The present disclosure relates to 2, 4, 7-substituted-7-denitrification-2 '-deoxy-2'-fluoro arabinosyl nucleosides and nucleotide prodrugs capable of inhibiting viral infections and methods of using these compounds in the treatment of viral infections, the viral infections such as human immunodeficiency virus (HIV), human papilloma virus (HPV), herpes simplex virus (HSV), human cytomegalovirus (HCMV), varicella, infectious mononuclear hyperplasia, parotitis, measles, rubella, herpes zoster, Ebola virus, viral gastroenteritis, viral hepatitis, viral meningitis, human metapneumovirus, human parainfluenza virus type 1, parainfluenza virus type 2, and the like. Parainfluenza virus type 3, respiratory syncytial virus, viral pneumonia, chikungunya virus (CHIKV), Venezuelan equine encephalitis (VEEV), dengue fever (DENV), influenza, West Nile virus (WNV), zika virus (ZIKV), 229E, NL63, OC43, HKU1, Middle East Respiratory Syndrome Coronavivirus (MERS), severely acute respiratory Syndrome Coronavivirus (SERS), and severely acute respiratory Syndrome Coronavivirus (SERS) This abstract is intended as a scanning tool for search purposes in the particular art and is not intended as a limitation on the present invention.