73 results about "Levamisole hydrochloride" patented technology

The invention provides a worm-disease-resisting compound niclosamide tablet for beasts and birds and a preparation method thereof. The worm-disease-resisting compound niclosamide tablet for beasts and birds respectively includes the following components by mass: 0.5-2 parts of tiandixiang (a flavoring agent), 0.5-2 parts of aspartame, 8-12 parts of starch, 20-40 parts of oral glucose or cane sugar, 0.5-2 parts of mannitol, 0.3-0.8 part of magnesium stearate, 40-60 parts of niclosamide and 2.5-5 parts of levamisole hydrochloride. The preparation method includes performing 17-mesh palletizing through a starch inside-outside addition and wet process mode, drying for 2-3 hours at the temperature of 65-75 DEG C, performing 17-mesh granulating straightening, additionally mixing the tiandixiang, the aspartame and the magnesium stearate, performing tabletting and the like to obtain the finished products. The worm-disease-resisting compound niclosamide tablet is bright and clean in appearance, fast in disintegration, good in desinsectization effect after being taken orally, simple in process, good in taste and suitable for industrial production, and various indexes of the tablet are optimized.

A medicine for treating the intractable tinea, including psoriasis and syphilis, is prepared from 17 raw materials including VB1, VB2, VB6, chlorpheniramine, furazolidone, dexamethasone acetate, etc.

The invention discloses a Newcastle disease-H9 subtype avian influenza bivalent dual-adjuvant inactivated vaccine and a preparation method thereof. The bivalent vaccine consists of a concentrated and inactivated ND and AI (H9) venom, levamisole hydrochloride and an oil adjuvant, wherein every milliliter of inactivated vaccine contains 0.5-16 mg of levamisole hydrochloride immunopotentiator. When the synergic ND-AI (H9) bivalent dual-adjuvant inactivated vaccine prepared with the method is applied to immunized chicken, the humoral immunity and cell immune levels of table poultry and laying hens can be raised effectively, the growth is promoted, and rate of live weight growth is increased. The bivalent dual-adjuvant inactivated vaccine has an immune effect which is remarkably superior to that of the conventional chicken ND-AI bivalent oil emulsion inactivated vaccine, and can be used for effectively protecting chicken flocks from being intruded by the ND virus and AI (H9) virus and preventing the Newcastle disease and H9 subtype avian influenza at the immune period.

The invention relates to a method for preparing animal composite agent which can be used to treat parasitism of animal. The inventive agent comprises main drug and findings, wherein, the main drug is formed by two of following materials as 2-10 deals of edeine, 2-10 deals of avermectin, 50-250 deals of abendazole, 50-250 deals of bisbendazole, 50-250 deals of aofenzole, and 50-250 deals of alcaine decaris; and the findings are prepared from one or two of following materials as 1-2 deals of anti-oxidant, 0.1-0.2 deals of metal complex builder, 740-950 deals of injection dissolvent, 740-950 deals of stuff, 50-200 deals of disintegration agent, 10-50 deals of adhesive and 3-60 deals of lubricant. The invention develops a novel animal agent for treating the parasitism, while it all uses relative high-effect drugs, with stable agent, long storage time, controllable quality and accurate agent consumption.

The present invention discloses a medicine for raising immunity of fowl body and curing avian immunosuppressive diseases. Its composition includes (by weight portion) 1-8 portions of levamisole hydrochloride, 1-10 portions of astragalus polysaccharide and 50-90 portions of carrier. Besides, said invention also provides the concrete steps of its preparation method.

The invention discloses a medicinal composition for enhancing immunity of cow and controlling mastitis, and relates to a medicament capable of enhancing the immunity of livestock and controlling diseases of the livestock, particularly breast diseases of the livestock. The medicinal composition comprises the following components based on every 100 weight parts: 2 to 6 parts of levamisole hydrochloride, 2 to 6 parts of water soluble vitamin E, 43 to 53 parts of astragalus polysaccharides, and 43 to 53 parts of epimedium herb. During preparation, the epimedium herb is crushed and screened, so that the granularity reaches 60 to 200 meshes; the epimedium herb is uniformly mixed with the levamisole hydrochloride, the water soluble vitamin E, and the astragalus polysaccharides; and the mixture is separately packaged, and the finished product is obtained. The medicinal composition for enhancing the immunity of cow and controlling mastitis has simple preparation method and low cost, and can fully utilize domestic rich Chinese medicament resources. The product can effectively prevent and control the cow mastitis, enhance the immunity of cow, has no side effect, cannot produce medicament resistance, particularly has no residue in the cow body after administration, and can further effectively solve the problem of milk drinking safety.

The invention relates to perfusate for treating cow recessive mastitis, which mainly comprises the raw materials with the following ratios: 4000-5000g of radix astragali, 4000-5000g of herba epimedii, 300-500g of levamisole hydrochloride, 300-400g of antibacterial pepetide, 2000-3000ml of glycerol, 400-500g of gelatine, and 50-100g of sodium benzoate, wherein pH of the perfusate is 5.5-7.5. The perfusate is used for treating cow recessive mastitis with determine curative effect, drug concentration for local application is high, absorption ratio is high, the direction is high, drug application is convenient and safe, thereby the goal of fast treating cow recessive mastitis is achieved, and the perfusate is compound perfusion preparation combining antibiosis, antiphlogosis and improving immunity of the organism.

The invention provides a residue testing method for levamisole hydrochloride in different tissues of an aquatic product, and belongs to the technical field of levamisole hydrochloride detection methods. The method comprises the steps of 1, setting the basic value of an ultraviolet detector of an ultra-high performance liquid chromatograph (UPLC); 2, extracting the residue of levamisole hydrochloride in the plasma of an aquatic product; 3, extracting the residues of levamisole hydrochloride in the muscle, the hepatopancreas and the kidney of the aquatic product; 4, determining the content of levamisole hydrochloride in the aquatic product. According to the technical scheme of the invention, pre-treatment technologies are optimized and rationally combined, so that the extraction and purification effect is ensured to be good. Meanwhile, the condition of the UPLC is explored and confirmed, and the sensitivity, the repeatability and the accuracy of the detection method are improved. Especially, the detection and analysis speed is accelerated by several times, and the reagent waste is lowered. The environmental pollution is reduced. The method is suitable for the residue detection of great batch of samples.

The invention relates to a method for integrally extracting levamisole hydrochloride by continuous distillation and drum crystallization. The method comprises the following steps of: enabling levamisole hydrochloride aqueous solution as a raw material to enter a rectifying tower by adopting a continuous medium feeding mode, wherein the tower top has the temperature of 99-102 DEG C and the tower reactor has the temperature of 124-127 DEG C; separating the raw material, wherein component on the tower top is water and the component in the tower reactor is levamisole hydrochlorid enrichment solution with the content of more than 85 percent and the yield of more than 89.9 percent; condensing the levamisole hydrochloride enrichment solution and crystallizing in a continuous drum crystallization device at a crystallization temperature controlled between 4 DEG C below zero and 3 DEG C below zero for 0.3-0.5h, extracting the crystal, filtering and drying to obtain a finished levamisole hydrochloride product with the concentration of more than 99 percent and the yield of 98.7 percent.

The invention discloses pharmaceutical composition for post-operative nursing for cholangitis and a preparation method of the pharmaceutical composition. The pharmaceutical composition for post-operative nursing for the cholangitis comprises components in parts by weight as follows: 12-30 parts of p-coumaric acid, 15-32 parts of naringin, 10-28 parts of cordacin, 10-25 parts of a water shield extract, 15-26 parts of mangiferin, 8-18 parts of red halloysite nano-powder, 12-24 parts of limonene, 16-28 parts of eucalyptol, 14-20 parts of chlorogenic acid, 6-12 parts of levamisole hydrochloride, 40-80 parts of a magnesium sulfate solution, 50-100 parts of corn steep liquor, 8-16 parts of potassium sorbate and 13-25 parts of mixed amino acid. Effective components of Chinese herbal medicines are added on the basis of Western medicines, the pharmaceutical composition has effects of resisting bacteria, diminishing inflammations, inhibiting intestinal infection and preventing cholestasis, effectively regulates functions of the liver, the gall bladder and intestines of a patient and improves various anomaly indexes of the body, so that relapse of the cholangitis is prevented, and post-operative body recovery of the patient can be accelerated. The pharmaceutical composition is simple in preparation process and convenient to use and has the great clinical significance.

The invention discloses a pharmaceutical composition for treating cow's bacteriological diseases, which is prepared from raw materials including dandelion, honeysuckle flower, capsule of weeping forsythia, goldthread root, astragalus root, epimeddium, sponge gourd, cottonrose hibiscus leaf, stem pith of the ricepapr plant, fritillary and levamisol hydrochloride. The invention can be applied to the treatment of cow mastitis and metritis.

The invention relates to levamisole organic acid salt, a synthetic method for the levamisole organic acid salt and a medicinal composition of the levamisole organic acid salt. The levamisole organic acid salt is represented by a general formula (I). The synthetic method for the levamisole organic acid salt comprises the following steps of: dripping an aqueous solution of sodium hydroxide into levamisole hydrochloride which is taken as an initial raw material, reacting for a period of time, extracting by using an organic solvent, and drying and concentrating to obtain white solid levamisole free alkali; and dissolving the levamisole free alkali into a reaction solvent, adding organic acid at certain temperature, reacting under stirring, filtering, freezing a filtrate till the temperature of 2 to 10 DEG C, slowly dripping a precipitation solvent under stirring, precipitating crystals, filtering, washing, and drying to obtain the levamisole organic acid salt. The method is simple and quick and is short in production cycle, low in cost and high in yield, and reaction conditions are mild. The levamisole organic acid salt has high water solubility, stability and bioavailability. The medicinal composition contains a therapeutically effective amount of levamisole organic acid salt shown as the formula (I) and a pharmaceutically acceptable carrier.

The invention discloses compound neomycin sulfate oral liquid for treating severe diarrhea of poultry. The oral liquid comprises the following components in parts by weight: 8 to 15 parts of neomycin sulfate, 3 to 6 parts of berberine hydrochloride, 1 to 3 parts of lactate TMP, 10 to 20 parts of injection astragalus polysaccharide, 2 to 4 parts of levamisole hydrochloride, 5 to 15 parts of acetaminophen, and 60 to 80 parts of injection water. The compound neomycin sulfate oral liquid for treating the severe diarrhea of the poultry is applied to the poultry, and is used for Gram-negative bacteria-induced gastrointestinal severe infection of the poultry and used for treating enteritis and diarrhea of the poultry. By using the oral liquid for treating escherichia coli infection and unknown severe diarrhea of the poultry, the significant efficiency is 94.1 percent, and the effective rate is 99.8 percent. The oral liquid is reasonable in formula compatibility, high in defecation level, low in dust content, low in pollution, high in oral bioavailability and convenient for industrialization.

The invention belongs to the technical field of an anti-parasitic drug, and particularly relates to an application of a composition containing ivermectin and levamisole hydrochloride to preparation ofa veterinary anti-parasitic drug, a transdermal solution of the veterinary anti-parasitic drug and a preparation method of the transdermal solution. The transdermal solution comprises components in parts by volume as follows: 20-50 parts of isopropanol, 10-40 parts of glycerol, 10-30 parts of absolute ethyl alcohol, 5-20 parts of dimethyl sulfoxide and 2-6 parts of azone; the content of ivermectin is 0.3-1 g per 100 mL of solution, and the content of levamisole hydrochloride is 5-15 g per 100 mL of solution. According to the invention, ivermectin and levamisole hydrochloride are combined, a synergistic effect is realized by simultaneous use of ivermectin and levamisole hydrochloride, and an anti-parasitic spectrum is improved; and meanwhile, with adoption of a transdermal absorption dosage form, toxic and side effects caused by correlation of the drug and the dosage are reduced, and a simultaneous internal and external anti-parasitic effect of the preparation is realized.

The invention belongs to the technical field of drug preparation and particularly relates to an anti-parasitic disease compound Triclabendazole granule for flocks and herds and a preparation method for the anti-parasitic disease compound Triclabendazole granule. The anti-parasitic disease compound Triclabendazole granule for the flocks and herds comprises the following components in parts by mass: 2.5-5 parts of Triclabendazole, 1-3 parts of levamisole hydrochloride and the balance auxiliary material. Compared with the prior art, the anti-parasitic disease compound Triclabendazole granule for the flocks and herds has the beneficial effects that as the Triclabendazole and the levamisole hydrochloride are combined for use, a disinsectization effect is better than that achieved by the addition of single components in the same proportion. Moreover, the recurrence rate is obviously reduced.

The invention relates to a freeze-dried vaccine drinking water immune protective agent for chicken and a preparation method thereof. The immune protective agent comprises the following components by weight: 5-10 parts of levamisole hydrochloride, 10-30 parts of mannose, 20-50 parts of lactose, 5-10 parts of n-caprylic acid, and 2-5 parts of Tween-80. The protective agent provided by the invention can regulate water quality, eliminate the interference of ions in water to vaccines, inhibit the combination of calcium ions and sodium ions with vaccines, has very good preventive and protective effects on the influence of various causes on freeze-dried vaccines in water, has no toxic or side effect, also does not produce drug residue, is convenient to use and low in cost, plays a very good role in the use of various freeze-dried vaccines in culture, and is a cheap freeze-dried vaccine protective agent simple to use.

The invention relates to a compound levamisole hydrochloride injection. Every 100 parts by weight of injection contains components in parts by weight: 3-5 parts of levamisole hydrochloride, 4-6 parts of astragalus polysaccharide, 15-20 parts of ethanol, 20-30 parts of propylene glycol, and the balance of water for injection. A preparation method of the compound levamisole hydrochloride injection comprises the following steps: (1) taking a proper amount of water for injection, sequentially adding the levamisole hydrochloride and the astragalus polysaccharide, adding the other substance after one substance is dissolved completely, and stirring to dissolve completely; and (2) sequentially adding the ethanol and the propylene glycol with prescription dosage into the solution obtained in step 1, mixing evenly, adjusting the pH value of the mixed liquor, adding the water for injection into the solution to the prescription dosage, mixing, filtering, sub-packaging, potting and sterilizing at 115-126 DEG C for 25-35 minutes. Due to the combination of traditional Chinese and western medicines, and the joint action of the levamisole hydrochloride and the astragalus polysaccharide, the compound levamisole hydrochloride injection provided by the invention can effectively improve the livestock and poultry immunity, reduce the morbidity, reduce drug residues and improve the quality of livestock and poultry products, and has a special effect on low immunity of livestock and poultry caused by the parasitic disease.

The invention relates to an osmanthus tree disease and insect pest preventing and controlling pesticide. The osmanthus tree disease and insect pest preventing and controlling pesticide is prepared from the raw materials in parts by weight: 30 to 40 parts of lithospermum, 15 to 20 parts of radix isatidis, 5 to 10 parts of rhizoma cimicifugae, 5 to 10 parts of radix zanthoxyli, 5 to 8 parts of white paeony root, 3 to 5 parts of prepared fleece-flower roots, 3 to 5 parts of selfheal, 15 to 20 parts of white radish, 0.5 to 0.8 part of norvancomycin, 0.1 to 0.2 part of levamisole hydrochloride, 0.1 to 0.5 part of copper sulphate, 0.1 to 0.5 part of quicklime, 1 to 2 parts of sodium chloride, 0.1 to 0.2 part of manganous nitrate, 1 to 2 parts of sodium carbonate, and 0.5 to 1 part of a dispersing agent. Experiment show that the osmanthus tree disease and insect pest preventing and controlling pesticide which is provided by the invention has a remarkable effect on preventing and controlling diseases and insect pests of an osmanthus tree, has a better effect than that of a pesticide which is sold on the market, and is worth of popularizing and using.

The invention discloses an animal composite immunization reinforcing agent and applications thereof, and a method for determining the optimal ratio of the components in the animal composite immunization reinforcing agent, wherein the animal composite immunization reinforcing agent is prepared from the following raw materials by weight: 20-80 parts of milkvetch root polysaccharide, 10-60 parts of concanavalin, and 7.5-30 parts of levamisole hydrochloride. According to the applications, various components of the formula are dissolved in 0.9% physiological saline according to a ration of levamisole hydrochloride to concanavalin to milkvetch root polysaccharide of 3:2:1, complete and uniform mixing is performed to prepare an injection with a concentration of 600 mg/ml, the animal is continuously injected with the injection for 3 days at a dose of 60 mg/kg/day in an intraperitoneal or intramuscular injection so as to prevent viral diseases of animals. According to the present invention, the animal composite immunization reinforcing agent has advantages of high safety, high efficiency, multipotency and low production cost.

The invention belongs to veterinary medicine for poultry, and in particular relates to a Chinese and western medicine mixture for improving an immunologic function of livestock and a preparation method thereof. The Chinese and western medicine mixture for improving the immunologic function of the livestock is characterized by comprising the following medicines in parts by weight: 1-5 parts of codonopsis pilosula, 1-4 parts of bighead atractylodes rhizome, 1-3 parts of tuckahoe, 1-3 parts of cordate houttuynia, 1-3 parts of liquorice root, 0.01-0.05 part of borneol, 0.004-0.006 part of levamisole hydrochloride and 0.01-0.03 part of cimetidine. The Chinese and western medicine mixture can be administrated by drinking water, and has the advantages of good immune-boosting effect, convenience in use and high bioavailability.