An automatic footwear production line with using space saved comprises an automatic vamp glue applying device and an automatic sole glue applying device, wherein the automatic vamp glue applying device and the automatic sole glue applying device are vertically arranged and adjacent to each other, the automatic vamp glue applying device comprises a first conveying belt, a first driving assembly and a first automatic glue spraying control assembly, the first automatic glue spraying control assembly comprises a three-dimensional scanning mechanism, a first treating water drying mechanism, a first glue drying mechanism and a first multi-station hoisting manipulator device, the first multi-station hoisting manipulator device comprises a controller, a first six-freedom-degree manipulator, a first transverse-movement control mechanism, a first spraying gun and a second spraying gun, and the first transverse movement control mechanism comprises a first fixing frame, a first guiding assembly, a first moving table and a first transmission assembly. Due to the automatic footwear production line, it can be guaranteed that the amount of glue sprayed to all the portions of a vamp tends to be consistent, waste of glue is greatly reduced, consistency of the glue spraying effect of vamps is improved, then, it is guaranteed that firmness degree of subsequent adhering between vamps and soles is improved, the service life of footwear is prolonged, and quality of footwear is improved.