Application of composition to preparation of veterinary anti-parasitic drug, transdermal solution of veterinary anti-parasitic drug and preparation method of transdermal solution

An anti-parasite and composition technology, which is applied in the field of veterinary anti-parasitic transdermal solution and its preparation, can solve the problems of increased drug and dose toxicity and side effects, poor deworming effect of ectoparasites, and increased labor costs, etc. , to prolong the effective time of action, improve the spectrum of insect resistance, and reduce labor costs

Inactive Publication Date: 2020-08-11
吉林吉力生物技术研究有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Levamisole hydrochloride is a broad-spectrum anti-nematode drug. Although it can significantly improve the immune response in addition to its anthelmintic activity, it is less effective against ectoparasites
[0004] In addition, the current dosage forms of antiparasitic drugs are injections, powders, tablets and pouring agents, and the treatment is carried out step by step by means of internal and external administration. Increase a lot of labor costs

Method used

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  • Application of composition to preparation of veterinary anti-parasitic drug, transdermal solution of veterinary anti-parasitic drug and preparation method of transdermal solution
  • Application of composition to preparation of veterinary anti-parasitic drug, transdermal solution of veterinary anti-parasitic drug and preparation method of transdermal solution
  • Application of composition to preparation of veterinary anti-parasitic drug, transdermal solution of veterinary anti-parasitic drug and preparation method of transdermal solution

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preparation example Construction

[0044] The present invention also provides a preparation method of the veterinary anti-parasitic transdermal solution described in the technical solution, comprising the following steps:

[0045] (1) Mix the isopropanol, glycerol, absolute ethanol, dimethyl sulfoxide, azone, ivermectin and levamisole hydrochloride to obtain a mixed solution;

[0046] (2) The mixed solution is sterilized and filtered by a microporous membrane to obtain a veterinary anti-parasitic transdermal solution.

[0047] The invention mixes the isopropanol, glycerol, absolute ethanol, dimethyl sulfoxide, azone, ivermectin and levamisole hydrochloride to obtain a mixed solution. In the present invention, the mixing method preferably includes the following steps:

[0048] (a) isopropanol and ivermectin are mixed and dissolved to obtain the first solution;

[0049] (b) mixing and dissolving absolute ethanol and levamisole hydrochloride to obtain levamisole hydrochloride ethanol solution; mixing dimethyl su...

Embodiment 1

[0055] A veterinary anti-parasitic ivermectin levamisole transdermal solution, its constituents and parts by weight are respectively (by every 100mL proportioning of raw and auxiliary materials, the following examples are the same):

[0056]

[0057] Preparation of the transdermal solution:

[0058] (1) Measure isopropanol and ivermectin according to the proportion, add isopropanol to ivermectin and stir until completely dissolved to obtain the first solution;

[0059] (2), take absolute ethanol and levamisole hydrochloride according to the ratio, add absolute ethanol to levamisole hydrochloride and stir until completely dissolved, measure dimethyl sulfoxide, glycerol, and azone according to the ratio, add into the levamisole hydrochloride ethanol solution, stirred until completely dissolved to obtain the second solution;

[0060] (3), mixing the first solution and the second solution, stirring evenly to obtain the third solution;

[0061] (4) After the third solution is ...

Embodiment 2

[0063] A veterinary anti-parasitic ivermectin levamisole transdermal solution, its constituents and parts by weight are respectively (by every 100mL proportioning of raw and auxiliary materials, the following examples are the same):

[0064]

[0065] The steps of its preparation method are the same as in Example 1.

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Abstract

The invention belongs to the technical field of an anti-parasitic drug, and particularly relates to an application of a composition containing ivermectin and levamisole hydrochloride to preparation ofa veterinary anti-parasitic drug, a transdermal solution of the veterinary anti-parasitic drug and a preparation method of the transdermal solution. The transdermal solution comprises components in parts by volume as follows: 20-50 parts of isopropanol, 10-40 parts of glycerol, 10-30 parts of absolute ethyl alcohol, 5-20 parts of dimethyl sulfoxide and 2-6 parts of azone; the content of ivermectin is 0.3-1 g per 100 mL of solution, and the content of levamisole hydrochloride is 5-15 g per 100 mL of solution. According to the invention, ivermectin and levamisole hydrochloride are combined, a synergistic effect is realized by simultaneous use of ivermectin and levamisole hydrochloride, and an anti-parasitic spectrum is improved; and meanwhile, with adoption of a transdermal absorption dosage form, toxic and side effects caused by correlation of the drug and the dosage are reduced, and a simultaneous internal and external anti-parasitic effect of the preparation is realized.

Description

technical field [0001] The invention belongs to the technical field of anti-parasitic drugs, and in particular relates to the application of a composition in the preparation of veterinary anti-parasitic drugs, a transdermal solution for veterinary anti-parasitic diseases and a preparation method thereof. Background technique [0002] The harm of parasites to animals is mainly through the consumption of nutrients in cattle and sheep, causing mechanical damage, or lack of nutrition, which reduces the utilization rate of feed for animals, resulting in slow growth of cattle and sheep, and a decrease in feed utilization rate. The current anti-parasitic drugs are mainly divided into anti-helminth drugs, anti-protozoal drugs and in vitro insecticides. Since animal parasitic diseases are mostly mixed infections, antiparasitic drugs with high efficiency, broad spectrum, low toxicity and convenient administration should be selected. [0003] At present, the antiparasitic drugs for ve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/429A61K9/08A61K47/22A61K47/10A61K47/20A61P33/14A61P33/10A61P33/02
CPCA61K9/0014A61K9/08A61K31/429A61K31/7048A61K47/10A61K47/20A61K47/22A61P33/02A61P33/10A61P33/14A61K2300/00
Inventor 张国军岑岳明陈博王兆哲齐宇
Owner 吉林吉力生物技术研究有限公司
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