5results about How to "Improve drug loading capacity" patented technology

The invention provides a drug carrier based on N-acetylglucosamine, a drug preparation and a preparation method. The drug carrier based on N-acetylglucosamine comprises N-acetylglucosamine and a cross-linking agent, the cross-linking agent is a compound with an aldehyde group or a ketone group, and the aldehyde group or the ketone group reacts with the deacetylated N-acetylglucosamine to generate one or more of a hydrazide bond, a hydrazone bond or an imine bond. The drug carrier based on N-acetylglucosamine shows remarkable advantages in the aspects of particle size distribution, drug loading capacity, encapsulation efficiency and cumulative drug release rate.

The present application belongs to the technical field of biological materials, and particularly relates to a microemulsion hydrogel as well as a preparation method and application thereof. The microemulsion hydrogel has a network structure hydrogel, and the network structure hydrogel can improve the solubility of hydrophobic drugs, thereby improving the drug loading capacity of the hydrogel. The drug-loaded hydrogel can slowly and continuously release the drugs at the site of spinal cord injury for repair treatment, avoid side effects caused by excessively high local concentration, and help the repair of movement and nerve function at the injury site. The hydrogel itself can provide a structural scaffold for axon and neuron regeneration for tissue regeneration, and further improve the therapeutic effect of the hydrophobic drugs. Moreover, the preparation method of the microemulsion hydrogel is simple, raw materials are cheap and easy to obtain, and the method is suitable for large-scale production.

This invention discloses a targeted nanodelivery system, its preparation method, and its applications. The targeted nanodelivery system is a pH / ROS-responsive sustained-release system loaded with chlorophyll copper / doxorubicin / NO donors. Specifically, it includes: a carrier material: a polythioacetal formed by the dimethylchlorosilane-catalyzed dehydration condensation of 4-formylphenylboronic acid and 3,6-dioxa-1,8-octanedithiol; a system modification component: DSPE-PEG-methyl; and active ingredients: doxorubicin as a chemotherapeutic drug, sodium chlorophyll copper as a photosensitizer / adjuvant therapy component, and N,N′-disec-butyl-N,N′-dinitroso-1,4-phenylenediamine as a NO donor. This nanodelivery system based on a dual-response mechanism provides a new and effective strategy for the precise and synergistic treatment of gliomas and has the potential for further clinical translation.

The invention discloses a composite sustained-release microsphere and a preparation method and application thereof.The composite sustained-release microsphere is provided with an inner core and a shell layer, the inner core is dsRNA, and the shell layer is made of alginate, carrageenan, modified starch and inulin; wherein alginate and carrageenan cooperate to form a compact interpenetrating polymer network, so that the microspheres are endowed with excellent mechanical strength, stability and drug loading capacity; the modified starch can enhance the toughness and economical efficiency of the microspheres; the inulin serves as a biological response type auxiliary material and can promote absorption of plant cells to the microspheres. The microspheres can effectively resist ribonuclease degradation and provide reliable protection for dsRNA in a complex environment; in addition, the microspheres have the pH response type slow release characteristic, the dsRNA is rapidly released in an alkaline environment, and the dsRNA is slowly released in neutral and acid environments, the characteristic is particularly suitable for prevention and control of pests with middle intestines slightly alkaline, targeted rapid release of the dsRNA in target pests can be achieved, and the drug utilization rate can be increased.

This invention relates to a short peptide and its application as a carrier for hydrophobic drugs. The amino acid sequence of the short peptide is (Y). n -Pro-X-X-Pro-(Y) n The short peptide of this invention can load a variety of hydrophobic drugs through a molecular self-assembly mechanism, forming uniformly sized nanosphere micelles with the hydrophobic drugs. This enables the effective transport of drugs into cells or tissues to exert their therapeutic effects. It is safe with no significant cytotoxicity, and the formulation process is simple, making it a highly promising carrier for hydrophobic drugs.