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Worm-disease-resisting compound niclosamide tablet for beasts and birds and preparation method thereof

A technology for compound niclosamide tablets and anti-helminth disease, which is applied in the direction of anti-infective drugs, pill delivery, oil/fat/wax non-active ingredients, etc., can solve the problem of poor taste and cost of compound niclosamide tablets Low-level problems, to achieve the effect of reducing cumbersome steps and medication time, simple production equipment, and good disintegration

Inactive Publication Date: 2013-01-09
TIANJIN BIJIA PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The prior art shows that the compound niclosamide insect repellent tablet has the disadvantages of bitter taste and poor taste. Even if it is mixed into the feed, livestock and poultry still have a certain disassembly of the drug. In addition, the tablet is a suitable auxiliary material for drug addition. The prepared tablet has a higher dissolution rate and bioavailability than powder, powder, and premix; the dose is accurate, and the difference in drug content in the tablet is small; the tablet is a dry solid, with stable quality, transportation, storage, carrying, The application is relatively convenient; mechanized production, large output, low cost, and easy to achieve hygienic standards

Method used

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  • Worm-disease-resisting compound niclosamide tablet for beasts and birds and preparation method thereof
  • Worm-disease-resisting compound niclosamide tablet for beasts and birds and preparation method thereof
  • Worm-disease-resisting compound niclosamide tablet for beasts and birds and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1. Prescription composition

[0030]

[0031] The Tiandixiang is a product of Beijing Tiandida Science and Technology Co., Ltd., which is divided into poultry and veterinary use. The main components are organic acids, natural plant essential oils, vanillin, alcohols, aldehydes, flavor enhancers, carriers, etc. The heaven and earth incense in this formula can be used for poultry or animals.

[0032] 2. Preparation method

[0033] Take 1 / 10 of the prescription amount of starch, add 3-5 times the amount of water, heat to 60-70°C, stir until it is completely gelatinized, and then get the starch paste; add the prescription amount of niclosamide, levamisole hydrochloride, manna Alcohol, oral glucose or sucrose, and 9 / 10 of the prescription amount of starch are mixed fully, stirred for 20 minutes, and the mixture is obtained; the starch paste is added to the above mixture and mixed, and wet method is used to make a soft material. , granulated with a 17 mesh sieve; then th...

Embodiment 2

[0035] 1. Prescription composition

[0036]

[0037] 2. Preparation method

[0038] The steps of the preparation method of this embodiment are the same as those in Example 1.

Embodiment 3

[0040] 1. Prescription composition

[0041]

[0042] 2. Preparation method

[0043] The steps of the preparation method of this embodiment are the same as those in Example 1.

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Abstract

The invention provides a worm-disease-resisting compound niclosamide tablet for beasts and birds and a preparation method thereof. The worm-disease-resisting compound niclosamide tablet for beasts and birds respectively includes the following components by mass: 0.5-2 parts of tiandixiang (a flavoring agent), 0.5-2 parts of aspartame, 8-12 parts of starch, 20-40 parts of oral glucose or cane sugar, 0.5-2 parts of mannitol, 0.3-0.8 part of magnesium stearate, 40-60 parts of niclosamide and 2.5-5 parts of levamisole hydrochloride. The preparation method includes performing 17-mesh palletizing through a starch inside-outside addition and wet process mode, drying for 2-3 hours at the temperature of 65-75 DEG C, performing 17-mesh granulating straightening, additionally mixing the tiandixiang, the aspartame and the magnesium stearate, performing tabletting and the like to obtain the finished products. The worm-disease-resisting compound niclosamide tablet is bright and clean in appearance, fast in disintegration, good in desinsectization effect after being taken orally, simple in process, good in taste and suitable for industrial production, and various indexes of the tablet are optimized.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, in particular to a helminthic compound niclosamide tablet for livestock and poultry and a preparation method thereof. Background technique [0002] Niclosamide, alias: 4′-nitro-2′, 5-dichlorosalicylanilide; it is a kind of tapeworm drug and a molluscicide, it can inhibit the absorption of glucose by tapeworms, and is effective against tapeworms The uncoupling of the oxidative phosphorylation process in the mitochondria blocks the tricarboxylic acid cycle, leading to the accumulation of lactic acid, thereby killing tapeworms, and has a good repelling effect on Pyrocephala equine, liquid Pyrecocephala and parapyrocephala pygmy. It is effective against Monitz's tapeworm, yolkless gland tapeworm and striped tapeworm in cattle and sheep, and has the same effect on the tapeworm scolex and somites. It has the effect of repelling and killing Taenia riley and Taenia funnelina in poultry. It...

Claims

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Application Information

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IPC IPC(8): A61K31/429A61K47/26A61K47/44A61K9/20A61P33/10A61K31/167
Inventor 要瑞丽元军英范培柱范培松裴毅
Owner TIANJIN BIJIA PHARMA CO LTD
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