4 results about "Schistosomiases" patented technology

This invention relates to the field of biopharmaceutical technology, and more particularly to the application of curcuminoid compounds in the preparation of drugs for treating schistosomiasis, and pharmaceutical compositions thereof. The curcuminoid compounds used in this invention contain different substituents on their benzene rings, which can effectively regulate the electrophilic and lipophilic properties of the compounds, making them easier to enter the schistosomiasis cell. They interact with redox enzymes within the schistosomiasis cell, disrupting the redox balance and promoting schistosomiasis death. Therefore, they exhibit highly effective therapeutic activity against schistosomiasis and show great promise for application in the preparation of drugs for treating schistosomiasis.

The use of a biomarker in the preparation of a diagnostic product and therapeutic drug for Schistosomiasis japonica, wherein the biomarker is uridine or Upase1, which is a key enzyme in uridine metabolism. By means of a large number of studies, changes in metabolites in early and chronic stages of Schistosomiasis japonica infection were analyzed to screen for characteristic metabolites and metabolic pathways. By means of exploring and analyzing abundant region-specific changes of a plurality of metabolites in the liver of mice at different infection stages, it was surprisingly found that Upase1, which is a key enzyme in uridine metabolism, was significantly up-regulated 6 weeks after infection, and the hepatic uridine level was negatively correlated with the abundance of a plurality of lipid-related metabolites. Moreover, verification, and specificity and sensitivity studies confirmed that uridine or Upase1, which is a key enzyme in uridine metabolism, could be used as a characteristic marker molecule for Schistosomiasis japonica infection, and for developing diagnostic products for Schistosomiasis japonica. Further studies have found that in vitro supplementation with uridine can exert an anti-fibrotic role, and uridine can be used as a therapeutic drug for Schistosomiasis japonica.

The utility model discloses a three-in-one tweezers relates to the field of schistosomiasis prevention and cure. The tool includes tweezers, and the tweezers tail end is connected with two tweezers arms through connecting shaft, and the connecting shaft is rotatably connected with sleeve with hammer handle, and the connecting shaft is equipped with limiting stopper to limit sleeve corner, and the hammer handle bottom end is fixed with hammer head, and the tweezers front end is equipped with telescopic steel needle, and the steel needle tip can extend or retract, and the front end is equipped with fastening knob to lock steel needle. The connecting shaft is composed of detachable left and right half shafts, is fastened through positioning plug, insertion slot and connecting screw, and is equipped with damping between sleeve and half shaft to make hammer handle can hover at will. The tool integrates clamping, crushing and picking functions, does not need to frequently change tools, and effectively improves detection snail efficiency.

This invention discloses an AI-assisted intelligent schistosomiasis control information monitoring, early warning, and management method and system, relating to the field of deep learning technology. The method includes: acquiring multi-source monitoring data through an intelligent data acquisition terminal network; constructing a multimodal spatiotemporal knowledge graph and a multi-timescale feature library; constructing a deep temporal network with enhanced spatiotemporal attention based on the multimodal spatiotemporal knowledge graph to capture the spatiotemporal evolution pattern of media propagation and generate predicted infection numbers for each grid unit; extracting historical weather features and infection number sequences from the multi-timescale feature library, calculating weighted baseline values ​​for weather-similar days and moving percentile anomaly reference values, and fusing them into a dynamic early warning baseline. This invention significantly improves prediction accuracy and interpretability in data-sparse areas by capturing key historical fragments through an attention mechanism in the temporal dimension and aggregating neighborhood propagation information through a graph structure in the spatial dimension.