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49 results about "Schistosomiases" patented technology
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Application of ackermann muciniphile or external vesicles thereof in preparation of drugs for treating schistosomiasis
The invention belongs to the technical field of biological medicines, and relates to application of Ackermann muciniphile or its external vesicles in preparation of a drug for treating schistosomiasis. The anti-infection immunity of a host is enhanced by adjusting intestinal flora balance (recovering diversity and composition) and improving immune response (adjusting macrophage, CD8 + T cell recruitment and Th1 / Th2 balance); meanwhile, the intestinal barrier function is improved, and pathogen invasion and inflammation are reduced; hepatic granuloma and hepatic fibrosis caused by schistosome infection are obviously relieved, and the liver function is improved; the key effect of the MIF gene in immunoregulation is disclosed, and a new direction is provided for schistosomiasis immunotherapy. Besides, the probiotics are high in treatment safety and free of obvious side effects, can be combined with chemotherapy to enhance the curative effect and reduce the side effects and drug resistance of chemical drugs, provides a lasting and comprehensive adjuvant therapy scheme for the schistosomiasis, and has important clinical application potential.
Owner:HUBEI UNIV OF MEDICINE
Schistosomiasis detection miracidia incubation observation device
Owner:HUBEI PROVINCIAL CENT FOR DISEASE CONTROL & PREVENTION (HUBEI ACAD OF PREVENTIVE MEDICINE)
Application of KLB protein in preparation of medicine for treating schistosome infection
The invention relates to the technical field of medicines, in particular to application of KLB protein in preparation of a medicine for treating schistosome infection. The invention verifies the treatment effect of the KLB protein on hepatic tissue EMT and fibrosis caused by schistosoma japonicum infection, and proves that the KLB can be used as a medicine for treating schistosoma japonicum hepatic fibrosis.
Owner:INST OF PARASITIC DISEASE PREVENTION & CONTROL CHINESE CENT FOR DISEASE CONTROL & PREVENTION (NAT RES CENT FOR TROPICAL DISEASES)
SiRNA for schistosoma japonicum hsc20 gene expression and application thereof
This invention relates to the fields of molecular biology and biomedicine, and discloses siRNA for the expression of the *Schistosoma japonicum* Hsc20 gene and its applications. The siRNA contains a nucleotide sequence that hybridizes to a target sequence of the *Schistosoma japonicum* Hsc20 gene, wherein the target sequence is selected from the sequences shown in SEQ ID NO. 1-SEQ ID NO. 4. The siRNA specifically inhibiting the expression of the *Schistosoma japonicum* Hsc20 gene provided by this invention can be used to interfere with the transcription and expression of the *Schistosoma japonicum* Hsc20 gene and the growth and development of *Schistosoma japonicum*. In vitro experiments have confirmed that the siRNA provided by this invention can efficiently silence the *SjHsc20* gene; and in vivo RNA interference experiments in mice show that this siRNA can induce 50.62% (…) P The insect reduction rate was <0.05% and 44.29% ( P A liver oocyte reduction rate of <0.01% is suitable for preparing drugs to treat schistosomiasis.
Owner:FOSHAN UNIVERSITY
Application of iron oxide nanoparticles in target treatment of schistosome eggs
The invention discloses application of iron oxide nanoparticles in target treatment of schistosome eggs, and relates to the cross technical field of nano material target delivery and disease prevention and control. On the basis of paramagnetism, a microtubule structure and surface electrical characteristics of schistosoma japonicum egg shells, electrically neutral Fe3O4 magnetic nanoparticles with the particle size of 8-15 nm or electropositive Fe3O4-NH2 magnetic nanoparticles with the surface modified by amino groups are innovatively adopted, efficient egg penetration is achieved through magnetic targeted enrichment and physical-static synergistic effect, and in-vivo and in-vitro experiments prove that the effect of effectively penetrating through the eggs is achieved. The Fe3O4 and Fe3O4-NH2 nanoparticles have obvious worm egg targeting capability, and the penetrating efficiency of the Fe3O4 and Fe3O4-NH2 nanoparticles on worm eggs exceeds 38%, so that an important experimental basis is provided for subsequent development of a nano-drug delivery system for preventing and treating schistosomiasis.
Owner:JIANGNAN UNIV +1
Application of combination of small organic molecule compound and bivalent copper ions in preparation of medicine for treating schistosomiasis japonicas
The invention belongs to the technical field of medicine treatment, and particularly relates to application of combination of an organic small molecule compound and bivalent copper ions in preparation of a medicine for treating schistosomiasis japonicas. The invention provides an application of combination of an organic small molecule compound and bivalent copper ions in preparation of a medicine for treating schistosomiasis japonicas. The organic small molecule compound is selected from one or more of a compound with a structure as shown in a formula 1-1, a compound with a structure as shown in a formula 2-2 and a compound with a structure as shown in a formula 3. According to the invention, development of schistosoma japonicum at multiple juvenile stages in vivo can be blocked in a targeted manner through combination, the schistosoma load and the spawning rate are reduced, compared with praziquantel, the drug has better schistosoma killing activity, and preparation and application of the drug for treating schistosoma japonicum with efficient insect killing can be realized.
Owner:GANNAN NORMAL UNIV
Schistosomiasis transmission risk dynamic simulation method based on data fusion and AI
The invention discloses a schistosomiasis transmission risk dynamic simulation method based on data fusion and AI, and relates to the technical field of intelligent medical treatment. The method comprises the following steps: firstly, collecting environment, biological media, crowd society and intervention measure multi-source heterogeneous data, and unifying the data to a standard spatio-temporal data cube; then data preprocessing is carried out, and feature variables strongly related to propagation risks are constructed; then the processed data and the characteristic variables are input into a risk simulation engine, the engine adopts a hybrid framework in which a mechanism model and an AI prediction model are deeply fused, a dynamic assimilation algorithm is introduced, and risk level maps of different spatial and temporal scales in the future are output; finally, intervention measure scene simulation is carried out based on the risk level map, the cost-benefit ratio is quantitatively evaluated, and an optimal prevention and control strategy suggestion is generated. According to the method, the hysteresis and static defects of a traditional method are overcome, and real-time sensing, dynamic prediction and intelligent decision support of the schistosomiasis transmission risk are achieved.
Owner:JIANGXI INST OF PARASITIC DISEASE CONTROL
Application of biomarker in preparation of schistosoma japonicum katsurada diagnosis product and treatment drug
PendingCN119827608AOrganic active ingredientsMaterial analysis by observing effect on chemical indicatorSchistosomiasesMetabolite
The invention discloses application of a biomarker in preparation of a schistosoma japonicum katsurada disease diagnosis product and a schistosoma japonicum katsurada disease treatment medicine. The biomarker is uridine or uridine metabolism key enzyme Upse1. According to the invention, through a large amount of research and analysis of changes of metabolites in early and chronic stages of schistosoma japonicum katsurada infection, characteristic metabolites and metabolic pathways are found; exploring and analyzing regional specificity change conditions of abundance of various metabolites in livers of mice with different infection times; surprisingly, a key enzyme Upse1 for uridine metabolism is obviously up-regulated 6 weeks after infection, and the liver uridine level is negatively related to the abundance of various lipid-related metabolites; through verification and specificity and sensitivity research, the uridine or the metabolic key enzyme Upase1 thereof can be used as a characteristic marker molecule of schistosoma japonicum katsurada infection and can be used for developing schistosoma japonicum katsurada diagnosis products. Further research finds that uridine supplemented in vitro can play an anti-fibrosis role, and uridine can be used as a drug for treating schistosoma japonicum katsurada.
Owner:JIANGSU INST OF PARASITIC DISEASES
Antigenic peptide, immunogenic composition against schistosomiasis containing the peptide, and uses
PCT designated stageWO2025166439A1Antibody medical ingredientsFermentationSchistosomiasesImmunogenicity
The present invention relates to a new vaccine candidate against schistosomiasis. This vaccine candidate is composed of peptides from different proteins of the parasite Schistosoma mansoni. Additionally, the present invention relates to use of the peptides for preparing a medicament for the prevention and / or treatment of schistosomiasis and to a method for preventing and / or treating schistosomiasis.
Owner:INSTITUTO BUTANTAN
Use of curcumin compounds in the preparation of a medicine for treating schistosomiasis, pharmaceutical composition
ActiveCN117281798BRedox enzymesSchistosomiases
This invention relates to the field of biopharmaceutical technology, and more particularly to the application of curcuminoid compounds in the preparation of drugs for treating schistosomiasis, and pharmaceutical compositions thereof. The curcuminoid compounds used in this invention contain different substituents on their benzene rings, which can effectively regulate the electrophilic and lipophilic properties of the compounds, making them easier to enter the schistosomiasis cell. They interact with redox enzymes within the schistosomiasis cell, disrupting the redox balance and promoting schistosomiasis death. Therefore, they exhibit highly effective therapeutic activity against schistosomiasis and show great promise for application in the preparation of drugs for treating schistosomiasis.
Owner:GANNAN NORMAL UNIV
Compounds and their use in treating schistosomiasis
ActiveCN115322199BOrganic active ingredientsGroup 5/15 element organic compoundsSchistosomiasesPharmaceutical drug
Owner:MERCK PATENT GMBH
Long-acting slow-release compound preparation for preventing and treating schistosomiasis
PendingCN119499251Asave energyeasy to solveOrganic active ingredientsPharmaceutical non-active ingredientsSchistosomiasesTreatment effect
The invention provides a long-acting slow-release compound preparation for preventing and treating schistosomiasis. The compound preparation comprises two active ingredients, namely niclosamide and praziquantel, the niclosamide accounts for 10-90% of the weight of the compound preparation; praziquantel accounts for 10%-90% of the weight of the compound preparation; the coating further comprises a biodegradable high polymer material and a dispersion medium. Optionally, a wetting agent; the biodegradable high polymer material accounts for 12.5%-14.3%; the dispersion medium accounts for 50.0%-57.1%; and the wetting agent accounts for 0-5.7%. The compound preparation can maintain long-acting slow release after being administrated once, has excellent prevention and control and treatment effects on schistosomiasis, particularly has good prevention and treatment effects on larvae and / or adults of schistosomiasis, blocks a transmission chain of the schistosomiasis, protects human beings and animals from schistosomiasis infection, and has huge economic benefits and social benefits.
Owner:INST OF PARASITIC DISEASE PREVENTION & CONTROL CHINESE CENT FOR DISEASE CONTROL & PREVENTION (NAT RES CENT FOR TROPICAL DISEASES)
A class of benzoyl hydrazide compounds, their preparation methods and applications
ActiveCN116947688BOrganic compound preparationCarboxylic acid nitrile preparationBenzoic hydrazideNew medications
The present invention provides a class of benzoyl hydrazide compounds, belonging to the technical field of pharmaceutical chemistry. The structure of the benzoyl hydrazide compounds is shown in general formula I. The benzoyl hydrazide compounds of the present invention have the effect of killing Schistosoma japonicum. The emergence of new drugs overcomes the problem of drug resistance caused by long-term use of existing anti-schistosomiasis drugs, and has important scientific value and research value for finding new anti-schistosomiasis drugs.
Owner:GANNAN NORMAL UNIV
Schistosoma japonicum miRNA simulant with apoptosis function and application of schistosoma japonicum miRNA simulant
The invention relates to the technical field of bioengineering, in particular to a schistosoma japonicum miRNA simulant with an apoptosis function and an application of the schistosoma japonicum miRNA simulant. The invention relates to a schistosoma japonicum miRNA (micro Ribonucleic Acid) simulant, which is characterized in that the schistosoma japonicum miRNA simulant is a simulant designed aiming at a schistosoma japonicum miRNA molecule as sja-miR-2a-3p, and the nucleotide sequence of the sja-miR-2a-3p is TCACAGCCAGTATTGATGAACG. The research shows that the sja-miR-2a-3p and the simulant of the sja-miR-2a-3p disclosed by the invention are expected to become an innovative medicine for treating the hepatic fibrosis related to the schistosoma japonicum katsurada.
Owner:SHANGHAI VETERINARY RESEARCH INSTITUTE CAAS (CHINESE ANIMAL HEALTH & EPIDEMIOLOGY CENTER SHANGHAI BRANCH)
Use of biomarker in preparation of diagnostic product and therapeutic drug for schistosomiasis japonica
The use of a biomarker in the preparation of a diagnostic product and therapeutic drug for Schistosomiasis japonica, wherein the biomarker is uridine or Upase1, which is a key enzyme in uridine metabolism. By means of a large number of studies, changes in metabolites in early and chronic stages of Schistosomiasis japonica infection were analyzed to screen for characteristic metabolites and metabolic pathways. By means of exploring and analyzing abundant region-specific changes of a plurality of metabolites in the liver of mice at different infection stages, it was surprisingly found that Upase1, which is a key enzyme in uridine metabolism, was significantly up-regulated 6 weeks after infection, and the hepatic uridine level was negatively correlated with the abundance of a plurality of lipid-related metabolites. Moreover, verification, and specificity and sensitivity studies confirmed that uridine or Upase1, which is a key enzyme in uridine metabolism, could be used as a characteristic marker molecule for Schistosomiasis japonica infection, and for developing diagnostic products for Schistosomiasis japonica. Further studies have found that in vitro supplementation with uridine can exert an anti-fibrotic role, and uridine can be used as a therapeutic drug for Schistosomiasis japonica.
Owner:JIANGSU INST OF PARASITIC DISEASES
Monoclonal antibody aiming at schistosoma japonicum SPRM1hc protein and application thereof
PendingCN122060061AOrganic active ingredientsImmunoglobulins against animals/humansAntigenSchistosomiases
The invention provides a monoclonal antibody aiming at schistosoma japonicum SPRM1hc protein and application of the monoclonal antibody, and belongs to the technical fields of parasite infection treatment, biological medicine, immunotherapy and in-vitro diagnosis. The invention provides two monoclonal antibodies A028 and A032 which can be specifically combined with the extracellular domain of SPRM1hc protein, the actual effect of the monoclonal antibodies A028 and A032 in treatment of schistosoma japonicum katsurada after infection is verified, and the monoclonal antibodies A028 and A032 have a remarkable treatment effect in an infected animal model, and can reduce polypide load, reduce egg deposition and improve tissue pathological damage. The application of the monoclonal antibody to preparation of drugs for resisting schistosoma japonicum katsurada infection and development of schistosoma japonicum katsurada antigen detection kits has very important practical significance.
Owner:SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY +1
Application of sodium percarbonate in the preparation of products for reducing acute toxicity of fish
The present invention provides the use of sodium percarbonate in the preparation of a product that reduces acute toxicity in fish, relating to the technical field of schistosomiasis control. The present invention uses sodium percarbonate to reduce the acute toxicity of niclosamide to fish. This novel application can, to a certain extent, resolve the conflict between schistosomiasis control and aquaculture, and can serve as an emergency protection measure during drug snail control in aquaculture areas.
Owner:丹阳市疾病预防控制中心 +1
Liver fibrosis detection grading model construction method applied to schistosomiasis
The invention discloses a liver fibrosis detection grading model construction method applied to schistosomiasis, and relates to the technical field of medical detection, multi-modal liver sample data is collected and subjected to standardization processing to generate standard multi-modal data, different standard multi-modal data is subjected to feature processing by adopting corresponding processing methods, and the classification model construction method is applied to the schistosomiasis. Liver image features, serum biochemical marker features and pathological section features representing the influence of the schistosomiasis on liver fibrosis are obtained, a multi-mode combined grading diagnosis model is constructed based on the features to conduct liver fibrosis detection on patients related to the schistosomiasis, and the detection result of liver fibrosis detection is verified. And performing dynamic optimization on the multi-modal joint grading diagnosis model based on a detection result, evaluating a model indication of the multi-modal joint grading diagnosis model after dynamic optimization is completed, and determining whether to adjust optimization parameters for performing dynamic optimization on the multi-modal joint grading diagnosis model or not based on the model indication.
Owner:JIANGSU INST OF PARASITIC DISEASES
Application of aspirin in preparation of anti-schistosoma japonicum katsurada medicine
The invention relates to application of aspirin in preparation of an anti-schistosoma japonicum medicine, and in the invention, by applying a schistosoma japonicum infection mouse model, the treatment effect of aspirin on schistosoma japonicum is found. Specifically, the aspirin can significantly reduce the number of insect bodies infected in mice and the number of eggs deposited in livers, and can effectively inhibit the antigen secretion ability of the eggs infected in the livers of the mice, the granuloma inflammation induced by the eggs and the hepatic fibrosis degree, so that the aspirin can be applied to treatment of schistosoma japonicum katsurada. And a new application of aspirin is added clinically. As a non-steroidal anti-inflammatory drug, aspirin is widely applied clinically, has the advantages of safety, reliability, stability, low cost, easiness in obtaining and the like, and is relatively deep in pharmacological research and relatively clear in action mechanism. Therefore, the scheme of the invention is suitable for clinical popularization and use.
Owner:SUN YAT SEN UNIV
A three-in-one forceps
The utility model discloses a three-in-one tweezers relates to the field of schistosomiasis prevention and cure. The tool includes tweezers, and the tweezers tail end is connected with two tweezers arms through connecting shaft, and the connecting shaft is rotatably connected with sleeve with hammer handle, and the connecting shaft is equipped with limiting stopper to limit sleeve corner, and the hammer handle bottom end is fixed with hammer head, and the tweezers front end is equipped with telescopic steel needle, and the steel needle tip can extend or retract, and the front end is equipped with fastening knob to lock steel needle. The connecting shaft is composed of detachable left and right half shafts, is fastened through positioning plug, insertion slot and connecting screw, and is equipped with damping between sleeve and half shaft to make hammer handle can hover at will. The tool integrates clamping, crushing and picking functions, does not need to frequently change tools, and effectively improves detection snail efficiency.
Owner:马鞍山市疾病预防控制中心(马鞍山市卫生监督所)
A kit for diagnosing schistosomiasis
ActiveCN114959062BMicrobiological testing/measurementMicroorganism based processesBacteroidesSchistosomiases
The present invention discloses a kit for diagnosing schistosomiasis, which detects the hepatic granuloma and liver fibrosis induced by schistosome invasion by using the abundance changes of three bacteria, namely Bacteroides, Blautia, and Enterococcus, as intestinal flora biomarkers. Compared with traditional methods such as serological indicators, it has the advantages of high sensitivity, strong specificity, and non-invasiveness, thereby specifically detecting the degree of liver injury and achieving precise detection of schistosome-induced liver injury; compared with traditional blood detection methods such as AST and ALT, it is non-invasive and reduces contact with blood products; compared with imaging examinations such as B-ultrasound and CT, it has the advantages of portability and simplicity; the required equipment is simple, the test results are intuitive, the requirements for operators are low, it can effectively reduce the detection cost, and it is suitable for primary medical institutions and population screening sites.
Owner:SUN YAT SEN UNIV
Method for detecting schistosoma japonicum katsurada and host oncomelania thereof through double-probe fluorescent quantitative PCR
PendingCN119320830Ahigh sensitivitygood effectMicrobiological testing/measurementDNA/RNA fragmentationSchistosomiasesTest sample
The invention discloses a method for detecting schistosoma japonicum katsurada and host oncomelania of the schistosoma japonicum katsurada through fluorescent quantitative PCR (polymerase chain reaction) by using a double probe method. The target gene of the schistosoma japonicum katsurada is one of 16S rRNA (ribosomal ribonucleic acid), 18S small subunit rRNA gene, non-LTR (long-term transposon) retrotransposon SjCHGCS19 and non-LTR retrotransposon SjCHGCS20; the host oncomelania quality control gene is one of a COX1 gene, a 18S rRNA (ribosomal Ribonucleic Acid) gene and a 28S rRNA (ribosomal Ribonucleic Acid) gene. Preferably, the target gene of the schistosoma japonicum katsurada is the 18S small subunit rRNA gene, and the host oncomelania quality control gene is the 28S rRNA gene. The method can be used for rapidly and accurately detecting the schistosoma japonicum katsurada and the host oncomelania of the schistosoma japonicum katsurada, so that whether a detection sample is infected by the schistosoma japonicum katsurada or not can be rapidly judged, the schistosoma japonicum katsurada can also be used for evaluating the schistosoma japonicum katsurada spreading risk, and reference is provided for
Owner:ANHUI PROVINCIAL CENT FOR DISEASE CONTROL & PREVENTION (PROVINCIAL HEALTH EDUCATION INST PROVINCIAL PUBLIC HEALTH RES INST)
Application of 5HTR1 and Sj5HTR1 gene segments, dsRNA for interfering schistosome and application of dsRNA
The invention discloses application of 5HTR1 and Sj5HTR1 gene segments, dsRNA for interfering schistosome and application of the dsRNA, the nucleotide sequence of a sense strand of the dsRNA is as shown in SEQ ID NO.1, the nucleotide sequence of an antisense strand of the dsRNA is as shown in SEQ ID NO.2, and the dsRNA can be applied to preparation of anti-schistosomiasis drugs. The dsRNA is targeted to a 5-hydroxytryptamine receptor 1, development and survival of schistosome and oviposition of female schistosome can be remarkably inhibited, damage of schistosome to host pathology can be effectively reduced, and it is also shown that Sj5HTR1 is a potential anti-schistosome treatment target and plays an important role in schistosome biology.
Owner:FUDAN UNIVERSITY
Schistosoma japonicum circulating DNA and application thereof
PendingCN120249494AMicrobiological testing/measurementDNA/RNA fragmentationSchistosomiasesNucleotide
The invention provides circulating DNA (deoxyribonucleic acid) of schistosoma japonicum katsurada and application thereof, and particularly provides a kit for detecting the infection condition of schistosoma japonicum katsurada in a patient, which comprises a component for detecting a circulating DNA sequence of schistosoma japonicum katsurada, the circulating DNA sequence of the schistosoma japonicum katsurada is selected from any one or a combination of more of the following groups: nucleotide sequences as shown in SEQ ID NO: 1, SEQ ID NO: 4, SEQ ID NO: 7, SEQ ID NO: 10, SEQ ID NO: 13 and SEQ ID NO: 16. The circulating DNA provided by the invention can be used for curative effect examination of schistosoma japonicum katsurada chemotherapy, and also can be used for diagnosing schistosoma japonicum katsurada; according to the detection method provided by the invention, a sample can be obtained by collecting peripheral blood, the blood can be collected at any time in the treatment process, and the chemotherapy effect is dynamically monitored in real time; the method has the advantages of low cost and effectiveness, is a promising method for examining the curative effect of the schistosomiasis, and is also used for nucleic acid diagnosis of the schistosomiasis.
Owner:THE NAVAL MEDICAL UNIV OF PLA
Application of baicalin in preparation of medicine for inhibiting and / or treating schistosoma japonicum katsurada and medicine
The invention discloses an application of baicalin in preparation of a medicine for inhibiting and / or treating schistosomiasis japonicas. The invention further discloses a medicine for inhibiting and / or treating schistosomiasis. Experiments prove that after praziquantel kills schistosoma japonicum adults, baicalin is used for treatment, so that liver and spleen injuries caused by schistosoma japonicum infection are effectively relieved, the liver function of a host is protected, the influence of eggs in the host and schistosoma japonicum egg protein secreted by the eggs on the host is reduced, and the survival rate of schistosoma japonicum adults is increased. The treatment effect of the praziquantel is obviously better than that of the existing praziquantel
Owner:THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
Double-stranded ribonucleic acid composition for targeted inhibition of SjHAT1 expression and application thereof
PendingCN121472217AOrganic active ingredientsAntiparasitic agentsRapid amplification of cDNA endsSchistosomiases
The invention relates to a double-stranded ribonucleic acid composition for targeted inhibition of SjHAT1 expression and application of the double-stranded ribonucleic acid composition, and relates to the technical field of biological medicines. The method comprises the following steps: firstly, acquiring a full-length cDNA sequence of SjHAT1 by utilizing a cDNA terminal rapid amplification (RACE) technology in early-stage work, and accurately positioning a transcription condition and a distribution condition of the SjHAT1 gene in schistosoma japonicum adults by utilizing the acquired full-length cDNA sequence. Furthermore, according to the full-length cDNA sequence of the SjHAT1, the dsRNA composition for knocking down the SjHAT1 in a targeted mode is designed, the dsRNA composition can efficiently knock down the SjHAT1, the interference effect is good, the validity period is long, the treatment effect is better than that of a targeted drug DW-3-15, the dsRNA composition shows a good action effect in both in-vivo and in-vitro experiments, and the dsRNA composition has good application prospects. Wide application prospects are realized in the aspects of treatment of schistosomiasis, preparation of insecticides and the like.
Owner:SUZHOU UNIV
Oral mRNA vaccine delivery system aiming at schistosoma japonicum katsurada insect protection host
The invention relates to an oral mRNA vaccine delivery system aiming at schistosoma japonicum katsurada parasite protecting hosts. The invention discloses an oral mRNA vaccine based on a bacillus subtilis spore delivery system for schistosoma japonicum parasite protection hosts, which has the characteristics of simplicity and convenience in preparation, friendly inoculation mode, good immune effect and the like, and is particularly suitable for large-scale immunization of the schistosoma japonicum parasite protection hosts such as cattle, sheep and the like so as to block the propagation of schistosoma japonicum from the source. The invention not only provides powerful scientific and technological support for achieving the goal of eliminating schistosomiasis in Healthy China 2030, but also greatly spans and innovates on the existing oral bacterial carrier technology.
Owner:SUN YAT SEN UNIV
Use of aakmanmuciniphilus or outer vesicle thereof in preparation of a drug for treating schistosomiasis
The application belongs to the technical field of biological medicine, and relates to application of mucinophilic Akkermansia or outer vesicles thereof in preparation of a schistosomiasis treatment drug. The application enhances host anti-infection immunity by regulating intestinal flora balance (restoring diversity and composition), improving immune response (regulating macrophages, CD8+ T cell recruitment and Th1 / Th2 balance), improving intestinal barrier function, reducing pathogen invasion and inflammation, significantly reducing liver granuloma and liver fibrosis caused by schistosome infection, and improving liver function. The application reveals the key role of MIF gene in immune regulation, and provides a new direction for schistosomiasis immunotherapy. In addition, the probiotic treatment has high safety, no obvious side effects, can be combined with chemotherapy, enhances the curative effect, reduces the side effects of chemical drugs and drug resistance, provides a persistent and comprehensive adjuvant treatment scheme for schistosomiasis, and has important clinical application potential.
Owner:HUBEI UNIV OF MEDICINE
Aryl hydantoin compounds and methods of use
Provided herein are aryl hydantoin compounds having the structure of Formula (I) wherein X, R1, R2, R3, R4, and n are described herein. Also provided herein are compositions comprising compounds of Formula (I) and methods of using compounds of Formula (I) in treating, inhibiting, and / or preventing a parasitic disease (e.g., Schistosomiasis).
Owner:BOARD OF RGT UNIV OF NEBRASKA
AI-assisted schistosomiasis intelligent blood prevention information monitoring and early warning management method and system
This invention discloses an AI-assisted intelligent schistosomiasis control information monitoring, early warning, and management method and system, relating to the field of deep learning technology. The method includes: acquiring multi-source monitoring data through an intelligent data acquisition terminal network; constructing a multimodal spatiotemporal knowledge graph and a multi-timescale feature library; constructing a deep temporal network with enhanced spatiotemporal attention based on the multimodal spatiotemporal knowledge graph to capture the spatiotemporal evolution pattern of media propagation and generate predicted infection numbers for each grid unit; extracting historical weather features and infection number sequences from the multi-timescale feature library, calculating weighted baseline values for weather-similar days and moving percentile anomaly reference values, and fusing them into a dynamic early warning baseline. This invention significantly improves prediction accuracy and interpretability in data-sparse areas by capturing key historical fragments through an attention mechanism in the temporal dimension and aggregating neighborhood propagation information through a graph structure in the spatial dimension.
Owner:HUNAN PROVINCE SCHISTOSOMIASIS CONTROL INSTITUTE (HUNAN PROVINCE THIRD PEOPLES HOSPITAL)