76results about How to "Promote percutaneous absorption" patented technology

Preparations for percutaneous absorption comprising a basic drug or its salt dissolved in a liquid component and having an enhanced percutaneous absorbability and a safety to the skin, i.e., the administration site. The preparations for percutaneous absorption, preferably patches, contain a basic drug or its salt, an organic acid or its salt and a liquid component having a solubility parameter of from 7 to 13 (cal/cm³)^1/2 and a have a very excellent skin permeability of the drug.

An adhesive composition for dermal patches, comprising (A) a (meth)acrylic acid-base polymer having repeating units represented by formulae (1) and (2): (wherein R¹ and R² each independently represents a hydrogen atom or a methyl group and M represents NH₄⁺ or an alkali metal) with the ratio of (1)/(2) being in a range of 100/0 to 90/10 (by mol), (B) water, (C) a polyhydric alcohol and (D) an aluminum compound, with the content of (B) water being from 5 to 30 mass %; and a production process thereof. The adhesive composition for dermal patch of the present invention can contain a large amount of polyhydric alcohol between skeletons of the adhesive layer and forms a stable between skeletons of the adhesive layer and forms a stable base material free from syneresis of the polyhydric alcohol. Furthermore, the dermal patch using the adhesive composition for dermal patch of the present invention is excellent in the release property and adherence and has high safety.

The invention discloses acne-removal cosmetic composition containing nano-zinc. The acne-removal cosmetic composition comprises nano-zinc and other cosmetic matrix components. Through synergistic interaction of nano-zinc and azelaic acid, the acne-removal cosmetic composition can perform the efficacy of pore clearing, balancing of grease secretion, sterilization, inflammation eliminating, acne mark removal, moisturization, sun blocking and the like, comprehensively repairs and improves the barrier function of skin and thoroughly removes acne.

The invention discloses a cosmetic or dermatological composition as well as a preparation method and application thereof, and belongs to medicines and cosmetics. The composition comprises 0.001%-10% of triterpene acid, 0%-10% of triterpenoid saponin, 0%-10% of vitamin A or vitamin A derivatives, 0.1%-20% of terpene-containing essential oil, 1%-40% of an emulsifier, 1%-40% of a co-emulsifier and a proper amount of water and additives. The preparation method comprises the following steps: dissolving the triterpenic acid, the triterpenoid saponin and the vitamin A or the derivatives thereof in the emulsifier, the co-emulsifier and the terpene-containing plant essential oil, performing dispersing in a water phase while stirring, and carrying out high-pressure homogenization. The prepared nano-emulsion is in an oil-in-water type, is excellent in water solubility, clear, transparent, good in stability and high in absorption efficiency, the effects of resisting aging, reducing wrinkles, whitening, inhibiting acnes, inhibiting sebum overflow, inhibiting scar formation, promoting skin wound repair and the like are greatly improved, the preparation method is simple, and the application value of the composition in the fields of medicines and cosmetics is improved.

The invention relates to an alprostadil nanoparticle preparation and a preparation method thereof. The preparation is essentially used for transdermal administration and used for treating diseases such as diabetic ulcer, ischemia of extremity end, burn and the like, and belongs to the technical field of medicine. The preparation consists of the raw materials by the following weight ratio that alprostadil:lipid component: emulsifier: excipient matrix: water is 0.01-0.1:0.5-10:0.5-5:550-950:5. The alprostadil nanoparticle preparation has the advantages of overcoming the chemical and physiological instability of the alprostadil, strengthening in vitro stability, reducing degradation of the alprostadil caused by inactivation effect of in vivo pulmonary circulation, enhancing concentration of the preparation on the local affected parts, being more easy to aggregate at the affected part, sustained release and long effect, and reducing irritation of the preparation.

Provided is a pressurized carbon dioxide mist bathing system whereby a carbon dioxide mist having a high carbon dioxide concentration can be efficiently absorbed through the skin and mucosa of a living body. A pressurized carbon dioxide mist bathing system comprising a carbon dioxide gas-supplying means (11), a liquid-supplying means (21), a carbon dioxide mist-forming means (31) in which the carbon dioxide gas and the liquid are ground and dissolved to give a carbon dioxide mist, a body cover member (41) covering the skin and mucosa of the living body and providing a space in which the carbon dioxide gas mist formed by the carbon dioxide mist-forming means (31) is enclosed , a liquid-circulating means (61) for supplying again the liquid pooled in the carbon dioxide mist-forming means (31) into the carbon dioxide mist-forming means (31), and a body cover member-pressurizing means (81) for pressurizing the inside of the body cover member (41).

The present invention relates to a compounding ingredients for basic cosmetics and basic cosmetics containing the compounding ingredients which contain enzymes or hydrolysis products of nucleoprotein and/or DNA or RNA, or deoxy oligonucleotide, deoxy mononucleotide, oligopeptide, oligonucleotide mononucleotide separated from the hydrolysis products, or at least two kinds of mixtures selected from the hydrolysis products or compounds as active ingredients. Because the active ingredients such as deoxy oligonucleotide and others have comparatively small molecular weights, they are easy to be absorbed percutaneously, and when they are percutaneously absorbed, they exhibit cellular stimulating effects and blood circulation promoting effects, and therefore, in the event that they are applied to the facial skin, they marvelously prevent skin roughness, blotches, freckles, wrinkles, etc. and exhibit superb skin-lightening effects.

The invention provides a composite phospholipid transfersome which promotes propranolol percutaneous absorption, and a preparation method thereof. According to the invention, two phospholipid materials with different phase-change temperatures, which are dipalmitoyl phosphatidyl choline and soybean lecithin, are adopted as a composite phospholipid material. Compared with a transfersome with a single phospholipid material in prior art, the propranolol composite phospholipid transfersome prepared with the phospholipid material provided by the invention has substantially improved encapsulation efficiency, reduced leakage, improved stability in rat plasma, and substantially improved bioavailability after percutaneous administration. The propranolol composite phospholipid transfersome provided by the invention is especially suitable to be used for treating infantile hemangioma. With the transfersome, propranolol percutaneous administration can be realized, and propranolol can directly act upon a hemangioma affected part. The treatment effect is improved, toxic and side effects are reduced, and children medication compliance can be improved. Also, the invention provides a preparation method of the propranolol composite phospholipid transfersome.

The invention relates to a slow-release patch used for external application and prepared from natural tobacco extracts (nicotine as the main component). The slow-release patch is prepared from the natural tobacco extracts and proper auxiliary materials and is used for achieving the aim of slowly releasing nicotine according to a particle slow-release principle. The nicotine slow-release patch provided by the invention comprises a back lining layer, a medicine-contained paste body and a cover lining layer, wherein the medicine-contained paste body is prepared from auxiliary materials such as nicotine micelle, an adhesive, a filling agent, a transdermal enhancer, a humectant and the like according to a certain ratio; each patch contains 20-40mg of nicotine. The nicotine slow-release patch has the characteristics of slow release, rapidness in taking effects, good moisture retention and air permeability, comfort in use and the like.

Provided is a pressurized carbon dioxide -containing mist bathing system which enables effective absorption of a carbon dioxide-containing mist having a high carbon dioxide concentration through the skin and mucosa of living body. A pressurized carbon dioxide -containing mist bathing system which comprises a carbon dioxide-supplying means (11), a liquid-supplying means (21), a carbon dioxide-containing mist-forming means (31) by which the carbon dioxide and the liquid are ground and dissolved to form a carbon dioxide-containing mist, a body-covering member (41) which covers the skin and mucosa of living body so as to provide a space wherein the carbon dioxide-containing mist formed by the carbon dioxide-containing mist-forming means (31) is enclosed, and a liquid circulation means (61) for supplying the liquid having been pooled in the carbon dioxide-containing mist-forming means (31) into the carbon dioxide-containing mist-forming means (31) again.

The invention discloses a traditional Chinese medicine composition with bacteriostatic, anti-inflammatory, hemostatic and analgesic effects and a preparation method thereof. According to the method, apithecellobium clypearia extract and a lamiophlomis rotata extract are used as raw materials; poly(lactic-co-glycolic acid) PLGA, vitamin E polyethylene glycol succinate TPGS and poloxamer are used as a drug-loaded matrix. The preparation method comprises the following steps: mixing raw medicinal materials with the drug-loaded matrix to form an oil phase and an oil-in-water phase, performing probe ultrasonic emulsification to obtain a nano-suspension, and adding carbomer, collagen tripeptide, oat beta-glucan and propylene glycol as a gel matrix to obtain traditional Chinese medicine composition nanogel. The prepared traditional Chinese medicine composition nanogel has the particle size of 120 nm-260 nm, has good drug loading capacity, obviously improves the solubility and bioavailabilityof hydrophobic drugs, inhibits bacteria, diminishes inflammation, stops bleeding and relieves pain, and is definite in curative effect.

The invention relates to an acne-removing essence and a preparation method thereof. The acne-removing essence is prepared from the following components in percentage by weight: 0.1-1% of xanthan gum, 0.5-3% of water-soluble jojoba oil, 1-10% of glycerin, 1-10% of 1,3-butanediol, 0.5-5% of water-soluble vitamin E, 1-10% of nano zinc, 0.1-1% of sodium hyaluronate, 0.2-1.5% of a preservative, 0.1-1% of a pH modifier, 0.01-0.3% of an essence and the balance of water, wherein the sum of the percentages of the components is 100%. The acne-removing essence is simple in preparation technology, the prepared nano zinc moisturizing and acne-removing essence has a relatively good moisturize effect and an excellent acne-removing effect, and a product is mild and free of thrill and has a good skincare effect.

Disclosed is a pharmaceutical composition containing tulobuterol. More specifically, disclosed is a transepidermal drug delivery system including a drug layer containing tulobuterol and a natural rubber-based adhesive material, and a supporter adhered to one surface of the drug layer to support the drug layer, wherein the natural rubber-based adhesive material comprises 10 to 40 parts by weight of a natural rubber, 54.5 to 85 parts by weight of a rosin ester resin and an acid value controller, and the drug layer has a thickness of 25 μm to 75 μm.

The invention discloses a hydrogel patch for skin care and a preparation method of the hydrogel patch. A hyaluronic acid substance serves as a main hydrogel matrix to be compounded with a small amountof gel polymers, so that the toughness and the strength of the hydrogel patch are improved. Meanwhile, the hydrogel patch is high in water locking property and low in drainage rate, has the effects of preserving moisture for a long time and promoting percutaneous absorption of active ingredients or medicines, and can be used for skin beauty care, skin trauma and ulcer care and application care ofsoft tissue sprain. Different shapes can be formed by pouring according to different use parts, including the whole face, the nose part, the eyes, the lip, the neck and the body parts such as the abdomen, the hip and the four limbs.

The present invention discloses a transdermal delivery based pharmaceutical composition. The composition comprises a compound as shown in a formula (I) or pharmaceutically acceptable salt thereof, a macromolecular dispersing carrier material, a hot melting protecting agent and an optional fluxing agent. A preparation method of the transdermal delivery based pharmaceutical composition comprises thesteps of micronizing the compound as shown in the formula (I) or the pharmaceutically acceptable salt thereof, the macromolecular dispersing carrier material and the hot melting protecting agent, optionally adding the fluxing agent, mixing the components uniformly, and performing hot melting extrusion and micronizing to obtain microparticles of the compound as shown in the formula (I) or the pharmaceutically acceptable salt thereof. In addition, the invention provides an application of the pharmaceutical composition. The transdermal delivery based pharmaceutical composition can enable the compound as shown in the formula (I) to be quickly absorbed, so that the purpose of calming before anesthesia is achieved, breathing is not affected, and the adverse psychological effects on children dueto intramuscular injection or intravenous injection are avoided. Meanwhile, the pharmaceutical composition also can be used for preventing and/or treating hyperactivity.

The invention belongs to the technical field of an anti-parasitic drug, and particularly relates to an application of a composition containing ivermectin and levamisole hydrochloride to preparation ofa veterinary anti-parasitic drug, a transdermal solution of the veterinary anti-parasitic drug and a preparation method of the transdermal solution. The transdermal solution comprises components in parts by volume as follows: 20-50 parts of isopropanol, 10-40 parts of glycerol, 10-30 parts of absolute ethyl alcohol, 5-20 parts of dimethyl sulfoxide and 2-6 parts of azone; the content of ivermectin is 0.3-1 g per 100 mL of solution, and the content of levamisole hydrochloride is 5-15 g per 100 mL of solution. According to the invention, ivermectin and levamisole hydrochloride are combined, a synergistic effect is realized by simultaneous use of ivermectin and levamisole hydrochloride, and an anti-parasitic spectrum is improved; and meanwhile, with adoption of a transdermal absorption dosage form, toxic and side effects caused by correlation of the drug and the dosage are reduced, and a simultaneous internal and external anti-parasitic effect of the preparation is realized.

The purpose of the present invention is to provide a nonaqueous tape that is stable and has high percutaneous absorption performance, and that contains pramipexole hydrochloride, which is slightly soluble in organic solvents and has high crystallinity. The present invention could produce a nonaqueous tape that is stable and has high percutaneous absorption performance by dissolving pramipexole, using a combination of a fatty acid ionic liquid and a divalent alcohol and a fatty acid ester. As a result, it has become possible to provide a transdermal patch (tape) containing pramipexole for the treatment of Parkinson's disease with which the problems associated with a conventional water-containing poultice of discoloration of the preparation and stability of the pramipexole can be solved.

The present invention relates to an isosorbide dinitrate-containing patch, in which an adhesive layer comprising an adhesive composition is formed on a flexible support, and the adhesive composition consists of an acrylic-based adhesive (A), a polyvinyl acetate-based adhesive (B), a plasticizing component (C) and isosorbide dinitrate (D), and satisfies the following weight ratios (1) through (3) of each of the components: (1) A:B = 70:30 to 10:90, (2) the weight ratio of the component C based on the adhesive composition is 10 to 40% by weight, and (3) the weight ratio of the component D based on the adhesive composition is 20 to 35% by weight. Provided is a patch excellent in percutaneous absorption, handleability, resistance to skin irritation, sustained release, adhesivity, etc.

The invention relates to the field of mosquito repellent liquids and discloses a spider freeze-dried powder mosquito repellent liquid and a preparation method thereof. The spider freeze-dried powder mosquito repellent liquid utilizes spider freeze-dried powder as a main agent and through compatibility, the spider freeze-dried powder mosquito repellent liquid has substantial mosquito repellent effects. Aiming at symptoms of redness, swelling and itching caused by mosquito bites, the spider freeze-dried powder mosquito repellent liquid has good effects of preventing scar, relieving itching, eliminating swelling and relieving pain. In subtropical zones and tropical rain forest zones, the spider freeze-dried powder mosquito repellent liquid has substantial effects of repelling mosquitoes, eliminating swelling, relieving itching, resisting bacteria and diminishing inflammation.

The invention discloses medical cold application plaster. The medical cold application plaster consists of a back lining layer, a gel layer and an antiseizing layer and is characterized in that the gel layer is prepared from the following components in percentage by mass of 4%-5.2% of sodium polyacrylate, 0.08%-0.12% of dihydroxyaluminum aminoacetate, 0.11%-0.12% of ethylenediaminetetraacetic aciddisodium salt, 0.15%-0.22% of tartaric acid, 21%-25% of glycerine, 0.01%-0.1% of a preservative, 0.1%-0.5% of a functional additive, 0.5%-2% of ethanol and the balance water. The invention further discloses a preparation method of the medical cold application plaster. The medical cold application plaster has high molecular gelatin being high in water content, effective components can rapidly penetrate into the fat layer, impregnate into subcutaneous tissue and achieve favorable effect through transdermic absorption.