26results about How to "Improve drug loading capacity" patented technology

The invention belongs to the field of drug preparation, and particularly relates to a preparation method and application of a drug delivery system based on hollow mesoporous polydopamine nanoparticles. The drug delivery system comprises hollow mesoporous polydopamine nanoparticles, a drug loaded inside and / or outside the hollow mesoporous polydopamine nanoparticles, and pectin wrapping the hollow mesoporous polydopamine nanoparticles, the medicine is a medicine with a nerve protection effect and an acetylcholin esterase inhibitor. The drug delivery system can reduce proinflammatory cytokines, regulate functions of target immune cells, synergistically reduce necrosis of neurons in intestinal tracts and induce neural crest stem cells in the intestinal tracts to be differentiated into neurons.

The invention discloses a bullfrog extracted biological collagen composition and a preparation method thereof in the technical field of collagen. The bullfrog extracted biological collagen composition comprises the following components in parts by weight: 1-1.5 parts of hydrophobic bullfrog source collagen peptide, 0.6-0.8 part of hydrophobic bullfrog source elastin peptide, 1-1.5 parts of polyglutamic acid and 1-1.5 parts of polylysine. Collagen and elastin in bullfrog skin and bullfrog cartilage are extracted in a combined mode through a three-enzyme co-production method, and after bullfrog source collagen peptide and bullfrog source elastin peptide are subjected to hydrophobic modification, polyglutamic acid and polylysine are added to form a collagen combination. The stability, the medicine carrying capacity and the slow release capacity of the composition can be improved.

The invention discloses an MQDs-PEI-coated miR43-CMCS / TA composite nanomaterial for preventing and treating plant viruses as well as a preparation method and application of the MQDs-PEI-coated miR43-CMCS / TA composite nanomaterial, and belongs to the technical field of genetic engineering. The composite nano material is prepared from Mxene-QDs, polyetherimide, carboxymethyl chitosan, tannic acid and miR43 nano microspheres, the nano composite material is small in particle size and high in drug loading capacity, has an excellent protection effect and pH release capacity on miR43, can deliver miR43 into a plant body in a spraying mode and the like, and can be used for preparing the miR43 in the plant body by specifically shearing NbIAA29 in the plant. Therefore, replication and infection of the PVY virus and the TMV virus are inhibited, and important significance is achieved on prevention and treatment of the PVY virus and the TMV virus.

The invention relates to a self-healing injectable dual-network hydrogel (GHUS-mPDA at HL) which is used for wound healing and has photo-thermal antibacterial activity and is synthesized on the basis of mesoporous polydopamine nanoparticles (mPDA), thiosemicarbazone (HL), ureido pyrimidone modified gelatin (GHU) and sodium alginate (SA). Sodium alginate and ureido pyrimidone modified gelatin containing quadruple hydrogen bonds have adhesion and antibacterial properties, and the hydrogel is endowed with self-repairing capability, injectability, adhesion and antibacterial properties by crosslinking. Mesoporous polydopamine nanoparticles (mPDA) with a photothermal effect and thiosemicarbazone (HL) with efficient antibacterial ability endow the hydrogel with excellent photothermal antibacterial performance. In addition, the hydrogel has good biocompatibility. Mouse skin incision model experiments show that the GHUS-mPDA-coated HL hydrogel can effectively promote full-thickness wound healing, and the GHUS-mPDA-coated HL hydrogel has great potential in the aspect of promoting wound healing.

The invention relates to a preparation method of a cannabidiol nano-lipid carrier, in particular to a preparation method of a cannabidiol nano-lipid carrier with a transdermal absorption function. The invention aims to solve the problem that the existing cannabidiol lipid carrier cannot have high water solubility and high transdermal absorption function at the same time, and is poor in stability and easy to irritate skin. The method comprises the following steps: 1, weighing raw materials; 2, preparing an oil phase; 3, preparing a water phase; 4, mixing; 5, performing ultrasonic homogenization; 6, cooling; and 7, removing impurities. The preparation method is used for preparing the cannabidiol nano-lipid carrier with the transdermal absorption function.

The invention relates to the technical field of biomedical materials, in particular to a hydrogel microneedle for skin improvement and a preparation method thereof.The hydrogel microneedle for skin improvement comprises a microneedle matrix and fisetin, the microneedle matrix is a hydrogel matrix, and the fisetin is embedded in the microneedle matrix. According to the hydrogel microneedle for skin improvement, the hydrogel microneedle has good mechanical performance, biocompatibility and degradability, the effect of slowly releasing medicine can be achieved, the hydrogel matrix wraps fisetin, the targeting performance of anti-aging active ingredients can be effectively enhanced, and the anti-aging effect of the skin is improved. The anti-aging agent is slowly released in a corium layer to play an anti-aging role, and has a wide application prospect in medical beauty and skin care products.

The invention provides a drug carrier based on N-acetylglucosamine, a drug preparation and a preparation method. The drug carrier based on N-acetylglucosamine comprises N-acetylglucosamine and a cross-linking agent, the cross-linking agent is a compound with an aldehyde group or a ketone group, and the aldehyde group or the ketone group reacts with the deacetylated N-acetylglucosamine to generate one or more of a hydrazide bond, a hydrazone bond or an imine bond. The drug carrier based on N-acetylglucosamine shows remarkable advantages in the aspects of particle size distribution, drug loading capacity, encapsulation efficiency and cumulative drug release rate.

The invention relates to the technical field of polysaccharide nanotechnologies, and discloses a preparation method of ginger paper loaded with polysaccharide nanoparticles, which comprises the following steps: taking hydrophilic plant fibers as a matrix, and taking mica powder modified active carrier particles with expanded micropores and positive ions as a skeleton to obtain a ginger paper fiber energy storage layer; the ginger paper with a three-layer structure including the ginger paper fiber matrix layer, the ginger paper fiber energy storage layer and the medicine carrying film loaded with the polysaccharide nano particles is prepared, active substances such as the polysaccharide nano particles in the energy storage layer pass through a micropore structure of mica, and the medicine carrying film loaded with the polysaccharide nano particles can be used for preparing the ginger paper with the three-layer structure of the ginger paper fiber matrix layer, the ginger paper fiber energy storage layer and the medicine carrying film loaded with the polysaccharide nano particles. By means of a transmission structure of the net-shaped framework, active substances in the medicine carrying film are rapidly activated, the active ingredients are absorbed by the human body, and the effects of outwards discharging moisture and cold and inwards transferring the active ingredients of traditional Chinese medicine in the moxibustion process are achieved.

The application relates to the technical field of drug delivery, in particular to a ZIF-8 / PDA composite material and a preparation method and application thereof. The ZIF-8 / PDA composite material provided by the application has good feasibility in terms of loading and delivering curcumin. The ZIF-8 material is modified by polydopamine, and the loading effect of the ZIF-8 material as a carrier on drugs is improved. The characterization results show that the drug loading performance of ZIF-8@PDA is obviously improved. The in-vitro release experiment results show that CuR@ZIF-8@PDA has more significant pH response drug release characteristics, shows good inhibition on Staphylococcus aureus and Escherichia coli, the hemolysis rate is 3.1%, is within a safe range, the inhibition on HepG2 cells is stronger than that of CuR@ZIF-8, and more obvious oxidative stress reaction and cell apoptosis can be induced.

The invention relates to a bone-promoting antibacterial biological functional material and a preparation method thereof, and belongs to the technical field of laser application. According to the method, the polished nickel-titanium alloy material is subjected to ultrasonic treatment and dried, and a self-organized composite periodic micro-ripple groove structure is prepared by utilizing a femtosecond laser direct writing technology and cooperatively regulating and controlling machining parameters such as laser flux, the moving speed of a machining translation table and the scanning interval in the machining process; performing anodic oxidation treatment to form rich nano holes on the basis of the structure, and preparing to obtain a groove-micro-ripple-micro-pore three-stage micro-nano composite structure; then, the prepared three-stage micro-nano composite structure is put into an alkaline Tris buffer solution containing dopamine hydrochloride to be coated with an agglomerated dopamine coating; and then placing the groove-micro-ripple-micro-pore three-stage micro-nano composite structure coated with the polydopamine coating in a silver nitrate solution to load nano-silver on the surface of the groove-micro-ripple-micro-pore three-stage micro-nano composite structure, and finally preparing the biological functional material with good bone combining capacity, bone growth promoting capacity and antibacterial capacity.

The present invention discloses a patch for treating fungal skin infection and a preparation method thereof, and belongs to the field of biomedical technology and pharmaceutical preparations. The soluble microneedle patch of fluconazole combined with doxycycline of the present invention comprises a base layer and a needle tip layer, wherein the needle tip layer comprises microneedles arranged in an array on the base layer, and fluconazole and doxycycline are loaded in the microneedles, thereby solving the problems of fluconazole drug instability and poor antibacterial effect. At the same time, the base material of the patch of the present invention is mainly chitosan, supplemented by other biocompatible organic high molecular polymers, and has the advantages of high mechanical strength and good formability compared with chitosan alone.

The invention provides an IAA (Indoleacetic Acid)-PAMAM (Polyamidoamine) G4 nano-composite. The nano-composite is prepared by combining 3-indoleacetic acid and a fourth-generation polyamide-amine type dendrimer together in an ultrasonic manner. The invention further discloses a preparation method of the IAA-PAMAM G4 nano-composite and application of the IAA-PAMAM G4 nano-composite in prevention or treatment of chronic obstructive pulmonary diseases. According to the IAA-PAMAM G4 nano compound disclosed by the invention, the water solubility and the stability of 3-indoleacetic acid are effectively improved, and the anti-inflammatory effect of the 3-indoleacetic acid is enhanced. The IAA-PAMAM G4 nano-composite disclosed by the invention can directly act on the lung in an aerosol inhalation manner, so that the inflammatory response is relieved, and the lung function is improved. In a mouse chronic obstructive pulmonary disease model, a remarkable effect is shown, the pathological change of chronic obstructive pulmonary diseases is relieved, and the lung function is remarkably improved. In addition, the IAA-PAMAM G4 nano-composite also shows an inhibition effect on expression of inflammatory factors in an in-vitro cell experiment, and the cell inflammation level is reduced.

The invention relates to a preparation method of block polymer nanoparticles. According to the invention, the quercetin and the pH-sensitive polymer are coated with the PLGA block polymer through an emulsion polymerization method, the pH-sensitive polymer is prevented from premature degradation of the nanoparticles, and the chitosan is used as the outer layer of the nanoparticles; under the combined action of the PLGA block polymer, the pH sensitive polymer and the chitosan, the drug release rate of the nano-particles when the pH value is 1.2 is reduced, so that the nano-particles have lower drug release rate and lower cytotoxicity.

The present invention relates to an antibacterial hydrogel dressing for diabetic wounds and a preparation method thereof, and relates to the field of hydrogel dressings. Sodium alginate is used as a carrier material, and attapulgite is used to improve the mechanical properties of the gel through the principle of fiber toughening, and the loading amount of glucose oxidase can be increased. The glucose oxidase can consume glucose at the wound in situ and generate hydrogen peroxide. The prepared hydrogel dressing can not only effectively consume glucose and alleviate the high-sugar environment of diabetic wounds, but also generate hydrogen peroxide. It can overcome the problem of difficult wound healing caused by the high-sugar environment of diabetes without adding additional antibacterial agents, and also overcome the problems of drug resistance and cytotoxicity of traditional antibacterial gels; the combination of calcium carbonate and GDL described in the present invention can effectively control Ca 2+ The formation rate of sodium alginate-based composite hydrogel is enhanced, which enhances the mechanical properties, drug loading properties and sustained release properties.

The present application belongs to the technical field of biological materials, and particularly relates to a microemulsion hydrogel as well as a preparation method and application thereof. The microemulsion hydrogel has a network structure hydrogel, and the network structure hydrogel can improve the solubility of hydrophobic drugs, thereby improving the drug loading capacity of the hydrogel. The drug-loaded hydrogel can slowly and continuously release the drugs at the site of spinal cord injury for repair treatment, avoid side effects caused by excessively high local concentration, and help the repair of movement and nerve function at the injury site. The hydrogel itself can provide a structural scaffold for axon and neuron regeneration for tissue regeneration, and further improve the therapeutic effect of the hydrophobic drugs. Moreover, the preparation method of the microemulsion hydrogel is simple, raw materials are cheap and easy to obtain, and the method is suitable for large-scale production.

This invention discloses a targeted nanodelivery system, its preparation method, and its applications. The targeted nanodelivery system is a pH / ROS-responsive sustained-release system loaded with chlorophyll copper / doxorubicin / NO donors. Specifically, it includes: a carrier material: a polythioacetal formed by the dimethylchlorosilane-catalyzed dehydration condensation of 4-formylphenylboronic acid and 3,6-dioxa-1,8-octanedithiol; a system modification component: DSPE-PEG-methyl; and active ingredients: doxorubicin as a chemotherapeutic drug, sodium chlorophyll copper as a photosensitizer / adjuvant therapy component, and N,N′-disec-butyl-N,N′-dinitroso-1,4-phenylenediamine as a NO donor. This nanodelivery system based on a dual-response mechanism provides a new and effective strategy for the precise and synergistic treatment of gliomas and has the potential for further clinical translation.

The invention relates to a ginger extracellular vesicle for treating alcoholic liver as well as a preparation method and application of the ginger extracellular vesicle. The ginger extracellular vesicles comprise shogaol in the ginger extracellular vesicles; the content of shogaol in the ginger extracellular vesicles is 8.0 to 14.0 [mu] g / mg. Experimental results show that the ginger extracellular vesicles provided by the invention can obviously improve the morbidity of alcoholic liver, animal liver blood indexes are obviously reduced, the liver necrosis area is obviously reduced, the animal weight is obviously increased, and alcoholic liver diseases can be effectively treated.

The invention relates to a transdermal drug delivery patch matrix, in particular to a high-plasticity-resistance pressure-sensitive adhesive matrix as well as a preparation method and application thereof. The pressure-sensitive adhesive matrix with high plasticity resistance is prepared from the following raw materials in parts by weight: 60 to 90 parts of acrylate soft monomer, 5 to 35 parts of acrylate hard monomer, 10 to 35 parts of acrylate functional monomer and 0.001 to 5 parts of organic silicon monomer. The pressure-sensitive adhesive matrix disclosed by the invention has a high plastic resistance effect, solves the problem of plasticization of the pressure-sensitive adhesive matrix after loading a plurality of drugs, remarkably reduces the cold flow area, has efficient drug loading capability and drug delivery capability, and remarkably improves the plastic resistance of the pressure-sensitive adhesive matrix by adding the organic silicon monomer.

The invention discloses a traditional Chinese medicine massage cream with rapid drug release capability and a preparation method thereof. The traditional Chinese medicine massage cream comprises a traditional Chinese medicine extract and a matrix, the matrix comprises modified sodium polyacrylate, a thickening agent, a humectant, cetostearyl alcohol and deionized water; the modified sodium polyacrylate is prepared by copolymerizing acrylic acid, acrylamide and cationic lignin; the cationic lignin is prepared from alkali lignin, epoxy chloropropane and 3-chloro-2-hydroxypropyl trimethyl ammonium chloride through a reaction. The medicine carrying capacity and the medicine releasing capacity of a matrix can be effectively improved, the infiltration effect of the massage cream can be improved, and then the absorption effect of a human body on traditional Chinese medicine ingredients in the massage process is promoted; meanwhile, the compounded traditional Chinese medicine components can effectively relieve diseases such as rheumatoid arthritis, scapulohumeral periarthritis, bone tuberculosis, cervical vertebra pain, lumbar disc herniation and limb pain and numbness, and can be widely applied to the field of traditional Chinese medicine massage ointment.

The invention relates to the technical field of medical apparatus and instruments, and provides a film-covered drug-loaded stent and a preparation method of the film-covered drug-loaded stent. The inner membrane is strip-shaped, and the outer side of the inner membrane is spirally attached to the inner wall of the stent body; the medicine carrying film is in a strip shape, is arranged on the outer side of the stent body corresponding to the inner film, and is attached to the outer side of the stent body and the inner film; the outer membrane is arranged on the outermost side of the stent, covers the stent body and the medicine carrying membrane and is attached to the part, not attached to the medicine carrying membrane, of the inner membrane, the outer membrane comprises a first area and a second area, the first area comprises the part corresponding to the inner membrane, and the second area comprises the part corresponding to the spiral gap of the inner membrane; the total endothelialization cycle of the second area, the stent body part corresponding to the second area and the inner side of the inner membrane is smaller than the degradation cycle of the first area and smaller than the degradation cycle of the inner membrane. The drug-loaded membrane is wrapped in the inner membrane and the outer membrane, and the outer membrane is divided into different areas, so that rapid endothelialization of the stent is realized, and excessive cell proliferation is avoided.

The invention discloses a solid fat vitamin C microcapsule and a preparation method thereof, and belongs to the technical field of vitamin C microcapsule preparation. Vitamin C is wrapped in a hydrophobic wall material, so that water vapor and oxygen can be effectively isolated, and the product stability is improved. The preparation method has the advantages that the preparation process is simple, the release control effect is achieved, loss caused by leakage in the processing step can be reduced, a mixture of active substances and molten lipid materials is atomized in a cold chamber in a spray condensation mode, the high-temperature preparation environment is avoided, and the heat-sensitive vitamin C is well protected; liquid oil with an unsaturated structure is added into solid lipid, and combination of liquid lipid and solid lipid leads to ordered disorder of a large number of crystals. The obtained lipid particle matrix shows great defects on crystal lattices and leaves enough space for accommodating medicine molecules, so that the medicine carrying capacity of the medicine is improved, and the encapsulation efficiency is effectively improved.

The invention provides a high-stability cough-relieving tangerine peel granule and a preparation method thereof. The cough-relieving tangerine peel granule is composed of an active composition, an auxiliary material and a carrier. The active composition is composed of gypsum, tangerine peel, dried orange peel, coltsfoot flower, French pinellia, tuckahoe, platycodon, bitter almond, aster, perilla seed, trichosanthes peel, rhizoma anemarrhenae, ophiopogon, rehmannia root and liquorice. The auxiliary material is composed of β-glucan, kudzu root polysaccharide, β-carotene and dipalmitoyl phosphatidylethanolamine, and the carrier is modified sodium carboxymethyl cellulose. β-glucan is used as a stabilizer to improve the stability of the drug particles, kudzu root polysaccharide and β-carotene are used as antioxidants to prevent oxidation, dipalmitoyl phosphatidylethanolamine is a synthetic phospholipid, has a single component, is wrapped on the surface of the active composition, improves stability, improves taste, and improves bioavailability, and the modified sodium carboxymethyl cellulose helps to evenly distribute the drug, improves drug loading capacity and biocompatibility, and enhances the dissolution and absorption of the drug.

The invention discloses a therapeutic substance-loaded zwitterionic eye drop which comprises a therapeutic substance, zwitterionic gel and a buffer solution, and the zwitterionic gel comprises a polymer containing a first structural unit and a second structural unit; the invention also discloses a preparation method of the zwitterionic eye drops. The preparation method comprises the following steps: step S100, premixing other components except the therapeutic substance; and step S200, adding the therapeutic substance to prepare the zwitterionic eye drops. According to the invention, the zwitterionic gel is used as a carrier, so that the zwitterionic gel not only has excellent biocompatibility and excellent adaptability to an ionic environment, but also can be better combined with a treatment object to achieve the effect of slow release of the medicine and improve the treatment effect.

The invention relates to a biomedical titanium alloy surface modification method, and belongs to the technical field of laser application. The method comprises the following steps: firstly, machining a groove-micro-ripple composite structure on the surface of a clean and polished nickel-titanium alloy material by using femtosecond laser; then, rich nanosheets are formed on the basis of the structure through alkali heat treatment, and a groove-micro ripple-nanosheet multistage micro-nano composite structure is obtained; then, the multi-stage micro-nano composite structure is put into an alkaline Tris buffer solution containing dopamine hydrochloride to be coated with a polydopamine coating; and finally, the multi-stage micro-nano composite structure coated with the polydopamine coating is placed in a silver nitrate solution to load silver ions, surface modification of the titanium alloy is completed, and the biological activity, the osseointegration capacity and the bacterial infection resistance of the titanium alloy are improved.

The invention discloses a composite sustained-release microsphere and a preparation method and application thereof.The composite sustained-release microsphere is provided with an inner core and a shell layer, the inner core is dsRNA, and the shell layer is made of alginate, carrageenan, modified starch and inulin; wherein alginate and carrageenan cooperate to form a compact interpenetrating polymer network, so that the microspheres are endowed with excellent mechanical strength, stability and drug loading capacity; the modified starch can enhance the toughness and economical efficiency of the microspheres; the inulin serves as a biological response type auxiliary material and can promote absorption of plant cells to the microspheres. The microspheres can effectively resist ribonuclease degradation and provide reliable protection for dsRNA in a complex environment; in addition, the microspheres have the pH response type slow release characteristic, the dsRNA is rapidly released in an alkaline environment, and the dsRNA is slowly released in neutral and acid environments, the characteristic is particularly suitable for prevention and control of pests with middle intestines slightly alkaline, targeted rapid release of the dsRNA in target pests can be achieved, and the drug utilization rate can be increased.

This invention relates to a short peptide and its application as a carrier for hydrophobic drugs. The amino acid sequence of the short peptide is (Y). n -Pro-X-X-Pro-(Y) n The short peptide of this invention can load a variety of hydrophobic drugs through a molecular self-assembly mechanism, forming uniformly sized nanosphere micelles with the hydrophobic drugs. This enables the effective transport of drugs into cells or tissues to exert their therapeutic effects. It is safe with no significant cytotoxicity, and the formulation process is simple, making it a highly promising carrier for hydrophobic drugs.