14results about How to "Prolong the effective time" patented technology

The invention relates to hydrogel for treating ischemic brain injury and a preparation method thereof. The hydrogel is prepared from the following raw materials: methylacryloylated hyaluronic acid, methylacryloylated gelatin, curcumin loaded HA-PPS (Hydroxypropyl-Polyphenylene Sulfite) nano-micelles and dendrobium polysaccharide loaded sodium alginate microspheres. Through combination of a nanotechnology and an intelligent response material, HA-PPS is adopted to load curcumin and sodium alginate microspheres are adopted to encapsulate dendrobium polysaccharide, so that the drug activity can be more effectively protected, the drug is protected to penetrate through a blood brain barrier and be accurately delivered to a brain injury area, and targeted release of the drug is realized; the anti-oxidation and anti-inflammatory effects are better under the combined action of the curcumin and the dendrobium polysaccharides, and meanwhile, a slow release function is also achieved.

The invention relates to the technical field of flocculating agents, and discloses a flocculating agent for high-concentration azo printing and dyeing wastewater, which is prepared from the following components in parts by weight: 4 to 5 parts of hydroxypropyl chitosan derivative, 2 to 3 parts of sodium silicate solution, 0.5 to 1 part of sulfuric acid, 2 to 3 parts of ferric sulfate solution, 1 to 3 parts of zinc sulfate solution, and 4 to 5 parts of polyaluminum chloride solution and composite antibacterial agent. The preparation method comprises the following steps: preparing a sodium silicate solution, slowly dropwise adding the sodium silicate solution into sulfuric acid, and activating to obtain a polysilicic acid solution; sequentially adding a ferric sulfate solution, a zinc sulfate solution and a 50-500mg / L polyaluminum chloride solution, and standing and curing to obtain the polysilicate ferric zinc aluminum flocculant. The preparation method comprises the following steps: firstly, preparing a polysilicate ferric zinc aluminum flocculant, then slowly adding a melamine solution, carrying out ultrasonic action to obtain a carbonitrided polysilicate ferric zinc aluminum flocculant, and carrying out carbonitriding treatment on the polysilicate ferric zinc aluminum flocculant combined with metal ions to delay gelation of the polysilicate flocculant, so that the polysilicate flocculant can be stored for a longer time.

The invention discloses a terbinafine hydrochloride needleless injection, a transdermal injection for treating superficial fungal infection and an administration device of the transdermal injection, belongs to the technical field of pharmaceutical preparations, and successfully develops the terbinafine hydrochloride needleless injection which takes benzyl alcohol and ethanol as auxiliary materials, the invention provides a terbinafine hydrochloride needleless injection or an injection administration device thereof, which is used for preparing the terbinafine hydrochloride needleless injection, and proves that a prescription containing low-concentration ethanol can have good safety and excellent infiltration and absorption promoting capability, and the medicine can quickly reach a focus part and has long effective action time. The invention also provides the administration device of the terbinafine hydrochloride needleless injection or the injection thereof. According to the dosing device, the replaceable injection head and the injection assembly are used, cross infection can be reduced, and the purity of liquid medicine is kept.

The invention belongs to the technical field of disease and pest control, and particularly relates to a control mechanism for forestry soil diseases and pests, which comprises a treatment box, the treatment box is internally provided with a high-temperature sterilizing and killing assembly, the high-temperature sterilizing and killing assembly comprises a plurality of groups of L-shaped connecting pipes arranged in the treatment box and a fixed plate fixedly arranged in the treatment box, and the L-shaped connecting pipes are fixedly connected with the fixed plate. According to the fact that the tolerance degrees of different types of diseases and pests to the temperature are different, the temperature can be adjusted, it can be guaranteed that the appropriate temperature enough for killing the diseases and the pests can be accurately set according to the specific disease and pest types, the pertinence and effectiveness of killing are improved, reciprocating killing operation can be achieved, the situation that the local temperature is too high or too low is avoided, and the working efficiency is improved. Therefore, it is ensured that diseases and pests in the whole sterilization area can be subjected to the effective temperature effect, the loose soil structure can make steam permeate into the soil more deeply, it is ensured that the steam can reach a deep area where the diseases and pests possibly hide, and therefore the comprehensiveness and effectiveness of sterilization are improved.

The present application relates to the technical field of artificial board, and discloses a kind of mould-proof composite board for wardrobe and a preparation method thereof.The composite board for wardrobe prepared by the present application is prepared by using rubberwood sheet as main raw material, impregnating treatment with mould-proof and antibacterial agent, and then adhesive treatment with adhesive containing mould-proof and antibacterial agent.The composite board realizes long-term inhibition of mould through multi-mechanism sterilization of components, synergistic effect and material level protection, and is suitable for wardrobe application in high-humidity environment.In addition, the use of mould-proof and antibacterial adhesive also endows the composite board with excellent bonding strength.

The present invention discloses a controlled-release type polymeric ferric sulfate water treatment agent and its preparation method, belonging to the technical field of water treatment functional materials. The water treatment agent consists of polymeric ferric sulfate, an iron ion color indicator, a gel matrix, a cross-linking calcium agent, amino diatomaceous earth, a pore-forming agent and an inert filler. The preparation method includes: first preparing a network gel, then preparing soft materials, and finally obtaining the product through pill-making and drying. The present invention realizes the slow release and controllability of polymeric ferric sulfate, and the color indicator can directly reflect the consumption state of polymeric ferric sulfate, facilitating storage, transportation, dosing and recovery.

The present invention discloses a blasting method and a charging device and an explosive bag structure for reducing damage to pipe shed support, belonging to the technical field of tunnel blasting construction, including: setting a pre-splitting zone near the bottom of the pipe shed on the face, setting a plurality of blastholes on the pre-splitting zone, and detonating the explosives after filling the blastholes with explosives; then setting a plurality of blastholes near the bottom of the pre-splitting zone on the face, and detonating the explosives after filling the blastholes with explosives; then setting a plurality of blastholes on the blasting surface between the middle of the face and the bottom of the pre-splitting zone, and detonating the explosives after filling the blastholes with explosives; then setting a plurality of blastholes near the bottom of the face below the middle of the face, and detonating the explosives after filling the blastholes with explosives. This scheme adopts the scheme of pre-splitting and polishing blasting, and can perform pre-splitting blasting below the pipe shed before slotting blasting to form pre-cracks, reduce the propagation of slotting blasting vibration, and thus reduce damage to the pipe shed.

The invention relates to the technical field of saline-alkali soil remediation, in particular to soil remediation equipment based on saline-alkali soil improvement, which comprises a walking structure, a crushing mechanism, a punching mechanism and a material injection mechanism, the walking structure comprises a walking platform; the crushing mechanism comprises a first hoisting plate, a plurality of crushing pipes and a first driving structure, the first hoisting plate is arranged above the walking platform in parallel, and the first driving structure is used for driving the crushing pipes to rotate; the punching mechanism comprises a plurality of punching pipes, and the punching pipes are arranged outside the crushing pipe in a sleeving manner; the material injection mechanism comprises a material storage box and a material guide pipe, one end of the material guide pipe communicates with the material storage box, the other end of the material guide pipe downwards penetrates through the crushing pipe, and a liquid outlet hole is formed in the material guide pipe; the device is provided with the crushing mechanism, the punching mechanism and the material injection mechanism, so that the effective action time of a treatment agent in soil is prolonged, and the saline-alkali soil improvement efficiency and effect are improved.

The invention provides pH response type hydrogel as well as a preparation method and application thereof. The pH-responsive hydrogel is prepared from the following raw materials: a hydrophobic monomer, a sensitive monomer, a cross-linking agent, an initiator and an organic solvent, the hydrophobic monomer comprises at least one of methyl acrylate, ethyl acrylate, benzyl acrylate and 2-phenoxyethyl acrylate, and the sensitive monomer comprises at least one of a cross-linking agent, an initiator and an organic solvent. The sensitive monomer comprises a sulfanilamide monomer containing an acryloyl group or a methacryloyl group. According to the pH response type hydrogel disclosed by the invention, the drug release rate difference is obvious under different pH values. Under a low pH value, a slow drug release speed can be maintained, and under a high pH value, rapid drug release can be realized. And the release amount at high pH for 24 hours can reach 150-600% of the release amount at low pH for the same time. The invention further provides a preparation method and application of the pH response type hydrogel.

The present invention relates to a composition and the use of the composition in preparing a medicine for treating eye diseases. The composition comprises 0.5-1.5% by weight of a muscarinic acetylcholine receptor M3 agonist; 0.005-0.5% by weight of naphazoline, a pharmaceutically acceptable salt thereof, or a combination thereof; and 0.1-1% by weight of ketorolac tromethamine. The composition enhances the effect of a muscarinic acetylcholine receptor M3 agonist such as a pilocarpine active ingredient in treating presbyopia, while effectively and significantly reducing or even eliminating the side effects caused by the pilocarpine active ingredient.

This invention belongs to the field of agricultural microbiology technology, and discloses a strain of Sphingomonas, a microbial agent, its preparation method and application, specifically disclosing a strain of Sphingomonas (… Sphingomonas Microbial agent (sp.) R7 was deposited on March 31, 2025, at the China Center for Type Culture Collection (CCTCC), Wuhan University, Wuhan, China, with accession number CCTCC NO: M 2025634. The invention discloses a microbial agent containing this bacterium, its preparation method, and its application in improving soil and / or promoting rice growth, as well as in reducing cadmium content in the aboveground parts of rice. This microbial agent not only increases the content of nutrients such as nitrogen and phosphorus in the soil, thus improving soil quality, but also significantly increases the dry matter weight of rice roots, stems, leaves, and brown rice, promoting rice plant growth; it also concentrates cadmium in the rice roots, reducing the cadmium content in the aboveground parts of rice.

The invention relates to the technical field of vaccine adjuvants and drug delivery, and discloses a 3D-MLA and QS-21 composite adjuvant as well as a preparation method and application of the 3D-MLA and QS-21 composite adjuvant. A saponin QS-21; polyethylene glycol sodium alginate; embedding particles with pH-sensitive calcium chloride; the preparation method of the vaccine antigen comprises the following steps: performing pegylation modification on sodium alginate; embedding calcium chloride with a pH sensitive polymer, and carrying out spray drying to prepare cross-linking agent particles; dissolving the synthetic monophosphoryl lipid A and saponin QS-21 to prepare a composite adjuvant solution; mixing the adjuvant solution with the pegylated sodium alginate solution to prepare a precursor preparation; and adding antigen and cross-linking agent particles into the precursor preparation, and uniformly mixing to obtain a final product. According to the invention, the composite adjuvant is delivered through the pH responsive in-situ gel, an immune reservoir is formed, and a powerful and lasting comprehensive immune response biased to the Th1 type is safely induced.

The utility model discloses a rewinding follow-up roller long-acting lubricating mechanism which comprises a follow-up roller, end shafts at the two ends of the follow-up roller are arranged on a lubricating assembly, the lubricating assembly comprises a lubricating body, an oil cavity is formed in one end of the lubricating body, an oil injection hole communicated with the oil cavity is formed in the side wall of the upper portion of the lubricating body, and a bearing is arranged in a cavity body of the oil cavity in a sleeved mode. An end shaft of the follow-up roller is fixed to a bearing inner ring, a sealing cover is arranged on the portion, located on one side of the oil cavity, of the lubricating body through bolt connection, and a sealing ring is arranged between the sealing cover and the lubricating body. The long-acting lubricating mechanism for the rewinding follow-up roller stores lubricating oil through the oil cavity, is matched with the oil injection hole to conveniently supplement oil, and is combined with the sealing cover and the sealing ring to form a reliable sealing structure, so that the leakage of the lubricating oil can be effectively reduced, the lubricating period is prolonged, and the maintenance frequency is reduced; meanwhile, the stable assembly structure of the bearing and the end shaft can improve the running stability and prolong the service life of the follow-up roller.

The invention relates to the technical field of ferro-titanium alloy smelting, in particular to a ferro-titanium alloy smelting process based on a composite aluminum material aluminothermy method, which specifically comprises the following steps: modifying aluminum skimmings by using an auxiliary agent for pretreatment, and preparing the ferro-titanium alloy through gradient mixing and layered distribution, aluminothermy reaction initiation and smelting. The composite fluoride-MgO compound is melted at the initial stage of the reaction, and the composite fluoride and the nano MgO form a physical-chemical dual membrane rupture effect. CaO and BaB6 micro powder are wrapped by Li2B4O7, so that the effects of protecting and avoiding layering are achieved. Internal active components are gradually released, so that the effective action time of the additive is prolonged. Li < + > and BaB6 which are released by melting Li2B4O7 react with each other to gradually generate BF3, and F <-> is chemically corroded to form synergistic membrane rupture of internal and external clamping, so that the membrane rupture efficiency is improved. CaO reacts with Li2B4O7 to generate Ca3B2O6, so that the slag phase viscosity is reduced, and the slag-metal separation is improved. And meanwhile, CaO has the desulfurization capacity, melt purification can be achieved, and the recovery rate of titanium and the alloy purity are improved.