88 results about "Early cirrhosis" patented technology

The invention discloses a traditional Chinese medicine composition used for curing chronic hepatitis and a preparation method thereof. The traditional Chinese medicine composition is made of raw material medicines with the weight proportion by parts: 40 to 160 parts of Chinese thorowax root, 40 to 160 parts of debark peony root, 40 to 160 parts of angelica, 40 to 160 parts of India madder root, 40 to 160 parts of largehead atractylodes rhizome, 40 to 160 parts of Tuckahoe, 40 to 160 parts of turtle carapace, 40 to 160 parts of massa medicata fermentata hunanensis, 60 to 240 parts of Codonopsis pilosula nannfeldt, 60 to 240 parts of Lalang Grass Rhizome, 24 to 96 parts of immature orange fruit, 20 to 80 parts of green tangerine peel, 12 to 48 parts of villous amomum fruit, 12 to 48 parts of earthworm and 12 to 48 parts of liguorice. The traditional Chinese medicine composition of the invention has the pharmacological efficacies of antagonizing hepatic damage, protecting liver, regulating immune function, reducing aminopherase, improving liver function and on the like, and the clinical efficacy observation experiments prove that the traditional Chinese medicine composition has the exact efficacies to the chronic hepatitis, in particular to chronic active hepatitis, chronic persisting hepatitis and early cirrhosis; and the clinical application is of safety and no toxicity and side effects.

Compound methilanin thiamin is used to assist treat that acute and chronic hepatitis, fatty liver, early cirrhosis of liver, toxic hepatitis brought by arsenic and barbiturate and other diseases in clinic. But, there is only liquid drugs injection supplied in market at present. Compound methilanin thiamin is unstable to heat; thiamin is easy to decompose on condition of solution, opacification or precipitate; after sterilization at high temperature, content of thiamin in liquid drugs injection will decrease for decomposition; meantime the storage and transport for liquid drugs injection is not convenient. The invention overcomes the shortage of methilanin thiamin liquid drugs injection, increases stability of drug, is propitious to transport and storage; and avoids freezing easily in winter and affecting quality of drug, prolongs drug storage life, improves quality of drug, in order to treat patients more safely and effectively.

The invention discloses a pharmaceutical composition for treating liver diseases, which is prepared by the following active ingredients according to the mixture ratio by weight: liquoric root: white paeony root is equal to 1: 1.1-1: 1.9. In addition, the invention further discloses a preparation method, a use and a quality detection method of the pharmaceutical composition. Clinical observation proves that the pharmaceutical composition can effectively reduce aminotransferase, stop liver area pain and effectively restore liver functions, so that the pharmaceutical composition can be used for treating acute and chronic viral hepatitis and early cirrhosis, and also has better efficacy for patients with advanced schistosomiasis. The medicament with the formula has no toxicity or side effects and can meet the period treatment demand of the patients with the acute and chronic viral hepatitis.

The medicine for dispelling heat and toxin of liver to treat hepatitis B has recipe comprising capillary artemisia, rhubarb, giant knotwoiod, patrinia herb, stringy stonecrop and other 11 kinds of Chinese medicinal materials. It is used to treat mainly acute viral hepatitis, acute serious hepatitis, acute and chronic hepatitis B and hepaticirrhosis in early stage, and may be used also to treat bile-silting up hepatitis and poisonous hepatitis owing to its functions of clearing away internal heat and toxic matter, promoting diuresis, eliminating icterus, dispersing stagnated liver energy, benefiting vital energy and dispelling blood clots.

The invention relates to a marker for intestinal microecology and application thereof, in particular to a biomarker used for early diagnoses of liver cancer. The biomarker used for early diagnoses ofliver cancer is composed of 34 kinds of genes shown as SEQ ID NO:1-34, and the genes are enriched in intestinal tracts. The invention also provides a detection reagent, and the reagent includes a primer used for detecting the 34 kinds of genes shown as SEQ ID NO:1-34. Feces of patients in groups are collected through a noninvasive method, and 16S rRNA Miseq sequencing of intestinal florae is conducted. During a discovery period of the biomarker, through a random forest law, microorganism gene markers with specificity of early liver cancer are identified among patients suffering from early cirrhosis and liver cancer, patients suffering from cirrhosis and healthy comparisons, an index of a probability of disease (POD) of liver cancer is created, and verification of the markers during the discovery period is achieved. During the verification period of the markers, the POD index of the patients during the verification period is calculated, and verification of the diagnosis value of the patients suffering from liver cancer during the verification period according to the POD index is achieved.

The invention provides gynostemma pentaphylla liver protecting and nourishing health-care tea which is characterized by comprising the following raw materials in parts by weight: 10-50 parts of gynostemma pentaphylla, 10-20 parts of glossy privet fruits, 10-20 parts of isatis roots, 10-20 parts of radix curcumae, 10-20 parts of salviae miltiorrhizae, 10-20 parts of poria cocos, 10-20 parts of notopterygium roots, 10-20 parts of capillary artemisia, 10-20 parts of radices trichosanthis, 10-20 parts of Scutellaria baicalensis, 10-20 parts of radix paeoniae alba, 10-20 parts of jasmine, 10-20 parts of loranthus parasiticus and 10-20 parts of schisandra chinensis, wherein gynostemma pentaphylla has the functions of reducing blood fat, blood pressure and blood sugar, calming, hypnotizing, resisting stress, ulcer and fatigue, prolonging lifetime of cells, enhancing appetite, enhancing resistance, promoting bowel movement, calming panting and suppressing cough, eliminating haemorrhoids, reducing weight, treating deficiency syndrome, inhibiting formation of gall-stone, preventing and treating side effects of glucocorticoid, preventing aging and the like. The tea has very high health-care effect to treat various liver diseases such as chronic hepatitis, forepart hepetocirrhosis, fatty liver, alcoholic liver and medicamentous liver lesion, and is strong in pertinence.

The invention discloses granules for treating chronic hepatitis and forepart hepetocirrhosis. The granules are prepared from the following substances in parts by weight of 14-18 parts astragalus mongholicus, 15-18 parts of codonopsis pilosula, 14-18 parts of white atractylodes rhizome, 15-18 parts of radices trichosanthis, 22-26 parts of rhizoma anemarrhenae, 15-17 parts of rhizoma sparganii, 15-18 parts of curcuma zedoary, 14-17 parts of endothelium corneum gigeriae galli, 20-25 parts of radix paeoniae alba, 22-26 parts of tuckahoe, 22-25 parts of angelica sinensis, 47-49 parts of root of red-rooted salvia, and 9-11 parts of leech. The granules disclosed by the invention can protect hepatocyte, reduces degeneration, necrosis and immune injury of the hepatocyte, promotes degradation of a collagenous fiber, adjusts cellular immune function, and reduces inflammation and necrosis of the hepatocyte. The traditional Chinese medicine granules are wide in the crowd in clinical use, long in application time, good in clinical curative effect and free of bad reaction.

The invention discloses a blood marker for diagnosing hepatic fibrosis and early cirrhosis. The blood marker refers to galectin 3. The concentration of the galectin 3 in the blood is analyzed by using the blood marker through enzyme linked immune reaction so as to analyze and evaluate hepatic fibrosis and early cirrhosis. By using the blood as the detection sample, early diagnosis on hepatic fibrosis and early cirrhosis can be achieved conveniently and rapidly.

The invention aims to provide a traditional Chinese medicine for treating forepart hepetocirrhosis and a preparation method thereof. The traditional Chinese medicine comprises evodia, Chinese angelica, white peony root, Sichuan lovage rhizome, tangshen, cassia twig, donkey-hide gelatin, tree peony bark, ginger, licorice, prepared pinellia tuber, dwarf lilyturf root, Chinese thorowax root, immature orange fruit and Poria cocos. According to the invention, evodia and cassia twig warm yang and dispel cold, Chinese angelica, Sichuan lovage rhizome, tree peony bark, white peony root and donkey-hide gelatin regulate blood conditions and remove blood stasis, tangshen, ginger, licorice, prepared pinellia tuber and Poria cocos invigorate the spleen and regulate middle warmer, and the dwarf lilyturf root nourishes yin and moisturizes dryness. The traditional Chinese medicine provided by the invention employs reasonably combined raw materials, uses combined therapy of cooling and warming, is capable of both purging and tonifying and can simultaneously treat principal and subordinate symptoms, thereby achieving the purposes of softening the liver and eliminating indigestion. The traditional Chinese medicine for treating forepart hepetocirrhosis has a good therapeutic effect on forepart hepetocirrhosis; no adverse reaction is spotted in usage of the traditional Chinese medicine, and the traditional Chinese medicine is safe and reliable.

The invention discloses an oral medicine composition containing disopropylamine dichloroacetate, which also contains gluconate and a pharmaceutically accepted pH regulator. The oral medicine composition has good medicine stability, and is used for treating diseases such as acute and chronic hepatitis, hepatomegaly, early-phase hepatocirrhosis and so on.

The invention discloses a medicament for treating chronic hepatitis, which comprises the following components in part by weight: 30 to 60 parts of heterophylly falsestarwort root, 20 to 50 parts of glossy ganoderma, 20 to 50 parts of hovenia dulcis, 30 to 60 parts of chicken's gizzard-membrane, 30 to 100 parts of mongolian dandelion herb, 30 to 60 parts of hawthorn fruit, 40 to 60 parts of shizandra berry, 20 to 40 parts of astragalus, 20 to 45 parts of common leafflower herb, 20 to 90 parts of liquoric root, 25 to 75 parts of honeysuckle, 30 to 45 parts of Chinese angelica and 30 to 70 parts of tangerine peel. Based on Chinese medicinal and pharmacologic theory, through years of clinical practice, the medicament for treating the chronic hepatitis is prepared from pure Chinese medicaments which are selected from Chinese medical treasury and have the effects of clearing away heat and toxic materials, eliminating stagnation and removing blood stasis, promoting blood circulation and regulating qi, activating immunity and inhibiting virus, has the good treatment effect on various kinds of acute and chronic hepatitis, and also has the good treatment effect on early liver cirrhosis ascites. The effective rate of the medicament can reach 93.3 percent through clinical statistics.

The present invention discloses a kind of hepatitis B treating medicine composition and its preparation process. The medicine composition is prepared with 40 kinds of Chinese medicinal materials, including oldenlandia, gromwell, chicken bone herb, ecliptae, etc. The medicine composition has the functions of resisting virus, regulating immunity, resisting liver fibrosis and improving liver function, so that it has obvious curative effect on chronic hepatitis B, early stage hepatocirrhosis, ascites of liver, hepatosplenomegaly and middle stage hepatocirrhosis, and no side effect.

The invention relates to a medicine for hepatic fibrosis and early cirrhosis treatment, belonging to Chinese herbal medicine, which comprises ten to twenty grams of bupleurum chinense, fifteen to thirty grams of red sage root, fifteen to twenty grams of turmeric root-tuber, ten to twenty grams of curcuma zedoariae, twenty to thirty grams of turtle shell, fifteen to twenty grams of rhizome corydalis, ten to twenty grams of costus roots, fifteen to twenty grams of largehead atractylodes rhizome, fifteen to twenty grams of fructus forsythiae, fifteen to twenty grams of alisma orientale, twenty to thirty grams of hiraute shiny bugleweed herb and twenty to thirty grams of fructus polygoni orientalis.

The invention relates to a traditional Chinese medicine used for treating hepatitis B, and specifically relates to a traditional Chinese medicine composition used for treating hepatitis B, wherein the medicine is prepared from Chinese herbal medicines. The traditional Chinese medicine is prepared from the medicine materials of: 15g of Chinese thorowax root, 10g of Baikal skullcap root, 10g of figwortflower picrorhiza rhizome, 10g of banksian rose, 30g of red peony root, 10g of raw rhubarb, 30g of capillary wormwood herb, 15g of male fern rhizome, 15g of asiabell root, and 15g of Mongolian milkvetch root. The traditional Chinese medicine used for treating hepatitis B has functions of liver soothing, qi regulating, heat clearing, dampness removing, blood cooling, detoxifying, pathogen eliminating, and qi supporting. The medicine provides substantial treatment effects against chronic hepatitis B and early-stage liver cirrhosis.

The invention relates to an anti-aging honey. 6-7?times?amount?of?water is added into selected traditional Chinese medicine raw materials, filtrate without precipitates is mixed with honey according to the weight ratio of 1:1.6-2.5, the mixture is concentrated until the content of the traditional Chinese medicines is 5-15% and then the concentrated mixture is fed to bees, bees take the mixture, honey is collected and poisonous impurities are removed from the honey, so that the anti-aging honey is obtained. The honey containing various kinds of traditional Chinese medicines are decomposed and made under action of biological enzymes of bees, and the test shows that the content of various beneficial?components is higher than 5-10 times that of the common honey. Various traditional Chinese medicines capable of tonifying and nourishing liver are added into the honey raw materials, so that the anti-aging honey has obvious efficacies of protecting liver and obvious therapy effect on chronic hepatitis and early chronic hepatitis. The anti-aging honey does not has any toxic and side effects, and is convenient to take and suitable for long-term?administration?of patients.

The invention relates to a medicament for treating chronic hepatitis and early-phase hepatocirrhosis and a preparation method thereof. The medicament is characterized by consisting of largehead atractylodes rhizome (fried), nutgrass galingale rhizome (processed), white paeony root, zedoary, common burreed rhizome, Chinese angelica, papaya, rhubarb, safflower, turtle shell (roasted), peach seed, turmeric root-tuber, virgate wormwood herb, seaweed, kelp, figwort root, rehmannia root, prepared rehmannia root, giant knotweed, ground beetle, bupleurum, tuber fleeceflower root (processed), Chinese trumpetcreeper flower, dung beetle, trogopterus dung, black bean and Chinese lobelia herb. The method comprises the following steps of: smashing raw materials according to the composition and weight ratio; continuously refluxing and extracting; concentrating the extract; and drying and smashing the condensate to obtain the medicament. The medicament has the remarkable advantages of improving liver fat metabolism and the organization structure of a pathologic liver, protecting the liver, remarkably saving water and steam by over 50 percent, reducing drying time, keeping the functions of the raw materials, contributing to absorbing, along with high bioavailability, high active ingredient content, low energy consumption, easy operation and the like.

The invention relates to the technical field of biology and discloses a non-alcoholic chronic fatty liver hepatitis (NASH) rat model and an establishment method and application thereof. An adult rat is fed with special feed (MCD feed) short of methionine and choline or a special high-fat feed (CDAA feed) short of choline, a certain amount of sodium nitrite solution is provided for the animal within a certain time, and the established non-alcoholic chronic fatty liver hepatitis rat model has the characteristics of chronic liver fibrosis and earlier liver fibrosis. The rat model is simple in establishment process, a technical means is easy, the establishment cost is low, the rat model has very high animal model value for scientific research and research and development of drugs, especially serves as a specific animal model with NASH accompanied with severe liver hepatitis and earlier liver fibrosis and belongs to a national initiative.

The invention aims at providing a prescription for treating hepatitis. The prescription comprises the following components: 12 grams of angelica sinensis, 12 grams of radix rubiae, 12 grams of radix bupleuri, 12 grams of lumbricus, 10 grams of radix paeoniae rubrathe, 12 grams of cattail pollen, 10 grams of immature bitter oranges, 12 grams of trogopterus dung, 10 grams of turtle shells, 12 grams of endothelium corneum gigeriae galli, 10 grams of pericarpium citri reticulatae viride, 20 grams of pork livers and 20 grams of couchgrass roots. The prescription provided by the invention puts an emphasis on liver protection, has an outstanding curative effect and is suitable for the treatment of multiple hepatitis symptoms, such as chronic hepatitis, early-phase hepatocirrhosis, banti syndrome, hepatalgia, abdominal fullness and distention, abnormal liver function, hyperhepatia, and the like.

Disclosed is a compound diisopropylamine dichloroacetate freeze dried preparation, which comprises unit dosage of tensicor 10-200mg, sodium gluconate 9.5-200mg, and at least one pharmaceutically acceptable carrier, the carrier comprises excipient, pH modifier, anti-oxidant agent, stabilizer, and is provided in the form of unit amount in the container.

The medicine for treating acute and chronic hepatitis B is prepared with 11 kinds of Chinese medicinal materials including pseudostellaria root, trogopterus dung, red sage, chicken's gizzard membrane, taraxacum, etc. The medicine can regulate immunological cell and liver function, excite body to produce interferon to inhibit the virus replication inside the liver, killing virus gene HBV-DNA to inhibit re-combination of hepatitis B virus and promote blood circulation to eliminate blood stasis. It has stable curative effect and no any toxic side effect. It has also high curative effect on early stage hepatocirrhosis.

The invention provides pure traditional Chinese medicine pills for treating hepatitis and a preparation method thereof. The pure traditional Chinese medicine pills are prepared from the following crude drugs: radix paeoniae alba, oldenlandia diffusa, polygonum cuspidatum, astragalus membranaceus, periostracum cicada, radix pseudostellariae, radix salviae miltiorrhizae, silkworm larva, radix sophorae flavescentis, radix bupleuri, stir-frying turtle shell with vinegar, poria cocos, Chinese wolfberries, human placenta, oriental wormwood, felwort, dandelion, sedum sarmentosum, radix rehmanniae recen, schisandra chinensis, ligusticum wallichii, isatis root, hawthorn, abrus cantoniensis hance, rhizoma atractylodis macrocephalae and liquorice. The crude drugs are used together to bring out the best in each other and have the efficacies of reinforcing qi and nourishing blood, protecting liver and reducing enzyme, clearing heat and promoting dieresis, soothing liver-qi stagnation, dispersing blood stasis and detoxifying, regulating liver and tonifying spleen, removing heat from the liver and benefiting gallbladder, detoxifying and eliminating acute communicable diseases; the pure traditional Chinese medicine pills can effectively restrain hepatitis C virus, have remarkable curative effect for negativing surface antigen of hepatitis B and reducing enzyme, contribute to recovering liver function, improve the immunity, have the efficacy of softening liver to remove stasis, are simple in preparation method, short in pharmacy course of treatment, small in toxic or side effect, easy to produce and low in cost, and facilitate large-scale popularization.

A drug for treating early cirrhosis ascites is prepared according to a routine preparation method by 18-30 parts of lanceolata, 20-40 parts of astragalus, 13-20 parts of deep-fried atractylodes, 13-20 parts of tangerine peel, 13-20 pars of Chinese yam, 12-18 parts of areca peel, 13-20 parts of wolfiporia cocos, 10-16 parts of sparganium, 10-16 parts of curcuma rhizome, 12-18 parts of citrus aurantium, 10-16 parts of magnolia cortex, 9-15 parts of rhubarb, 12-15 parts of eucommia, 15-20 parts of flos caryophyllata, 12-15 parts of costus root, 12-15 parts of curcuma tuber, 12-15 parts of coptis, 12-15 parts of scutellaria, 12-15 parts of phellodendron, 15-25 parts of artemisia capillaries, 12-15 parts of alpinia officinarum hance, 20-25 parts of each component of Jiaosanxian, 12-15 parts of faeces trogopterpri, 12-15 parts of rhizoma corydalis, 6-10 parts of licorice, 13-20 parts of plantain seed, 20-25 pars of fenugreek seed, and 15-20 parts of gardenia. The drug of the invention has the efficacy of invigorating energy and elevating yang, supplementing qi and generating body fluid, diuresis and detumence, drying moisture and alleviating water retention, relieving pain and expelling pus, and has a high cure rate when treating early cirrhosis ascites with few side effects on human body.

The invention belongs to the field of health-care products, and in particular relates to a ganoderma liver-protection tea and a preparation method thereof. The preparation method of the ganoderma liver-protection tea comprises the steps of: crushing, mixing, stirring, pelletizing and drying ganoderma capense, ganoderma sinense, ganoderma lucidum karst and raw ganoderma lucidum spore powder to obtain pure ganoderma tea particles, and then spraying traditional Chinese medicine extract on the surface of the pure ganoderma tea particles for drying, thus obtaining the ganoderma liver-protection tea. The ganoderma liver-protection tea adds various traditional Chinese medicinal materials for tonifying and nourishing the liver into raw ganoderma, thus having the obvious effect of protecting the liver; when being supplied for patients with different types of hepatopathy for long-term drinking, the ganoderma liver-protection tea can be cooperative with the conventional hepatopathy drugs so as to protect the liver, degrade enzyme, prevent and treat diseases, and has an obvious curative effect especially on chronic hepatitis, chronic active hepatitis earlier-cirrhosis. The ganoderma liver-protection tea has no toxic and side effects, can be conveniently administrated, and is suitable for long-term administration by patients.

A dripping pill of silybin for treating hepatitides, early hepatocirrhosis and hyperlipemia is prepared from silybin and matrix chosen from polyglycol 6000, polyglycol 4000, sodium stearate, poloxamer, and monoglyceride stearate. Its preparing process is also disclosed.

The invention discloses a spleen-invigorating and diuresis-promoting preparation for patients with earlier period cirrhosis and a preparation method for the preparation. The spleen-invigorating and diuresis-promoting preparation is prepared from the following main raw materials in parts by weight: 10-15 parts of curcuma aromatica, 8-16 parts of rhizoma anemarrhenae, 12-18 parts of poria cocos, 5-10 parts of cortex acanthopanacis, 7-15 parts of kummerowia striata, 16-20 parts of angelica sinensis, 11-17 parts of dahurian patrinia herb, 6-13 parts of rosa davurica pall, 11-16 parts of dried radix rehmanniae, 15-20 parts of codonopsis pilosula, 9-13 parts of fingered citron, 4-9 parts of fried malts and 8-15 parts of sargentodoxa cuneata. The preparation can be used for treating both symptoms and root causes; low possibility of relapse is achieved, and the treating cost is low; the economic burden of the patient can be relieved; no side effect, and no adverse effect are achieved; the paint of the patient can be obviously relieved.

The invention provides a Chinese medicinal broth preparation for treating early phase cirrhosis and its preparation process, wherein the medicament is prepared from the following raw materials (by weight portion): astragalus root, radix salvia miltiorrhiza each 25-30g, Siberian solomonseal rhizome, chicken's gizzard-skin, isatic root, capsule of weeping forsythia, herba patriniae each 18-20g, white atractylodes rhizome, poria cocos, curcuma aromatica, Chinese angelica root, ligustrum japonicum, pilose asiabell root, panax ginseng each 12-15g, dried human placemta each 4-5g.

The invention relates to a medicament for treating hepatosis, and the effective constituents of the medicament is made by crude drugs of Astragalus root, carapax amydae, red sage root, ganoderma lucidum, chicken-bone herb or stringy stonecrop or phyllanthus, Atractylis ovata, radices paeoniae rubra and radix bupleuri; the crude drugs can be made into various oral preparations and external preparations by proper treatment and / or adding acceptable supplementary materials in pharmaceutics; and the medicament of the invention can benefit the vital energy and disperse the depressed liver-energy as well as promoting blood flow and softening hard mass, so the invention is mainly used for the treatment of early cirrhosis, chronic hepatitis and hepatic fibrosis.

The invention relates to the field of detection technology and particularly discloses a direct quantitative detection kit for alpha-ketoglutaric acid in human serum. The direct quantitative detection kit comprises a serum sub-packaging tube, a hepes buffer solution, a reducing coenzyme, an enzyme stabilizer, a fluorescent dye and an alpha-KG standard. The kit disclosed by the invention can quickly and efficiently detect alpha-ketoglutaric acid in the serum of patients suffering from liver cirrhosis and liver cancer, thereby providing a technical guarantee for detecting and screening patients suffering from early liver cirrhosis and liver cancer. Compared with the traditional chromatography coupled detection method, nuclear magnetic resonance method and the like, the kit disclosed by the invention is low in cost and simple to operate and has the characteristics of high speed and high throughput; the kit for detecting alpha-ketoglutaric acid in serum has specific selectivity and relatively high stability; and compared with a biological detection method, the kit is obviously improved in operation repeatability, can be used as an effective tool for diagnosing liver cirrhosis and liver cancer, is of great significance to early detection of liver diseases and evaluation of treatment effects, and has broad application prospects.

The invention is concerned with the Chinese traditional medicine combination for clearing away the heat-evil and expelling superficial evils, consists of capillary artemisia, Scutellaria barbata D.Don, tuckahoe, radix curcumae, herba lycopi, safflower, bupleurum, amber, and paeonia lactiflora pallas, which can treat clearing hepatitis B virus and early liver cirrhosis. The invention is also concerned with the preparation method and preparation of the Chinese traditional medicine combination.