12 results about "Niclosamide" patented technology

The present invention concerns compositions comprising at least one niclosamide compound, such as niclosamide or a pharmaceutically acceptable salt thereof, and at least one permeability enhancer, such as glycerol or dimethylpalmityl-ammonio propanesulfonate (PPS), and their use of such compositions as niclosamide agents. Advantageously, the niclosamide compound is capable of being transported across a Caco-2 cell membrane by at least 150% relative to the amount capable of being transported across the Caco-2 cell membrane in the absence of the permeability enhancer. Compositions, including oral dosage forms, and methods for delivering niclosamide compounds, such as for treatment or prevention of human coronavirus infections, are also provided.

The present invention concerns compositions comprising at least one niclosamide compound, such as niclosamide or a pharmaceutically acceptable salt thereof, and at least one permeability enhancer, such as glycerol or dimethylpalmityl-ammonio propanesulfonate (PPS), and their use of such compositions as niclosamide agents. Advantageously, the niclosamide compound is capable of being transported across a Caco-2 cell membrane by at least 150% relative to the amount capable of being transported across the Caco-2 cell membrane in the absence of the permeability enhancer. Compositions, including oral dosage forms, and methods for delivering niclosamide compounds, such as for treatment or prevention of human coronavirus infections, are also provided.

The present invention relates to a pharmaceutical composition for prevention or treatment of coronavirus infections, comprising a delayed-release composition of niclosamide or a pharmaceutically acceptable salt thereof, and a method for preventing or treating coronavirus infections by using the same.

The present invention provides a pyridine ester compound containing urea structure and its preparation method and application, which belong to the technical field of chemical molluscicides. The pyridine ester compound containing urea structure provided by the present invention has a good killing effect on golden apple snails and is almost non-toxic to non-target organisms, and is environmentally friendly. The results of the embodiments show that the pyridine ester compounds of the structure shown in D-1~D-15 provided by the present invention all have certain molluscicidal activity as molluscicides, among which D-1, D-2, D-3, D-6, D-7, and D-8 are similar to niclosamide in molluscicidal activity against golden apple snails after 72h of immersion method, that is, under 2mg / L drug concentration, after 72h, the snail mortality rate is more than 87.5% of niclosamide, and the fish toxicity is significantly reduced compared with niclosamide.

The present invention provides a combination comprising niclosamide and spironolactone for use in the treatment of diseases caused by RNA virus in a subject in need thereof. The present invention further provides a combination comprising niclosamide and spironolactone for simultaneous, separate, or sequential use.

The present invention provides the use of sodium percarbonate in the preparation of a product that reduces acute toxicity in fish, relating to the technical field of schistosomiasis control. The present invention uses sodium percarbonate to reduce the acute toxicity of niclosamide to fish. This novel application can, to a certain extent, resolve the conflict between schistosomiasis control and aquaculture, and can serve as an emergency protection measure during drug snail control in aquaculture areas.

The utility model discloses a washing and drying device for preparing niclosamide ethanolamine salt, and relates to the technical field of biological medicine products, the washing and drying device comprises a bottom plate, the top of the bottom plate is fixedly connected with a conveying device, the top of the bottom plate is fixedly connected with a warning board, and the top of the bottom plate is provided with a washing device; the washing device comprises a motor, the motor is arranged above the bottom plate, and a support is fixedly connected to the top of the bottom plate. Through mutual cooperation of the motor, the water tank, the rotating shaft, the baffle, the waste water tank and other components in the washing device, when the motor is started, the baffle on the rotating shaft intermittently opens the water outlet, and the waste water is discharged; water in the water tank flows downwards for washing, the washed water enters the waste water tank through the water leakage groove, the touch button is touched when the water in the waste water tank reaches a certain weight, the sound box gives an alarm, the washing effect is achieved, and meanwhile waste water is collected.

This invention belongs to the field of electrochemical sensor technology and aims to solve the problems of low sensitivity, insufficient charge transport efficiency, and weak target enrichment ability of existing electrochemical detection methods for niclosamide. It provides a highly sensitive electrochemical detection method and sensor for niclosamide based on MOF / COF composite materials. The sensor uses a glassy carbon electrode modified with MOF / COF composite material as the working electrode, combined with an auxiliary electrode and a reference electrode to form a three-electrode system. It utilizes the synergistic effect of the high specific surface area and high catalytic activity of MOF and the good conductivity and ordered porous structure of COF to enhance the adsorption, enrichment, and electron transfer efficiency of niclosamide. The detection method achieves accurate detection of niclosamide by optimizing electrochemical test parameters and employing square wave voltammetry. This invention features a low detection limit, wide linear range, strong anti-interference ability, excellent stability and reproducibility, and can rapidly detect niclosamide in water, soil, fish, and tablets, possessing broad practical application value.

Methods of treating cancer in a subject in need thereof are provided. The methods include administering to the subject a therapeutically effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt or derivative thereof. Compounds and compositions are also provided.

The utility model relates to the technical field of pesticides, in particular to niclosamide ethanolamine preparation centrifugal equipment which comprises a box body, a sleeve is arranged on the side wall of one side of the box body, a third motor is arranged on the side wall of the sleeve, a conveying plate is connected with the box body in a sliding mode, a straight toothed plate is arranged at the bottom end of the conveying plate and meshed with a gear, and the gear is connected with the box body in a sliding mode. A third motor runs to drive a conveying plate to move towards the front end and the rear end, materials are conveyed through a conveying belt, potential safety hazards caused by manual material taking and feeding of workers are prevented through automatic discharging and discharging, a rotating drum rotating at a high speed is buffered through springs at the top ends of two sets of supporting columns, and the safety of the rotating drum is improved. According to the centrifugal equipment for preparing niclosamide ethanolamine, materials are loaded uniformly, the phenomenon that due to the fact that the materials are loaded unevenly or the equipment has problems, operation is unbalanced, and strong vibration is caused is avoided, the whole device is stabilized through the reinforcing rods and the base, and the situation that due to vibration generated by centrifugal force, the equipment topples over or is damaged, and danger is caused is avoided.

The present invention relates to a novel cocrystal, a pharmaceutical composition comprising same and a preparation method therefor. By using the cocrystal of the present invention, cancers, inflammatory diseases, or viral infection diseases may be effectively prevented and / or treated.