200results about How to "Prolong the effective time" patented technology

The invention discloses a microorganism deodorant and a preparation method thereof. The microorganism deodorant has the following strain composition: 106-109/mL of Lactobacillus acidophilus, 106-109/mL of Bacillus pumilus, 106-109/mL of Bacillus subtilis, 105-107/mL of Pseudomonas fluorescens, 105-107/mL of Rhodopseudomonas palustris, 104-106/mL of Bantu Brettanomyces, 104-106/mL of common Candida albican, 104-106/mL of Penicillium expansum, 104-106/mL of Rhizopus oryzae, 104-106/mL of Trichoderma viride, 104-106/mL of Streptomyces Microflavus and 104-106/mL of Streptomyces griseus. Accordingto the microorganism deodorant, the release amount of obnoxious gas can be effectively lowered, and the technical support is provided for effectively processing fetor in livestock and poultry farms and protecting environment.

The invention relates to the field of Chinese medicine, and discloses a Chinese medicinal composition for preventing and treating xerophthalmia. The composition comprises chrysanthemums, medlar, phellodendron, red sage roots, pearls, borneol and menthol. The medicinal composition preferably comprises the following in part by weight: 2.5 to 3 parts of chrysanthemums, 2.5 to 3 parts of medlar, 2.5 to 3 parts of phellodendron, 1.5 to 2 parts of red sage roots, 0.08 to 0.1 parts of pearls, 0.08 to 0.1 parts of borneol and 0.15 to 0.2parts of menthol. The invention also provides a wet application of the Chinese medicinal composition and a preparation method thereof. The Chinese medicinal composition has the effects of clearing heat, releasing toxin and moistening dryness, enables people to feel cool and comfortable after using the composition, and has the advantages of no toxic or side effects, easy absorption, quick response, good curative effect and good application prospects.

The invention provides a self-cleaning hydrophilic composite material and a preparation method thereof, wherein the self-cleaning hydrophilic composite material comprises a transparent substrate and a composite film positioned on the transparent substrate surface; the composite film comprises hollow microspheres with cavities therein, a spherical shell material of the hollow microspheres is a composite particle; the composite particle is a core-shell coating structure, a core material is SiO2 nano particle, a shell material is TiO2, the particle size of the shell material TiO2 is less than that of the core material SiO2. By improving a film structure on the basis of a microscopic structure, the self-cleaning hydrophilic composite material simultaneously has ultra-hydrophilic antifogging, anti-microbial and dustproof effects, and the time of the ultra-hydrophilic effectiveness is prolonged.

The present invention discloses a retardance and low damage acid solution system for high temperature condensate oil gas reservoir acidification. The acid solution system is suitable for acidification modification of high temperature deep well, particularly condensate gas reservoir, and comprises the following components, by weight, 0.5-3 parts of hydrofluoric acid or 6-12 parts of fluoroboric acid, 8-10 parts of an organic ester, 0.01-0.05 part of a catalyst, 0.1-1 part of a corrosion inhibitor, 0.1-1 part of an iron ion stabilizer, 0.1-1 part of a clay stabilizer, 1-2 parts of a cleanup additive, and 80-100 parts of water. According to the present invention, effects of retardance and corrosion inhibition of the acid solution system can be well achieved at a high temperature, and water blocking can be released and acid solution backflow can be easily achieved with the finally produced methanol and the carbon dioxide.

The invention relates to an antibacterial anti-acarien microcapsule and a preparation method thereof. An antibacterial anti-acarien liquid is used as a core material, and the methyl methacrylate added with nano-silver particles is used as a wall material. The preparation method is as follows: (a) shearing a water phase under a high-speed shearing machine, adding an oil phase and stirring to obtain uniform emulsion; (b) adding methyl methacrylate and an initiator in the emulsion obtained in the step (a), stirring, and then adding a silver nitrate solution; (c) cooling the liquid obtained after the reaction of the step (b), standing, and then washing, rinsing and drying precipitate to obtain the antibacterial anti-acarien microcapsule. At early stage, the microcapsule is used for inhibiting the crosslinking of polysaccharide chain and tetrapeptide by using the formation of the Ag<+> interfering bacteria cell wall so that the cell wall is out of completeness, the protection effect to the osmotic pressure is lost, the bacteria are damaged and dead, and the added silver nitrate solution is embedded in the micropore of the microcapsule wall to reduce the size or number of the micropore; at late stage, the cleanness of the fabric can be continuously maintained through the slow releasing of the antibacterial anti-acarien liquid.

The invention discloses an environment-friendly snow/ice melting composition which comprises the following components in percentage by mass: 50ppm-2% of ray absorbent B and 200ppm-2% of long-acting additive C and the balance of snow melting agent A. The application range of the composition is 0--60 DEG C, the snow melting property can be adjusted according to demands, and the composition can satisfy the requirements in GB/T23851-2009. The snow/ice melting composition can fully utilize solar energy and waste heat emitted by vehicles running on the road, has long effective acting time of snow/ice melting, and does not damage the pavements, buildings and metal box plants; and the molten water can satisfy the biological oxygen demand (BOD) index in Natural Discharge Standard. The composition is simple in production technique, convenient to use and easy for popularization.

The invention relates to a long-acting cefquinome sulfate injection. The injection is prepared by a method in the following steps: adding cefquinome sulfate into an ethanol solution containing ethyecellulose and hydroxy propyl cellulose; filtering, sterilizing and performing spray-drying to obtain a cefquinome sulfate carrier; adding a suspending agent, a dispersing agent and a stabilizing agent into partial injection solvent, dissolving at 100 DEG C, and adding an injection solvent to the whole amount, and performing dry heat sterilization at 150 DEG C for 1 hour; cooling the dispersion liquid to room temperature, adding the cefquinome sulfate carrier into the dispersion liquid, and uniformly stirring; passing through a high-speed cutting dispersion machine to prepare the long-acting cefquinome sulfate injection. The prepared suspension injection is uniform in granularity, good in fluidity, slow in settlement, good in redispersion property, wall adhesion prevention of liquid medicine, good needle cleaning performance, no discoloration after long-term storage and stable chemical property. After the preparation is injected in a pig in an intramuscular manner, the preparation is slowly released, long in elimination half life and smooth in plasma concentration, can be used for prolonging the effective action duration of the medicine in the body and reducing the number of administration times, and is convenient to use.

The invention provides a method for preparing biodegradable polymer nano particles. The method comprises the following main steps of: mixing an oil phase solution of a biodegradable polymer and an aqueous phase solution of a surfactant; uniformly filtering the mixed solution for a few times through a manual membrane filtering device to obtain biodegradable polymer emulsion with uniform size; and volatilizing the organic solvent to obtain an aqueous solution of the biodegradable polymer nano particles, removing the surfactant by high-speed centrifuging, then dispersing with deionized water, and thus obtaining dispersion of the biodegradable polymer nano particles. By the method, experimental parameters such as the concentration of the biodegradable polymer, the membrane aperture, the membrane filtering times, the concentration of the surfactant, the molecular weight of the biodegradable polymer and the like can be conveniently adjusted, and the medicament release rate can be controlled by effectively controlling the particle diameter; the prepared nano particles have uniform size; control of medicament loading quantity is facilitated, so that the medicament release efficiency is improved, and the effective acting time is increased; and the method is simple and quick, and is suitable for large-scale production.

The invention discloses a method for preparing insect-proof nets. The method includes mixing polyethylene, polylactic acid, PET (polyethylene terephthalate), coupling agents and compatilizers with one another, melting the polyethylene, the polylactic acid, the PET, the coupling agents and the compatilizers at the temperatures of 170-210 DEG C to obtain mixtures, placing the obtained mixtures in an extruder and heating, extruding and smashing the mixtures to obtain mixture powder; heating the obtained mixture powder, photosensitive color-changing agents, insect repellent agents, nanometer titanium dioxide and magnesium stearate until the temperatures of the mixture powder, the photosensitive color-changing agents, the insect repellent agents, the nanometer titanium dioxide and the magnesium stearate reach 160-180 DEG C, shearing the mixture powder, the photosensitive color-changing agents, the insect repellent agents, the nanometer titanium dioxide and the magnesium stearate at the high speeds of 2000-3000 rpm for 20-30 min to obtain mixtures, cooling the mixtures, then feeding the mixtures into the extruder and heating and extruding the mixtures to obtain master batch; carrying out wire drawing on the master batch to obtain the insect-proof nets. The method has the advantages that the insect repellent rates of the insect-proof nets prepared by the aid of the method can reach 91%, the insect killing rates of the insect-proof nets can reach 83%, the repellent rates can reach 62% after the insect-proof nets are washed by 50 times, and the killing rates can reach 37% after the insect-proof nets are washed by 50 times; the light transmittance of the insect-proof nets is 78%, and the flexibility of the insect-proof nets can reach 80.2 Mpa.

The invention belongs to the technical field of the pharmacy of medicine, which relates to a gemcitabine-albumin nano microsphere preparation used for the chemotherapy of the tumors of pancreatic cancer and the like and a preparation method thereof. The invention uses an ethanol precipitation-glutaric dialdehyde crosslinking denaturation method to prepare a slow-release gemcitabine biodegradable albumin nano microsphere. By animal experiments, the result confirms that the invention can obviously enhance the slow-release property and the tissue retention property of the medicine, enhances the concentration of gemcitabine in tumors and other target organs effectively, prolongs the effective acting time of the gemcitabine and reduces the side effect of the medicine. The nano microsphere can be used for the chemotherapy and the interventional chemotherapy of pancreatic cancer and non-small cell lung cancer and is suitable for the venous chemotherapy, the arterial interventional treatment, the local tumor injection interstitial chemotherapy, the celiac chemotherapy and the oral chemotherapy of tumor patients with gemcitabine adaptive diseases.

The invention relates to a jet laser composite cleaning method and a cleaning system. A water film and a water film cavitation bubble breaking impact cleaning base material surface are generated, andmeanwhile, a laser is focused in the water film, the water film explodes in a super-heating state, the water film is vigorously vaporized, steam bubbles are generated to impact the surface of base materials, and the effective action time of cavitation jet is prolonged. The cleaning system comprises an cavitation jet device and a laser cleaning device; and the laser beam and the center line of thecavitation jet are coplanar, the cavitation jet flow generates the water film on the surface of a workpiece, the laser beam is focused in the water film and keeps a distance from the surface of the workpiece, and the laser beam and the cavitation jet flow act on the surface of the workpiece on a workbench to be cleaned, so that the effect is obviously superior to that of the existing cleaning technology, solid particles with the surface diameter larger than 50 nm can be removed, and the surface processing requirements of the wafer base materials can be met.

The invention relates to an antibacterial material, as well as a preparation method and application thereof. The antibacterial material comprises a carrier, an inorganic bacteriostatic agent and an organic bacteriostatic agent, wherein the carrier comprises montmorillonite, the granularity of the inorganic bacteriostatic agent is 1-50 nm. The antibacterial material provided by the invention is rapid in interaction speed, excellent in antibacterial effect and long in effective acting time and cannot loss the antibacterial activity due to the dissolution and loss.

The invention relates to an aivlosin injection for swine. Each 100ml of tylosin injection contains 20g of acetylisovaleryl tylosin tartrate, 20-35g of propylene glycol, 10-15g of N,N-dimethyl acetamide, 2-4g of benzyl alcohol, 0.1-1.0g of di-tert-butyl-4-methylphenol and balance of glyceryl triacetate. The preparation method comprises the following steps of: mixing the glyceryl triacetate, the propylene glycol, the benzyl alcohol and the N,N-dimethyl acetamide evenly to obtain an oil phase; adding an antioxidant to the oil phase and stirring until the added particles are dissolved; and adding the aivlosin and stirring to dissolve. The aivlosin injection for swine adopts the oily solvent as a solvent, the medicament is dissolved in the oily solvent, and the elimination half life of the medicament in an animal body is prolonged by the characteristic of slow elimination of the oily solvent after intramuscular injection.

The invention provides a fabric antioxidant containing seaweed extract and a preparation method thereof. The specific operation steps are as follows: (1) wash the chlorella surface attachments and sand grains with filtered seawater, and dry it at room temperature. Place in an oven to dry to remove excess moisture, remove, chop and grind to form chlorella powder; (2) place the chlorella powder prepared in step (1) in a mixed solvent of methanol and chloroform, reflux extraction twice, and combine the filtrates , the filtrate is evaporated to form a chlorella extract; (3) the chlorella extract prepared in step (2) is placed in a supercritical carbon dioxide extraction device, and extracted to obtain a chlorella extract; (4) the step (3) ) to the chlorella extract prepared by adding additives, heating and stirring evenly, rinsing and filtering, and naturally cooling to room temperature to obtain the fabric antioxidant containing seaweed extract. The fabric antioxidant containing the seaweed extract prepared by the invention has very strong antioxidant activity and low side effects, and expands the application range of the seaweed.

The invention discloses a polypeptide vaccine against tumor-targeted drug resistance sites and a design method thereof. The design method includes the steps: collecting data of targeted drug resistance mutations; intercepting a drug resistance mutant polypeptide sequence and predicting the affinity and immunogenicity of MHC molecules; obtaining the relationship between targeted drugs and drug resistance sites, and performing drug clustering; and artificially designing a corresponding vaccine polypeptide sequence. The targeted drug combination polypeptide vaccine combination obtained by the method can cover common targeted therapeutic drugs, can effectively reduce the probability of tumor drug resistance, can prolong the effective action time of the targeted drugs, can increase the diseaseresponse rate of the patient, has broad-spectrum, can shorten the time from analysis to treatment of individualized peptide vaccines, and can reduce medical costs.

The present invention provides a plant vermicide-nimbic oil microcapsule. Its composition includes (by wt%) 50.23-73.29% of nimbic oil and 26.71-49.77% of capsule material, in which the capsule material is obtained by using one or several kinds of isocyanic ester, polyvinyl alcohol, polyethylene glycol, polyvinyl acetaldehyde, glycerol, sodium alginate and calcium chloride. Said invention also provides its preparation method.

The invention discloses an application of lambda-carrageenan oligosaccharide to preparation of an anti-rabies virus drug. Experiments prove that the lambda-carrageenan oligosaccharide is low in cytotoxicity so that rabies viruses of various strains can be inhibited on various types of cells and inhibition effect is provided to each stage of the rabies viruses invading the cells; and particularly in the stage after virus adsorption, namely, 12 hours after the cells are infected by the viruses, the lambda-carrageenan oligosaccharide is still capable of remarkably decreasing the rabies virus amount in the cells. According to above discovery, the lambda-carrageenan oligosaccharide can be used as a low-cost effective wound treating agent to replace the anti-rabies virus immune globulin, and has the advantages of decreasing the viruses at the wound part to the greatest extent and reducing the rabies morbidity.