Antiparasitic closantel sodium transdermal solution for ox and sheep and preparation method thereof

A technology of iodosamide sodium and iodosamide sodium, which is applied in the field of drug preparation, can solve the problems of decreased feed utilization rate, reduced feed utilization rate, and slow growth of cattle and sheep, so as to reduce inter-individual differences, Reduce the decomposition rate and increase the effect of transdermal absorption

Inactive Publication Date: 2010-04-14
TIANJIN BIJIA PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The harm of parasites to cattle and sheep is mainly through the consumption of nutrients in the body of cattle and sheep, causing mechanical damage, or lack of nutrition, which reduces the utilization rate of feed for cattle and sheep, resulting in slow growth of cattle and sheep and a decr...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A kind of anti-parasitic iodosamide sodium transdermal solution for cattle and sheep, its constituents and parts by weight are respectively (by every 100ml proportioning of raw and auxiliary materials, the following examples are the same):

[0027] Closantamide Sodium 2.5g

[0028] Ethyl acetate 10ml

[0029] Dimethyl sulfoxide 24ml

[0030] Azone 4ml

[0031] Isopropanol 2ml

[0032] Propylene Glycol 58ml.

[0033] The bulk drug of the closamide sodium transdermal solution involved in the present invention is closamide sodium, and its alias is: N-{5-chloro-4[(4-chlorophenyl)cyanomethyl]- 2-Tolyl}-2-hydroxy-3,5-diiodobenzoyl sodium salt.

[0034] A method for preparing an anti-parasitic iodosamide sodium transdermal solution for cattle and sheep, comprising the steps of:

[0035] (1) the clocyanamide sodium of recipe quantity is put into ethyl acetate under stirring to dissolve completely, obtain clocyanamide sodium solution;

[0036] (2) Add dimethyl sulfoxide, ...

Embodiment 2

[0041] A kind of animal anti-parasitic clocyansamide sodium transdermal solution, its constituents and parts by weight are respectively:

[0042] Closantamide Sodium 5g

[0043] Ethyl acetate 10ml

[0044] Dimethyl sulfoxide 25ml

[0045] Azone 4ml

[0046] Isopropanol 2ml

[0047] Propylene Glycol 60ml.

[0048] The steps of the preparation method of this embodiment are the same as those in Example 1.

Embodiment 3

[0050] A kind of animal anti-parasitic clocyansamide sodium transdermal solution, its constituents and parts by weight are respectively:

[0051] Closantamide Sodium 5g

[0052] Ethyl acetate 10ml

[0053] Dimethyl sulfoxide 25ml

[0054] Azone 4ml

[0055] Isopropanol 2ml

[0056] Ethanol 58ml.

[0057] The steps of the preparation method of this embodiment are the same as those in Example 1.

[0058] Test data: after 12 hours of administration of azone and dimethyl sulfoxide in the drug formulation, the penetration rate reaches 90.1%, exceeding the standard penetration rate.

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Abstract

The invention relates to an antiparasitic closantel sodium transdermal solution for ox and sheep and a preparation method thereof, the composing components of the solution and the parts by weight thereof are respectively that 5-15 parts of ethyl acetate, 20-30 parts of dimethyl sulfoxide, 2-6 parts of azone, 1-3 parts of isopropanol and 50-70 parts of propanediol or ethanol, the content of closantel sodium is 2.5-5 g per 100 ml, and the finished product is formed through dissolving, mixing, filtering and injecting. The azone related in the solution is a novel skin penetration accelerant, can effectively increase the absorption of the skin to various drugs through the skin, effectively prevents the pass effect of hepar, avoids the peak valley phenomenon during the absorbing process of the drugs, reduces the toxic side effect caused by about the drugs and the dosage, prolongs the effective acting time, changes the drug feeding area and effectively regulates the drug feeding dosage, reduces the difference between independent bodies, and has the characteristic of simple, convenient and rapid use. Compared with the other types of preparations, the solution is more suitable for antiparasitic preventive treatment and parasite killing in pasturing areas.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, in particular to a transdermal solution of iodosamide sodium transdermal solution for anti-parasitic diseases of cattle and sheep and a preparation method thereof. Background technique [0002] Transdermal preparation is a new dosage form of transdermal administration, that is, the drug enters the whole body through the blood circulation through the capillary of the skin to reach an effective blood concentration, and the drug plays a role in treating or preventing diseases in various tissues or lesion parts. Compared with ordinary preparations, transdermal preparations have three aspects: avoiding side effects caused by oral administration and gastrointestinal administration, such as hepatic effect and gastrointestinal inactivation, maintaining a constant blood concentration, and prolonging the effective time of action. The advantages. [0003] Clocyanidosamide sodium has repellent ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/275A61K47/22A61P33/10A61P33/00
Inventor 要瑞丽聂江力裴毅元军英
Owner TIANJIN BIJIA PHARMA CO LTD
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