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Active substance carrier comprising biopolymer

A technology of active substances and carriers, which is applied in the field of active substance carriers, can solve problems such as toxicity and allergies, and achieve the effect of promoting percutaneous absorption and enhancing effects

Pending Publication Date: 2021-06-04
AMOREPACIFIC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned amphiphilic enhancer is a synthetic compound or an organic solvent is used in the manufacturing process, so there are safety problems such as toxicity and allergy to the human body, so it is desired to avoid its use in the cosmetic industry and the pharmaceutical industry recently these compounds

Method used

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  • Active substance carrier comprising biopolymer
  • Active substance carrier comprising biopolymer
  • Active substance carrier comprising biopolymer

Examples

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preparation example Construction

[0049] In one embodiment, the present invention may provide a method for preparing the structure or an active substance carrier containing it. In one embodiment, the method may include: adding prolamin into an alcohol solvent and dispersing to form a nucleus; adding pullulan drop-by-drop into the an alcoholic solution to form a shell surrounding the core; coating the uppermost layer of the shell by adding pectin to the alcoholic solution to which the pullulan is added, and between the shells a step of forming a network; and a step of evaporating alcohol from the solution added with the pectin to obtain a solution formed with a core-shell network structure dissolved in an aqueous phase.

[0050] In one embodiment, the present invention may provide a preparation method of a composition, wherein the active substance is loaded in the core-shell network structure of the composition. In one embodiment, the method may include: adding the prolamin and the active substance into an alc...

Embodiment 1

[0066] An active material carrier comprising a core-shell network structure according to an embodiment of the present invention is prepared by the following method.

[0067] Powdered zein was weighed so as to be 0.5% by weight based on the total weight of the composition, added to a 70% alcohol aqueous solution, and then dispersed by stirring. Next, weigh the pullulan dissolved in the aqueous phase of pH 7 or below at room temperature so that it reaches 0.5% by weight based on the total weight of the composition, and drop it into the alcohol solution drop by drop, stirring to dissolve. The aqueous phase pectin was weighed to make 0.5% by weight, based on the total weight of the composition, and added to the solution. Then, use an evaporator to evaporate the alcohol in the solution, so as to obtain the final core-shell network solution dissolved in the water phase.

Embodiment 2

[0069] , a composition comprising a core-shell network structure loaded with an active substance as an embodiment of the present invention was prepared by the following method.

[0070] Powdered zein (zein) was weighed so that it reached 0.5% by weight based on the total weight of the composition, and after being added to a 70% alcohol aqueous solution, dissolved by stirring, added to the solution Red ginseng saponins (BioGF1K Complex TM , Amorepacific Company), and make it reach 1% by weight based on the total weight of the composition, and disperse by sufficient stirring to form a hydrophobic interaction between the zein and the active substance. Next, at room temperature, the pullulan dissolved in the aqueous phase of pH 7 or below is weighed so that it reaches 0.5% by weight based on the total weight of the composition, added to the solution and stirred to dissolve, and then added to the water Phase pectin is weighed so that it reaches 0.5% by weight based on the total we...

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Abstract

The present disclosure relates to an active substance carrier comprising a core-shell network structure formed using a biopolymer. In an aspect of the present disclosure, the core-shell network structure comprises a core-shell particle comprising: a core comprising prolamin; and a shell comprising pullulan and pectin, wherein the pullulan comprised in the shell surrounds the core and the pectin is located in the outermost layer of the shell, so that a network is formed between the core-shell particles. It can effectively facilitate the transdermal absorption of an active substance.

Description

technical field [0001] This specification relates to an active substance carrier using a biopolymer. [0002] 【Related Application】 [0003] This application claims priority to Korean Patent Application No. 10-2019-0159034 filed on December 3, 2019, the entire contents of which are incorporated herein by reference. Background technique [0004] In the cosmetic industry or the pharmaceutical industry, when an active substance that is difficult to penetrate into the stratum corneum is contained in an external preparation for skin, skin absorption of the active substance is promoted by using a synthetic surfactant or the like. In addition, a widely used method is to increase skin penetration of active substances by using polymer nanoparticles utilizing synthetic polymers such as polyethylene glycol or liposome nanoparticles as carriers. For example, use ethanol, propylene glycol, dimethyl sulfoxide, amphiphilic compounds and other low-molecular-weight polar solvents at the sa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61K8/73A61K47/42A61K47/36A61K9/00A61Q19/00
CPCA61K8/645A61K8/73A61K47/42A61K47/36A61K9/0014A61K8/0279A61K9/5161A61K2800/91A61K2800/5922A61K2800/412A61Q19/00A61K2800/10A61K8/0245A61K9/0087A61K2800/413A61K2800/56A61K9/5169A61K9/4816A61K9/4891
Inventor 金恩美裵日弘俞载元
Owner AMOREPACIFIC CORP
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