201results about How to "Reduce necrosis" patented technology

The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides methods and compositions for the use of nanoemulsion compounds as mucosal adjuvants to induce immunity against environmental pathogens. Accordingly, in some embodiments, the present invention provides nanoemulsion vaccines comprising a nanoemulsion and an inactivated pathogen or protein derived from the pathogen. The present invention thus provides improved vaccines against a variety of environmental and human-released pathogens.

The invention relates to a microscopic surgical operation navigation system based on augmented reality and a navigation method. The navigation system comprises a fixing frame, a graph mark, a camera, a controller and display equipment, wherein the fixing frame comprises a foundation, a connection member, a fixing rod and a supporting board. The navigation method comprises steps that, S1, the fixing frame is fixed on an ill body; S2, the fixing frame and the ill body are scanned through a CTA, and a three-dimensional model is reconstructed; S3, a three-dimensional coordinate of the three-dimensional model is adjusted through software 3ds MAX to make the graph mark be at the world coordinate center; and S4, the three-dimensional model is projected by ARToolkit software onto a right center of the graph mark, so the three-dimensional model and the ill body image are superposed and fused. The system and the method are advantaged in that, the augmented reality technology is utilized, so the real world information, namely the ill body, is superposed and fused with virtual world information, namely the three-dimensional model of blood vessel muscle bones, so entity information which is difficult to experience in the real world can be acquired by operation doctors.

The present invention provides methods of treating pathologic conditions associated with intestinal ischemia. In the methods, patients at risk for or suffering from intestinal ischemia are treated with a heparin-binding epidermal growth factor product.

Provided herein are methods of treating or ameliorating primary sclerosing cholangitis and inflammatory bowel disease by administering to an individual in need thereof a therapeutically effective amount of an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTI) or a pharmaceutically acceptable salt thereof. Also provided are methods for treating or ameliorating primary sclerosing cholangitis comprising administering to an individual in need thereof a therapeutically effective amount of ASBTI or a pharmaceutically acceptable salt thereof.

The present invention features compounds, pharmaceutical compositions, and methods for treating trauma, ischemia, stroke, degenerative diseases associated with cellular necrosis, and other conditions. Screening assays for identifying compounds useful for treating these conditions are also described.

Disclosed are compositions and methods useful for targeting tissue undergoing angiogenesis or to cells or tissue expressing αv integrins. The compositions and methods are based on peptide sequences that selectively bind to and home to tissue undergoing angiogenesis or to cells or tissue expressing αv integrins in animals. The disclosed targeting is useful for delivering therapeutic and detectable agents to tissue experiencing angiogenesis or to cells or tissue expressing αv integrins.

Disclosed are compositions and methods useful for targeting and internalizing molecules into cells of interest and for penetration by molecules of tissues of interest. The compositions and methods are based on peptide sequences, such as truncated CAR peptides, that are selectively internalized by a cell, penetrate tissue, or both. The disclosed internalization and tissue penetration is useful for delivering therapeutic and detectable agents to cells and tissues of interest.

The invention features methods for decreasing necrosis. The invention also features methods for treating a subject with a condition in which necrosis occurs. The invention further features chemical compounds used to decrease necrosis.

The invention discloses a medicine for treating chronic hepatitis B, which contains the raw materials by the mixture ratio: 6-18% of herba artemisiae capillaries, 1-7% of Chinese thorowax, 1-7% of angelica, 3-12% of radix paeoniae alba, 3-12% of salvia miltiorrhiza, 1-10% of radix curcumae, 1-7% of rhizoma corydalis, 1-7% of common burreed rhizome, 1-7% of rhizoma zedoariae, 1-7% of nutgrass galingale rhizome, 1-7% of fructus meliae toosendan, 1-10% of dangshen, 1-7% of largehead atractylodes rhizome, 6-18% of radix astragali, 3-12% of indian bread, 1-7% of immature bitter orange, 1-7% of amomum villosum, 1-7% of areca, 0.5-5% of Chinese eaglewood and 1-7% of liquorice; the medicine is prepared by adopting conventional method. The medicine has the efficacies of clearing heat and promoting diuresis, nourishing the liver and invigorating the spleen, regulating the flow of qi and removing blood stasis, and can be used for treating chronic hepatitis B with remarkable effects, short period of treatment and rapid effects.

The invention provides a premix containing organic microelements and a feed prepared from the premix, wherein the premix is formed by small peptide chelate type organic microelements and high-efficiency protein selenium. The piglet complete feed is characterized in that in each ton of piglet complete feed, 200-2000g of the premix is added, each 500g of premix contains 50-200g of small peptide chelate iron, 50-250g of small peptide chelate zinc, 20-50g of small peptide chelate copper, 25-100g of small peptide chelate manganese, and 5-15g of protein selenium. The small peptide chelate type organic microelements include Optimin zinc, Optimin manganese, Optimin copper and Optimin iron, all of which contains 2-3 amino acids. According to the premix and the piglet complete feed provided by the invention, dosage of inorganic microelements is reduced, pollution of inorganic microelements and heavy metals to the environment is obviously reduced, further, the feed utilization ratio and productivity of piglets are improved, the oxidative deterioration of the feed is reduced, the palatability of the feed is improved, and the growth healthy state of the piglets is promoted.

The invention relates to the technical field of medical plastic surgery, in particular to the technical field of facial filling and anti-wrinkle, in particular, it is an injection filling cosmetic modification anti-aging, skin beautification and facial rejuvenation material. The preparation formula of the present invention includes hyaluronic acid, collagen, vitamin E and PLGA. The preparation method comprises: 1) preparing high-viscosity gel; 2) preparing PLGA nano-microspheres; 3) fully mixing high-viscosity gel and PLGA nano-microspheres; 4) sterilizing and filling. Compared with the prior art, the present invention has the beneficial effect that: the combined use of collagen and hyaluronic acid reduces skin erythema, swelling, hardening or itching, muscle pain, urticaria or Other symptoms such as rash. It reduces the probability of severe complications such as peripheral blood circulation embolism, skin necrosis, retinal artery embolism, and cardiocerebral artery embolism that may be caused by simple hyaluronic acid injection, and the safety of product use is improved.

The invention discloses a fixing device for fractures of an anterior column, a posterior column and a square area of an acetabulum and a use method thereof. The fixing device comprises a trapezoid main board and a pubic auxiliary board; the integral shape of the trapezoid main board and the pubic auxiliary board is matched with anatomical structures of the insides of the anterior column and the posterior column of the acetabulum and the square area of the acetabulum; an arcus marginalis steel plate positioned at an ilium arcus marginalis is arranged at the upper part of the trapezoid main board; a posterior column steel plate is arranged at one side edge of the trapezoid main board; after being crossed, the posterior column steel plate and the arcus marginalis steel plate are bent and extend towards the fossa iliaca to form a posterior column side wall; an ischium steel plate is arranged at the lower part of the trapezoid main board; a square area baffle is arranged among the arcus marginalis steel plate, the posterior column steel plate and the ischium steel plate; the pubic auxiliary board is matched with an anatomical structure of the inside of the superior pubic ramus, is bent near a pubic tubercle and extends towards the upper surface of the superior pubic ramus to form a pubic side wall; the trapezoid main board and the pubic auxiliary board are provided with a plurality of screw holes. By using the fixing device, the acetabulum fractures can be stably reduced and fixed and quality of fracture reduction and internal fixation is improved.

The present invention features compounds of Formula (I), pharmaceutical compositions, methods of synthesis, and methods for treating diseases and conditions associated with cellular necrosis. Screening assays for identifying compounds useful for treating these conditions are also described.

The invention provides an umbilical cord tissue cryopreservation and resuscitation method. The method comprises the following steps: S1, cutting umbilical cord tissues to obtain first tissue strips; S2, immersing the first tissue strips in a vitrification solution, and then directly cryopreserving the first tissue strips to obtain second tissue strips; and S3, resuscitating the second tissue strips to obtain third tissue strips, wherein the vitrification solution includes a first vitrification solution, a second vitrification solution and a third vitrification solution, and the step S2 includes the following processes: sequentially immersing the first tissue strips in the first vitrification solution, the second vitrification solution and the third vitrification solution, transferring thefirst tissue strips into liquid nitrogen, and cryopreserving the first tissue strips to obtain the second tissue strips. The umbilical cord strips are cryopreserved and resuscitated through a vitrification technology, so the operation time is shortened, the cryopreservation efficiency is improved, and the necrosis rate of the umbilical cord tissues in the cryopreservation and resuscitation processis reduced.

The present invention relates to the field of pharmaceutical chemistry and therapeutics, and particularly relates to an optically active butylphthalide open-ring derivative as shown in the general formula I or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier, preparation methods thereof, pharmaceutical compositions containing the compounds, and medical application thereof, especially application in medicines for prevention and treatment of cardiovascular and cerebrovascular and improvement of heart and brain circulatory disturbance, antiplatelet aggregation medicines, antithrombotic medicines, anti-ischemic medicines, anti-dementia medicines, anti-atherosclerotic medicines, and medicines for anti-diabetes and complications thereof. Pharmacological experimental results show that the compounds have good anti-platelet aggregation activity, anti-thrombotic activity, anti-ischemic activity and neuroprotective effects, and are clinically useful for the preparation of medicines for preventing or treating diseases associated with platelet aggregation.

A terramycin injection composition has long pharmacodynamic action time, wherein each unit of the terramycin injection composition contains 30% terramycin free alkali, 2%-3% magnesium compound, 30%-50% 2-ketopyrrolidine, 5%-20% propylene glycol, 5%-20% glycerol formal, 1%-5% moderator and the rest is water for injection. The invention prolongs pharmacodynamic action time of terramycin, decreases possibilities of pain, swelling, tissue stimulation and tissue necrosis at the injection sites of animals and improves stability of terramycin at high temperature.

A Chinese medicine for treating fistulas, piles and anal fistula is prepared from 15 Chinese-medicinal materials including astragalus root, dandelion, honeysuckle flower, red sage root, etc. Its advantages are high curative effect and quickly taking its effect.

The present invention features compounds, pharmaceutical compositions, and methods for treating trauma, ischemia, stroke, degenerative diseases associated with cellular necrosis, and other conditions. Screening assays for identifying compounds useful for treating these conditions are also described.

The invention relates to the technical field of medicine, in particular to the use of 13-methylamino-18-thiomatrine compound (I) and its salts in the preparation of anti-fibrosis drugs. The present invention proves from cytological tests that 13-methylamino-18-thiomatrine can inhibit proliferation and activation of extracellular matrix producing cells hepatic stellate cells, and inhibit fibrotic liver epithelial cell-mesenchymal transition. In addition, it also has inhibitory effects on various other extracellular matrix-producing cells that lead to organ or tissue fibrosis. Animal experiments have proved that 13-methylamino-18-thiomatrine has a very significant anti-hepatic fibrosis effect. The results show that 13-methylamino-18-thiomatrine has definite anti-hepatic fibrosis or fibrosis of other tissues and organs, and can be used to prepare medicines for preventing and treating liver fibrosis or fibrosis of other tissues and organs.

The invention pertains to the field of biomedicine, and the technical problem that the invention solves is to provide a new use of IL-4, which particularly provides the use of IL-4 in preparing the drug combination for treating chronic liver fibrosis. When the dosage is 0.1ug / kg / d-5ug / kg / d, the effect for treating chronic liver fibrosis is good, thus providing a new choice for treating chronic liver fibrosis.

The invention belongs to the field of pharmacology of Chinese medicines and discloses an application of a Chinese herb Pien Tze Huang and a preparation thereof in preparation of drugs for treating non-alcoholic fatty liver disease (NAFLD). The Chinese herb Pien Tze Huang can be used for remarkably improving the liver function of a fatty liver rat, reducing the AST (Aspartate Aminotransferase), TG (Triglyceride) and (gamma-Glutamyl Transpeptidase) level of serum, reducing the degree of fatty liver and relieving inflammatory reaction and has a remarkable curative effect on the aspect of treating NAFLD.

The hepatitis treating Chinese medicine composition is prepared with bupleurum root, red peony root, asafetida, green tangerine orange peel, magnolia bark and other 25 kinds of Chinese medicinal materials. The medicine is prepared into various preparation forms, medicine powder, decoction, pill, ointment, etc. preferably medicine powder, water pills and decoction.

The invention mainly relates to pathogenic microorganism preventing antiviral tea beverage granules capable of boosting immunity. The granules are characterized by comprising raw materials in parts by weight as follows: 10-30 parts of radix angelicae extract, 10-30 parts of honeysuckle extract, 10-30 parts of fructus lycii, 10-30 parts of mint extract, 10-30 parts of longan aril extract, 10-30 parts of radix asparagi extract, 300-400 parts of dextrin, 10-30 parts of ophiopogon root extract, 10-20 parts of cinnamon extract, 10-20 parts of ginger extract, 300-400 parts of starch, 10-20 parts of white granulated sugar, 10-100 parts of green tea extract and 10-30 parts of cordate houttuynia. According to the invention, based on traditional Chinese medicine theory, materials are choosen and formula is strict. In the formula, radix angelicae relieves swelling and pain, honeysuckle is anti-inflammatory, fructus lycii adjusts blood lipid and blood sugar, cordate houttuynia prevents viruses, cinnamon activates blood to promote menstruation, ginger induces sweat and dispels exogenous evils, and dextrin can improve permeability of slurry. The formula can integrally improve physical condition, boosts immunity and prevents pathogenic microorganisms and viruses.

The invention features methods for decreasing necrosis. The invention also features methods for treating a subject with a condition in which necrosis occurs. The invention further features chemical compounds used to decrease necrosis.

The present invention belongs to the field of medicinal chemistry, and particularly relates to a bicyclol-based derivative and a pharmaceutically acceptable salt thereof, a preparation method of the bicyclol-based derivative, and applications of the bicyclol-based derivative in preparation of drugs for prevention and / or treatment of liver diseases and the like. The formula I is defined in the specification.

The invention discloses a bone connecting device for treating femoral neck fracture. The bone connecting device comprises a bone connecting plate, wherein the bone connecting plate comprises a bone connecting plate upper part and a bone connecting plate lower part which are connected in sequence; the bone connecting plate upper part is outwards and obliquely arranged at the upper end of the bone connecting plate lower part, and the middle of the bone connecting plate is thicker than the two ends of the bone connecting plate; the bone connecting plate upper part is provided with three sleeves arranged in an invertedly triangular manner, and hollow screws are arranged in the sleeves; threads are formed in the front ends of the hollow screws, and no threads are formed in the rear parts of the hollow screws; during use, the hollow screws are obliquely arranged in the femoral head through the femoral neck from the greater trochanter; the threads are fixed in the femoral head, the rear parts of the hollow screws are connected with the femoral neck and the sleeves in a sliding manner, and locking screw holes locked with fixing screws in a thread manner are formed in the bone connecting plate lower part. Therefore, the fracture part can be pressurized in a femoral neck healing process, the fracture line is reduced, the blood supply rebuilding of the femoral neck fracture end becomes possible, the angular stability is relatively good, the fracture displacement can be prevented, and the occurrence rate of femoral head necrosis is reduced.

The invention relates to the technical filed of biology, in particular to application of a plant as a host in expressing a vaccine of Middle East Respiratory Syndrome. According to the technical scheme, lettuce is utilized to instantly express the vaccine to deal with Middle East Respiratory Syndrome, and high-content protein can be produced within a short time (4d). The biology safety problem is reduced to the largest limit, the lettuce basically contains no botanical toxic substances, and the fiber of the lettuce itself is little, which is conducive to protein purification in the downstream. As test results show, through the adoption of a lettuce system to produce the vaccine, the production period can be sharply shortened, and the production cost can be sharply reduced.

The invention discloses a tracheotomy sleeve with double-layer air bags and a preparation and use method thereof. The tracheotomy sleeve comprises an inserting tube, wherein the inserted end of the inserting tube is provided with 1-2 double-layer air bags at interval; each double-layer air bag comprises a safety air bag and a fixed air bag which are sheathed outside the inserting tube in sequence; a safety air chamber is enclosed by each safety air bag and the corresponding inserting tube and is communicated with an inner hole of the inserting tube; each fixed air chamber is enclosed by each fixed air bag, the inserting tube and the corresponding safety air bag and is connected with an air injecting tube. The tracheotomy sleeve disclosed by the invention has the advantages that the inserted end of the inserting tube is provided with the double-layer air bags, so that the opportunity that the same part is pressed for a long time to influence local blood circulation and cause necrosis of the airway mucosa is reduced; simultaneously, due to the double-layer air bags, the whole airway can be in a sealed state all the time, and normal mechanical ventilation is maintained.

The present invention provides methods of treating pathologic conditions associated with intestinal ischemia. In the methods, patients at risk for or suffering from intestinal ischemia are treated with a heparin-binding epidermal growth factor product.

The invention relates to a shRNA (Short Hairpin Ribonucleic Acid) kit for treating an animal model suffered from an alzheimer disease. The kit internally comprises shRAN slow virus expression plasmid vector concentrated liquor capable of specifically suppressing a caspase-3 gene, and shRAN slow virus expression plasmid vector concentrated liquor as negative control, wherein the shRAN comprises sequences of SEQ ID No.1 and SEQ ID NO.2 in a sequence table. Compared with other means, the shRAN sequence or a reagent obtained therefrom can specifically and conveniently suppress the expression of disease-related proteins at high efficiency when entering the body of the animal model in a certain manner and lead disease-related genes to be silent, thereby achieving the treatment purpose; and therefore, the kit provided by the invention can be used for gene therapy for the animal model suffered from the alzheimer diseases.