Biodegradable filling and making up injection material and preparation method thereof

Abstract

The invention relates to the technical field of medical plastic surgery, in particular to the technical field of facial filling and anti-wrinkle, in particular, it is an injection filling cosmetic modification anti-aging, skin beautification and facial rejuvenation material. The preparation formula of the present invention includes hyaluronic acid, collagen, vitamin E and PLGA. The preparation method comprises: 1) preparing high-viscosity gel; 2) preparing PLGA nano-microspheres; 3) fully mixing high-viscosity gel and PLGA nano-microspheres; 4) sterilizing and filling. Compared with the prior art, the present invention has the beneficial effect that: the combined use of collagen and hyaluronic acid reduces skin erythema, swelling, hardening or itching, muscle pain, urticaria or Other symptoms such as rash. It reduces the probability of severe complications such as peripheral blood circulation embolism, skin necrosis, retinal artery embolism, and cardiocerebral artery embolism that may be caused by simple hyaluronic acid injection, and the safety of product use is improved.

Description

Technical field:

[0001] The invention relates to the technical field of medical plastic surgery, in particular to the technical field of facial filling and anti-wrinkle, in particular, it is a material for injection filling, cosmetic modification, anti-aging, skin beautification and facial rejuvenation. Background technique:

[0002] With the growth of age, the degenerative changes of human skin continue to intensify. The reduction of collagen content in the dermis and the reduction of water content in the skin are one of the main causes of wrinkles. Therefore, direct injection of collagen and water retention in the dermis or subcutaneous The strong hyaluronic acid is seen as an effective solution to wrinkle problems. With the progress of society and the improvement of people's living standards, people's demand for medical bioinjection materials for facial rejuvenation and anti-aging is increasing year by year, and the service organizations of anti-aging industry and beauty ...

Examples

Embodiment 1

[0078] A biodegradable injection filling modification material, comprising the following components by weight:

[0079]

[0080] Its preparation method comprises the following steps:

[0081] 1) Mix 10 parts of hyaluronic acid and 25 parts of collagen to prepare a high-viscosity gel;

[0082] 2) Take 0.2 parts of vitamin E and 35 parts of PLGA and fully mix, so that vitamin E is embedded and sealed by PLGA to make nano-microspheres;

[0083] 3) the high-viscosity gel prepared in step 1) and the PLGA nanospheres prepared in step 2) are fully mixed;

[0084] 4) Filling after disinfection and sterilization.

Embodiment 2

[0086] A biodegradable injection filling modification material, comprising the following components by weight:

[0087]

[0088]

[0089] Its preparation method comprises the following steps:

[0090] 1) Mix 35 parts of hyaluronic acid and 5 parts of collagen to prepare a high-viscosity gel;

[0091] 2) Take 0.5 parts of vitamin E and 20 parts of PLGA and fully mix, so that vitamin E is embedded and sealed by PLGA to make nano-microspheres;

[0092] 3) the high-viscosity gel prepared in step 1) and the PLGA nanospheres prepared in step 2) are fully mixed;

[0093] 4) Filling after disinfection and sterilization.

Embodiment 3

[0095] A biodegradable injection filling modification material, comprising the following components by weight:

[0096]

[0097] Its preparation method comprises the following steps:

[0098] 1) Mix 20 parts of hyaluronic acid and 10 parts of collagen to prepare a high-viscosity gel;

[0099] 2) Take 0.25 parts of vitamin E and 30 parts of PLGA and mix well, so that vitamin E is embedded and sealed by PLGA to make nano-microspheres;

[0100] 3) the high-viscosity gel prepared in step 1) and the PLGA nanospheres prepared in step 2) are fully mixed;

[0101] 4) Filling after disinfection and sterilization.

Technical field:

[0001] The invention relates to the technical field of medical plastic surgery, in particular to the technical field of facial filling and anti-wrinkle, in particular, it is a material for injection filling, cosmetic modification, anti-aging, skin beautification and facial rejuvenation. Background technique:

[0002] With the growth of age, the degenerative changes of human skin continue to intensify. The reduction of collagen content in the dermis and the reduction of water content in the skin are one of the main causes of wrinkles. Therefore, direct injection of collagen and water retention in the dermis or subcutaneous The strong hyaluronic acid is seen as an effective solution to wrinkle problems. With the progress of society and the improvement of people's living standards, people's demand for medical bioinjection materials for facial rejuvenation and anti-aging is increasing year by year, and the service organizations of anti-aging industry and beauty ...

Examples

Embodiment 1

[0078] A biodegradable injection filling modification material, comprising the following components by weight:

[0079]

[0080] Its preparation method comprises the following steps:

[0081] 1) Mix 10 parts of hyaluronic acid and 25 parts of collagen to prepare a high-viscosity gel;

[0082] 2) Take 0.2 parts of vitamin E and 35 parts of PLGA and fully mix, so that vitamin E is embedded and sealed by PLGA to make nano-microspheres;

[0083] 3) the high-viscosity gel prepared in step 1) and the PLGA nanospheres prepared in step 2) are fully mixed;

[0084] 4) Filling after disinfection and sterilization.

Embodiment 2

[0086] A biodegradable injection filling modification material, comprising the following components by weight:

[0087]

[0088]

[0089] Its preparation method comprises the following steps:

[0090] 1) Mix 35 parts of hyaluronic acid and 5 parts of collagen to prepare a high-viscosity gel;

[0091] 2) Take 0.5 parts of vitamin E and 20 parts of PLGA and fully mix, so that vitamin E is embedded and sealed by PLGA to make nano-microspheres;

[0092] 3) the high-viscosity gel prepared in step 1) and the PLGA nanospheres prepared in step 2) are fully mixed;

[0093] 4) Filling after disinfection and sterilization.

Embodiment 3

[0095] A biodegradable injection filling modification material, comprising the following components by weight:

[0096]

[0097] Its preparation method comprises the following steps:

[0098] 1) Mix 20 parts of hyaluronic acid and 10 parts of collagen to prepare a high-viscosity gel;

[0099] 2) Take 0.25 parts of vitamin E and 30 parts of PLGA and mix well, so that vitamin E is embedded and sealed by PLGA to make nano-microspheres;

[0100] 3) the high-viscosity gel prepared in step 1) and the PLGA nanospheres prepared in step 2) are fully mixed;

[0101] 4) Filling after disinfection and sterilization.

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