6 results about "Niclosamide" patented technology

The present invention concerns compositions comprising at least one niclosamide compound, such as niclosamide or a pharmaceutically acceptable salt thereof, and at least one permeability enhancer, such as glycerol or dimethylpalmityl-ammonio propanesulfonate (PPS), and their use of such compositions as niclosamide agents. Advantageously, the niclosamide compound is capable of being transported across a Caco-2 cell membrane by at least 150% relative to the amount capable of being transported across the Caco-2 cell membrane in the absence of the permeability enhancer. Compositions, including oral dosage forms, and methods for delivering niclosamide compounds, such as for treatment or prevention of human coronavirus infections, are also provided.

The present invention relates to a pharmaceutical composition for prevention or treatment of coronavirus infections, comprising a delayed-release composition of niclosamide or a pharmaceutically acceptable salt thereof, and a method for preventing or treating coronavirus infections by using the same.

The present invention provides a combination comprising niclosamide and spironolactone for use in the treatment of diseases caused by RNA virus in a subject in need thereof. The present invention further provides a combination comprising niclosamide and spironolactone for simultaneous, separate, or sequential use.

This invention belongs to the field of electrochemical sensor technology and aims to solve the problems of low sensitivity, insufficient charge transport efficiency, and weak target enrichment ability of existing electrochemical detection methods for niclosamide. It provides a highly sensitive electrochemical detection method and sensor for niclosamide based on MOF / COF composite materials. The sensor uses a glassy carbon electrode modified with MOF / COF composite material as the working electrode, combined with an auxiliary electrode and a reference electrode to form a three-electrode system. It utilizes the synergistic effect of the high specific surface area and high catalytic activity of MOF and the good conductivity and ordered porous structure of COF to enhance the adsorption, enrichment, and electron transfer efficiency of niclosamide. The detection method achieves accurate detection of niclosamide by optimizing electrochemical test parameters and employing square wave voltammetry. This invention features a low detection limit, wide linear range, strong anti-interference ability, excellent stability and reproducibility, and can rapidly detect niclosamide in water, soil, fish, and tablets, possessing broad practical application value.

The present invention relates to a novel cocrystal, a pharmaceutical composition comprising same and a preparation method therefor. By using the cocrystal of the present invention, cancers, inflammatory diseases, or viral infection diseases may be effectively prevented and / or treated.