201results about How to "Prolong the effective time" patented technology

The invention discloses a microorganism deodorant and a preparation method thereof. The microorganism deodorant has the following strain composition: 106-109 / mL of Lactobacillus acidophilus, 106-109 / mL of Bacillus pumilus, 106-109 / mL of Bacillus subtilis, 105-107 / mL of Pseudomonas fluorescens, 105-107 / mL of Rhodopseudomonas palustris, 104-106 / mL of Bantu Brettanomyces, 104-106 / mL of common Candida albican, 104-106 / mL of Penicillium expansum, 104-106 / mL of Rhizopus oryzae, 104-106 / mL of Trichoderma viride, 104-106 / mL of Streptomyces Microflavus and 104-106 / mL of Streptomyces griseus. Accordingto the microorganism deodorant, the release amount of obnoxious gas can be effectively lowered, and the technical support is provided for effectively processing fetor in livestock and poultry farms and protecting environment.

The invention relates to the field of Chinese medicine, and discloses a Chinese medicinal composition for preventing and treating xerophthalmia. The composition comprises chrysanthemums, medlar, phellodendron, red sage roots, pearls, borneol and menthol. The medicinal composition preferably comprises the following in part by weight: 2.5 to 3 parts of chrysanthemums, 2.5 to 3 parts of medlar, 2.5 to 3 parts of phellodendron, 1.5 to 2 parts of red sage roots, 0.08 to 0.1 parts of pearls, 0.08 to 0.1 parts of borneol and 0.15 to 0.2parts of menthol. The invention also provides a wet application of the Chinese medicinal composition and a preparation method thereof. The Chinese medicinal composition has the effects of clearing heat, releasing toxin and moistening dryness, enables people to feel cool and comfortable after using the composition, and has the advantages of no toxic or side effects, easy absorption, quick response, good curative effect and good application prospects.

The invention discloses a solid phase synthesis method and a liquid phase synthesis method of chitosan and / or zinc, silver, bismuth and rare earth metal composite of chitosan derivative. The solid phase synthesis comprises the following steps: (1) grinding chitosan and / or chitosan derivative to fine powder; (2) grinding the oxides of zinc and / or silver and / or bismuth and rare earth metal to fine powder of which content is 0.0005-2wt% of the weight of chitosan and / or chitosan derivative; (3) mixing the fine powders obtained in step (1) and step (2) and fully grinding for 1-6h to obtain the chitosan and / or metal composite of chitosan derivative. The product of the preparation method can be used to cure diseases such as female vaginitis, cervicitis, cervical erosion, bedsore, skin ulcer, fireburn, empyrosis, trauma, other dermatitis disease, tinea of feet and hands and the like and can be used to prepare various surgical dressings such as film, sponge, gynecological suppository, adhesivefilm and the like.

The invention relates to a method for removing a polycyclic aromatic hydrocarbon methylnaphthalene substance by adopting double oxidants including persulfate and calcium peroxide. The method comprises the steps of adding persulfate and calcium peroxide into a water body containing methylnaphthalene, stirring uniformly, and reacting for 4-5 days under the condition that the pH of the system is neutral and weakly acidic, thus removing the pollutant by oxidization. The double oxidants are added into the water, and free hydroxy and sulfate radicals are generated to attack the pollutant, so that the pollutant is effectively degraded. The double oxidants including persulfate and calcium peroxide can simultaneously generate free hydroxy and sulfate radicals with extremely strong oxidation, so that the acting pollutant range is wider than that of a traditional method, and the pollutant sensitive to the free hydroxy and sulfate radicals can be simultaneously removed. The acting time is long, the applicable pH range is wide, a promotion effect on microbes in the environment is achieved, the bioremediation efficiency of microbes in environmental media can be improved, and then the repair efficiency of a polluted area is improved. The method is applicable in the field of polluted underground water repair.

The invention provides a self-cleaning hydrophilic composite material and a preparation method thereof, wherein the self-cleaning hydrophilic composite material comprises a transparent substrate and a composite film positioned on the transparent substrate surface; the composite film comprises hollow microspheres with cavities therein, a spherical shell material of the hollow microspheres is a composite particle; the composite particle is a core-shell coating structure, a core material is SiO2 nano particle, a shell material is TiO2, the particle size of the shell material TiO2 is less than that of the core material SiO2. By improving a film structure on the basis of a microscopic structure, the self-cleaning hydrophilic composite material simultaneously has ultra-hydrophilic antifogging, anti-microbial and dustproof effects, and the time of the ultra-hydrophilic effectiveness is prolonged.

The present invention discloses a retardance and low damage acid solution system for high temperature condensate oil gas reservoir acidification. The acid solution system is suitable for acidification modification of high temperature deep well, particularly condensate gas reservoir, and comprises the following components, by weight, 0.5-3 parts of hydrofluoric acid or 6-12 parts of fluoroboric acid, 8-10 parts of an organic ester, 0.01-0.05 part of a catalyst, 0.1-1 part of a corrosion inhibitor, 0.1-1 part of an iron ion stabilizer, 0.1-1 part of a clay stabilizer, 1-2 parts of a cleanup additive, and 80-100 parts of water. According to the present invention, effects of retardance and corrosion inhibition of the acid solution system can be well achieved at a high temperature, and water blocking can be released and acid solution backflow can be easily achieved with the finally produced methanol and the carbon dioxide.

The invention provides a fruit fresh keeping agent. The fruit fresh keeping agent is prepared from fresh keepingcompounds, latic acid, chitosan, carnosol or rosmanol, a colloid film former, sodium carboxymethylcellulose, aloe gel powder, cinnamic acid, citric acid, glycerin and the like, wherein the fresh keeping compounds comprise glycine betaine, resveratrol, vitamin C, bacterium resistant plantflavone and the like. The fruit fresh keeping agent forms an inner-outer double-layer water gel during use, the inner-layer water gel includes antioxidation antibacteria fresh keeping components, andthe outer-layer water gel isolates air from the inner-layer water gel. Combination of the inner-layer water gel and the outer-layer water gel has double effects on fruits and effectively prolongs thestorage period of the fruits.

The invention discloses gunpowder for realizing deep well deep bumming and fracturing, the gunpowder includes solid powder and liquid powder; the solid powder comprises a binder, a plasticizer, an oxidizing agent, a metal combustion agent, a high-energy additive, a stabilizer and a catalyst; and the liquid powder comprises an oxidizing agent, a combustion agent, a performance modifier and water. The solid powder of the gunpowder can overcome the restriction of large stress difference coefficient and high fracturing pressure of deep-layer and ultra high pressure formation, a plurality of radial cracks and branched cracks are formed in a broken rock layer, main crack is preliminarily extended, the fracture pressure is reduced to help the liquid powder to continue to fracture the formation, at the same time, the role of ignition of the liquid powder is played, after the solid powder is burn out, the liquid powder continues to maintain a high pressure environment in a wellhole, and effects on the formation for longer time, the main crack length is further extended, the branched cracks are developed, natural cracks are communicated, and a complex fracture network structure is formed in a larger-range purpose layer near the wellbore.

The invention relates to an antibacterial anti-acarien microcapsule and a preparation method thereof. An antibacterial anti-acarien liquid is used as a core material, and the methyl methacrylate added with nano-silver particles is used as a wall material. The preparation method is as follows: (a) shearing a water phase under a high-speed shearing machine, adding an oil phase and stirring to obtain uniform emulsion; (b) adding methyl methacrylate and an initiator in the emulsion obtained in the step (a), stirring, and then adding a silver nitrate solution; (c) cooling the liquid obtained after the reaction of the step (b), standing, and then washing, rinsing and drying precipitate to obtain the antibacterial anti-acarien microcapsule. At early stage, the microcapsule is used for inhibiting the crosslinking of polysaccharide chain and tetrapeptide by using the formation of the Ag<+> interfering bacteria cell wall so that the cell wall is out of completeness, the protection effect to the osmotic pressure is lost, the bacteria are damaged and dead, and the added silver nitrate solution is embedded in the micropore of the microcapsule wall to reduce the size or number of the micropore; at late stage, the cleanness of the fabric can be continuously maintained through the slow releasing of the antibacterial anti-acarien liquid.

The invention discloses an environment-friendly snow / ice melting composition which comprises the following components in percentage by mass: 50ppm-2% of ray absorbent B and 200ppm-2% of long-acting additive C and the balance of snow melting agent A. The application range of the composition is 0--60 DEG C, the snow melting property can be adjusted according to demands, and the composition can satisfy the requirements in GB / T23851-2009. The snow / ice melting composition can fully utilize solar energy and waste heat emitted by vehicles running on the road, has long effective acting time of snow / ice melting, and does not damage the pavements, buildings and metal box plants; and the molten water can satisfy the biological oxygen demand (BOD) index in Natural Discharge Standard. The composition is simple in production technique, convenient to use and easy for popularization.

The invention relates to a long-acting cefquinome sulfate injection. The injection is prepared by a method in the following steps: adding cefquinome sulfate into an ethanol solution containing ethyecellulose and hydroxy propyl cellulose; filtering, sterilizing and performing spray-drying to obtain a cefquinome sulfate carrier; adding a suspending agent, a dispersing agent and a stabilizing agent into partial injection solvent, dissolving at 100 DEG C, and adding an injection solvent to the whole amount, and performing dry heat sterilization at 150 DEG C for 1 hour; cooling the dispersion liquid to room temperature, adding the cefquinome sulfate carrier into the dispersion liquid, and uniformly stirring; passing through a high-speed cutting dispersion machine to prepare the long-acting cefquinome sulfate injection. The prepared suspension injection is uniform in granularity, good in fluidity, slow in settlement, good in redispersion property, wall adhesion prevention of liquid medicine, good needle cleaning performance, no discoloration after long-term storage and stable chemical property. After the preparation is injected in a pig in an intramuscular manner, the preparation is slowly released, long in elimination half life and smooth in plasma concentration, can be used for prolonging the effective action duration of the medicine in the body and reducing the number of administration times, and is convenient to use.

The invention provides a method for preparing biodegradable polymer nano particles. The method comprises the following main steps of: mixing an oil phase solution of a biodegradable polymer and an aqueous phase solution of a surfactant; uniformly filtering the mixed solution for a few times through a manual membrane filtering device to obtain biodegradable polymer emulsion with uniform size; and volatilizing the organic solvent to obtain an aqueous solution of the biodegradable polymer nano particles, removing the surfactant by high-speed centrifuging, then dispersing with deionized water, and thus obtaining dispersion of the biodegradable polymer nano particles. By the method, experimental parameters such as the concentration of the biodegradable polymer, the membrane aperture, the membrane filtering times, the concentration of the surfactant, the molecular weight of the biodegradable polymer and the like can be conveniently adjusted, and the medicament release rate can be controlled by effectively controlling the particle diameter; the prepared nano particles have uniform size; control of medicament loading quantity is facilitated, so that the medicament release efficiency is improved, and the effective acting time is increased; and the method is simple and quick, and is suitable for large-scale production.

The invention discloses an ivermectin transdermal liniment for animals, which is prepared from medicinal liquor and ivermectin, wherein the medicinal liquor is prepared from the following components in percentage by volume: 20-40% of ethyl acetate, 2-5% of azone and 55-75% of propylene glycol; and the ratio of ivermectin to medicinal liquor is (0.5-1g):100mL. The novel transdermal accelerator selected in the formula can enhance the absorption of skin for medicines, does not have toxicity or irritation on the skin and body, does not have pharmacological action, and does not react with the medicines and other additives. The invention is simple to prepare and convenient to use, has high stability, and can achieve favorable anthelminthic effect.

The invention discloses a method for preparing insect-proof nets. The method includes mixing polyethylene, polylactic acid, PET (polyethylene terephthalate), coupling agents and compatilizers with one another, melting the polyethylene, the polylactic acid, the PET, the coupling agents and the compatilizers at the temperatures of 170-210 DEG C to obtain mixtures, placing the obtained mixtures in an extruder and heating, extruding and smashing the mixtures to obtain mixture powder; heating the obtained mixture powder, photosensitive color-changing agents, insect repellent agents, nanometer titanium dioxide and magnesium stearate until the temperatures of the mixture powder, the photosensitive color-changing agents, the insect repellent agents, the nanometer titanium dioxide and the magnesium stearate reach 160-180 DEG C, shearing the mixture powder, the photosensitive color-changing agents, the insect repellent agents, the nanometer titanium dioxide and the magnesium stearate at the high speeds of 2000-3000 rpm for 20-30 min to obtain mixtures, cooling the mixtures, then feeding the mixtures into the extruder and heating and extruding the mixtures to obtain master batch; carrying out wire drawing on the master batch to obtain the insect-proof nets. The method has the advantages that the insect repellent rates of the insect-proof nets prepared by the aid of the method can reach 91%, the insect killing rates of the insect-proof nets can reach 83%, the repellent rates can reach 62% after the insect-proof nets are washed by 50 times, and the killing rates can reach 37% after the insect-proof nets are washed by 50 times; the light transmittance of the insect-proof nets is 78%, and the flexibility of the insect-proof nets can reach 80.2 Mpa.

The invention belongs to the technical field of the pharmacy of medicine, which relates to a gemcitabine-albumin nano microsphere preparation used for the chemotherapy of the tumors of pancreatic cancer and the like and a preparation method thereof. The invention uses an ethanol precipitation-glutaric dialdehyde crosslinking denaturation method to prepare a slow-release gemcitabine biodegradable albumin nano microsphere. By animal experiments, the result confirms that the invention can obviously enhance the slow-release property and the tissue retention property of the medicine, enhances the concentration of gemcitabine in tumors and other target organs effectively, prolongs the effective acting time of the gemcitabine and reduces the side effect of the medicine. The nano microsphere can be used for the chemotherapy and the interventional chemotherapy of pancreatic cancer and non-small cell lung cancer and is suitable for the venous chemotherapy, the arterial interventional treatment, the local tumor injection interstitial chemotherapy, the celiac chemotherapy and the oral chemotherapy of tumor patients with gemcitabine adaptive diseases.

The invention discloses a manufacturing method of an environment-friendly snow / ice melting composition, which comprises the following steps: manufacturing a snow melting A, manufacturing a ray absorbent B and manufacturing a long-acting additive C. The composition comprises the following components in percentage by mass: 50ppm-2% of ray absorbent B and 200ppm-2% of long-acting additive C and the balance of snow melting agent A. The application range of the composition is 0--60 DEG C, and the snow melting property can be adjusted according to demands. The snow / ice melting composition can fully utilize solar energy and waste heat emitted by vehicles running on the road, has long effective acting time of snow / ice melting, and does not damage the pavements, buildings and metal box plants; and the molten water can satisfy the biological oxygen demand index in Natural Discharge Standard. The composition is simple in production technique, convenient to use and easy for popularization.

The invention relates to a jet laser composite cleaning method and a cleaning system. A water film and a water film cavitation bubble breaking impact cleaning base material surface are generated, andmeanwhile, a laser is focused in the water film, the water film explodes in a super-heating state, the water film is vigorously vaporized, steam bubbles are generated to impact the surface of base materials, and the effective action time of cavitation jet is prolonged. The cleaning system comprises an cavitation jet device and a laser cleaning device; and the laser beam and the center line of thecavitation jet are coplanar, the cavitation jet flow generates the water film on the surface of a workpiece, the laser beam is focused in the water film and keeps a distance from the surface of the workpiece, and the laser beam and the cavitation jet flow act on the surface of the workpiece on a workbench to be cleaned, so that the effect is obviously superior to that of the existing cleaning technology, solid particles with the surface diameter larger than 50 nm can be removed, and the surface processing requirements of the wafer base materials can be met.

The invention relates to an antibacterial material, as well as a preparation method and application thereof. The antibacterial material comprises a carrier, an inorganic bacteriostatic agent and an organic bacteriostatic agent, wherein the carrier comprises montmorillonite, the granularity of the inorganic bacteriostatic agent is 1-50 nm. The antibacterial material provided by the invention is rapid in interaction speed, excellent in antibacterial effect and long in effective acting time and cannot loss the antibacterial activity due to the dissolution and loss.

The invention discloses a high-strength composite plugging agent material for plugging a developed pipe flow channel of an oil-water well and a preparation method thereof. The method comprises the following steps: superfine cement, hydroxypropyl guar gum, floating beads, a hydrophobic water-swelling agent and modified latex are used as main materials; the main materials form gum viscous liquid by the hydroxypropyl guar gum, and superfine cement and hydrophobic water-swelling agent particles are suspended; a system enters into the depth of a plugging purpose formation, the superfine cement particles are settled, gathered and solidified, and the pipe flow channel space is shortened; and the hydrophobic water-swelling agent particles suck a lot of water to be swelled to fill the surplus channel space, and the binding and filling type plugging of the plugging agent and the pipe flow channel is realized. In addition, the supporting effect of the modified latex and the floating beads is utilized, the superfine cement and the hydroxypropyl guar gum are isolated, and the phenomenon that the superfine cement is easy to flocculate and non-condense in a hydroxypropyl guar gum basic solution is eliminated. The site configuration process is simple, the water cement ratio is high, the amount of formed slurry is large, the cost is low, the plugging strength of the solidified system is large, and the effective acting time is long.

The invention relates to an aivlosin injection for swine. Each 100ml of tylosin injection contains 20g of acetylisovaleryl tylosin tartrate, 20-35g of propylene glycol, 10-15g of N,N-dimethyl acetamide, 2-4g of benzyl alcohol, 0.1-1.0g of di-tert-butyl-4-methylphenol and balance of glyceryl triacetate. The preparation method comprises the following steps of: mixing the glyceryl triacetate, the propylene glycol, the benzyl alcohol and the N,N-dimethyl acetamide evenly to obtain an oil phase; adding an antioxidant to the oil phase and stirring until the added particles are dissolved; and adding the aivlosin and stirring to dissolve. The aivlosin injection for swine adopts the oily solvent as a solvent, the medicament is dissolved in the oily solvent, and the elimination half life of the medicament in an animal body is prolonged by the characteristic of slow elimination of the oily solvent after intramuscular injection.

The invention discloses a fouling basket and a hydrogenation technological method for reducing the skimming of a catalyst. The fouling basket which runs through a whole catalyst bed layer is adopted; a partition plate is arranged at the middle and the bottom of the fouling basket; an overflow pipe is welded on each partition plate; a pressure rupture film is arranged at the top of each overflow pipe; and the bottoms of the overflow pipes are communicated with the lower part of the fouling basket or a gas-liquid distribution disk of a next catalyst bed layer through the partition plates. The rupture differential pressure of the pressure rupture films is lower than 0.45 MPa and higher than 0.1 MPa. With the adoption of the fouling basket and the hydrogenation technological method, when the upper part of the catalyst bed layer is subjected to coking or blockage, the shutdown of a device for the skimming is not needed, and the catalyst at the lower part of the bed layer can also be maximally utilized, so that the waste is reduced.

The invention provides a fabric antioxidant containing seaweed extract and a preparation method thereof. The specific operation steps are as follows: (1) wash the chlorella surface attachments and sand grains with filtered seawater, and dry it at room temperature. Place in an oven to dry to remove excess moisture, remove, chop and grind to form chlorella powder; (2) place the chlorella powder prepared in step (1) in a mixed solvent of methanol and chloroform, reflux extraction twice, and combine the filtrates , the filtrate is evaporated to form a chlorella extract; (3) the chlorella extract prepared in step (2) is placed in a supercritical carbon dioxide extraction device, and extracted to obtain a chlorella extract; (4) the step (3) ) to the chlorella extract prepared by adding additives, heating and stirring evenly, rinsing and filtering, and naturally cooling to room temperature to obtain the fabric antioxidant containing seaweed extract. The fabric antioxidant containing the seaweed extract prepared by the invention has very strong antioxidant activity and low side effects, and expands the application range of the seaweed.

The invention discloses a polypeptide vaccine against tumor-targeted drug resistance sites and a design method thereof. The design method includes the steps: collecting data of targeted drug resistance mutations; intercepting a drug resistance mutant polypeptide sequence and predicting the affinity and immunogenicity of MHC molecules; obtaining the relationship between targeted drugs and drug resistance sites, and performing drug clustering; and artificially designing a corresponding vaccine polypeptide sequence. The targeted drug combination polypeptide vaccine combination obtained by the method can cover common targeted therapeutic drugs, can effectively reduce the probability of tumor drug resistance, can prolong the effective action time of the targeted drugs, can increase the diseaseresponse rate of the patient, has broad-spectrum, can shorten the time from analysis to treatment of individualized peptide vaccines, and can reduce medical costs.

The present invention provides a plant vermicide-nimbic oil microcapsule. Its composition includes (by wt%) 50.23-73.29% of nimbic oil and 26.71-49.77% of capsule material, in which the capsule material is obtained by using one or several kinds of isocyanic ester, polyvinyl alcohol, polyethylene glycol, polyvinyl acetaldehyde, glycerol, sodium alginate and calcium chloride. Said invention also provides its preparation method.

The invention relates to a danofloxacin mesylate microsphere preparation, which is prepared by the following steps: adding gelatin, or gelatin and polyglycol, or gelatin and polyglycol as well as xanthan gum into water, and adding danofloxacin mesylate for dissolution to obtain a water phase; adding an emulsifying agent into liquid petrolatum to mix evenly to obtain an oil phase; and adding the water phase into the oil phase, emulsifying, cross linking and solidifying the mixed phases and removing supernatant to obtain the danofloxacin mesylate microsphere preparation for livestock and birds. The preparation adopts an emulsifying and condensing method to wrap the danofloxacin mesylate in microspheres, can release slowly after using the microspheres for intramuscular injection, and prolong elimination half-life of medicament in vivo. The preparation technology has the advantages of simple operation, low requirements on preparation equipment and conditions, round shape of the obtained microspheres, and good dispersing property in water solution; and can prolong effective acting time of the medicament in vivo after intramuscular injection for pigs.

The invention discloses an application of lambda-carrageenan oligosaccharide to preparation of an anti-rabies virus drug. Experiments prove that the lambda-carrageenan oligosaccharide is low in cytotoxicity so that rabies viruses of various strains can be inhibited on various types of cells and inhibition effect is provided to each stage of the rabies viruses invading the cells; and particularly in the stage after virus adsorption, namely, 12 hours after the cells are infected by the viruses, the lambda-carrageenan oligosaccharide is still capable of remarkably decreasing the rabies virus amount in the cells. According to above discovery, the lambda-carrageenan oligosaccharide can be used as a low-cost effective wound treating agent to replace the anti-rabies virus immune globulin, and has the advantages of decreasing the viruses at the wound part to the greatest extent and reducing the rabies morbidity.

The invention discloses a veterinary mixed suspension with amoxicillin and baicalein and a preparation method of the veterinary mixed suspension. The veterinary mixed suspension is formed by dispersing active components in a dispersion medium, wherein the active components include amoxicillin and baicalein. Each 100 mL of mixed suspension is prepared from 3-10 g of amoxicillin, 3-10 g of baicalein and the balance dispersing medium. According to the mixed suspension, oily solvent is adopted as the dispersing medium of the preparation, the problem that amoxicillin is easy to degrade in an aqueous solution is solved, and the problem that medicine is slowly released in an oily mixed suspension is solved; for time-depending antibiotics, T>MIC is prolonged, effective acting time is prolonged, a user only needs to consecutively take medicine three times at time intervals of 12 hours, repeated dosage is avoided, and manpower and material are saved. According to the veterinary mixed suspension, the mixed suspension is obtained by dispersing amoxicillin and baicalein in the dispersing medium through a dispersing method, adding suspending agent, wetting agent and antioxidant and grinding the materials through a colloid mill, and the mixed suspension is simple in production process, reduces cost and is easy to obtain industrially.