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Kit for combined detection of 2019 novel coronavirus IgM and IgG antibodies and preparation method thereof

A coronavirus, combined detection technology, applied in measurement devices, instruments, scientific instruments, etc., can solve problems such as affecting the accuracy of test results, false negative test results, affecting test results, etc., and is suitable for large-scale screening, widening Storage conditions and storage environment, the effect of simplifying the assembly process

Active Publication Date: 2020-07-17
山东康华生物医疗科技股份有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, nucleic acid is mainly used for detection, but due to the difficulty in sample collection, and the relatively high requirements for laboratory conditions and the technical level of testing personnel, any one of the above-mentioned influencing factors will affect the test result, resulting in a false negative test result. Affect the accuracy of test results

Method used

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  • Kit for combined detection of 2019 novel coronavirus IgM and IgG antibodies and preparation method thereof
  • Kit for combined detection of 2019 novel coronavirus IgM and IgG antibodies and preparation method thereof
  • Kit for combined detection of 2019 novel coronavirus IgM and IgG antibodies and preparation method thereof

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Embodiment 1

[0035]A dry immunofluorescence kit for joint detection of 2019 novel coronavirus IgM and IgG antibodies, said kit comprising a dual detection card and a detection buffer; said dual detection card is provided with a 2019 novel coronavirus IgM antibody detection kit Test paper strip and 2019 novel coronavirus IgG antibody detection test strip, described 2019 novel coronavirus IgM antibody detection test strip and 2019 novel coronavirus IgG antibody detection test strip comprise sample pad, nitrocellulose membrane and absorbent pad respectively , wherein the sample pad is coated with anti-sheep erythrocyte antibody (the sample pad is placed in a final concentration of 5mg / ml anti-sheep erythrocyte antibody, soaked for 30min, and obtained after drying), and the nitrocellulose membrane is provided with a fluorescent antibody solidus, Test lines and quality control lines.

[0036] Wherein the fluorescent antibody solid phase line of the nitrocellulose membrane of the 2019 novel coro...

Embodiment 2

[0048] A dry immunofluorescence kit for joint detection of 2019 novel coronavirus IgM and IgG antibodies, said kit comprising a dual detection card and a detection buffer; said dual detection card is provided with a 2019 novel coronavirus IgM antibody detection kit Test paper strip and 2019 novel coronavirus IgG antibody detection test strip, described 2019 novel coronavirus IgM antibody detection test strip and 2019 novel coronavirus IgG antibody detection test strip comprise sample pad, nitrocellulose membrane and absorbent pad respectively , wherein the sample pad is coated with anti-sheep erythrocyte antibody (the sample pad is placed in a final concentration of 5mg / ml anti-sheep erythrocyte antibody, soaked for 30min, and obtained after drying), and the nitrocellulose membrane is provided with a fluorescent antibody solidus, Test lines and quality control lines.

[0049] Wherein the fluorescent antibody solid phase line of the nitrocellulose membrane of the 2019 novel cor...

Embodiment 3

[0061] A dry immunofluorescence kit for joint detection of 2019 novel coronavirus IgM and IgG antibodies, said kit comprising a dual detection card and a detection buffer; said dual detection card is provided with a 2019 novel coronavirus IgM antibody detection kit Test paper strip and 2019 novel coronavirus IgG antibody detection test strip, described 2019 novel coronavirus IgM antibody detection test strip and 2019 novel coronavirus IgG antibody detection test strip comprise sample pad, nitrocellulose membrane and absorbent pad respectively , wherein the sample pad is coated with anti-sheep erythrocyte antibody (the sample pad is placed in a final concentration of 5mg / ml anti-sheep erythrocyte antibody, soaked for 30min, and obtained after drying), and the nitrocellulose membrane is provided with a fluorescent antibody solidus, Test lines and quality control lines.

[0062] Wherein the fluorescent antibody solid phase line of the nitrocellulose membrane of the 2019 novel cor...

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Abstract

The invention relates to the technical field of in-vitro diagnostic reagents, in particular to a kit for combined detection of novel 2019 coronavirus IgM and IgG antibodies and a preparation method ofthe kit. The kit comprises a duplex detection card and a detection buffer solution; a 2019 novel coronavirus IgM antibody detection test strip and a 2019 novel coronavirus IgG antibody detection teststrip are arranged in the duplex detection card; the 2019 novel coronavirus IgM antibody detection test strip and the 2019 novel coronavirus IgG antibody detection test strip respectively comprise asample pad, a nitrocellulose membrane and a water absorption pad, wherein the sample pad is coated with an anti-sheep erythrocyte antibody, and the nitrocellulose membrane is provided with a fluorescent antibody solidus, a detection line and a quality control line. By using the kit, the detection rate can be improved, and the operation is simple.

Description

technical field [0001] The invention relates to the technical field of in vitro diagnostic reagents, in particular to a kit for joint detection of 2019 novel coronavirus IgM and IgG antibodies and a preparation method thereof. Background technique [0002] The 2019 novel coronavirus, or "COVID-19", was named by the World Health Organization on February 11, 2020. The new coronavirus belongs to the new coronavirus of the genus β, with an envelope, and the particles are round or oval, often pleomorphic, with a diameter of 60-140nm. The S protein is one of the main proteins of the virus, and its coding gene is used for virus typing. The N protein wraps the viral genome and can be used as a diagnostic antigen. Based on the current epidemiological investigation, its clinical manifestations: the incubation period is generally 3 to 7 days, and the longest does not exceed 21 days. The crowd is generally susceptible, with fever, fatigue, and dry cough as the main manifestations. A...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/569G01N33/533
CPCG01N33/56983G01N33/533G01N2333/165Y02A50/30
Inventor 杨帆杨致亭姚瀚鑫杨金红彭芹
Owner 山东康华生物医疗科技股份有限公司
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