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34 results about "Erythrocyte antibody" patented technology
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Method for separating red corpuscle from whole blood
InactiveCN101469323AFaster magnetic separationFast separationBlood/immune system cellsElectrical/wave energy microorganism treatmentPhytohemagglutininsMicrosphere
The invention relates to a novel method for quickly separating erythrocyte in whole blood of human beings, in particular to a method for separating the erythrocyte in the whole blood of the human beings by using polymer microsphers which are pre-coated by phytohemagglutinin or anti-erythrocyte antibodies and contain magnetic materials. The method can quickly and highly efficiently separate the erythrocyte from a whole-blood sample of the human beings.
Owner:INTEC PROD INC
Multiple Analysis of Blood Samples
ActiveUS20100178656A1The process is simple and fastSimple and rapid methodBioreactor/fermenter combinationsBiological substance pretreatmentsErythrocyte membraneRed blood cell
Owner:BIO RAD EURO GMBH
Kit for combined detection of 2019 novel coronavirus IgM and IgG antibodies and preparation method thereof
ActiveCN111426831AImprove structural stabilityHigh sensitivityBiological material analysisAgainst vector-borne diseasesIgm antibodyErythroid cell
The invention relates to the technical field of in-vitro diagnostic reagents, in particular to a kit for combined detection of novel 2019 coronavirus IgM and IgG antibodies and a preparation method ofthe kit. The kit comprises a duplex detection card and a detection buffer solution; a 2019 novel coronavirus IgM antibody detection test strip and a 2019 novel coronavirus IgG antibody detection teststrip are arranged in the duplex detection card; the 2019 novel coronavirus IgM antibody detection test strip and the 2019 novel coronavirus IgG antibody detection test strip respectively comprise asample pad, a nitrocellulose membrane and a water absorption pad, wherein the sample pad is coated with an anti-sheep erythrocyte antibody, and the nitrocellulose membrane is provided with a fluorescent antibody solidus, a detection line and a quality control line. By using the kit, the detection rate can be improved, and the operation is simple.
Owner:山东康华生物医疗科技股份有限公司 +1
Detection of Antigens Carried by Erythrocytes and of Anti-Erthrocyte Antibodies
ActiveUS20100184101A1Reduce background noiseStrong specificityBioreactor/fermenter combinationsBiological substance pretreatmentsErythrocyte membraneErythrocyte antibody
The invention relates to a method for detecting a plurality of antigenic molecules carried by erythrocytes and / or a plurality of anti-erythrocyte antibodies, said antigenic molecules carried by the erythrocytes consisting of antigenic molecules carried not only by the erythrocytes, but also by at least one other cell population, other than the blood group antigen molecules, said method comprising bringing a sample into contact with distinguishable beads, on which are attached a) antibodies specific for said antigens, or b) erythrocytes or erythrocyte membrane fragment.
Owner:BIO RAD EURO GMBH
SPA-antibody tripolymer, cell treating kit containing tripolymer, preparation method and application thereof
InactiveCN101799473ASimple methodLow costBlood/immune system cellsBiological testingProgenitorRed blood cell
The invention relates to an SPA-antibody tripolymer, a cell treating kit containing the tripolymer, a preparation method and application thereof. The tripolymer comprises an anti erythrocyte antibody, an SPA and an antibody of a certain anti leukocyte antigen or other antigens. The tripolymer is combined with an erythrocyte through the anti erythrocyte antibody per se, the other antibody is combined with a corresponding leukocyte antigen (or other antigens), and then leukocyte (other cells, factors) and the erythrocyte are deposited through an erythrocyte sedimentation process or other methods of density gradient centrifugation and the like, thereby achieving the purpose of eliminating ingredients of corresponding cells and the like, connecting the erythrocyte with a corresponding antigen by the SPA, and being used as a mean for detecting a certain antigen. The invention has convenience and simpleness, and can be directly used for clinically separating and extracting stem cells / progenitor cells; and the collected and extracted stem cells / progenitor cells have no external markers. Meanwhile, the kit based on the tripolymer can be industrially produced so as to realize the popularization of the separation and purification technology of hematopoietic stem cells.
Owner:王信
Method for rapidly separating supernatant from human whole blood or suspended red blood cells by utilizing lyophilized preparation
InactiveCN101445793ASuspension fastSimple designBlood/immune system cellsErythrocyte antibodyRed Cell
The invention relates to a method for rapidly separating supernatant from human whole blood or suspended red blood cells by utilizing lyophilized preparation. The method comprises the following steps: the phytoagglutinin or the anti erythrocyte antibody is pre-coated on a magnetic polymer microsphere to be prepared into isolating reagent for the liquid whole blood or suspended red blood cells; the isolating reagent for the liquid whole blood or suspended red blood cells is absorbed by insoluble polymer, and after lyophylization, the isolating reagent is cut into thin slices to be prepared into isolating reagent for lyophilized whole blood or suspended red blood cells; and the isolating reagent for the lyophilized whole blood or suspended red blood cells is added to the human whole blood or suspended red blood cells to be uniformly mixed and then placed above a magnetic body, and the supernatant is rapidly separated. The lyophilized preparation preserved for long term at the normal temperature can be prepared by the method, and the supernatant can be rapidly separated form the human whole blood or suspended red blood cells under the conditions without ensuing the electric power and the centrifugal machine.
Owner:NANJING GENERAL HOSPITAL NANJING MILLITARY COMMAND P L A +2
Blood group antigen chip and application thereof in detection of unexpected erythrocyte antibodies
ActiveCN107643409AHigh sensitivityWide linear rangeBiological testingErythrocyte membraneGroup A - blood
The invention discloses a blood group antigen chip and application thereof in detection of unexpected erythrocyte antibodies. The detection comprises: (1) coating a carrier with a blood group erythrocyte membrane antigen; (2) contacting a tested sample with the antigen of the carrier; (3) adding a second antibody labeled with a marker; and (4) performing signal detection on the marker. The blood group antigen chip and a detection method of unexpected erythrocyte antibodies are high in sensitivity, good in accuracy, independent of erythrocytes, and capable of detecting binding antibodies of a plurality of rare blood group antigens.
Owner:GENERAL HOSPITAL OF PLA
Electrochemical blood detection method and device for reducing red blood cell interference
PendingCN107436318AGuaranteed accuracyEliminate measurement effectsMaterial analysis by electric/magnetic meansCoatingsElectrochemical detectorElectrochemical biosensor
The invention discloses an electrochemical blood detection method and device for reducing blood red cell interference, and the method comprises the following steps: blood and anti red cell antibody beads are reacted, blood red cells are bonded with the anti red cell antibody beads to obtain red cell beads; the anti red cell antibody beads are anti red cell antibodies combined with nano magnetic beads; 2) the blood red cell beads are absorbed by a magnetic material to exclude the blood red cell interference in subsequent blood electrochemical detection process; and 3) magnetic material adsorption blood is routinely electrochemically detected. The device is an electrochemical biosensor test paper or / and an electrochemical detector. The beneficial effects are that through the detection method, during electrochemical blood detection, the influence of large volume of red blood cells on the measurement is eliminated, and the accuracy of detection results is ensured.
Owner:WUHAN J H BIO TECH
Method for quickly separating human total blood or suspended red cell supernatant
InactiveCN100584942CSuspension fastSimple designBlood/immune system cellsBiological testingErythrocyte antibodyRed Cell
Owner:NANJING GENERAL HOSPITAL NANJING MILLITARY COMMAND P L A +2
Method of detecting red cell antigen-antibody reactions
InactiveUS20080261248A1High test sensitivityEasy to disperseBioreactor/fermenter combinationsBiological substance pretreatmentsSerum igeCellular antigens
A process for the detection of antibodies in a test sample by carrying out the following steps:(a) preparing a suspension of erythrocytes with a test serum or plasma by mixing a test serum or plasma with erythrocytes;(b)incubating the suspension formed in step (a) at a temperature of from 37° C. to 45° C. for a period of time from sixty seconds to 10 minutes to bind any antibodies in the test serum or plasma to the surface of said erythrocytes(c)combining said suspension with an amount of a solution of a macromolecule which is effective for agglutination of said erythrocytes;(d) packing the resultant red cell agglutinates by centrifugation from the suspension of step (c); and,(f) determining the presence of anti-erythrocyte antibodies by observing if antibody-dependent erythrocyte aggregation has occurred.
Owner:CLAVINA DIAGNOSTICS
Kit and use of SPA (staphylococcal protein A)-antibody trimer
InactiveCN103361313AEfficient removalSimple methodBlood/immune system cellsProgenitorStem Cell Isolation
The invention relates to a kit and use of SPA (staphylococcal protein A)-antibody trimer. The antibody trimer is formed by an anti erythrocyte antibody, SPA and antibodies of some anti-leukocyte antigen or other antigens. According to the antibody trimer, the self anti erythrocyte antibody is combined with erythrocyte, the other antibody is combined with corresponding leukocyte antigen (or other antigen), then leukocyte (or other cell, factor) and erythrocyte are deposited by a blood sedimentation process or methods, such as density gradient centrifugation to achieve the purpose of eliminating components of corresponding cell and the like, and the erythrocyte can be also connected with corresponding antigen by virtue of the SPA to be used as means for detecting certain antigens. The kit is convenient and simple and can be directly used for clinical separation and extraction of stem cells / progenitor cells, and the collected and extracted stem cells / progenitor cells do not have any foreign markers. The kit based on the trimer can be industrially produced to realize popularization of human hematopoietic stem cell separation and purification technology.
Owner:王信
Piperacillin induced hemolysis detection reagent kit and method for preparing same
PendingCN107132323AHigh sensitivityGood repeatabilityDisease diagnosisTesting medicinal preparationsHemolysisRed blood cell
The invention relates to a piperacillin induced hemolysis detection reagent kit and a method for preparing the same. The piperacillin induced hemolysis detection reagent kit comprises piperacillin inducible hemolysis detection reagent cards I, piperacillin inducible hemolysis detection reagent cards II, piperacillin treated red blood cells, non-piperacillin treated red blood cells, antibody positive control liquid and antibody negative control liquid. The piperacillin treated red blood cells are normal O Rh (rhesus) negative red blood cells treated by piperacillin medicine solution; the non-piperacillin treated red blood cells are normal O Rh negative red blood cells with the concentration of 2-2.5%; the piperacillin antibody positive control liquid is piperacillin antibody positive serum; the piperacillin antibody negative control liquid is piperacillin antibody negative serum. The piperacillin induced hemolysis detection reagent kit and the method have the advantages that the piperacillin inducible hemolysis detection reagent kit is high in sensitivity, good in repeatability and stable in quality, detection procedures are short in time consuming, the method is simple, convenient and feasible, and results are easy to judge.
Owner:江苏中济万泰生物医药有限公司
Test paper for quantitatively determining urea and preparation method of test paper
InactiveCN111983235ASimple structureShorten detection timeMaterial analysis by observing effect on chemical indicatorBiological testingHemagglutininAntiendomysial antibodies
The invention discloses test paper for quantitatively determining urea and a preparation method of the test paper, and belongs to the field of in-vitro diagnosis. The test paper comprises a diffusionlayer, a blood filtering layer, a reaction layer and a hydrophobic breathable color developing layer, wherein the blood filtering layer comprises buffer salt, divalent metal ions, polyvinylpyrrolidone, hemagglutinin or an anti-erythrocyte antibody, and the reaction layer comprises buffer salt, a surfactant, divalent metal ions, urease, polysaccharide, ascorbic acid oxidase, polyol, polyvinylpyrrolidone and an enzyme protective agent; the color developing layer contains an alcohol and a color developing agent. A blood filtering solution, a reaction solution and a color developing agent solutioncontaining related components are prepared, a blood filtering layer and a reaction layer material are soaked in the blood filtering solution and the reaction solution respectively, the color developing agent solution is sprayed on a hydrophobic breathable color developing layer material and dried to obtain a blood filtering layer, a reaction layer and a hydrophobic breathable color developing layer, and the blood filtering layer, the reaction layer and the hydrophobic breathable color developing layer are assembled with other components to obtain the test paper. The test paper provided by theinvention can simply, rapidly and quantitatively detect the content of urea in whole blood, plasma and serum.
Owner:湖北金鉴生物有限公司
Method and reagent card for whole blood quick determination of homocysteine
InactiveCN105300951AGood removal effectGuaranteed test accuracyPreparing sample for investigationFluorescence/phosphorescenceRed blood cellFluorescence
The invention belongs to a method for whole blood quick determination of homocysteine. The method comprises the following steps: (1) filtering whole blood by a filter material to filter red cells in the whole blood; (2) performing absorption processing on the filtered whole blood by anti-erythrocyte antibodies to adsorb unfiltered red cells; (3) reducing homocysteine in the whole blood subjected to the absorption processing by a reducing agent into reduced homocysteine, and then performing pyrolysis on the reduced homocysteine by homocysteine lyase to generate H2S; (4) performing a fluorescence reaction on the H2S and a color developing agent and finally reading a result. The method needs no special separation device, can remove the red cells in the whole blood by the filter material and the anti-erythrocyte antibodies, and is good in removing effect, thus ensuring the testing accuracy and greatly simplifying the operation.
Owner:ANHUI DAQIAN BIO ENG LIMITED
Use of heat shock protein gp96 in treatment on autoimmune hemolytic anemia
InactiveCN106975072ALower titerPeptide/protein ingredientsImmunological disordersRegulatory T cellProtein engineering
The invention provides a use of a heat shock protein gp96 in treatment on autoimmune hemolytic anemia and belongs to the technical field of protein engineering and biomedical application. The amino acid sequence of the heat shock protein gp96 is shown in the formula of SEQ ID NO. 2 or is a specific fragment of the amino acid sequence shown in the formula of SEQ ID NO. 2. The heat shock protein gp96 can induce the production of regulatory T cells, can reduce anti-erythrocyte antibody titer, can improve the number of red blood cells and content of hemoglobin, can be used for preparation of a drug for treating autoimmune hemolytic anemia and has a wide application prospect.
Owner:FOSHAN HEAT SHOCK BIOTECH CO LTD
Immunomagnetic bead for separating red blood cells, and preparation method and application of immunomagnetic bead
InactiveCN111662869AImprove bindingImprove accuracyCell dissociation methodsBlood/immune system cellsHemolysisRed blood cell
The invention relates to an immunomagnetic bead for separating red blood cells, and a preparation method and application of the immunomagnetic bead, and relates to the technical field of preparation of immunomagnetic beads. The preparation method of the immunomagnetic bead comprises the following steps: S1, activating a magnetic bead with an activating agent, wherein a weight ratio of the magneticbead to the activating agent is 1:(0.1-5), and an activation time is 5-30 min; S2, adding an anti-red blood cell antibody into the activated product obtained in the step S1, and carrying out ultrasonic treatment; and S3, adding a sealing agent into the product obtained in the step S2 for sealing, and performing strong magnetic separation to obtain the immunomagnetic bead for separating red bloodcells. The immunomagnetic bead obtained by the method disclosed by the invention is used for separating red blood cells in blood plasma, the separation of the blood cells can be completed within 1-2 min, the time is saved, a basis is provided for the rapid detection, and meanwhile, the hemolysis phenomenon caused by factors such as centrifugation is avoided, so that the accuracy of a detection result is improved.
Owner:北京康思润业生物技术有限公司
Rapid immune detection method and detection kit for blood sample
InactiveCN102192982AWill not cause churnAchieve separationMaterial analysisRed blood cellNormal blood volume
The invention relates to a rapid immune detection method and a detection kit for a blood sample. The method comprises the following step of: removing erythrocyte from the sample. The step of removing the erythrocyte is that: the whole blood sample is enabled to flow through a solid phase carrier which is coated and fixed with an anti erythrocyte antibody or an active section of the anti erythrocyte antibody; in the process that the sample flows through the solid phase carrier, the erythrocyte is combined with the anti erythrocyte antibody or the active section of the anti erythrocyte antibody, so that the erythrocyte is retained in the solid phase carrier; and the solid phase carrier consists of a water absorption medium which is subjected to sealing treatment. By the rapid immune detection method and the detection kit for the blood sample, the erythrocyte in the blood sample is effectively retained; and compared with the prior art, the invention has the advantages that: the detection can be directly performed by taking the whole blood as the sample, the limitation of a blood serum test method which only takes blood serum as a sample is overcome, blood volume and detection time are saved, and the detection sensitivity is high.
Owner:SUZHOU HAOOUBO BIOPHARML
Anti-interference film and liver function combined test strip
ActiveCN109900689AImprove anti-interference abilityGood biological detection anti-interference performanceMaterial analysis by observing effect on chemical indicatorLiver function testsCatalase
The invention provides an anti-interference film and a liver function combined test strip. The anti-interference film is obtained by wetting and treating a substrate with anti-interference treatment fluid. The anti-interference treatment fluid comprises 10-100KU / L of pyruvic oxidase, 100-500KU / L of catalase, 3-30 micronM of cupric salt and 0.1-0.3g / L of erythrocyte antibody. The liver function combined test strip comprises a diffusion film, the anti-interference film, a blood filter film, a reaction film, a color development film and a bottom board, which are stacked up in sequence. The liverfunction combined test strip prepared by the anti-interference film can detect ALT and AST two substances simultaneously and can obtain ALT, AST and ALT / AST three indicators, thereby providing more reliable guidance for clinical diagnosis; and the test strip is simple and fast, adopts smaller matched instruments and is flexible and wide in application.
Owner:复星诊断科技(长沙)有限公司
In vitro diagnosis device comprising beads and uses thereof
PendingUS20200408749A1High sensitivityStrong specificityBiological material analysisBiological testingAntiparasiticViral antibody
The present invention relates to an in-vitro diagnosis device for detecting and / or identifying antigen and / or antibody from a sample of biological fluid, particularly from a sample of blood or sample of blood components. The invention also relates to different uses of this device such as the detection and / or the identification of red blood cells antigens, platelet antigens, viralantigens, bacterial antigens, parasite antigens, the detection and / or the identification of anti-red blood cells antibodies, antiplatelet antibodies, antiviral antibodies, antibacterial antibodies and antiparasitic antibodies.
Owner:DIAGAST
Method of detecting red cell antigen-antibody reactions
InactiveUS7919266B2High test sensitivityAntibody uptake by the red cells is noticeably increasedBioreactor/fermenter combinationsBiological substance pretreatmentsSerum igeTest sample
A process for the detection of antibodies in a test sample by preparing a suspension of erythrocytes with a test serum or plasma by mixing a test serum or plasma with erythrocytes; incubating the suspension of erythrocytes at a temperature of from 37° C. to 45° C. to bind any antibodies in the test serum or plasma to the surface of said erythrocytes; combining the suspension of erythrocytes with an amount of a solution of a macromolecule which is effective to agglutinate the erythrocytes; packing the resultant red cell agglutinates by centrifuging the suspension of erythrocytes; and, determining the presence of anti-erythrocyte antibodies by observing if antibody-dependent erythrocyte agglutination has occurred.
Owner:CLAVINA DIAGNOSTICS
Fluorescence immunochromatography test strip for quantitatively detecting anti-PLA2R antibody and preparation method of fluorescence immunochromatography test strip
PendingCN114441766AHigh sensitivityImprove accuracyDisease diagnosisBiological testingErythrocyte antibodyFluorescence immunoassay analyzer
The invention provides a fluorescence immunochromatography test strip for quantitatively detecting an anti-PLA2R antibody and a preparation method thereof, the fluorescence immunochromatography test strip comprises a bottom plate, and a sample pad, a combination pad, a nitrocellulose membrane and absorbent paper which are sequentially carried on the bottom plate, the conjugate pad is coated with a PLA2R fluorescent microsphere conjugate and a rabbit IgG fluorescent microsphere conjugate, the nitrocellulose membrane is coated with a mouse anti-human IgG antibody as a detection line, and the nitrocellulose membrane is also coated with goat anti-rabbit IgG as a quality control line. The fluorescence immunochromatography test strip disclosed by the invention is high in sensitivity and accuracy, extremely small in dosage of required clinical samples and simple to operate, and signal detection and concentration value conversion can be realized by only one fluorescence immunoassay analyzer.
Owner:迪亚莱博(张家港)生物科技有限公司 +1
Filtering membrane pretreatment liquid for improving immunofluorescence detection sensitivity and preparation method and application thereof
PendingCN113588610AHigh sensitivityImprove filtration efficiencyLaboratory glasswaresFluorescence/phosphorescenceAntiendomysial antibodiesImmunofluorescence
The invention discloses a filtering membrane pretreatment liquid for improving immunofluorescence detection sensitivity and a preparation method and application thereof. The filtering membrane pretreatment liquid for improving the immunofluorescence detection sensitivity comprises a solvent and solute, the solvent is a buffer solution Tris-HCL, the concentration of the Tris-HCL is 50-100 Mm / L, the solute comprises 2-6 g / L of a surfactant, 1-5 g / L of PVP, 3-6 g / L of PEG6000, 20-60 g / L of saccharides, 30-60 g / L of inert protein, 1-5 mg / L of heterophagy antibody, 1-5 mg / L of anti-erythrocyte antibody and 0.5-1 g / L of preservative. The filter membrane pretreatment liquid has the advantage of improving the detection sensitivity of the micro-fluidic chip.
Owner:重庆创芯生物科技有限公司
Blood collection card and application thereof
PendingCN114410441AHigh plasma recoveryBioreactor/fermenter combinationsBiological substance pretreatmentsBlood collectionWhite blood cell
The invention provides a blood collection card and application thereof, and belongs to the technical field of sample collection devices.The blood collection card comprises a blood collection card basic component and a bottom plate; the blood collection card basic component comprises a rubber plate; a red blood cell separation pad, a white blood cell preservation pad and a blood plasma preservation pad are sequentially adhered to the rubber plate in a mutual overlapping manner; or the red blood cell separation pad and the plasma preservation pad are sequentially adhered to the rubber plate in a mutual overlapping manner; the blood collection card basic component is fixed on the bottom plate; the red blood cell separation pad comprises a red blood cell antibody and / or lectin; the leukocyte preservation pad is made of a hydrophilic filter membrane, and the aperture of the hydrophilic filter membrane is 0.5-5 microns. According to the method, the lateral chromatography effect of blood on the surface of the membrane is fully utilized, red blood cells can be separated out, interference of the red blood cells on leukocytes and / or plasma is eliminated, and effective separation and preservation of the leukocytes and / or plasma are achieved.
Owner:浙江嘉孚生物科技有限公司
Immunochromatographic test strip and device comprising the same
ActiveCN111781347AIncrease in sizeMany binding sitesBiological testingAgainst vector-borne diseasesGlass fiberRed blood cell
The present invention relates to an immunochromatographic test strip, which comprises: a sample pad; a marker pad, which is connected to the sample pad; a coating pad, which is connected to the markerpad, and is equipped with a detection line and a quality control line sequentially; and a water absorption pad, which is connected to the coating pad; wherein the sample pad comprises a glass fiber pad, and an RBC antibody compound is sprayed on the glass fiber pad. The invention also provides a device comprising the immunochromatographic test strip. The invention relates to the immunochromatographic test strip and the device comprising the same, an RBC antibody in the RBC antibody compound and red blood cells are subjected to immunoaffinity reaction to form a cross-linked substance of "red blood cell-RBC antibody compound-red blood cell", compared with a single RBC antibody, the RBC compound is larger in size and more in red blood cell binding sites, so that the RBC compound is easier tobind with red blood cells and is intercepted on the sample pad.
Owner:北京康思润业生物技术有限公司
Kit and detection method for detecting thymidine kinase 1 in whole blood
PendingCN114460295ARealize detectionHigh sensitivityChemiluminescene/bioluminescenceBiological material analysisAntiendomysial antibodiesMonoclonal antibody
The invention discloses a kit for detecting thymidine kinase 1 in whole blood and a detection method, belongs to the technical field of immunodetection, and solves the technical problem of long time consumption of an existing detection method. The kit comprises a reagent R1, a reagent R2 and a reagent R3, wherein the R1 reagent comprises a magnetic separation reagent and an anti-erythrocyte antibody; the R2 reagent comprises a TK1 monoclonal antibody labeled by horse radish peroxidase; the R3 reagent comprises a TK1 monoclonal antibody marked by Acridan; the method comprises the following steps: S1, adding a reagent R4 and a reagent R1 into human whole blood, reacting, and carrying out magnetic separation to obtain a reaction solution A; s2, adding a reagent R2 and a reagent R3 into the reaction solution A, and incubating to obtain a reaction solution B; and S3, adding an excitation liquid separant into the reaction liquid B, and determining. The kit and the method are used for detecting the TK1 content in human whole blood, and have the advantages of high detection efficiency and less time consumption.
Owner:BEIJING HOMA BIOLOGICAL ENG
Method
PendingUS20200247903A1Immunoglobulins against blood group antigensAntipyreticAntiendomysial antibodiesRed blood cell
The invention relates to an antibody to a red blood cell for use in treating or preventing an inflammatory disorder, and to methods of treating or preventing an inflammatory disorder comprising administering to a subject in need thereof a therapeutically effective amount of an antibody to a red blood cell.
Owner:CANADIAN BLOOD SERVICES +1
A test paper suitable for quantitative detection of peripheral blood immunochromatography and its application
ActiveCN109799338BHigh sensitivityHigh detection sensitivityBiological testingEpitopeAntiendomysial antibodies
The invention discloses a test paper suitable for the quantitative detection of peripheral blood immunochromatography and its application, comprising a bottom plate, and the bottom plate is sequentially provided with a sample pad, a sealing pad, a reaction pad and a water-absorbing pad along the length direction of the bottom plate; it is characterized in that : the sample pad is coated with a first antibody, the first antibody has a tracer marker and can recognize an antigenic epitope of the target to be tested; the blocking pad is coated with an anti-erythrocyte antibody, and the blocking pad A pad is partially laminated to the reaction pad. The present invention also includes the application of the above-mentioned test paper in the preparation of the immunochromatography detection box or in the quantitative detection of the peripheral blood immunochromatography. Compared with the prior art, the test paper provided by the invention has the advantages of high sensitivity, wide linear range and the like.
Owner:湖南达道生物工程有限公司
SPA-antibody tripolymer, cell treating kit containing tripolymer, preparation method and application thereof
InactiveCN101799473BEasy to operateLow costBlood/immune system cellsBiological testingProgenitorStem Cell Isolation
The invention relates to an SPA-antibody tripolymer, a cell treating kit containing the tripolymer, a preparation method and application thereof. The tripolymer comprises an anti erythrocyte antibody, an SPA and an antibody of a certain anti leukocyte antigen or other antigens. The tripolymer is combined with an erythrocyte through the anti erythrocyte antibody per se, the other antibody is combined with a corresponding leukocyte antigen (or other antigens), and then leukocyte (other cells, factors) and the erythrocyte are deposited through an erythrocyte sedimentation process or other methods of density gradient centrifugation and the like, thereby achieving the purpose of eliminating ingredients of corresponding cells and the like, connecting the erythrocyte with a corresponding antigen by the SPA, and being used as a mean for detecting a certain antigen. The invention has convenience and simpleness, and can be directly used for clinically separating and extracting stem cells / progenitor cells; and the collected and extracted stem cells / progenitor cells have no external markers. Meanwhile, the kit based on the tripolymer can be industrially produced so as to realize the popularization of the separation and purification technology of hematopoietic stem cells.
Owner:王信
Kit for detecting calcium ossein and detection method
PendingCN114460309ARealize detectionShort detection timeChemiluminescene/bioluminescenceBiological testingErythrocyte antibodyAntiendomysial antibodies
The invention discloses a kit for detecting calcium ossein and a detection method, belongs to the technical field of immunodetection, and solves the problem of long time consumption of related detection methods. The kit comprises a calibrator, normal saline, a reagent R1, a reagent R2 and a reagent R3, the R1 reagent comprises a magnetic separation reagent and an anti-erythrocyte antibody; the R2 reagent comprises a BGP monoclonal antibody marked by HRP (horse radish peroxidase); the R3 reagent comprises a BGP monoclonal antibody marked by Acridan; the method comprises the following steps: S1, adding normal saline and an R1 reagent into human whole blood, reacting, and carrying out magnetic separation to obtain a reaction solution A; s2, adding a reagent R2 and a reagent R3 into the reaction solution A, and incubating to obtain a reaction solution B; s3, adding excitation liquid and spacer liquid into the reaction liquid B, and measuring; and S4, drawing a standard curve, and determining the BGP content. The kit and the method are used for detecting the BGP content in human whole blood, and have the advantages of high detection efficiency and less time consumption.
Owner:BEIJING HOMA BIOLOGICAL ENG
Applications of SPA-antibody trimer as indicator in detection of blood antigens
InactiveCN103616516AEasy to operateLow costBiological material analysisBlood/immune system cellsRed blood cellErythrocyte binding
The invention relates to applications of an SPA-antibody trimer as an indicator in detection of blood antigens. The trimer is formed of anti erythrocyte antibodies, SPA and some kind of anti leucocyte or other antigen antibodies. The self anti erythrocyte antibodies are combined with erythrocytes, another kind of antibodies are combined with corresponding leucocyte antigens (or other antigens), then leucocytes (or other cells and factors) and erythrocytes are sedimentated through a blood sedimentation process or other methods such as density gradient centrifugation and the like, so the trimer has the effect of removing components of corresponding cells and the like. The trimer also can combine erythrocytes and corresponding antigens by means of SPA and is used for detecting certain antigens.
Owner:王信
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