, 1-3 parts of isopropanol and 50-70 parts of propanediol or ethanol, the content of closantel sodium is 2.5-5 g per 100 ml, and the finished product is formed through dissolving, mixing, filtering and injecting. The azone related in the solution is a novel skin penetration accelerant, can effectively increase the absorption of the skin to various drugs through the skin, effectively prevents the pass effect of hepar, avoids the peak valley phenomenon during the absorbing process of the drugs, reduces the toxic side effect caused by about the drugs and the dosage, prolongs the effective acting time, changes the drug feeding area and effectively regulates the drug feeding dosage, reduces the difference between independent bodies, and has the characteristic of simple, convenient and rapid use. Compared with the other types of preparations, the solution is more suitable for antiparasitic preventive treatment and parasite killing in pasturing areas.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, in particular to a transdermal solution of iodosamide sodium transdermal solution for anti-parasitic diseases of cattle and sheep and a preparation method thereof. Background technique [0002] Transdermal preparation is a new dosage form of transdermal administration, that is, the drug enters the whole body through the blood circulation through the capillary of the skin to reach an effective blood concentration, and the drug plays a role in treating or preventing diseases in various tissues or lesion parts. Compared with ordinary preparations, transdermal preparations have three aspects: avoiding side effects caused by oral administration and gastrointestinal administration, such as hepatic effect and gastrointestinal inactivation, maintaining a constant blood concentration, and prolonging the effective time of action. The advantages. [0003] Clocyanidosamide sodium has repellent ...

AI Technical Summary

Problems solved by technology

[0004] The harm of parasites to cattle and sheep is mainly through the consumption of nutrients in the body of cattle and sheep, causing mechanical damage, or lack of nutrition, which reduces the utilization rate of feed for cattle and sheep, resulting in slow growth of cattle and sheep and a decrease in feed utilization

At present, the most widely used dosage forms of antiparasitic drugs are injections, tablets, and pour-ons. Among them, pour-ons are mainly used to deworm in vitro, and there are very few drugs that really use the mechanism of transdermal absorption to deworm in vivo and in vitro.