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270results about How to "High test sensitivity" patented technology

Diagnostic testing process and apparatus

A method and apparatus for use in a flow through assay process is disclosed. The method is characterised by a “pre-incubation step” in which the sample which is to be analysed, (typically for the presence of a particular protein), and a detection analyte (typically an antibody bound to colloidal gold or a fluorescent tag) which is known to bind to the particular protein may bind together for a desired period of time. This pre incubation step occurs before the mixture of sample and detection analyte come into contact with a capture analyte bound to a membrane. The provision of the pre-incubation step has the effect of both improving the sensitivity of the assay and reducing the volume of sample required for an assay. An apparatus for carrying out the method is disclosed defining a pre-incubation chamber for receiving the sample and detection analyte having a base defined by a membrane and a second membrane to which a capture analyte is bound. In one version the pre-incubation chamber is supported above the second membrane in one position but can be pushed into contact with the membrane carrying the capture analyte thus permitting fluid transfer from the incubation chamber through the capture membrane. In another version the membrane at the base of the incubation chamber is hydrophobic and its underside contacts the capture membrane and when a wetting agent is applied to the contents of the pre-incubation chamber fluid transfer occurs.
Owner:PROTEOME SYST LTD

Diagnostic testing process and apparatus

A method and apparatus for use in a flow through assay process is disclosed. The method is characterised by a “pre-incubation step” in which the sample which is to be analysed, (typically for the presence of a particular protein), and a detection analyte (typically an antibody bound to colloidal gold or a fluorescent tag) which is known to bind to the particular protein may bind together for a desired period of time. This pre incubation step occurs before the mixture of sample and detection analyte come into contact with a capture analyte bound to a membrane. The provision of the pre-incubation step has the effect of both improving the sensitivity of the assay and reducing the volume of sample required for an assay. An apparatus for carrying out the method is disclosed defining a pre-incubation chamber for receiving the sample and detection analyte having a base defined by a membrane and a second membrane to which a capture analyte is bound. In one version the pre-incubation chamber is supported above the second membrane in one position but can be pushed into contact with the membrane carrying the capture analyte thus permitting fluid transfer from the incubation chamber through the capture membrane. In another version the membrane at the base of the incubation chamber is hydrophobic and its underside contacts the capture membrane and when a wetting agent is applied to the contents of the pre-incubation chamber fluid transfer occurs.
Owner:PROTEOME SYST LTD

Diagnostic testing process

A method and apparatus for use in a flow through assay process is disclosed. The method is characterised by a “pre-incubation step” in which the sample which is to be analysed (typically for the presence of a particular protein), and a detection analyte (typically one or more antibodies bound to colloidal gold or a fluorescent tag) which is known to bind to the particular protein may bind together for a desired period of time. This pre-incubation step occurs before the mixture of sample and detection analyte come into contact with a capture analyte bound to a membrane. The provision of the pre-incubation step has the effect of both improving the sensitivity of the assay and reducing the volume of sample required for an assay. An apparatus for carrying out the method is disclosed defining a pre-incubation chamber for receiving the sample and detection analyte having a base defined by a membrane and a second membrane to which a capture analyte is bound. In one version the pre-incubation chamber is supported above the second membrane in one position but can be pushed into contact with the membrane carrying the capture analyte thus permitting fluid transfer from the incubation chamber through the capture membrane. In another version the membrane at the base of the incubation chamber is hydrophobic and its underside contacts the capture membrane and when a wetting agent is applied to the contents of the pre-incubation chamber fluid transfer occurs.
Owner:PROTEOME SYST LTD

Microscopic Raman imaging spectrum rapid detection apparatus and method thereof

The invention discloses a microscopic Raman imaging spectrum rapid detection apparatus and a method thereof, which belong to the technical field of optical microscopic imaging and spectral measurement. The microscopic Raman imaging spectrum rapid detection apparatus comprises a light source, a multifunctional sample room, a composite optical system, an image acquisition system, a data fusion processing system, a Raman spectrum detection system, and a computer control and display system. According to white light or laser emitted by the light source, sample in-situ observation and microscopic Raman imaging spectrum real-time on-line detection are respectively realized, the data fusion processing system performs real-time analysis processing on images and spectrum information, and images andspectrum information are displayed and output in the computer control and display system. The microscopic Raman imaging spectrum rapid detection apparatus has the characteristics of compact structure,high spatial resolution, convenient usage, and stable performance, can be used in the fields of water quality detection, material analysis, petrochemical engineering, environment monitoring, and industrial precision detection, is convenient for field on-site investigation experiment and on-line test real-time analysis, and has a wide application prospect.
Owner:CHONGQING INST OF GREEN & INTELLIGENT TECH CHINESE ACADEMY OF SCI

Device for simulating and measuring heat flux of continuous casting covering slag

InactiveCN102507637ASolve the problem that thermodynamic changes cannot be observed in situHigh test sensitivityMaterial heat developmentMeasuring equipmentTest sample
The invention provides a device for simulating and measuring a heat flux of continuous casting covering slag, and the device comprises a heat flux emission system, a copper mould crystallizer, a power control system, a data acquisition/computer control system and a digital imaging system, wherein one end of the power control system is connected with the heat flux emission system and the other end of the power control system is connected with the data acquisition/computer control system; the copper mould crystallizer is placed below the heat flux emission system; and the digital imaging system is arranged beside the copper mould crystallizer. According to the invention, by virtue of comprehensively simulating a working condition and approaching to an actual production, the heat flux under instantaneous and stable conditions of the covering slag can be measured, and the size of the interface heat resistance between a slag film and a copper mould can be measured; and meanwhile, the thickness of the covering slag is accurate and controllable. Heat flux measuring equipment has the functions of controllable input heat flux waveform/amplitude and high testing flexibility; and the device has the advantages of good test repeatability, low equipment investment and maintenance cost, convenience for operation, stability, reliability, unique and novel structure, convenience for preparing test samples and low manufacturing cost, so that the device is novel heat flux measuring equipment.
Owner:CENT SOUTH UNIV

Enrichment analysis instrument of carbon and nitrogen of greenhouse gases of CO2 and N2O

InactiveCN103424462AEnrichment is complete and fastIncreased Gas Test SensitivityPreparing sample for investigationMaterial analysis by electric/magnetic meansAssayWater trap
The invention discloses an enrichment analysis instrument of carbon and nitrogen of the greenhouse gases of CO2 and N2O. A greenhouse gas sample collected by a sampling tube is led through a sample guiding valve under the He gas, is dehydrated by an electron cold trap, undergoes enrichment and transferring in a liquid nitrogen cold trap, undergoes separation by a chromatographic column and dehydrating by a water trap and is led into a gas isotope mass spectrometer through an opened shunting port for being detected. The enrichment analysis instrument has the port which is directly connected with an isotope mass spectrometer mainframe, is an independent accessory device of the isotope mass spectrometer and carries out assay determination on isotope abundance of the carbon and the nitrogen of the greenhouse gases of CO2 and the N2O which are greenhouse gases at the same time. The gas is transferred from a cold trap T1 to a cold trap T2 through conversion of gas-carrying flow and by changing a freezing state of the target gas in the traps. Meanwhile, other impurity gases which are captured by a freezing gas are released and thus, good chromatographic peak shapes and higher purity of the sample are achieved and the testing precision is improved.
Owner:COLD & ARID REGIONS ENVIRONMENTAL & ENG RES INST CHINESE

10560 NANO bandpass infrared filter and making method of same

The invention discloses a 10560 nano bandpass infrared filter and a making method of the same. The infrared filter is characterized in that a monocrystalline germanium Ge with the dimension Phi being 25.4*0.5mm is adopted as a base plate; the surface iris diaphragm N is less than or equal to 5, the partial iris diaphragm Delta N is less than or equal to 0.5, the parallelism Theta is less than or equal to 1 minute, and the surface smoothness is better than 60 / 40; zinc sulfide ZnS and monocrystalline germanium Ge are adopted for film plating materials, a main film system surface film Sub / HLHLH2LHLHLHLHLH2LHLHL / Air and an interference stop film system surface film Sub / 0.76(0.5HL0.5H)5 0.5 (0.5HL0.5H)5 0.35 (0.5HL0.5H)5 0.25 (0.5HL0.5H)6 0.16(0.5HL0.5H)6 / Air are respectively deposited on the two surfaces of the base plate, and the film plating process conditions are that under the high vacuum (vacuum degree less than or equal to 10-3Pa), heating and baking under 300 DEG C is carried out and the physical gas phase depositing method is adopted for auxiliary film plating with the ion resource. The 10560 nano bandpass infrared filter made through the making method of the same has the peak value transmission amounting to more than 90%, greatly improves the signal noise ratio, satisfactorily restrains the interference of other gases, and improves the detecting precision and efficiency of the instrument.
Owner:MULTI IR OPTOELECTRONICS

Distributed crack sensor based on coaxial cable

The invention relates to a distributed crack sensor based on a coaxial cable, belonging to the technical field of an engineering structure safety monitoring. The distributed crack sensor provided by the invention is characterized in that a metal conductor core on the inner layer, an insulating layer in the middle, the metal conductor layer provided with a weak link (such as sunk weak threads, dot mode weak threads and the like) and a surface anticorrosive material are sequentially arranged from inside to outside; the weak threads are machined by applying the rotation advancing traction to the coaxial cable and simultaneously utilizing a drill to carve grooves on an outer conductor layer or utilizing a puncher to continuously punch on the outer conductor layer; the depth and pitch of the weak threads select different numerical values according to the requirements of the structure on the test sensitivity and the space resolution; and when cracks are monitored, the attenuation signals which are generated because of the crack modulation of the coaxial cable are obtained through an electric time domain reflectometer to determine the occurrence position and expansion degree of the cracks. The sensor provided by the invention has the beneficial effects that the sensor is a coaxial cable distributed crack sensor provided with weak threads, the structure is simple, the durability is good, the crack monitoring scale is large, and a structural damage memory function is achieved.
Owner:DALIAN UNIV OF TECH

Gold nanoparticle-molybdenum disulfide-gold ultra-sensitive SERS substrate material and preparation method thereof

The invention relates to a gold nanoparticle-molybdenum disulfide-gold ultra-sensitive SERS substrate material and a preparation method thereof. The structure is a gold nanoparticle/molybdenum disulfide/gold sandwich structure with the gold nanoparticle as a core, the molybdenum disulfide as a shell, and a layer of gold particles with a certain "hot sopt" effects evaporated on the surface of the core-shell structure in a vacuum mode. The molar ratio of the nano-material element is molybdenum: sulfur: gold being 1.0:1.9: 1.0. The chemical formula of molybdenum disulfide is MoS2. Compared with the prior art, the preparation method of the gold nanoparticle-molybdenum disulfide-gold ultra-sensitive SERS substrate material is convenient and fast. According to the gold nanoparticle-molybdenum disulfide-gold SERS substrate material, MoS2 serves as a supporting body to adsorb target molecules, a double-plasma coupling effect exists between the Au nano particles, the "hot spot" effect enhancedan SERS signal, the MoS2 is in bridge connection with the Au so as to realize the ultra-sensitive detection of rhodamine B molecules, the detection limit can reach 10-10 mol/L, and the repeatability and the stability of the rhodamine B is detected to be good.
Owner:NORTHWESTERN POLYTECHNICAL UNIV

Pressure sensor encapsulation structure containing silicon through holes

The invention provides a pressure sensor encapsulation structure containing silicon through holes, which uses a silicon base to substitute a traditional boron-phosphorosilicate glass base, and adopts a flip chip bonding technology and a bonding technology (such as CuSn bonding, AuSn eutectic bonding, Cu-Cu bonding and Au-Au bonding) to realize the airtight vacuum encapsulation of pressure sensors; a monocycle or bi-cycle bonding metal ring is adopted for encapsulation, and plays the role of reducing the bonding stress on the encapsulation of the pressure sensors with different piezoresistance strip distribution under the condition of ensuring the measurement sensitivity; and conductive columns are adopted for replacing metal wires to be used as signal lead wires, so the mutual connection reliability is increased. Compared with encapsulation structures of the silicon glass electrostatic bonding technology, the metal wire bonding technology, the metal isolating membrane technology and the airtight cavity silicone oil filling technology which are adopted traditionally, the pressure sensor encapsulation structure cancelled silicone oil filling and the metal isolating membrane, contributes to the improvement in the pressure sensor sensitivity, can also be used for dynamic pressure detection, and has the advantages of small size and high integration level.
Owner:PEKING UNIV

System for measuring micro vibration by using femtosecond laser and micro vibration measuring method

The invention specifically relates to a system for measuring micro vibration by using a femtosecond laser based on balanced optical cross-correlation and a micro vibration measuring method, and belongs to the field of photoelectric precision measurement. The system comprises a microwave atomic clock, an optical fiber femtosecond laser, servo control equipment, data acquisition equipment, an upper computer and an optical measurement assembly. The basic principle of the system is a balanced optical cross-correlation principle. Femtosecond pulses emitted by the locked femtosecond laser pass through the optical measurement assembly, the data acquisition equipment acquires optical signals, output signals respectively get into the servo control equipment and computer processing equipment, the servo control equipment controls the repetition frequency of the laser, and the computer outputs a measurement result in real time. The greatest advantage of the method lies in that the method is sensitive in measurement and simple in data processing, and the method is mainly used for realizing high-precision micro vibration measurement in real time. The system and the method provided by the invention can be applied to measurement for one-dimensional micro vibration signals and calibration for a micro vibration sensor, and can also be used for manufacturing vibration measurement instrument and equipment and the like.
Owner:BEIJING CHANGCHENG INST OF METROLOGY & MEASUREMENT AVIATION IND CORP OF CHINA

Non-contact life sign monitoring signal processing system

The invention provides a non-contact life sign monitoring signal processing system, comprising an I/Q channel signal processing module, a respiration frequency estimation module, a modulation component removing module and a heartbeat frequency estimation module, wherein the I/Q channel signal processing module is used for combining I/Q channel signals I(t) and Q(t) into a complex signal S(t); the respiration frequency estimation module is used for defining a frequency rotation operator according to the baseband signal mathematic model characteristic, multiplying S(t) by, performing Fourier transformation, performing optimizing estimation on a parameter P by the spectrum concentrated index, and estimating firstly to obtain respiration frequency fr; the modulation component removing module is used for multiplying S(t) by the frequency rotation operator estimated in the step 2 and removing the modulation component caused by respiration in S(t); and the heartbeat frequency estimation module is used for estimating the heartbeat frequency fh. According to the non-contact life sign monitoring signal processing system provided by the invention, the matched frequency rotation operators are constructed based on a radar baseband signal model to perform parameterization optimizing estimation, and high-precision fr and fh estimation values can be obtained by short sampling length data, so the test sensitivity and the noise resistance are high.
Owner:SHANGHAI JIAO TONG UNIV

High-sensitivity gas sensor based on microchannel plate three-dimensional structure and production method of high-density gas sensor

The invention discloses a high-sensitivity gas sensor based on a microchannel plate three-dimensional structure and a production method of the high-sensitivity gas sensor. The high-sensitivity gas sensor consists of a detection module and a heating module; the detection module is bonded with the heating module through an electrically-conductive sizing agent; the detection module and the heating module are respectively provided with two lead leading-out electrodes, i.e. a detection electrode and a heating electrode, the detection module and the heating module are packaged inside a packaging tube shell, and the packaging tube shell is provided with at least four electrodes; the detection module is sequentially formed by an upper electrode, a microchannel plate and a lower electrode from top to bottom; the heating module is sequentially formed by a heat insulation substrate, a heating resistance coil and an insulation film from bottom to top. The high-sensitivity gas sensor has the beneficial effects that the effective specific surface area of a gas-sensitivity film can be improved, so that the sensitivity of the gas sensor can be improved; the porous structure of the microchannel plate favors the successful passing of detected gas, so that the test sensitivity and reaction speed of a device can be improved.
Owner:EAST CHINA NORMAL UNIV +1

Thick loose rock-soil layer bottom water injection sedimentation deformation analog device and method

The invention discloses a thick loose rock-soil layer bottom water injection sedimentation deformation analog device and method. The thick loose rock-soil layer bottom water injection sedimentation deformation analog device is characterized in that the two ends of a model barrel of the device are connected to flanges, and the two sides of the model barrel are connected to a water drainage flange and a pressure measuring pipe; a constant-pressure water injection pump is connected to a water source, the other end of the constant-pressure water injection pump is connected to a flowmeter, the other end of the flowmeter is connected to a water injection pipe which is connected to a water injection floral pipe in the model barrel, the bottom of a cavity is connected to a perforated plate, an optical cable is connected to a fiber grating sensor, and the other end of the optical cable is connected to a fiber grating demodulator, a computer and remote transmission equipment. The sedimentation analog method comprises the steps that the constant-pressure water injection pump is used for injecting water so as to cause the sedimentation and the deformation of a thick loose rock-soil layer, a light source in the demodulator is applied to the sensor, the demodulator is used for converting an optical signal returned by the sensor into a wavelength value and sending the wavelength value to the computer, the wavelength drift distance is calculated, and the wavelength value is converted into an internal stress value of the thick loose rock-soil layer. The thick loose rock-soil layer bottom water injection sedimentation deformation analog device has the advantages of being complete in monitoring, high in testing flexibility, repeated in manufacturing and wide in suitability for the research of a sedimentation problem of coal mines, foundation ditches, side slope roads and railways, and the wireless data transmission can be realized.
Owner:XIAN UNIV OF SCI & TECH
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