Biological-material complex patch

Abstract

The invention provides a novel biological-material complex patch which is of a laminated structure comprising a basic layer and an additional layer. The novel biological-material complex patch is characterized in that the basic layer is an patch made from an artificial synthetic material; the additional layer is a biological patch made from an extracellular matrix / acellular tissue matrix material, or a synthetic-material patch made from an artificial synthetic biological material or the artificial synthetic biological material and an artificial synthetic degradable material; and the basic layer and the additional layer are integrated through a surgical suture or a medical adhesive or other methods. The biological-material complex patch has the advantages of easiness for peripheral tissue growth and angiogenesis, adhesion prevention, degradability, good infection resistance and the like of the biological material and the advantages of easiness for tissue growth by of a big mesh, excellent infection resistance, difficulty for generating hydrops, non-degradability, high late mechanical strength and durability of the artificial-synthetic-material patch, adopts a simple production method, is more effective after being applied in clinic, and ensures recent and late relapse and infection rates to be lower.

Description

【Technical field】 [0001] The invention relates to a novel biomaterial composite patch for repairing various tissue defects, and is mainly used for repairing abdominal wall defects clinically. 【Background technique】 [0002] A certain organ or tissue in the body leaves its normal anatomical part and enters another part through a congenital or acquired weak point, defect or gap, which is called a hernia (Hernia). Hernias can occur in the brain, chest, and abdomen, but most occur in the abdomen, including external abdominal hernias and internal abdominal hernias, and external abdominal hernias are the most common in clinical practice. External abdominal hernia is formed by the organs or tissues in the abdominal cavity, together with the peritoneal wall, protruding to the body surface through the weak points or pores of the abdominal wall. The clinical types include inguinal hernia, femoral hernia, umbilical hernia, white line hernia, semilunar line hernia, Pelvic floor hernia,...

AI Technical Summary

Problems solved by technology

Although it has been proved to be the most popular implant in the field of surgical implants today, there are some problems in the application of polypropylene mesh: first, when it is used for the repair of full-thickness abdominal wall defects, the mesh must be in contact with the internal organs. Tissue isolation, if it is in direct contact with internal organs, it can cause severe abdominal adhesions, digestive tract obstruction, and may even erode the intestinal wall, causing intestinal fistula, increasing the pain of the patient and even requiring a second operation to remove the patch

[0007] Acellular tissue matrix / extracellular matrix bio-patch is the current clinical application trend and research hotspot. Biomaterials are easy to grow into surrounding tissues and angiogenesis, anti-adhesion, degradable, and have good ability to tolerate infection, etc. Compared with other commonly used artificial synthetic materials in clinical practice, it has great advantages, but when it is applied to the repair or reconstruction of huge abdominal wall defects, its lack of long-term strength may limit its clinical application, especially for the repair of huge defects. This disadvantage is more prominent, which may lead to an increased recurrence rate after surgery

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