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213 results about "Coronavirus antibody" patented technology

Detection kit of IgM/IgG antibodies of novel coronavirus (SARS-CoV-2)

The invention provides a detection kit of IgM / IgG antibodies of novel coronavirus (SARS-CoV-2), and relates to the technical field of biology. According to the detection kit of IgM / IgG antibodies of novel coronavirus (SARS-CoV-2), the IgM / IgG antibodies of novel coronavirus (SARS-CoV-2) are detected through adoption of a colloidal gold capture method, a colloidal gold indirect method and a colloidal gold double antigen sandwich method, wherein adopted antigens are highly active recombinant antigens which are obtained through fusion expression of N protein fragments and S protein dominant epitope fragments, and colloidal gold is labeled indirectly, so that steric hindrance is reduced, and the activity, reaction consistency and accuracy of the antigens are increased. Since a sample pad is pretreated, the interference of complex components in a blood sample to a reaction can be reduced greatly, the detection kit has no requirements for instruments during detection, simple and flexible operation, direct and manual interpretation of results and a short test time, the results can be interpreted in only 15 minutes, and the test results are accurate.
Owner:北京新创生物工程有限公司

Colloidal gold kit for jointly detecting coronavirus IgM/IgG antibody, and preparation method thereof

The invention discloses a colloidal gold kit for jointly detecting coronavirus IgM / IgG antibody, and a preparation method thereof, and relates to the field of biological medicine. Whether anti-novel coronavirus nucleocapsid protein IgM antibody and / or anti-novel coronavirus nucleocapsid protein IgG antibody exists in human serum or plasma or not by adopting an antigen-antibody sandwich method anda colloidal gold immunochromatography method principle, the novel coronavirus nucleocapsid protein containing 6xHis mark is marked by applying colloidal gold, thereby forming gold-marked N protein tobe adsorbed on a gold-marked pad, the novel coronavirus nucleocapsid protein containing 6xHis mark is used as an indication marker, the mouse-anti-human u chain monoclonal antibody is coated on the IgM detection line of a NC membrane, the mouse-anti-human IgG monoclonal antibody is coated on the IgG detection line and the mouse-anti 6xHis monoclonal antibody is coated on a quality control line ofthe NC membrane, the qualitative detection of the anti-novel coronavirus nucleocapsid protein IgG antibody is realized, and the colloidal gold kit disclosed by the invention has the advantages of being convenient to use, high in sensitivity and short in detection time.
Owner:中山生物工程有限公司

Novel coronavirus antigen epitope and application thereof

The invention provides a novel coronavirus antigen epitope and application thereof. A super computer is used for simulating S, E, M and N protein structures of the novel coronavirus, and novel coronavirus epitopes SEQ ID NO 1-38 are obtained through calculation. The epitopes have very good immunogenicity; an antibody generated by inducing a part of epitope polypeptide has the effect of neutralizing the novel coronavirus; the antigen epitope can be combined with antibodies in serum of novel coronavirus patients at home and abroad, has the potential of resisting various novel coronavirus strains, and also has the potential of identifying and applying different strains. The epitope provided by the invention can be used for (1) research and development of novel coronavirus vaccines and universal coronavirus vaccines such as MERS viruses and SARS viruses; and (2) preparing a novel coronavirus antibody, and further detecting and typing viruses and treating diseases caused by the viruses. Thenovel coronavirus antigen epitope has a wide application prospect in the aspects of prevention of coronavirus and propagation and outbreak thereof, and detection and diagnosis of virus strains.
Owner:INST OF PROCESS ENG CHINESE ACAD OF SCI

Novel fluorescence immunochromatography test strip for joint inspection of SARS-CoV-2 IgG-IgM antibodies of coronaviruses

The invention discloses a novel fluorescence immunochromatography test strip for joint inspection of SARS-CoV-2 IgG-IgM antibodies of coronaviruses. The test strip comprises a bottom plate, a sample pad, a combination pad, a nitrocellulose membrane and a water absorption pad, wherein the sample pad, the combination pad, the nitrocellulose membrane and the water absorption pad are sequentially connected end to end and adhered to the bottom plate; the combination pad is coated with an SARS-CoV-2 structural protein-marker and a goat anti-rabbit IgG-marker, and the nitrocellulose membrane is provided with a detection line T1 coated with a mouse anti-human IgG monoclonal antibody, a detection line T2 coated with a mouse anti-human IgM monoclonal antibody and a quality control line C coated withrabbit IgG. When the test strip is used for quantitatively detecting SARS-CoV-2 IgG and IgM antibodies, the detection sensitivity is high, and the specificity is good and can reach 96%; the batch-to-batch difference is small, and good repeatability is achieved; the test strip can be stored for half a year at normal temperature without reducing the sensitivity and has good stability; the test strip is simple to operate and low in cost, can quickly and quantitatively detect the levels of SARS-CoV-2 IgG and IgM antibodies in a human body, assists a nucleic acid detection means, and provides powerful support for epidemic situations.
Owner:NANJING AGRICULTURAL UNIVERSITY

2019 novel coronavirus IgG antibody detection kit

The invention provides a 2019 novel coronavirus (SARS-CoV-2) IgG antibody detection kit, and belongs to the technical field of biology. The detection kit provided by the invention comprises two antigens coated on a solid phase carrier and a mouse anti-human IgG antibody marked by a detectable marker, wherein the two antigens are a novel coronavirus RBD antigen and a novel coronavirus N antigen. The detection kit provided by the invention has the advantages of high sensitivity and good specificity, and is suitable for detecting a novel 2019 coronavirus (SARS-CoV-2) IgG antibody.
Owner:SICHUAN MACCURA BIOTECH CO LTD

Novel coronavirus rapid detection test paper and detection method

PendingCN111337669ASuitable for on-site screeningReduce the risk of infectionImmunoassaysReceptorHorse radish peroxidase
The invention discloses novel coronavirus rapid detection test paper and a detection method. The novel coronavirus rapid detection test paper is composed of a sample pad, a colloidal gold pad, a reaction color development area, a water absorption area and a supporting plate; the sample pad and the water absorption pad are arranged on the supporting plate and located on the two opposite sides of the supporting plate respectively, and the sample pad is suction filter paper or a glass fiber membrane and used for bearing an object to be detected; a nitrocellulose membrane is fixed on the supporting plate, and the absorbent pad is absorbent paper; through double binding of a novel coronavirus antibody and a receptor ACE2 protein of a virus, a coronavirus protein antigen is specifically capturedand bound by adopting double enzyme-linked immunosorbent assay; the ACE2 antibody in the test paper reaction color development area is combined with biotin, avidin is connected with horse radish peroxidase, and through a biotin-avidin system, rapid judgment can be achieved through chemical color development, and the virus content can also be accurately detected through a microplate reader.
Owner:NANTONG UNIVERSITY +1

Method for screening 2019-coronavirus and pre-judging severe pneumonia by double indexes

Provided are a detection reagent and a kit. The reagent detects a 2019-coronavirus SARS-CoV-2 immunoglobulin A (SARS-CoV-2 IgA) antibody in blood and a salivary liquefied sugar chain antigen KL-6 at the same time, and is used for screening, especially for early screening of 2019-coronavirus infected pneumonia, and for pre-judging the detection reagent for severe patients. The kit comprises a testcard, and the test card is composed of an SARS-CoV-2 IgA test strip, a KL-6 test strip and a plastic box. The reagent and the kit disclosed by the invention can be used for diagnosing the new coronavirus pneumonia at an earlier stage and can be used for judging whether a patient suffering from the new coronavirus pneumonia has lung injury or not.
Owner:GUANGZHOU KANGRUN BIOTECHNOLOGY CO LTD +1

Novel detection reagent card for coronavirus antibody detection and preparation method of detection reagent card

The invention relates to a novel detection reagent card for coronavirus antibody detection. The reagent card comprises a sample pad, a quantum pad, a nitrocellulose membrane, absorbent paper and a lining plate, the quantum pad is coated with a quantum dot microsphere labeled anti-human IgM antibody or IgG antibody, a detection line arranged on the nitrocellulose membrane is coated with an SARS-COV2 recombinant antigen, and a quality control line is coated with goat anti-mouse IgG. According to the detection reagent card for detecting the novel coronavirus (SARS-COV2) IgM antibody or IgG antibody provided by the invention, a result can be rapidly and accurately obtained, and auxiliary diagnosis is provided for clinical COVID-19.
Owner:重庆新赛亚生物科技有限公司

Neutralizing antibody of coronavirus or antigen-binding fragment thereof

The invention relates to a neutralizing antibody of coronavirus or an antigen-binding fragment thereof, a nucleic acid molecule encoding the antibody or the antigen-binding fragment thereof, a vectorcontaining the nucleic acid molecule, a host cell containing the vector, application of the antibody or the antigen-binding fragment thereof in preparation of drugs for treating or preventing diseasescaused by coronavirus, and application in detection of products. The coronavirus antibody and the antigen-binding fragment thereof have broad-spectrum and strong neutralizing ability for various coronaviruses including SARS-CoV-2, and have good clinical application prospects in the future.
Owner:超非凡(上海)医疗科技有限公司

Kit for combined detection of 2019 novel coronavirus IgM and IgG antibodies and preparation method thereof

The invention relates to the technical field of in-vitro diagnostic reagents, in particular to a kit for combined detection of novel 2019 coronavirus IgM and IgG antibodies and a preparation method ofthe kit. The kit comprises a duplex detection card and a detection buffer solution; a 2019 novel coronavirus IgM antibody detection test strip and a 2019 novel coronavirus IgG antibody detection teststrip are arranged in the duplex detection card; the 2019 novel coronavirus IgM antibody detection test strip and the 2019 novel coronavirus IgG antibody detection test strip respectively comprise asample pad, a nitrocellulose membrane and a water absorption pad, wherein the sample pad is coated with an anti-sheep erythrocyte antibody, and the nitrocellulose membrane is provided with a fluorescent antibody solidus, a detection line and a quality control line. By using the kit, the detection rate can be improved, and the operation is simple.
Owner:山东康华生物医疗科技股份有限公司 +1

Detection kit capable of being used for detecting neutralizing antibody of novel coronavirus

The invention relates to a detection kit capable of being used for detecting a neutralizing antibody of a novel coronavirus. The novel coronavirus SARS-CoV-2 antibody (IgG) detection device provided by the invention comprises a solid carrier, and a combination of specific polypeptide and protein connected to the solid carrier.
Owner:中国疾病预防控制中心病毒病预防控制所 +1

Test strip for detecting novel coronavirus antibody, and preparation method and application of test strip

The invention discloses a test strip for detecting a novel coronavirus antibody, and a preparation method and application of the test strip. The colloidal gold immunochromatography test strip preparedby the method has good sensitivity, specificity and stability, is convenient to store, long in storage life, simple to operate and high in detection speed, is suitable for rapid diagnosis of SARS-CoV-2 virus infection, and can be used for in-situ detection of basic tissues.
Owner:JIANGSU PROVINCIAL CENT FOR DISEASE CONTROL & PREVENTION PUBLIC HEALTH RES INST OF JIANGSU PROVINCE

Recombinant protein and test strip for detection of antibodies of 2019 novel coronavirus through double-antigen sandwich method and preparation method and application of recombinant protein and test strip

The invention relates to a recombinant protein and test strip for detection of antibodies of 2019 novel coronavirus through a double-antigen sandwich method and a preparation method and application ofthe recombinant protein and test strip, and belongs to the technical field of virus detection. The amino acid sequence of the recombinant protein for detection of the antibodies of the 2019 novel coronavirus through the double-antigen sandwich method is shown in SEQ ID NO. 1. The recombinant protein is a fusion protein of multiple dominant epitopes of the 2019-nCoV, a reagent for detection of theantibodies of the 2019-nCoV through the double-antigen sandwich method can be prepared, storage at room temperature, fast and single detection with high sensitivity, high throughput and low instrument cost can be achieved at any time, the operation is simple, and convenience of clinical use can be improved greatly.
Owner:GENERAL HOSPITAL OF PLA +1

Novel coronavirus antigen and influenza virus antigen combined detection reagent strip and preparation method thereof

PendingCN112198312AReduce false positive interferenceHigh sensitivityBiological testingImmunoassaysReagent stripCoronavirus antibody
The invention discloses a novel coronavirus antigen and influenza virus antigen combined detection reagent strip which comprises a bottom plate. A sample pad, a gold-labeled pad, a nitrocellulose membrane and absorbent paper are sequentially pasted on the bottom plate, and the surface of the nitrocellulose membrane is sequentially coated with an anti-novel coronavirus antibody, an anti-influenza Avirus antibody and an anti-influenza B virus antibody. A rabbit anti-mouse IgG antibody coats the end close to the absorbent paper. A colloidal gold labeled anti-novel coronavirus antibody, an anti-influenza A virus antibody and an anti-influenza B virus antibody are sprayed on the gold-labeled pad. The binding protein A / G is marked on the surface of the colloidal gold, the protein A / G is specifically bound with the Fc end of the antibody, so that the ideal conformation of Fab end abduction is constructed, and meanwhile, the binding of the protein A / G with the Fc can reduce the false positiveinterference of rheumatoid factors on a detection structure. The reagent strip can simultaneously realize qualitative detection of the novel coronavirus antigen and the influenza antigen in one test,and is convenient to use, good in sensitivity, high in specificity and short in detection time.
Owner:南京佰抗生物科技有限公司

Method for detecting novel coronavirus 2019-nCoV by multi-protein joint inspection combination

The invention relates to a method for detecting novel coronavirus 2019-nCoV through multi-protein joint inspection combination, which belongs to the technical field of novel coronavirus 2019-nCoV detection. The invention provides the method for detecting the novel coronavirus 2019-nCoV through multi-protein joint inspection combination. A detection test strip for detecting the novel coronavirus 2019-nCoV antibody is prepared by directly scribing a high-purity and specific novel coronavirus antigen on a nitrocellulose membrane, and IgG, IgM and / or IgA antibodies in a sample can be simultaneously detected by utilizing multiple antigens. Through joint inspection of three or four specific antigens, protein sequences of the antigens are optimally designed, so that the sensitivity and specificity are effectively improved, and the problems of false negative and false positive are effectively avoided.
Owner:无锡市孚维尔生物医疗科技有限公司

Novel coronavirus antibody detection kit based on magnetic particle chemiluminescence

The invention provides a novel coronavirus antibody detection kit based on magnetic particle chemiluminescence. The detection kit comprises streptavidin magnetic particles, a biotin-labeled novel coronavirus antigen, an acridine sulfonamide-labeled secondary antibody, a sample diluent and a quality control material, wherein the biotin-labeled novel coronavirus antigen comprises a recombinant nucleocapsid protein and a recombinant spinous process protein S1. A to-be-detected sample, the biotin-labeled antigen and the streptavidin magnetic particles are mixed, incubated and washed, then the acridine sulfonamide-labeled antibody is added, a magnetic particle-streptavidin-biotin-antigen-novel coronavirus antibody-secondary antibody compound is formed, and then the luminous intensity is detected to achieve qualitative analysis of the to-be-detected sample.
Owner:DYNAMIKER BIOTECH TIANJIN

Fluorescence detection test strip for canine coronavirus antibody as well as preparation method and application thereof

The invention discloses a fluorescence detection test strip for a canine coronavirus antibody as well as a preparation method and application thereof. The test strip provided by the invention comprises a sample absorption pad, a conjugate release pad a, a conjugate release pad b, a nitrocellulose membrane, a water absorption pad and a bottom plate, wherein a chicken anti-dog anti-antibody-biotin conjugate is sprayed on the conjugate release pad a; a streptavidin-fluorescent microsphere marker is sprayed on the conjugate release pad b; a detection line and a quality control line are arranged onthe nitrocellulose membrane; the detection line is coated with a canine coronavirus N expression protein; and the quality control line is coated with a sheep anti-chicken anti-antibody. The test strip disclosed by the invention has the advantages of high sensitivity, high specificity, easiness in operation, economical efficiency and practicability, and can realize field rapid quantitative detection of the canine coronavirus antibody.
Owner:BEIJING KWINBON BIOTECH

Sensitization type immunochromatographic kit for sensitively detecting novel coronavirus antibody

The invention relates to a sensitization type immunochromatographic kit for sensitively detecting a novel coronavirus antibody, which introduces a controllable copper growth technology to amplify theoptical signal intensity of a colloidal gold probe of a detection line on the basis of a colloidal gold immunochromatographic test strip so as to realize high-sensitivity detection of an object to bedetected. The kit comprises the colloidal gold immunochromatography test strip and a copper growth solution, wherein the colloidal gold immunochromatography test strip is formed by sequentially fixinga sample pad, a combination pad, a nitrocellulose membrane and absorbent paper on a PVC plastic bottom plate; the copper growth solution comprises a copper growth solution A and a copper growth solution B. The kit provided by the invention is simple to operate, high in sensitivity, good in stability, high in detection speed (20-30 minutes) and easy in result reading, does not need other auxiliaryinstruments and equipment, and can be used for on-site rapid ultra-sensitive detection and large-scale epidemiological investigation of clinical and emergency events.
Owner:NANCHANG UNIV

Test strip for detecting human novel coronavirus IgG antibody, kit and preparation method of test strip

The invention provides a test strip for detecting a human novel coronavirus IgG antibody, a kit and a preparation method of the test strip. A nitrocellulose membrane of the test strip is provided witha detection line and a quality control line; the detection line is coated with novel coronavirus nucleocapsid protein and S1 protein, and the quality control line is coated with a chicken IgY antibody; the combination pad of the test strip is coated with a quantum dot labeled goat anti-human IgG antibody and a quantum dot labeled goat anti-chicken IgY antibody. According to the test strip provided by the invention, the sensitivity and specificity of human novel coronavirus IgG antibody detection can be improved, misdiagnosis caused by a false positive result is prevented, and when the test strip is used for repeatedly detecting the same sample, the obtained T / C value is relatively close; and meanwhile, the test strip is simple in use method and can realize on-site rapid detection.
Owner:BIOISLAND LAB +2

Method for preparing rapid detection test paper of novel coronavirus IgA antibody

The invention provides a recombinant protein and test paper for detecting a novel coronavirus 2019-nCoV IgA antibody, and a preparation method and application, and belongs to the technical field of virus detection. The amino acid sequence of the recombinant protein is shown in SEQ ID No.1; the test paper comprises a bottom plate as well as a sample absorption pad, a fluorescent microsphere pad, anitrocellulose membrane and a water absorption pad which are in sequential lap joint and adhesion to the bottom plate; a 2019 novel coronavirus specific antigen marked by fluorescent microspheres is sprayed to the fluorescent microsphere pad; a detection zone and a quality control zone are fixed on the nitrocellulose membrane; an anti-human IgA antibody is sprayed to the detection zone; and a sheep anti-chicken IgY antibody is sprayed to the quality control zone. By detecting the IgA antibody in a saliva sample, the test paper provided by the invention is capable of simply, rapidly and accurate detecting novel coronaviruses, and early-stage detection on the novel coronaviruses can be achieved.
Owner:BEIJING DIAGREAT BIOTECH CO LTD

Test strip and kit for detecting human novel coronavirus IgM antibody and preparation method thereof

The invention provides a test strip and a kit for detecting a human novel coronavirus IgM antibody and a preparation method of the test strip and the kit. A nitrocellulose membrane of the test strip is provided with a detection line and a quality control line; the detection line is coated with novel coronavirus nucleocapsid protein and S1 protein, and the quality control line is coated with a chicken IgY antibody; the combination pad of the test strip is coated with a quantum dot labeled goat anti-human IgM antibody and a quantum dot labeled goat anti-chicken IgY antibody. According to the test strip provided by the invention, novel coronavirus N protein and S1 protein are simultaneously coated on the detection line; the goat anti-human IgM antibody and the goat anti-chicken IgY antibody are labeled by using quantum dots; the human IgM antibody is a serum specific antibody firstly appearing after being infected with novel coronavirus; and the obtained test strip can be used for effectively and accurately detecting patients infected with the novel coronavirus at the early stage, and has important significance for preventing further diffusion of the virus.
Owner:BIOISLAND LAB +2

Synthetic polypeptide composition for novel coronavirus immunodetection and application thereof

The invention provides a synthetic polypeptide composition for novel coronavirus immunodetection. The synthetic polypeptide composition contains four synthetic polypeptides, the synthetic polypeptidedisclosed by the invention can react with an antibody IgG / IgM of a novel coronavirus (2019-nCoV), does not react with other pulmonary infectious coronaviruses and the like, and does not react with serum of a normal person; the synthetic polypeptide disclosed by the invention is used for detecting a novel coronavirus (2019-nCoV) IgM / IgG antibody in serum, the sensitivity can reach 90% or above, thespecificity can reach 99% or above, and the polypeptide can be obtained through chemical synthesis, does not need to be recombined through a biotechnology, and is lower in cost, easier to obtain andconvenient to apply and popularize.
Owner:BIOSCIENCE (TIANJIN) DIAGNOSTIC TECH CO LTD +1

Preparation method of novel coronavirus 2019-nCoV IgM/IgG antibody combined detection kit

The invention discloses a preparation method of a novel coronavirus 2019-nCoV IgM / IgG antibody combined detection kit, and belongs to the technical field of biological detection. According to the kit,latex chromatography is adopted, a PVC plate is used as a carrier, a sample pad, a compound pad, a nitrocellulose membrane and absorbent paper are sequentially overlapped and attached from left to right to form a latex test strip, and the latex test strip is loaded in a plastic clamping shell. The kit disclosed by the invention has the beneficial effects that the kit adopts latex chromatography,and IgM antibodies and IgG antibodies of the novel coronavirus 2019-nCoV in human whole blood, serum or plasma are detected by an immunocapture method. The situation that the body immune system responds to the new coronavirus can be rapidly mastered, and great reference significance is achieved for early diagnosis and post-cure reexamination of patients. In addition, the detection kit has the characteristics of high sensitivity, strong specificity, simplicity in operation, no need of complex equipment, short detection time and the like, and can play an important assistant role in eliminating the new coronavirus for human beings.
Owner:浙江峻山生物科技有限公司 +1

High-stability novel coronavirus spike protein, related biological material, application of related biological material, detection test paper and detection kit

The invention discloses a high-stability novel coronavirus spike protein, a related biological material, application of the related biological material, detection test paper and a detection kit, relates to the field of biotechnology and biomedicine. The bottleneck of the industry is broken through through internal crosslinking modification on the optimal antigen spike protein, namely S protein, onthe surface of novel coronavirus, The high-stability full-length S protein trimer is obtained through expression and purification in mammals, all antigen epitopes of the new coronavirus surface spikeprotein are reserved to the maximum extent, the stable S protein serves as an antigen to capture a new coronavirus antibody in a patient sample, and a novel coronavirus antibody instant detection kitwith high accuracy, high sensitivity and high stability is produced.
Owner:深圳粒影生物科技有限公司

Quantum dot microsphere immunochromatography test strip for detecting total amount of SARS-CoV-2 IgM-IgG antibody

The invention discloses a quantum dot microsphere immunochromatography test strip for detecting the total amount of a novel coronavirus IgM-IgG antibody. The test strip comprises a bottom plate, a sample pad, a combination pad, a nitrocellulose membrane and a water absorption pad, wherein the sample pad, the combination pad, the nitrocellulose membrane and the water absorption pad are sequentiallyconnected end to end and adhered to the bottom plate, the combination pad is coated with an N protein-marker and an S protein-marker, and the nitrocellulose membrane is provided with a detection linecoated with an N protein and S protein mixture and a quality control line coated with an N protein antibody and S protein antibody mixture. The total amount of the novel coronavirus antibody is quantitatively detected by utilizing the test strip, the detection sensitivity is high, the accuracy is good, and the repeatability and the stability are good; the test strip is simple to operate and low in cost, can quickly and quantitatively detect the total amount level of the SARS-CoV-2 IgM-IgG antibody in a human body, and provides powerful support for epidemic situations.
Owner:NANJING AGRICULTURAL UNIVERSITY

Novel severe acute respiratory syndrome coronavirus 2 N proteantigen variant and application thereof to detection of novel severe acute respiratory syndrome coronavirus 2 antibody

The invention provides a novel severe acute respiratory syndrome coronavirus 2 N proteantigen variant and an application thereof to detection of the novel severe acute respiratory syndrome coronavirus2 antibody, and relates to variants of N protein important epitope polypeptide. The variants reduce the non-specific reaction of the novel severe acute respiratory syndrome coronavirus 2 protein as acapture antigen with other coronavirus antibodies such as SARS and human influenza coronavirus antibodies. The polypeptide has coronavirus N protein epitope peptide activity, and cysteine residues are added to the C end of the polypeptide. Amino acid residue sites of the mutation are selected from: lysine at the 342rd site, lysine at the 347 site, lysine at the 387 site and lysine atthe 388 site are mutated into amino acids with relatively low homology. The sequence of the N protein 340-419 polypeptide is shown as SEQ ID NO 7. The invention further discloses an antigen composition, use and method of the variant.
Owner:SHANGHAI NAT ENG RES CENT FORNANOTECH

Novel coronavirus antibody and ELISA detection kit of novel coronavirus antibody

The invention discloses a novel coronavirus antibody and an ELISA detection kit of the novel coronavirus antibody. The antibody comprises CDR1 as shown in SEQ ID NO.1, CDR2 as shown in SEQ ID NO.2, CDR3 as shown in SEQ ID NO.3 and CDR4 as shown in SEQ ID NO.4, CDR1 shown in SEQ ID NO.5, CDR2 shown in SEQ ID NO.6, and CDR3 shown in SEQ ID NO.7. The antibody provided by the invention can be used fornovel coronavirus detection or novel coronavirus infection diagnosis.
Owner:JIANGSU PROVINCIAL CENT FOR DISEASE CONTROL & PREVENTION PUBLIC HEALTH RES INST OF JIANGSU PROVINCE

Detection kit for detecting coronavirus antibody and preparation method thereof

The invention discloses a detection kit for detecting a coronavirus antibody. The detection kit comprises a first reagent and a second reagent, the first reagent is a solution containing first microspheres, and the first microspheres are latex microspheres coated with coronavirus recombinant protein; and the second reagent is the solution containing second microspheres, and the second microspheresare latex microspheres coated with anti-coronavirus recombinant protein antibodies. According to the detection kit disclosed by the invention, latex microspheres are coated with a novel coronavirus recombinant protein antigen and a paired monoclonal antibody; whether a novel coronavirus antibody exists in a sample to be detected or not is judged through a change of solution absorbance (absorbance) by utilizing an indirect competition method that the latex microspheres coated with recombinant protein antigens are firstly combined with the novel coronavirus antibody in the sample to be detectedand then combined with the latex microspheres coated with anti-recombinant protein monoclonal antibodies. The detection kit for detecting the novel coronavirus antibody is strong in specificity, highin sensitivity and wide in detection range, and reagent cost can be greatly reduced.
Owner:SUZHOU KANGHESHUN MEDICAL TECH
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