Amphiphilic block copolymer micelle containing lepidopteron sex pheromone

A lepidopteran, amphiphilic block technology, which is applied in the fields of trapping or killing insects, pest control, animal repellants, etc., can solve health effects, reduce rapid decomposition of sex pheromones, and last limited and other problems, to achieve the effect of less dosage, excellent drug passability, and good stability

Active Publication Date: 2015-12-16
INST OF PLANT PROTECTION FAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Use these materials to make rubber heads, capillary lures, and misty wires (Li Qingyan, Liu Jinlong, Zhao Longlong, et al. 2012. Application of slow-release technology in sex pheromone control of pests [J]. Chinese Journal of Biological Control, 28 (4 ):589-593.), to a certain extent reduced the rapid decomposition of sex pheromones (Lu Pengfei. 2007. Research on the biological basis and application technology of using sex pheromones to control bean moth [D]. Wuhan: Huazhong Agricultural University Doctoral dissertation.), but the duration of use in the field is still limited, and organic solvents will also have a certain impact on the health of lure preparation operators. .Journal of Shanghai Jiaotong University (Agricultural Science Edition), 21(12):52-55.)

Method used

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  • Amphiphilic block copolymer micelle containing lepidopteron sex pheromone
  • Amphiphilic block copolymer micelle containing lepidopteron sex pheromone
  • Amphiphilic block copolymer micelle containing lepidopteron sex pheromone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A preparation of a micellar attractant that embeds the sex pheromone of diamondback moth:

[0034] (1) Dissolve the sex pheromone components of Plutella xylostella in DMF at the ratio of Ald:Ac:OH=25:25:1 to prepare a 5mg / ml solution;

[0035] (2) Add 1ml of diamondback moth sex pheromone solution to 1ml of 1% (M / V) MPEG-PCL (MPEG-PCL: 10mg) DMF solution to obtain a mixed solution;

[0036] (3) Add 8ml of deionized water dropwise under the conditions of 40°C and 1300r / min electromagnetic stirring, and stir for 30min to prepare micelles;

[0037] (4) Divide the prepared micelles into two equal parts, the first group is stored directly in a 10ml centrifuge tube, and the second group is dialyzed with a semipermeable membrane for 24 hours and then stored in a 10ml centrifuge tube;

[0038] (5) The peak areas of 2h and 24h of dialysis were detected by gas chromatography, and the active ingredient content, encapsulation rate and free rate were calculated according to the sta...

Embodiment 2

[0041] A preparation of a micellar attractant that embeds the sex pheromone of diamondback moth:

[0042] (1) Dissolve the sex pheromone components of Plutella xylostella in DMF at the ratio of Ald:Ac:OH=50:5:1 to prepare a 5mg / ml solution;

[0043] (2) Add 0.8ml diamondback moth sex pheromone solution to 2ml 1% (M / V) MPEG-PCL (MPEG-PCL: 20mg) DMF solution to obtain a mixed solution;

[0044] (3) Add 10ml of deionized water dropwise under the conditions of 50°C and 1400r / min electromagnetic stirring, and stir for 40min to prepare micelles.

Embodiment 3

[0046] A preparation of a micellar attractant that embeds the sex pheromone of diamondback moth:

[0047] (1) Dissolve the sex pheromone components of Plutella xylostella in DMF at the ratio of Ald:Ac:OH=5:50:1 to prepare a 5mg / ml solution;

[0048] (2) Add 0.6ml diamondback moth sex pheromone solution to 1.5ml 1% (M / V) MPEG-PCL (MPEG-PCL: 15mg) DMF solution to obtain a mixed solution;

[0049] (3) Under the conditions of 35°C and 1200r / min electromagnetic stirring, 5ml of deionized water was added dropwise, and stirred for 35min to prepare micelles.

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Abstract

The invention relates to an amphiphilic block copolymer micelle containing a lepidopteron sex pheromone, wherein one of a plutella xylostella sex pheromone, a prodenia litura sex pheromone and a beet armyworm sex pheromone is adopted as the lepidopteron sex pheromone. A waterborne block of an amphiphilic block copolymer comprises at least a polyethylene glycol (MPEG) series polymer unit, and a lipophilic block comprises at least a polycaprolactone (PCL) series polymer unit. MPEG-PCL has the good biocompatibility and the good medicine passing ability for small-molecule medicine, is high in medicine loading capacity and good in stability and is a biodegradable and environment-friendly material; in addition, the usage amount of organic solvent is little in the preparation process, so that environment pollution in the usage process is avoided; the lepidopteron sex pheromone is slowly released through pores in the wall, so that the effect of lasting and stable releasing is achieved.

Description

technical field [0001] The invention relates to an insect pheromone-based amphiphilic block copolymer micelle composition, in particular to an amphiphilic block copolymer micelle containing lepidopteran insect sex pheromone. Background technique [0002] diamondback moth [ Plutellaxylostella (L.)] belongs to Lepidoptera Plutella, and is a worldwide pest that damages cruciferous vegetables. There have been many reports at home and abroad about using sex pheromones of diamondback moth to replace traditional chemical insecticides to control diamondback moths, such as using sex pheromones of diamondback moths for population density monitoring, mass trapping and misdirection. The main components of sex pheromones in diamondback moth include cis-11-hexadecenal (Z11-16:Ald), cis-11-hexadecene acetate (Z11-16:Ac) and cis-11-hexadecenal Carbenol (Z11-16:OH). Among them, cis-11-hexadecenal is unstable in the air and is easily oxidized by air. Beet armyworm ( Spodoptera exigua Hu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N37/02A01P19/00A01M1/02A01N25/10A01N31/02A01N35/02
Inventor 魏辉田厚军陈艺欣孙渐盛林硕顾晓军
Owner INST OF PLANT PROTECTION FAAS
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