Medicinal composition for oral use containing diisopropylamine dichloroacetate

A technology of diisopropylamine dichloroacetate and composition, which is applied in the field of oral pharmaceutical composition containing diisopropylamine dichloroacetate, and achieves the effects of good stability, thermal stability, and convenient administration

Inactive Publication Date: 2009-06-24
AVENTIS PHARMA HAINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention has prepared various oral forms of diisopropylamine dichloroacetate compound preparations, which effectively solves the deficiencies in the use of existing injection preparations, and solves the heat stability of diisopropylamine dichloroacetate compound preparations in a specific way at the same time sexual defect

Method used

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  • Medicinal composition for oral use containing diisopropylamine dichloroacetate
  • Medicinal composition for oral use containing diisopropylamine dichloroacetate
  • Medicinal composition for oral use containing diisopropylamine dichloroacetate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] (the existence form of this embodiment is granule)

[0017]

[0018] Preparation:

[0019] Weigh the prescribed amount of diisopropylamine dichloroacetate, sodium gluconate, citric acid and sucrose, mix evenly, add water to granulate, dry, granulate, put into a plastic composite film bag; that is.

Embodiment 2

[0021] (the existence form of this embodiment is capsule)

[0022]

[0023] Preparation:

[0024] Weigh the prescribed amount of diisopropylamine dichloroacetate, sodium gluconate, citric acid, microcrystalline cellulose, and lactose, mix evenly, add water to granulate, dry, granulate, and pack into capsule shells; to obtain.

Embodiment 3

[0026] (the existing form of this embodiment is oral liquid)

[0027]

[0028] Preparation:

[0029] Take by weighing citric acid, glycerin, sorbitol, lemon essence, tartrazine in the purified water of prescription quantity, stir evenly, obtain solution I; Take by weighing prescription quantity diisopropylamine dichloroacetate, sodium gluconate in solution In I, stir until dissolved, filter, fill, and obtain.

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Abstract

The invention discloses an oral medicine composition containing disopropylamine dichloroacetate, which also contains gluconate and a pharmaceutically accepted pH regulator. The oral medicine composition has good medicine stability, and is used for treating diseases such as acute and chronic hepatitis, hepatomegaly, early-phase hepatocirrhosis and so on.

Description

technical field [0001] The invention relates to an oral pharmaceutical composition for treating acute and chronic hepatitis, fatty liver, liver cirrhosis and other liver diseases, in particular to an oral pharmaceutical composition containing diisopropylamine dichloroacetate. Background technique [0002] Diisopropylamine dichloroacetate is a vitamin B 15 , the active ingredient of pangemic acid, has a strong lipotropic effect, can inhibit and reduce the deposition of fat in the liver, prevent liver cell damage, and promote the regeneration of damaged liver cells. It can also improve the oxygen utilization rate of brain tissue and increase the blood flow of brain tissue, thereby strengthening brain tissue metabolism, increasing brain tissue respiration and promoting the process of glucose aerobic enzymatic hydrolysis. It can be used for the treatment of acute and chronic hepatitis, fatty liver, liver cirrhosis and other liver diseases. It can also be used for sequelae of st...

Claims

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Application Information

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IPC IPC(8): A61K31/205A61K9/16A61K9/48A61K9/20A61K9/08A61P1/16
Inventor 袁筝
Owner AVENTIS PHARMA HAINAN
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