Drug-loaded embolism microsphere with developing function and preparation method thereof

A technology of embolization and microspheres, applied in the fields of medical developing materials and medical devices, can solve the problems of residual organic solvent, affect the reactivity, complicated operation steps, etc., and achieve the effect of avoiding the use of heavy metal elements, fully reacting, and high safety.

Pending Publication Date: 2020-08-25
科睿驰(深圳)医疗科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this method has cumbersome operation steps, and the microsphere activation process is carried out under the condition of the participation of organic solvents. Due to the network structure properties of microspheres, the penetration and removal of organic solvents are difficult, and there is a risk of organic solvent residues. At the same time, due to this Network steric hindrance, which may affect the reactivity of this covalent link, reducing the imaging properties of the final microspheres

Method used

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  • Drug-loaded embolism microsphere with developing function and preparation method thereof
  • Drug-loaded embolism microsphere with developing function and preparation method thereof
  • Drug-loaded embolism microsphere with developing function and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Example 1: Preparation of Developable Polyvinyl Alcohol Embolization Microspheres

[0062] Step 1: Preparation of reverse phase suspension polymer oil phase

[0063] Using the reverse phase suspension polymerization method, add 100ml of butyl acetate into a four-necked bottle, weigh 1.2g of cellulose acetate butyrate, and dissolve it under the condition of heating and stirring in a constant temperature water bath at 60°C until a uniform oil phase system is formed. The reaction device is an electric stirrer (model JJ-1A) routinely used in the laboratory, and the constant temperature water bath is Changzhou Jintan digital display constant temperature water bath.

[0064] Step 2: Prepare the water phase of the reversed-phase suspension polymerization system

[0065] Prepare an aqueous solution of polyvinyl alcohol with a mass fraction of 10% under the condition of heating in a constant temperature water bath at 90°C for subsequent use;

[0066] Weigh 3.73g of iohexol and...

Embodiment 2

[0070] Example 2: Preparation of Developable Polyvinyl Alcohol Embolization Microspheres

[0071] Step 1: Preparation of reverse phase suspension polymer oil phase

[0072] Using the reverse-phase suspension polymerization method, add 100ml of butyl acetate into a four-necked bottle, weigh 1.5g of cellulose acetate butyrate, and dissolve it under the condition of heating and stirring in a constant temperature water bath at 60°C until a uniform oil phase system is formed. The reaction device is an electric stirrer (model JJ-1A) routinely used in the laboratory, and the constant temperature water bath is Changzhou Jintan digital display constant temperature water bath.

[0073] Step 2: Prepare the water phase of the reversed-phase suspension polymerization system

[0074] Prepare a polyvinyl alcohol aqueous solution with a mass fraction of 15% under the heating condition of a 95°C constant temperature water bath (the constant temperature water bath is Changzhou Jintan digital d...

Embodiment 3

[0079] Example 3: Preparation of Developable Gelatin Embolization Microspheres

[0080] Step 1: Preparation of reverse phase suspension polymer oil phase

[0081] Using the reverse phase suspension polymerization method, add 100ml of liquid paraffin into the four-necked bottle, measure 1.5ml of Span 80 into the four-necked bottle, stir the mixture of liquid paraffin and Span 80 until a uniform oil phase system is formed, The stirring reaction device used is an electric stirrer (model JJ-1A) routinely used in the laboratory.

[0082] Step 2: Prepare the water phase of the reversed-phase suspension polymerization system

[0083] Prepare a gelatin aqueous solution with a mass fraction of 15% under the heating condition of a constant temperature water bath at 50°C (the constant temperature water bath is Changzhou Jintan digital display constant temperature water bath);

[0084] Weigh 1.2g of triiodobenzyl alcohol and dissolve it in 7ml of dimethyl sulfoxide to prepare a triiodob...

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Abstract

The invention relates to a drug-loaded embolism microsphere with a developing function and a preparation method thereof, and belongs to the technical field of medical instruments. The preparation method of drug-loaded embolism microsphere with the developing function under X-rays comprises the following steps of step 1, preparing a reversed-phase suspension polymerization oil phase; step 2, preparing an aqueous phase of a reversed-phase suspension polymerization system; and 3, carrying out reverse suspension polymerization. The method has the advantages that iodide reacts with microsphere hostmolecules in the synthetic reaction process, a steric hindrance effect is avoided, the reaction is more sufficient, the iodine element is uniformly distributed in the microspheres, and a complete andclear development image is formed under X-ray fluoroscopy; the iodine-containing alcohol is used as an X-ray-impermeable substance, so that the safety risk caused by additional addition of an organicsolvent or addition of a toxic and difficult-to-remove organic solvent is avoided; the microspheres are high in hydrophilicity, good in expansion capacity and rapid in adsorption and drug loading capacity and high in drug loading capacity. The preparation method is simple and can be completed through one-time polymerization reaction, and grafting modification and then polymerization reaction arenot needed.

Description

technical field [0001] The invention relates to a drug-loaded embolism microsphere with imaging function and a preparation method thereof, in particular to a preparation and method of an X-ray-opaque drug-loadable embolism microsphere material with imaging function; it belongs to medical equipment, Technical field of medical imaging materials. Background technique [0002] Interventional embolization therapy is under the guidance and supervision of X-ray perspective, through the synergistic effect of micro-guide wire and micro-catheter, embolization drugs are delivered to the target embolized blood vessel, so as to occlude the target artery, block the blood supply of tumor tissue, and cause tumor Ischemia and hypoxia achieve the purpose of inhibiting tumor cell growth, promoting tumor cell necrosis and apoptosis. In recent years, interventional embolization therapy has played an increasingly important role in clinical medicine, and it is being more and more widely used in t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00A61L24/04A61L24/10A61L24/08
CPCA61L24/001A61L24/0015A61L24/046A61L24/08A61L24/104A61L2300/23A61L2300/416A61L2300/602C08L29/04C08L5/08
Inventor 卢金华孙宏涛孙蓬车海波
Owner 科睿驰(深圳)医疗科技发展有限公司
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