302 results about "Adhesion prevention" patented technology

The present invention relates to protein matrix materials and devices and the methods of making and using protein matrix materials and devices. More specifically the present invention relates to protein matrix materials and devices that may be utilized for various medical applications including, but not limited to, drug delivery devices for the controlled release of pharmacologically active agents, encapsulated or coated stent devices, vessels, tubular grafts, vascular grafts, wound healing devices including protein matrix suture material and meshes, skin/bone/tissue grafts, biocompatible electricity conducting matrices, clear protein matrices, protein matrix adhesion prevention barriers, cell scaffolding and other biocompatible protein matrix devices. Furthermore, the present invention relates to protein matrix materials and devices made by forming a film comprising one or more biodegradable protein materials, one or more biocompatible solvents and optionally one or more pharmacologically active agents. The film is then partially dried, rolled or otherwise shaped, and then compressed to form the desired protein matrix device.

The present invention provides a liquid polymer composition which can be implanted into a living mammal and which forms a solid hydrogel by in situ polymerization upon contact with body fluid and tissue. The composition also can be used as a coating on a medical device, or for the formation of a medical device. Formation of a solid implant or coating involves crosslinking of the adhesive with itself and with surrounding tissue. The liquid implant, by itself or in conjunction with various prostheses, can be used for many purposed, including fixation of the urethra for providing treatment for incontinence, and repair of herniations in the abdominal cavity, including rectocele, cystocele, enterocele, and inguinal hernia. The adhesive may be used to establish adhesion prevention during such repairs, in part by coating or being the material of a repair mesh.

A modified starch material for biocompatible hemostasis, biocompatible adhesion prevention, tissue healing promotion, absorbable surgical wound sealing and tissue bonding, when applied as a biocompatible modified starch to the tissue of animals. The modified starch material produces hemostasis, reduces bleeding of the wound, extravasation of blood and tissue exudation, preserves the wound surface or the wound in relative wetness or dryness, inhibits the growth of bacteria and inflammatory response, minimizes tissue inflammation, and relieves patient pain. Any excess modified starch not involved in hemostatic activity is readily dissolved and rinsed away through saline irrigation during operation. After treatment of surgical wounds, combat wounds, trauma and emergency wounds, the modified starch hemostatic material is rapidly absorbed by the body without the complications associated with gauze and bandage removal.

The present invention relates to protein biocoacervates and biomaterials and the methods of making and using protein biocoacervates and biomaterials. More specifically the present invention relates to protein biocoacervates and biomaterials that may be utilized for various medical applications including, but not limited to, drug delivery devices for the controlled release of pharmacologically active agents, coated medical devices (e.g. stents, valves . . . ), vessels, tubular grafts, vascular grafts, wound healing devices including protein suture biomaterials and biomeshes, dental plugs and implants, skin/bone/tissue grafts, tissue fillers, protein biomaterial adhesion prevention barriers, cell scaffolding and other biocompatible biocoacervate or biomaterial devices.

The invention discloses postoperation anti-adhesion hydrogel and a preparing method thereof. The hydrogel is prepared from sodium alginate powder, chitosan powder, acrylamide monomers, N,N'-methylene bisacrylamide, calcium sulfate, ammonium persulfate and N,N,N',N'-tetramethylethylenediamine. The preparing method of the high-strength high-tenacity chitosan and sodium alginate compound hydrogel is easy to operate, parameters are controllable, the materials are easy to obtain, and the solvent is nontoxic or low in toxicity and safe to treat and use; the method integrates advantages of the two natural biological materials, and the requirement for postoperation adhesion prevention of patients and the requirement for nursing care and treatment of medical workers can be met well. The hydrogel is soft, can be attached to the skin easily, has good flexibility and can effectively prevent wound surface adhesion and be degraded and absorbed, secondary trauma is avoided, and the hydrogel is expected to become a novel postoperation anti-adhesion material.

The present invention includes methods for the inhibition of post-operative adhesion formation between tissue surfaces in a body cavity having been subjected to a surgical procedure, which methods involve administering Pemirolast, or an analog thereof, directly to tissue surfaces in the body cavity in amounts and under conditions effective to inhibit formation of adhesions, and to delivery vehicles and compositions suitable for use for local, non-systemic administration of a drug to the body and directly to tissue within a body cavity having been subjected to a surgical procedure.

The invention provides a vacuum milling method for a metal compound plate, which relates to a compound plate production method and comprises the following steps that: 1, circumference lead angle beveled edges are processed on the circumference of the single side of a base plate, and the circumference dimension of a stainless steel plate is smaller than the dimension of the circumference lead angle beveled edges; 2, a right-angle hole is drilled between the lead angle beveled edges; 3, the stainless steel plate is flatly paved on the lead angle beveled edges side of the base plate, in addition, a soldering flux layer is flatly paved between the stainless steel plate and the base plate, and the circumference sealing welding is carried out on a pressure platform; 4, the vacuum pumping is carried out through the right-angle hole of the base plate, and the sealing and plugging is carried out after the vacuum pumping; 5, the two prepositive blank stainless steel surfaces are combined, in addition, a high-temperature adhesion-prevention agent layer is flatly paved between the two prepositive blank stainless steel surfaces, then, separation plates with the same circumference lengths are in dot welding on the circumference, and next, submerged arc welding sealing welding is carried out between the two lead angle beveled edges and the separation plates; 6, a plurality of vent holes are drilled on a sealing and welding ring frame and the separation plates, 7, the hot milling is carried out; and 8, the edge milling separation is carried out. The vacuum milling method has the advantages that the prepositive blank processing and the vacuum pumping are firstly carried out, then, air holes are drilled, excessive air can be exhausted during the milling, and the plate material quality is ensured.

As a wound dressing that includes a perforated material having through-holes, in which the perforated material can be coated with a low-adhesive resin without closing the through-holes, and that has excellent adhesion prevention properties to wounds, provided is a wound dressing 1 that includes a sheet-shaped perforated material 11 having through-holes 111 and a low-adhesive resin 12 with which at least one face of the perforated material 11 is coated without closing the through-holes 111, the perforated material 11 is a knitted fabric or a woven fabric formed of a multifilament, and the perforated material 11 has an average opening area of the through-holes 111 of 0.02 to 1.2 mm² and an average number of through-holes of 40 to 220 cm⁻². By designing the opening area of the through-hole 111 and the number of through-holes 111 in the perforated material 11 within the particular numerical ranges, such a wound dressing can be prevented from adhering to granulation tissues that invade the through-holes 111 and can ensure sufficient permeation properties of exudate through the through-holes 111.

The invention provides a novel biological-material complex patch which is of a laminated structure comprising a basic layer and an additional layer. The novel biological-material complex patch is characterized in that the basic layer is an patch made from an artificial synthetic material; the additional layer is a biological patch made from an extracellular matrix/acellular tissue matrix material, or a synthetic-material patch made from an artificial synthetic biological material or the artificial synthetic biological material and an artificial synthetic degradable material; and the basic layer and the additional layer are integrated through a surgical suture or a medical adhesive or other methods. The biological-material complex patch has the advantages of easiness for peripheral tissue growth and angiogenesis, adhesion prevention, degradability, good infection resistance and the like of the biological material and the advantages of easiness for tissue growth by of a big mesh, excellent infection resistance, difficulty for generating hydrops, non-degradability, high late mechanical strength and durability of the artificial-synthetic-material patch, adopts a simple production method, is more effective after being applied in clinic, and ensures recent and late relapse and infection rates to be lower.

The invention provides a method for improving the brittleness of crispy fruit slices and preventing the adhesion through combining high vacuum with negative pressure pulse microwave drying, and belongs to the technical field of fruit and vegetable food processing. According to the method, the processes for processing the high-vacuum drying crispy fruit slices comprise the steps of fresh fruit selection, cleaning, peeling, denucleation, slicing, color protection, brittleness protection, adhesion prevention, high-vacuum drying, negative pressure pulse microwave later-period short-time drying and package. A recipe adopted in the brittleness protection work procedure comprises 0.01 percent to 6.0 percent of white granulated sugar, 0.01 percent to 5.0 percent of calcium chloride, 0.01 percent to 2.0 percent of pectin and 0.01 percent to 2.0 percent of xanthan gum, the materials are subjected to vacuum osmosis in the combined water solution, and then, the negative-pressure pulse miciowave later-stage short-time drying is combined. A recipe adopted in the adhesion prevention work procedure comprises 0.01 percent to 10 percent of maltodextrin and 0.01 percent to 10 percent of lactose, the materials are soaked for 10 to 300 minutes in combined water solution, and then, the later-stage short-time microwave surface drying is combined. The improved crispy slices have the advantages that the mouth feeling is crispy, the nutrition content is high, the moisture absorption of products during the eating is avoided, and the eating time of the high-vacuum drying crispy fruit slice product is prolonged.

The present invention relates to medicine material technology, and is especially one kind of antiphlogistic medicine and growth factor slow releasing system and its preparation process and application. The prepared nanometer fiber medicine carrying film may be used in surgical operation to resist inflammation as skin tissue engineering rack. As post-operational adhesion resisting film, the present invention is biodegradable and biocompatible and has antiphlogistic effect. At the same time, medicine is combined with growth factor in controlled release speed and used in skin tissue engineering to prevent inflammation and to release growth factor promoting skin cell regeneration and healing simultaneously. The present invention has wide application foreground in post-operational adhesion prevention and skin tissue engineering.

The invention discloses an energy-saving and environment-friendly paper destruction device, which comprises a base, a shredded paper box, a feeding pipe, a destruction frame, a water storage chamber, a water pump, a movable rod, incomplete gears and an anti-hanging wall assembly. When the present invention is in use, the paper is first shredded to obtain shredded paper, and then the shredded paper is wetted and squeezed by a pressing plate, and the paper is deeply destroyed under the action of the first crushing tooth and the second crushing tooth, avoiding the risk of information leakage Potentially dangerous, at the same time, the destroyed paper can be recycled and reused, which is more energy-saving and environmentally friendly than direct incineration; after spraying the shredded paper, the excess water falls from the filter plate and returns to the water storage chamber through the return port, thereby The recycling of water resources is completed; there is also an anti-hanging wall component, which can effectively prevent the shredded paper from adhering to the inner pipe wall of the feeding pipe, and ensure that the shredded paper can be completely destroyed.

A developing device constituted to be capable of reliably making toner flare, and carrying out developing normally in the developing area, by preventing toner from adhering to the toner carrier. A developing device having a toner carrier which is disposed in opposition to a latent image carrier and which carries toner for developing an electrostatic latent image on the latent image carrier, the developing device including: a plurality of electrodes aligned at a predetermined interval within the toner carrier; voltage application means for applying a voltage to the electrodes so that the electric field between the plurality of electrodes varies with time, wherein the electric field between the electrodes causes the toner on the toner carrier to hop and form a cloud; and a toner adhesion prevention member that is provided upstream of a developing area where the latent image carrier is in opposition to the toner carrier and that prevents adhesion of toner to the toner carrier. According to the developing device, it is possible to prevent toner from adhering to the toner carrier, and it is possible to make the toner flare reliably.

A hydrogel tissue adhesive having increased degradation time is described. The hydrogel tissue adhesive is formed by reacting an oxidized polysaccharide with a water-dispersible, multi-arm amine in the presence of a polyol additive, which retards the degradation of the hydrogel. The hydrogel may be useful as a tissue adhesive or sealant for medical applications, including but not limited to, ophthalmic applications such as sealing wounds resulting from trauma such as corneal lacerations, or from surgical procedures such as vitrectomy procedures, cataract surgery, LASIK surgery, glaucoma surgery, and corneal transplants; neurosurgery applications, such as sealing the dura; as a plug to seal a fistula or the punctum; adhesion prevention to prevent undesired tissue to tissue adhesions resulting from trauma or surgery; and as a hemostat sealant.

The water-soluble lubricating oil composition of this invention contains animal fats and oils and/or plant fats and oils, and the nonionic surfactant of polyoxyethylene sorbitol fatty acid ester. The water-soluble lubricating oil composition of this invention is excellent in emulsion stability, and it can reduce environmental pollution. It is suitably as metal processing oils such as cutting oil and plastic working oils, and release agent such as asphalt mixture adhesion prevention agent and concrete release agent.

A polymer material capable of gradient degradation. The polymer material is formed by at least two types of aliphatic polyesters having different degradation velocities, the aliphatic polyesters being arranged in an ascending order or descending order of the degradation velocities and fused together. The polymer material may be manufactured as thread materials, barrier materials, tube materials, and controlled drug release carriers, which specifically comprise sutures, medical dressings, adhesion prevention material, hemostasis material, guided tissue regeneration barriers, tissue repair materials, enhancement surgical meshes, drug carriers, cartilage tissue culture scaffolds, scaffolds, and especially urethral scaffolds.

The invention relates to a bionic in-situ regeneration repair nano sticking patch, which is formed by overlapping an layer A with a cationic group material and a layer B with an anionic group material sequentially, wherein the sticking patch comprises 20 to 80 percent by mass of the A layer with the cationic group material and the balance of the layer B with the anionic group material; layer A with the cationic group material comprises at least one of polysaccharide with a cationic group, protein with the cationic group or opypeptide (polypeptide) with the cationic group; layer B with the anionic group material comprises at least one of polysaccharide with an anionic group, protein with the anionic group or opypeptide (polypeptide) with the anionic group; and the sticking patch comprises not more than 10 percent by mass of added functional factors and/or functional polypeptide. The raw materials used by the invention are materials which can be degraded in vitro and have biocompatibility. The sticking patch is flexible, has good tissue adhesivity, is suitable for concave-convex surfaces of visceral organs, has strong stretching resistance and air pressure resistance, is suitable for application of sticking, sealing, leak stoppage, hemostasia, isolation, repair, adhesion prevention and artificial meninges of defect tissues and can also be used as a slowly-releasing carrier of a medicament and a nano-grade tissue engineering support material.

The invention discloses an environment-friendly marine antifouling coating which comprises the following raw materials in parts by weight: 20-45 parts of epoxy phenolic resin, 0.5-1 part of titanium dioxide, 1-10 parts of a biological antifouling agent, 5-10 parts of titanium white, 3-8 parts of kaolin, 8-15 parts of mica powder, 18-28 parts of a solvent, 0.05-1 part of an anti-settling agent and 0.05-1 part of a wetting dispersant. Capsaicine in the biological antifouling agent has a very good avoidance effect on marine organisms; sodium benzoate and gallotannic acid have effective adhesion inhibition effects on barnacles and have paralyzing effects on beetles; shogaol has a very good adhesion prevention effect on mussels and cannot injure mussels, and the adhesion prevention effect of the shogaol is 4 times that of copper sulfate; P-cinnamic acid sulfate has a very good adhesion inhibition effect on marine bacteria and the barnacles, cannot cause any injury to the marine organisms, and is pure natural and pollution-free.

The invention relates to the technical field of medicine, in particular to a composite scaffold material and a preparation method and application thereof. The provided composite scaffold material includes a charged fiber skeleton material, and the fiber skeleton material is coated with alternately superimposed positive charge biocompatibility materials and negative charge biocompatibility materials through electrostatic attraction. As the fiber skeleton material is coated with the alternately superimposed positive charge biocompatibility materials and negative charge biocompatibility materialsthrough electrostatic attraction, the provided composite scaffold material overcomes the defects of an existing scaffold material, such as poor hydrophilicity, poor biocompatibility, poor histocyte adhesion ability and weak biological induction activity, has better applicability when used in tissue adhesion, sealing, leaking stoppage, hemostasis, isolation, repair and adhesion prevention and thelike, and can be used for preparation of carriers (such as sustained release carriers) of drugs, tissue engineering scaffold materials and the like, and thus the composite scaffold material can be widely used.