13 results about "Raman imaging" patented technology

The invention relates to a hybrid nanocarrier system comprising engineered metal nanoparticles (MeNP), a flavonoid (Fl), a Raman-active molecule (RAM), poly(allylamine hydrochloride) (PAH), genetic material (GM), and poly(styrene sulfonate) (PSS), designed for use in fields such as gene therapy, cancer treatment, chemotherapy, treatment of genetic diseases, innovative vaccine technologies, the production of innovative antibiotics for antibacterial and antimicrobial therapies, drug delivery, the dietary supplement market, Raman imaging systems, biotechnological applications, and the agrochemical industry.

This invention belongs to the field of imaging analysis technology and discloses a rapid detection method for illegal food additives based on Raman imaging. The method includes: at the start of the detection task, performing sparse Raman imaging scanning on the boundary of the target region of the sample to be tested to obtain a target pixel spectrum set; constructing a reference spectrum set, and generating a detection wavenumber interval by analyzing the stability changes of the wavenumber highlight ratio in the reference spectrum set and the spatial thermal variation characteristics of different wavenumbers in the sample to be tested; obtaining an evidence heatmap by analyzing the similarity of the detection intensity of candidate gratings in the reference spectrum set and the target pixel spectrum set within the detection wavenumber interval; continuously updating the target pixel spectrum set by analyzing the correlation between the change attributes of evidence gain and the growth of connected regions in the evidence heatmap; and outputting suspicious regions by analyzing the convergence change attributes of the evidence coverage heat increment and the stability characteristics of the region to be matched. This invention generates spatial evidence and location results for suspicious regions more quickly.

Electrode for lithium secondary battery and lithium secondary battery comprising the same. This disclosure relates to an electrode for a lithium secondary battery that not only effectively suppresses heat generation or ignition and thus has additional enhanced stability, but also enables the arrangement of batteries that exhibit excellent charge / discharge characteristics, and a lithium secondary battery comprising the same.The electrode for a secondary lithium battery comprises a metal current collector; and an active electrode material and a conductive material, and also comprises an active material layer formed on the metal current collector, wherein the active material layer further comprises a conductive polymer that exhibits a peak in the 1350 to 1600 cm⁻¹ band during Raman spectrum analysis, and exhibits PTC (positive temperature coefficient) characteristics, and wherein, when a cross-section of the active material layer is subjected to Raman imaging analysis, the conductive polymer is distributed in an amount of 90% by weight or more within a region that reaches 10% of the thickness of the active material layer from the surface of the metal current collector.

This invention discloses a hardware-software co-processing method for real-time spectral signal processing in Raman microscopy, belonging to the field of spectral signal processing technology. The method includes: establishing strict temporal constraints between physical displacement and cloud inference, and initiating asynchronous communication using the physical gaps in stage movement; simultaneously, deploying a deep learning model (F2P) pre-trained with a self-supervised masking strategy in the cloud. This pre-trained model utilizes the structural correlation between the Raman broadband background and narrowband characteristic peaks to directly perform real-time forward inference on the input single-frame noisy spectrum, achieving millisecond-level high-fidelity reconstruction of a single frame without any complex parameter tuning or the need for a clean control spectrum. This invention completely eliminates the physical lag in multi-frame processing and the general technical bias of supervised learning algorithms, achieving true "synchronization between acquisition and display," and significantly improving the real-time processing performance and cross-device automated deployment capabilities of in-situ Raman imaging.

The application belongs to the technical field of biological probes, and relates to a PD-L1 guided specific targeted CTC detection combined with tumor boundary distinguishing biological probe and a preparation method thereof. The PD-L1 guided specific targeted CTC detection combined with tumor boundary distinguishing biological probe comprises a core, a covalent organic framework and a PD-L1 antibody, the core comprises a superparamagnetic nanoparticle, the covalent organic framework is coated on the surface of the core, and the PD-L1 antibody is combined on the surface of the covalent organic framework. The PD-L1 guided specific targeted CTC detection combined with tumor boundary distinguishing biological probe prepared by the application can be transported into the body across the membrane, smoothly enter a PD-L1 positive malignant tumor lesion, and perform Raman imaging to microscopically distinguish the tumor boundary.

This invention relates to the field of photoelectric detection technology and discloses a perovskite charge transport element, which consists of a conductive substrate, an electron transport layer, and a perovskite photosensitive layer. The perovskite charge transport element can be used to fabricate perovskite solar cells. This invention also discloses a method for detecting the effectiveness of charge transport at the electron transport layer / perovskite photosensitive layer interface in a perovskite solar cell. By utilizing the signal intensity of probe molecules in surface Raman imaging, the effectiveness of charge transport at the electron transport layer / perovskite photosensitive layer interface in a perovskite solar cell can be rapidly detected using surface-enhanced Raman spectroscopy. This method can complete the detection without assembling a noble metal back electrode, is simple to operate, low in cost, and exhibits high sensitivity and accuracy.

The invention discloses a near-infrared light triggered nano-drug controlled release integrated system for precise tumor treatment, and relates to the technical field of tumor treatment, and the key points of the technical scheme are as follows: the system comprises a tumor positioning module for precisely positioning a tumor part and obtaining tumor information; the near-infrared light trigger module emits near-infrared light to trigger the nano-drug carrier module to release drugs; the drug release monitoring module monitors the drug release amount and the release rate in real time; and the central control module sends a control signal according to the tumor information and the monitoring data, and adjusts the wavelength, the intensity and the irradiation time of the near-infrared light so as to realize accurate control of drug release. The tumor three-dimensional information is extracted through an image algorithm to realize accurate positioning of the tumor, near-infrared light parameters are dynamically adjusted in combination with drug release monitoring data, accurate regulation and control of drug release are completed, meanwhile, distribution and release of drugs in vivo are tracked through fluorescence or Raman imaging, and the accuracy of drug release is improved. The problems that traditional treatment medicine release is invisible, and the effect is difficult to evaluate are solved.

The invention discloses a micro-plastic organism in-vivo in-situ integrated analysis method based on phthalocyanine blue labeling and Raman imaging, and belongs to environmental toxicology and analytical chemistry technologies. The method comprises the following steps: firstly, exposing organisms to be researched and analyzed in phthalein blue dyed micro-plastic particles; then obtaining exposed biological tissues, preparing paraffin sections and staining the tissues; positioning a biological tissue area under an optical microscope, acquiring a spectrum of the area by adopting a Raman spectrum point scanning mode, and confirming a target area by identifying characteristic Raman peaks of phthalocyanine blue and micro-plastic; raman surface scanning is carried out on a target area, intensity information of characteristic Raman peaks of phthalocyanine blue or micro-plastic is obtained through a peak clamping method, a spatial distribution image of corresponding components in biological tissue is generated, and quantification of the micro-plastic can be achieved. According to the method, the problem that the marking stability of a traditional plastic dyeing method is difficult to be compatible with a standard slide making process is solved, in-situ association of micro-plastic distribution and tissue lesion can be realized, and the method is suitable for accurate detection of submicron micro-plastics.

This invention discloses a low-power laser line-scanning Raman imaging system and method for detecting blood lipids and blood glucose in the nailfold. The system includes: a low-power laser rapid line-scanning light source module for generating a linear light spot and performing rapid line-scanning Raman imaging on the nailfold region; a positioning imaging module for observing the nailfold region under visible light and guiding the line-scanning light spot to be precisely projected onto the non-keratinized area; a Raman signal collection module for collecting Raman scattered light emitted by stimulated emission from the nailfold tissue; a spectral dispersion and detection module for dispersing the Raman scattered light and converting it into an electrical signal; and a data processing and control module for simultaneously extracting blood lipid-related features and / or blood glucose-related features from the Raman imaging data or the spatially averaged aggregated spectrum, and calculating the blood lipid index and blood glucose concentration or relative index respectively. This invention achieves completely non-invasive, safe, and rapid combined detection of blood lipids and blood glucose, suitable for simultaneous screening and home monitoring of people with diabetes and dyslipidemia.

This invention relates to a method, apparatus, device, and medium for single-cell feature analysis based on hyperspectral coherent Raman scattering imaging, used for single-cell feature analysis. The invention provides an apparatus for performing hyperspectral coherent Raman scattering imaging of samples at different Raman shifts; the method performs hyperspectral coherent Raman imaging on samples enriched with cells using medium A, acquiring images and Raman spectra of different substances at multiple Raman shifts; a multivariate curvature resolution method is used to obtain concentration distribution maps of different substances, and an image is obtained after removing medium A; deep learning technology is used to segment single-cell regions, extracting morphological and metabolic features of cells; simultaneously, a spectral phasor method combined with Lorentz fitting is used to extract morphological and metabolic features of single cells and their subcellular structures. This invention solves the problem of medium structure occlusion, resulting in richer extracted morphological and metabolic features of cells, facilitating more accurate differentiation of cell types.

This invention discloses a high-speed Raman imaging method based on physical dimensionality reduction and latent space restoration, comprising: S1, constructing a spectral physical encoder (SPE) module and training the SPE module; S2, constructing a spatial structure restoration (SSI) module and training the SSI module; S3, acquiring the original Raman hyperspectral image I based on sparse sampling. sparse S4. Use the trained SPE module to test I. sparse Compression is performed to output the latent vector map IZ. sparsei S5. Extract Z using the trained SSI module. sparsei Spatial context information in Z, and Z sparsei After repairing the zero-value region, the latent vector map II Z is output. dense_recon S6. Using the SPE decoder corresponding to the SPE module, the low-dimensional feature vector is nonlinearly mapped back to the high-dimensional space to obtain the initial reconstructed image Irecon_raw; S7. Linear calibration is performed on each pixel value in Irecon_raw to obtain the reconstructed hyperspectral image Irecon, completing high-speed Raman imaging. This invention can achieve high-speed, high-fidelity Raman imaging under highly sparse sampling conditions (e.g., 5%-10%).

The invention relates to the technical field of spectral analysis and microscopic imaging, and discloses a dynamic surface scanning Raman imaging system and a spectral data acquisition method, and the system comprises a light beam output module which is used for outputting a collimated laser beam; the device comprises a spatial light modulator, an excitation light path module, a sample stage, a collection light path module, an imaging spectrometer and a control module, the control module generates a corresponding driving signal according to a preset image sequence, and the preset image sequence comprises a plurality of preset excitation images arranged according to a set sequence; controlling a spatial light modulator to generate a corresponding dynamic structure light field through a driving signal, obtaining Raman spectrum data of a plurality of excitation light field distribution diagrams through an imaging spectrometer, and reconstructing and decoupling the Raman spectrum data to obtain Raman imaging cube data. Complete Raman imaging cube data can be reconstructed through a small amount of pattern switching and exposure, and the spectrum acquisition efficiency is greatly improved.

The present application relates to a kind of PLS-based raman imaging method and the quantitative analysis method of polymer material, the imaging method includes (1) start raman testing instrument and calibration;(2) to the sample with single state change is carried out large spot raman test;(3) after using raman spectrum analysis technique to the raman spectrum data obtained in step (2) is preprocessed, using PLS is analyzed, and thus establish state-spectrum model;(4) using the wavelength range where characteristic peak is located carries out raman mapping scanning test;(5) using raman spectrum analysis technique to the mapping result obtained in step (4) is preprocessed, to make mapping scanning data and the model obtained in step (3) compatible;(6) according to the peak intensity of characteristic peak or the model to the mapping scanning data obtained in step (5) is plotted, to obtain distribution diagram.The present application patent broadens raman imaging application field, and it is important to obtain the sample topography and component distribution under microscale.