Veterinary compound ivermectin liposome medicine and preparation method thereof

A technology of ivermectin lipid and ivermectin, applied in the field of veterinary medicine, can solve problems such as unpredictable effects and different action mechanisms, and achieve the advantages of improving the survival rate of livestock and poultry, reducing drug toxicity and improving drug efficacy. Effect

Active Publication Date: 2011-12-21
SHANDONG ENKANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main reason is that the mechanism of action of ivermectin and levamisole hydrochloride is different, and those skilled in the art cannot predict the effect of the combination of the two.

Method used

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  • Veterinary compound ivermectin liposome medicine and preparation method thereof
  • Veterinary compound ivermectin liposome medicine and preparation method thereof
  • Veterinary compound ivermectin liposome medicine and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A kind of veterinary compound ivermectin liposome medicine, its raw material components are as follows:

[0027] 1 part of ivermectin, 5 parts of levamisole hydrochloride, 5 parts of lecithin, 1 part of cholesterol, 20 parts of ethyl acetate, 10 parts of propylene glycol, 0.1 part of laurocaprazine, and 58 parts of water for injection.

[0028] The preparation method of above-mentioned veterinary compound ivermectin liposome medicine, the steps are as follows:

[0029] (1) Lecithin and cholesterol are dissolved in an organic solvent, and ivermectin is added to obtain a suspension;

[0030] (2) Evaporate the suspension prepared in step (1) under reduced pressure for 10-20min at 35-50°C, pressure 0.02-0.06Mpa, speed ≥ 70r / min, a film forms on the container wall, stop evaporation , Nitrogen 10 ~ 20min.

[0031] (3) Wash the liposome film prepared in step (2) with phosphate buffer at a speed of ≥90r / min and 35-50°C for 1h, then let it stand for 1h to prepare multilocular ...

experiment example

[0035] Li, who was raising 116 sheep in Changshan Town, Zouping County, suddenly became ill, manifested as digestive disorders, loss of appetite and diarrhea, early cough, special odor in the mouth, a lot of mucus or bloody stools, weak and emaciated animals, and mental retardation , Weak hind limbs, unstable standing, pathological autopsy, found that there were worms in the small intestine of the dead cow, and migratory larvae in the blood vessels and lungs, and the comprehensive diagnosis was bovine digestive tract nematode disease. Treat with the liposome of the present invention, the specification of injection is 10ml / branch, and dosage is 0.1ml / kg, after injection once, symptom is obviously alleviated, continues treatment, after three days, basically recovers, and cure rate reaches 96.55%. The results are shown in Table 1.

[0036] Safety test results: There was no abnormal death of sick pigs after injection. After 30 days of observation, the animals suffering from the a...

Embodiment 2

[0044] Compound ivermectin liposome medicine as described in Example 1, the difference is that the raw material components are as follows:

[0045] 1.5 parts of ivermectin, 7.5 parts of levamisole hydrochloride, 10 parts of lecithin, 2 parts of cholesterol, 30 parts of glycerin formal, 10 parts of propylene glycol, 0.25 parts of laurocaprolactone, and 38 parts of water for injection.

[0046] The preparation steps are as described in Example 1, the difference is that the obtained compound ivermectin liposome drug is mixed with glucose and stirred evenly to obtain the compound ivermectin liposome powder.

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Abstract

The invention relates to a compound ivermectin liposome medicine and a preparation method thereof, in particular to a veterinary compound ivermectin liposome medicine which is developed by an encapsulating technology and a preparation method thereof, and belongs to the technical field of veterinary medicines. The veterinary compound ivermectin liposome medicine comprises the following raw material components in part by weight: 0.5 to 1.5 parts of ivermectin, 1 to 10 parts of levamisole hydrochloride, 5 to 20 parts of lecithin, 1 to 10 parts of cholesterol, 10 to 40 parts of organic solvent, 10 to 20 parts of propylene glycol, 0.1 to 1.0 part of iaurocapram and 30 to 60 parts of injection water. The veterinary compound ivermectin liposome medicine has target performance and long-acting performance, reduces toxicity, improves the stability of encapsulated medicines and has extremely high potential capacity of improving the survival rate of livestock; simultaneously, the ivermectin is creatively compounded with the levamisole hydrochloride, so that the curative effect of the medicine is improved, and the toxicity of the medicine is reduced.

Description

technical field [0001] The invention relates to a compound ivermectin drug and a preparation method thereof, in particular to a veterinary compound ivermectin liposome drug developed by encapsulation technology and a preparation method thereof, belonging to the technical field of veterinary drugs . Background technique [0002] Ivermectin is a macrolide antibiotic, abamectin B 1 Derivatives of two components B 1a and B 1b in C 22 and C 23 A mixture of saturated double bonds. Ivermectin has a good killing effect on internal and external parasites, especially arthropods and internal nematodes. Its deworming mechanism is to promote the release of Y-amino acid (GABA) from presynaptic neurons, thereby opening the GABA-mediated chloride ion channel. The nearby glutamate-mediated ion channel is also selective and high-affinity. It is mainly used for gastrointestinal nematodes, lung nematodes and parasitic arthropods of horses, cattle, sheep and pigs, intestinal nematodes, e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/429A61K9/127A61P33/14
Inventor 陈建波李世江陈抗
Owner SHANDONG ENKANG PHARMA
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